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Tag Archives: Amyloid Proteins
Cerebral Amyloid Angiopathy (JGCR)
Summary Cerebral Amyloid Angiopathy (CAA) is characterised mainly by impaired perceptual speed, episodic memory, semantic memory, attention and executive function. It has much in common with global cognitive impairment, and diagnosis may overlap with that for Alzheimer’s Disease or other … Continue reading
Posted in Depression, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Quick Insights, Universal Interest
Tagged Ageing Population, Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Boston Radiological Criteria for Probable CAA, Cerebral Amyloid Angiopathy, Cerebral Amyloid Angiopathy (CAA), Cerebral Amyloid Angiopathy (CAA): Clinical Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychiatric Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychopathology, Cerebral Amyloid Angiopathy: Neuropsychiatric Patterns, Cerebral Amyloid Angiopathy: Psychiatric Presentations in Old Age, Cognitive Impairment, Computed Tomography (CT) Scan, Dementia and Cognitive Impairment, Differential Diagnosis, Impulsivity, Journal of Geriatric Care and Research (JGCR), Magnetic Resonance Imaging (MRI) Scan, Neurodegenerative Diseases, Neurodegenerative Disorders, New Zealand, Waitemata District Health Board (Auckland)
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The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)
Summary An experimental drug for the treatment of Huntington’s Disease shows early signs of being able to lower the level of misfolded proteins (safely) in the brains of patients, thereby having the potential to slow or halt the progression of … Continue reading
Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, UK, Universal Interest
Tagged Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Antisense Oligonucleotides (ASO), Biomedical Research Centres (NIHR), Canada, Clinical Trial NCT02519036, Gene Silencing to Suppress Transcription and Translation of Huntingtin, Gene-Silencing, Genetic Research, Genetics, Germany, Huntingtin Protein, Huntingtin Protein (HTT), Huntington Disease, Huntington's Disease (HD): an Autosomal-Dominant Inherited Neurodegenerative Disorder, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, Ionis Pharmaceuticals, IONIS-HTTRx: Huntingtin-Lowering Drug, α-Synuclein, α-Synuclein Aggregation, Leonard Wolfson Experimental Neurology Centre (LWENC), Leonard Wolfson Experimental Neurology Centre: University College London, Misfolded Proteins, Mutant HTT (mHTT) Protein, Mutant Huntingtin (mHTT), National Institute for Health Research (NIHR), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuronal Loss, Neuroprotection, Prof. Giovanna Mallucci, Professor Sarah Tabrizi: IONIS-HTTRx Global Chief Investigator, Professor Sarah Tabrizi: UCL Institute of Neurology, Protein Misfolding, Roche, Synucleinopathy, Tau, Tau Protein, Tauopathy, University College London (UCL), University College London Hospitals Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust / University College London (NIHR) Biomedical Research Centre
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Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)
Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Non-Pharmacological Treatments, Quick Insights, Universal Interest
Tagged 40 Hz Light-Flickering Regime, Amyloid, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid Deposits, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Amyloid-β Protein, BBC Health News, Broad Institute of Harvard and MIT, Department of Brain and Cognitive Sciences: Massachusetts Institute of Technology, Departments of Biological Engineering and Brain and Cognitive Sciences: Massachusetts Institute of Technology, Flashing Light Therapy, Gamma Frequency Entrainment: Attenuation of Amyloid Load, Gamma Frequency Light, Gamma Light Oscillations (20-50 Hz), Gamma Rhythms, Immune Cells (Microglia), Institute of Medical Engineering and Sciences: Massachusetts Institute of Technology, Light Therapy, Light Therapy for Dementia, Massachusetts General Hospital (Boston), Massachusetts Institute of Technology, Massachusetts Institute of Technology (MIT), McGovern Institute for Brain Research: Massachusetts Institute of Technology, Mice, Microglia, MIT Media Lab: Massachusetts Institute of Technology, Nature, Non-Invasive 40 Hz Light-Flickering Regime, Picower Institute for Learning and Memory: Massachusetts Institute of Technology, Rodents, Strobe Light Therapy, Transgenic Mice, United States, USA
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Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)
Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading
Posted in BBC News, For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Alzheimer’s and Dementia (Journal), Alzheimer’s Disease Clinical Trials, Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Avid Radiopharmaceuticals (Philadelphia), BBC Health News, Big Pharma, Clearance of Amyloid Beta Protein, Drug Trials, Drug Trials Failure Rate, Eli Lilly, Eli Lilly and Company (Indianapolis), EXPEDITION Studies, Intervention Trials, β-amyloid, LZAM, LZAN, Mild Alzheimer’s Disease, Misfolded Proteins, Neurofibrillary Tangles, Neuronal Loss, Progression of Mild Cognitive Impairment to Dementia, Progression to Alzheimer's Disease, Reasons for Termination of Trials, Solanezumab (Eli Lilly), Solanezumab EXPEDITION Trials, Solanezumab for Mild-to-Moderate Alzheimer’s Disease, Solanezumab Trials, Solanezumab: Humanised Monoclonal Antibody, United States, USA
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Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)
Summary Further evidence points to a theoretical risk of Alzheimer’s Disease being potentially transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). Full Text Link Reference New clues that Alzheimer’s may have been spread during surgery. London: NHS … Continue reading
Posted in Acute Hospitals, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease Contracted Via Brain Surgery, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Austria, Behind the Headlines, Brain Parenchymal Aβ Plaques, Cleaning and Decontamination, Congophilic Amyloid Angiopathy, Contaminated Surgical Instruments, Decontamination of Surgical Instruments, Dural Grafting, Human Transmission of Aβ, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Institute of Neurology: Medical University Vienna, Institute of Neuropathology: University Hospital Zurich, Medical University Vienna, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Surgical Transmission of Prions, Swiss Medical Weekly, Switzerland, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible Spongiform Encephalopathy Agents: General Principles of Decontamination and Waste Disposal, University Hospital Zurich
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