Tag Archives: Amyloid

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

Summary Research published in the Neurology journal claims a significant breakthrough in the development of a blood test (for plasma Aβ42/Aβ40) which may be able to predict Alzheimer’s Disease onset with 94% accuracy. Due caution: “But it’s important to note … Continue reading

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Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)

Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading

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BBC iWonder Guide: How Close Are We to Stopping Alzheimer’s Disease? (BBC News)

Summary The BBC’s iWonder Guides provide “thought-provoking answers to the questions sparked by everyday life”. This particular collection of brief digestible articles, animations and videos covers: A frightening prospect (epidemiological statistics). How the disease affects your brain cells (an interactive … Continue reading

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Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)

Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading

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Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

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Dietary Exposure to Environmental Toxin Triggers Neurodegeneration? (BBC News / Royal Society Proceedings B Journal)

Summary Exposure to a toxin, Beta-N-methylamino-L-alanine (BMAA), from algae may be linked to dementia. This finding could offer fresh clues for the possible causes of the condition and potential future treatments. Research suggests that provision of L-serine in the diet … Continue reading

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Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)

Summary Further evidence points to a theoretical risk of Alzheimer’s Disease being potentially transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). Full Text Link Reference New clues that Alzheimer’s may have been spread during surgery. London: NHS … Continue reading

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