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Tag Archives: APOE e4 (Apolipoprotein E e4)
Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)
Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading →
Posted in Alzheimer’s Research UK, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Personalisation, Quick Insights, Systematic Reviews, UK, Universal Interest
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Tagged 18F-florbetaben, 18F-flutemetamol, 18Fflorbetapir, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Alzheimer’s Research UK (ARUK), Amyloid and Tau PET, APOE e4 (Apolipoprotein E e4), Apolipoprotein E (APOE) e4 Allele, Behavioural Biomarkers, Beta-Amyloid PET Imaging, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Canonical Syndromes of Primary Progressive Aphasia: Non-Fluent / Agrammatic Variant (nfvPPA), Canonical Syndromes of Primary Progressive Aphasia: Semantic Variant (svPPA), Carbon-11 Pittsburgh Compound-B (C-PIB) Radioisotope Tracer, Cerebral Metabolic Rate for Glucose (CMRgl), Cerebrospinal Fluid (CSF) Biomarkers, Cerebrospinal Fluid and Serum MHPG, CMRgl Decline, Corticobasal Degeneration (CBD), CSF 3-methoxy-4-hydrox-yphenylglycol (MHPG), Dementia With Lewy Bodies (DLB), Differential Diagnosis, DLB: Dementia with Lewy Bodies, Docosahexaenoic Acid (DHA), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Eicosapentaenoic Acid (EPA), Frontotemporal Dementia (FTD), α-Synuclein, Journal of Geriatric Care and Research (JGCR), Lewy Body Dementia (LBD), Magnetic Resonance Imaging (MRI), Medial Temporal Lobe Atrophy (MTA), Medial Temporal Lobes (MTL), Metabolic Syndrome (MetS), MRI Brain Imaging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroimaging, Neuroimaging in Dementia Diagnosis, Non-Invasive Biomarkers, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Primary Progressive Aphasia (PPA), Progressive Supranuclear Palsy (PSP), Rapid Screening, Screening for Dementia, Sea Hero Quest (SHQ) Game, Sea Hero Quest VR, Tau PET, Timely Diagnosis, VaD: Vascular Dementia, Variants of Primary Progressive Aphasia (PPA), Vascular Dementia, [18F]THK5351
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Potential Association Between Tea Consumption and a Reduced Risk of Developing Dementia? (NHS Choices / Journal of Nutrition, Health and Aging)
Summary There is some evidence from Singapore that tea drinkers may be less likely to develop brain disorders such as dementia. Researchers discovered that Chinese elderly tea drinkers appeared to be less likely to develop dementia compared to non-drinkers. “The … Continue reading →
Posted in For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Quick Insights, Statistics, Universal Interest
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Tagged Agency for Science Technology and Research, Alice Lim Memorial Fund, Alzheimer's Gene (APOE4 Gene), APOE e4 (Apolipoprotein E e4), Behind the Headlines, Biomedical Research Council, China, Chinese Elderly Tea Drinkers, Chinese Older Adults, Clinical Dementia Rating (CDR), Cognitive Benefits of Tea Drinking, Critical Appraisals, Department of Psychological Medicine: National University of Singapore, Epidemiology, Epidemiology and Statistics, Healthy Lifestyles, Journal of Nutrition Health and Aging, Lifestyle, Lifestyle Advice, Lifestyle Factors, Modified Mini-Mental State Examination (3-MS), National University Health System (Singapore), National University of Singapore, Neurocognitive Disorders, Neuroprotection Research, Neuroprotective Agents, Neuroprotective Lifestyles, Singapore, Singapore Longitudinal Ageing Studies (SLAS), Singapore Longitudinal Aging Study, Tea and Cognitive Health in Late Life, Tea Consumption, Tea Consumption and Dementia, Tea Drinking, Virtual Institute for the Study of Ageing, Yong Loo Lin School of Medicine: National University of Singapore
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On “SuperAgers”: People Who Avoid Age-Related Memory Problems (BBC News / Journal of Neuroscience / Journal of Cognitive Neuroscience / JINS)
Summary Researchers have been studying “SuperAgers”, and the associated phenomenon of SuperAging, to discover possible physiological and genetic mechanisms behind the fortuitous preservation of superior memory into old age. Full Text Link Reference ‘Super agers’ offer clue to keeping a … Continue reading →
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
