Tag Archives: Amyloidopathy

Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Early Signs of a Historic Breakthrough in the Treatment of Alzheimer’s Disease? (BBC News / Nature)

Summary Early results, based on small numbers of patients in a Phase I trial, indicate unprecedented progress in the development of a pharmacological treatment of Alzheimer’s Disease. The drug Aducanumab appears to combat (and reverse) the build-up of amyloid protein … Continue reading

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Models of Dementia Care, Pharmacological Treatments, Quick Insights, Scotland, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

EPPS Clears Amyloid Plaques in Mice: Alzheimer’s Disease Potentially Reversible? (BBC News / NHS Choices / Nature Communications)

Summary Korean researchers have identified a chemical (EPPS) which appears to be capable of clearing amyloid plaques from the brains of transgenic mice. The amount of plaques present in these animals’ brains was reduced in treated mice, and the treated … Continue reading

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Treatment of Visual Hallucinations in Neurodegenerative Diseases (Future Neurology)

Summary Treatment of visual hallucinations in neurodegenerative disorders is at an early stage of development due to the underlying mechanisms being imperfectly understood. The authors consider various potential approaches to developing treatments, but caution readers that any single treatment is … Continue reading

Posted in Acute Hospitals, Antipsychotics, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Management of Condition, Mental Health, Models of Dementia Care, NHS, Non-Pharmacological Treatments, Patient Care Pathway, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment