Tag Archives: Alzheimer’s Disease

Deep Brain Stimulation for Improving Symptoms in Alzheimer’s Disease (BBC News)

Posted on January 30, 2018 by Dementia and Elderly Care News

Summary A brief BBC News item explores the potential of deep brain stimulation (DBS) therapy for improving wellbeing and cognitive function in patients with Alzheimer’s Disease and other forms of dementia. “Although we are not talking about treating the Alzheimer’s … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Alzheimer's Disease, Andres Lozano (Neurosurgeon), Brain Imaging, Canada, Deep Brain Stimulation, Deep Brain Stimulation (DBS), Deep Brain Stimulation for the Treatment of Alzheimer Disease, Deep Brain Stimulation for the Treatment of Dementia, Deep Brain Stimulation of Nucleus Basalis of Meynert (NBM DBS), Dr Carol Routledge: Alzheimer's Research UK, LaVonne Moore, Neurodegeneration, Neurodegenerative Diseases, Neurological Disease, Nucleus Basalis of Meynert, Nucleus Basalis of Meynert (NBM), Ohio State University Wexner Medical Center, Parkinson’s Dementia, Parkinson’s Disease Dementia, Treatment of Alzheimer's Disease, United States, USA, Wexner Medical Center: Ohio State University | Leave a comment

The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)

Posted on December 15, 2017 by Dementia and Elderly Care News

Summary An experimental drug for the treatment of Huntington’s Disease shows early signs of being able to lower the level of misfolded proteins (safely) in the brains of patients, thereby having the potential to slow or halt the progression of … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, UK, Universal Interest | Tagged Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Antisense Oligonucleotides (ASO), Biomedical Research Centres (NIHR), Canada, Clinical Trial NCT02519036, Gene Silencing to Suppress Transcription and Translation of Huntingtin, Gene-Silencing, Genetic Research, Genetics, Germany, Huntingtin Protein, Huntingtin Protein (HTT), Huntington Disease, Huntington's Disease (HD): an Autosomal-Dominant Inherited Neurodegenerative Disorder, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, Ionis Pharmaceuticals, IONIS-HTTRx: Huntingtin-Lowering Drug, α-Synuclein, α-Synuclein Aggregation, Leonard Wolfson Experimental Neurology Centre (LWENC), Leonard Wolfson Experimental Neurology Centre: University College London, Misfolded Proteins, Mutant HTT (mHTT) Protein, Mutant Huntingtin (mHTT), National Institute for Health Research (NIHR), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuronal Loss, Neuroprotection, Prof. Giovanna Mallucci, Professor Sarah Tabrizi: IONIS-HTTRx Global Chief Investigator, Professor Sarah Tabrizi: UCL Institute of Neurology, Protein Misfolding, Roche, Synucleinopathy, Tau, Tau Protein, Tauopathy, University College London (UCL), University College London Hospitals Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust / University College London (NIHR) Biomedical Research Centre | Leave a comment

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Posted on April 20, 2017 by Dementia and Elderly Care News

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Prion Protein, Alzheimer's Disease, Alzheimer's Research UK, Alzheimer’s Drug Discovery Foundation, Alzheimer’s Research UK (ARUK), Alzheimer’s Research UK Drug Discovery Institute, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, BBC Health News, Behind the Headlines, Brain (Journal), Centre for Analytical Bioscience: University of Nottingham, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Clinical Neurosciences: University of Cambridge, Dibenzoylmethane, Dibenzoylmethane (DBM): Potential Anti-Cancer Drug, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr David Dexter: Parkinson's UK, Dr Doug Brown: Director of Research and Development at Alzheimer's Society, Drug Discovery Programmes, eIF2a-P-Mediated Translational Repression (Pathway of Neurodegeneration), Frontotemporal Dementia (FTD), Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council’s (MRC) Toxicology Unit, Microscopic Worms, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, MRC: Medical Research Council, Multiple Sclerosis, National Institute for Neurological Disorders and Stroke, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Parkinson's, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Prion Diseases, Prion Protein (PrP(C)), Prion-Infected Mice, Prof. Giovanna Mallucci, Professor Giovanna Mallucci: Associate Drector of UK Dementia Research Institute, Protein Misfolding, Rare Prion Diseases, Repurposing of Drugs, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Trazodone, Trazodone Hydrochloride (Antidepressant), UK Dementia Research Institute, UK Dementia Research Institute (UK DRI), Unfolded Protein Response (UPR), University of Cambridge, University of Leicester, University of Nottingham, Worms: C. elegans | Leave a comment

Fourth Annual Deep Brain Stimulation (DBS) Think Tank (Frontiers in Integrative Neuroscience / International Journal of Neuroscience)

Posted on December 15, 2016 by Dementia and Elderly Care News

Summary An annual round-up of developments in the field of Deep Brain Stimulation (DBS). (x3). Full Text Link Reference Deeb, W. Giordano, JJ. [and] Rossi, PJ. [et al] (2016). Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: a … Continue reading →

Exploring the Relationship Between Worsening Depression and Increased Dementia Risk (BBC News / Lancet Psychiatry / JGCR)

Posted on May 1, 2016 by Dementia and Elderly Care News

Summary Researchers in the Netherlands, following 3325 adults aged over 55 years for 11 years, have discovered an association between symptoms of depression which increase steadily over time in older adults and a greater likelihood of developing early signs of … Continue reading →

Posted in BBC News, Depression, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Mental Health, Quick Insights, Statistics, Universal Interest | Tagged Alzheimer's Disease, Association Between Worsening Depression and Increased Dementia Risk, Australia, BBC Health News, Center for Epidemiology Depression Scale (CES-D), Conversion to Dementia From Prodromal Disease, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction and Prevention, Department of Developmental Disability and Centre for Healthy Brain Ageing: University of New South Wales, Department of Epidemiology: Erasmus Medical Center, Department of Neurology: Erasmus Medical Center, Department of Psychiatry: Erasmus Medical Center, Department of Psychiatry: King George’s Medical University (India), Department of Radiology: Erasmus Medical Center, Depression and Dementia, Depression in Adults, Depression in Dementia: Risk Factors, Depression in Older People, Depressive Symptoms, Depressive Symptoms (Five Trajectories), Disease Predictors, Early Dementia, Epidemiology, Epidemiology and Statistics, Erasmus Medical Center (Rotterdam), Erasmus University Medical Center, Etiopathogenesis Model of Depression in Dementia, Faculty of Medicine: University of New South Wales, Five Trajectories of Depressive Symptoms, Hospital Anxiety and Depression Scale-Depression, Hypothetical Prodromes of Dementia, Increasing Depressive Symptoms, Increasing Depressive Symptoms Associated with a Higher Risk of Dementia, Increasing Depressive Symptoms: Statistical Prodrome of Dementia, India, Journal of Geriatric Care and Research (JGCR), King George’s Medical University (India), Lancet Psychiatry, Latent Class Trajectory Modelling, Netherlands, Netherlands Ministry for Health Welfare and Sports, Netherlands Ministry of Education Culture and Science, Overlapping Risk Factors, Patterns of Depression, Prodromal Alzheimer's Disease, Risk Factors, Risk Factors of Depression and Dementia in Elderly, Risk Prediction and Stratification, Rotterdam (Netherlands), School of Psychiatry: University of New South Wales, Trajectories of Depression, Trajectories of Depressive Symptoms and Risk of Dementia, University of New South Wales, Worsening Depression, Worsening Depression and Elevated Dementia Risk | Leave a comment

Severe, Persistent and Fatal Delirium (Dementia and Geriatric Cognitive Disorders Extra)

Posted on August 8, 2015 by Dementia and Elderly Care News

Summary Delirium is typically a transient syndrome, but this study concentrates on severe persistent and potentially fatal delirium. Just 15 cases are considered, involving diverse diagnoses including Alzheimer’s Disease, dementia with Lewy bodies, Creutzfeldt-Jakob disease and progressive supranuclear palsy. Full … Continue reading →

Posted in Acute Hospitals, Delirium, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Quick Insights | Tagged Academic Medical Center: University of Amsterdam, Alzheimer's Disease, Amsterdam, Confusion, Confusion (Delirium), Creutzfeldt-Jakob Disease, Creutzfeldt-Jakob Disease (CJD), Delirium and Dementia With Lewy Bodies, Delusions, Dementia and Geriatric Cognitive Disorders Extra, Dementia in Creutzfeldt-Jakob disease, Dementia with Lewy Bodies, Dementia With Lewy Bodies (DLB), Department of Neurology: University of Amsterdam, DLB: Dementia with Lewy Bodies, Fatal Delirium, Hallucinations, Institution for Mental Health Care 'Dijk en Duin' (Netherlands), Netherlands, Neurodegeneration, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurological Conditions, Neurological Disease, Neuropathology, Parnassia Groep, Persistent Delirium, Progressive Supranuclear Palsy, Psychogeriatric Observation Unit: Institution for Mental Health Care 'Dijk en Duin', Severe Delirium, Severe Persistent and Fatal Delirium, University of Amsterdam | Leave a comment

Novel Approach to Prevention of Alzheimer’s Disease Explored in Laboratory (Express / PloS One)

Posted on May 4, 2015 by Dementia and Elderly Care News

Summary Researchers at the University of California, San Diego, have explored a different approach to mainstream research into the prevention of Alzheimer’s Disease. It is believed that Alzheimer’s Disease develops when amyloid precursor protein (APP) gets cut-up by enzymes and … Continue reading →

Posted in Animal Studies, For Doctors (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights | Tagged Aβ40, Aβ42, Alzheimer's Disease, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid Precursor Protein, ß-amyloid, Beta-Amyloid, Binding Affinity Measurement by Biolayer Interferometry, Candidate Drugs for Alzheimer's Disease, Confocal Microscopy, Cultured Jurkat Cells, Department of Biology: University of California San Diego, Department of Medicine: University of California San Diego, Department of Neuroscience Imaging Core: University of California San Diego, Department of Neurosciences: University of California-San Diego, Disease Modifying Treatment by 2025 (Aim), Experimental Therapeutic Approaches to Reduce ß-Amyloid (Alzheimer’s Disease), Express (Newspaper), FortéBio, Genetically Engineered Mice, Human Neuroblastoma Cell-Line IMR-32 (ATCC CCL-127), β-Amyloid (Aβ) Accumulation, β-Amyloid Precursor Protein (APP), Mouse Model of Alzheimer's Disease, Notch Intracellular Domain (NICD), P4 and P8: Protein Site-Specific Small Peptides to Reduce Aβ Production, Pall Corporation, Peptides of Presenilin-1, Peptides P1 Through P10, PLoS One, Presenilin, Specific Binding of P4 and P8 to APP, Transgenic Mice, United States; Cenna Biosciences Incorporated, University of California, University of California San Diego, USA | Leave a comment

Drug Alteration to Brain’s Immune System Prevents Mice Developing Alzheimer’s Dementia? (BBC News / Journal of Neuroscience)

Posted on April 17, 2015 by Dementia and Elderly Care News

Summary Latest research evidence, from Duke University in the US, suggests that the immune system plays a part in the development of Alzheimer’s Disease (in mice). It appears that immune cells which attack nutrients in the brain may be an … Continue reading →

Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Alzheimer's Disease, Amino Acid Deprivation, Arginase, Arginine, Arginine Catabolism, Arginine Deprivation, BBC Health News, Causes of Alzheimer's Disease, CVN-AD Mouse Model of Alzheimer’s Disease, Department of Immunology: Duke University Medical Center, Department of Laboratory Medicine: University of Washington, Department of Medicine: Duke University Medical Center, Department of Neurobiology and Anatomy: West Virginia University School of Medicine, Department of Neurology: Duke University Medical Center, Duke University, Duke University Medical Center, Duke University Medical Center (North Carolina), Extracellular Arginase, Immune Suppression, Immune System, Immunohistochemistry, Immunology, Immunosuppressive CD11c+ Microglia, Inflammation, Inhibition of Arginase, Journal of Neuroscience, Local Immune Suppression, Local Immune-Mediated Amino Acid Catabolism, Mice, Microglia, Mouse Model of Alzheimer's Disease, Neuroinflammation, Ornithine Decarboxylase, Potential Cause for Alzheimer’s Disease: Arginine Deprivation, Proinflammatory Factors, United States, University of Washington, USA, West Virginia University School of Medicine | Leave a comment

Alzheimer’s Disease: Persistent Perplexity (BMJ)

Posted on July 14, 2014 by Dementia and Elderly Care News

Summary A recent British Medical Journal article examines what is known, and remains uncertain, about the pathogenesis of Alzheimer’s Disease. It also touches on the difficulty of diagnosis, and current prospects for disease-modifying treatments. Full Text Link (Note: This article … Continue reading →

Posted in Acute Hospitals, Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Non-Pharmacological Treatments, Pharmacological Treatments, Quick Insights, Systematic Reviews, UK | Tagged Alzheimer's Disease, Alzheimer’s Disease Biomarkers, Alzheimer’s Disease: Causes, BMJ, British Medical Journal (BMJ) | Leave a comment

Pharmacological Treatments for Alzheimer’s Disease in Primary Care / Management of Cognitive Symptoms (DTB / Nursing Times)

Posted on June 16, 2014 by Dementia and Elderly Care News

Summary A Drug and Therapeutics Bulletin (DTB) article reviews the evidence concerning drugs prescribed for cognitive symptoms in Alzheimer’s Disease and discusses some issues in their prescription. Donepezil, galantamine and rivastigmine are licensed for mild to moderate Alzheimer’s Disease in … Continue reading →

Posted in Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Management of Condition, Models of Dementia Care, NICE Guidelines, Pharmacological Treatments, Practical Advice, Quick Insights, UK | Tagged Acetylcholinesterase Inhibitors (AChEIs), AChEIs, Alzheimer's Disease, Anti-Dementia Medication, Aricept, BMJ Publishing Group Ltd, Cognitive Symptoms, Donepezil, Drug and Therapeutics Bulletin (DTB), DTB, Ebixa, Eisai Ltd, Exelon, Galantamine, Management of Cognitive Symptoms, Memantine, Memantine Hydrochloride, Memory Clinic Services: Nurse Prescribing, National Institute for Health and Care Excellence (NICE), Nurse Prescribing, Nursing Times, Primary Care, Reminyl, Rivastigmine | Leave a comment

Tag Archives: Alzheimer’s Disease

Deep Brain Stimulation for Improving Symptoms in Alzheimer’s Disease (BBC News)

The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Fourth Annual Deep Brain Stimulation (DBS) Think Tank (Frontiers in Integrative Neuroscience / International Journal of Neuroscience)

Exploring the Relationship Between Worsening Depression and Increased Dementia Risk (BBC News / Lancet Psychiatry / JGCR)

Severe, Persistent and Fatal Delirium (Dementia and Geriatric Cognitive Disorders Extra)

Novel Approach to Prevention of Alzheimer’s Disease Explored in Laboratory (Express / PloS One)

Drug Alteration to Brain’s Immune System Prevents Mice Developing Alzheimer’s Dementia? (BBC News / Journal of Neuroscience)

Alzheimer’s Disease: Persistent Perplexity (BMJ)

Pharmacological Treatments for Alzheimer’s Disease in Primary Care / Management of Cognitive Symptoms (DTB / Nursing Times)

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