Tag Archives: ApoE e4 Allele

Genetic Mutation Which Delays Alzheimer’s Disease? (NHS Choices / Molecular Psychiatry)

Summary A study of 71 persons from an extended family (comprising around 5,000 people) in northern Colombia, who carry a mutation in a gene called PSEN1 (the so-called the Paisa mutation, which causes a rare, severe form of early-onset Alzheimer’s disease), … Continue reading

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Non-Alzheimer’s Dementias: Three Reviews (Lancet)

Summary The Lancet has published a series of three up-to-date reviews concerning non-Alzheimer’s dementia. Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access). Reference Dementia – not all about Alzheimer’s. [Editorial]. … Continue reading

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Patient Care Pathway, Person-Centred Care, Pharmacological Treatments, Quick Insights, Statistics, Systematic Reviews, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | 1 Comment

Blood Test Could Assist Early Diagnosis of Alzheimer’s Disease (BBC News)

Summary Researchers at the University of Nottingham are developing a quick and easy blood test to detect proteins linked strongly with Alzheimer’s Disease, such as amyloid and APOE, in combination with other markers linked to inflammation. The test has not been fully validated yet, and could be … Continue reading

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Hormone Replacement Therapy to Slow Dementia Onset? (NHS Choices / PLoS One)

Summary This NHS Choices critical appraisal examines press coverage of recent research which investigated the relationship between the genetic variant APOE-e4 (which increases the risk of developing Alzheimer’s Disease), hormone replacement therapy (HRT) and telomere length (an indicator of cell … Continue reading

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Alzheimer’s Brain Plaques Cleared Rapidly by Cancer Drug in Mice (BBC News / NHS Choices)

Summary Clumps of a protein called beta-amyloid are a feature of Alzheimer’s Disease. The clearance of these plaques is widely thought to be a promising target for Alzheimer’s research. It has now been found that the destructive plaques found in the … Continue reading

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