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Tagged Age-Related Cognitive Impairment, Age-Related Memory Loss, Age-Related Pathologies, Ageing Population, Ageing Well, Anterior Cingulate Cortex in Right Hemisphere, APOE e4 (Apolipoprotein E e4), Apolipoprotein E, Apolipoprotein E (APOE) e4 Allele, Apolipoprotein E4, BBC Health News, Bilateral Midcingulate Cortex (MCC) Paracingulate Cortex, Bilateral Rostral Medial Prefrontal Cortex (rmPFC), Calcarine Cortical Regions (calc 1 and calc 2), California Verbal Learning Test (CVLT), California Verbal Learning Test Long Delay Free Recall Test, Center for Biomedical Imaging: Massachusetts General Hospital, Cingulate Integrity in Elders With Exceptional Memory Capacity, Cognitive Impairment, Cognitive Impairment (Potential Risk Factors), Cognitive Neurology and Alzheimer's Disease Center: Northwestern University, Cortical Neuroanatomy of Superagers, Cortical Thickness In Superaging, Department of Neurology: Massachusetts General Hospital, Department of Neurology: Northwestern University, Department of Pathology: Northwestern University, Department of Preventive Medicine: Northwestern University, Department of Psychiatry and Behavioral Sciences: Northwestern University, Department of Psychology: Northeastern University, Elders With Exceptional Memory, Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (EXAMINER) Battery, ɛ4 Allele, Frontotemporal Disorders Unit: Massachusetts General Hospital, Functional Magnetic Resonance Imaging (fMRI), Harvard Medical School, Journal of Cognitive Neuroscience, Journal of Neuroscience, Journal of the International Neuropsychological Society: JINS, Left Anterior Middle Temporal Gyrus (aMTG), Left Dorsomedial Prefrontal Cortex (dmPFC), Left Lateral Occipital Cortex (lOcc), Left Midinsula (MI), Left Primary Somatosensory Cortex (S1), Long Delay Free Recall Measure of CVLT (CVLT-LD), Massachusetts General Hospital, MCI: Mild Cognitive Impairment, Memory Loss, Memory Problems, Mild Cognitive Impairment (MCI), Mild Memory Problems, Mini Mental State Examination (MMSE), MRI Scans, MRI Structural Analysis, Neural Network Integrity, Northwestern Cognitive Neurology and Alzheimer Disease Center: Northwestern University Feinberg School of Medicine, Northwestern SuperAging Project, Northwestern University (USA), Northwestern University Feinberg School of Medicine, Northwestern University: Chicago, Primary Sensorimotor Cortical Zones, Psychiatric Neuroimaging Division: Massachusetts General Hospital, Right Angular Gyrus (AG), Right Dorsal Anterior Insula (dAI), Right Dorsolateral Prefrontal Cortex (dlPFC), Right Frontal Operculum (FO), Right Inferior Frontal Gyrus (IFG), Right Superior Frontal Gyrus (SFG), Super Agers (Super-Agers aka SuperAgers), Super-Agers: aka SuperAgers, SuperAgers: 80+ Year-Olds With Episodic Memory Equal To or Better Than Individuals 20-30 Years Younger, SuperAgers: Cerebral Cortex Thickness, SuperAging, Trail Making Test Part B (TMT-B), von Economo Neuron Density In Anterior Cingulate Cortex, von Economo Neurons, Youthful Memory Capacity in Older Individuals
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Non-Alzheimer’s Dementias: Three Reviews (Lancet)
Summary The Lancet has published a series of three up-to-date reviews concerning non-Alzheimer’s dementia. Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access). Reference Dementia – not all about Alzheimer’s. [Editorial]. … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Patient Care Pathway, Person-Centred Care, Pharmacological Treatments, Quick Insights, Statistics, Systematic Reviews, UK, Universal Interest
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Tagged Akershus University Hospital and University of Oslo, Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC), Alzheimer's Disease With Cardiovascular Disease, APOE e4 (Apolipoprotein E e4), ApoE e4 Allele, Association of RBD with Synucleinopathies, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Biomarkers, Brain Imaging, BV-FTD, C677T, C9orf72 MAPT and GRN Genes, Cambridge Biomedical Campus, Campus for Ageing and Vitality: Newcastle upon Tyne, Center for Sleep Medicine: Mayo Clinic, Center for Sleep Medicine: Mayo Clinic College of Medicine, Centre for Age-Related Diseases: Stavanger University Hospital, Cerebrovascular Disease, CeVD: Cerebrovascular Disease, Clinical Symptoms Characteristic of Frontotemporal Dementia, Cognitive Assessments / Screening Tools, Constipation, Delirium and Dementia With Lewy Bodies, Dementia with Lewy Bodies, Dementia With Lewy Bodies (DLB), Dementia with Lewy Bodies Symptoms, Department of Geriatric Psychiatry: Akershus University Hospital, Department of Neurology: Mayo Clinic College of Medicine, Department of Psychiatry: University of Cambridge, Diagnosis of Vascular Dementia, Differential Diagnosis, Differential Diagnosis of Memory Problems, Division of Psychiatry: University College London, DLB: Dementia with Lewy Bodies, Dopamine Transporter Single Photon Emission CT, Early Diagnosis, Epidemiology, Epidemiology and Statistics, Epidemiology of Frontotemporal Dementia, Epidemiology of Major Neurological Disorders, Fluctuating Cognition, Fluctuations, Fluorodeoxyglucose PET, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Frontotemporal Dementia Symptoms, Frontotemporal Dementia With Motor Neurone Disease (FTD-MND), Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Lobar Degeneration FUS, FTLD: Frontotemporal Lobar Degeneration, Genetic and Pathological Correlation in FTLD, Genetics, Genetics of DLB, Haemorrhagic Dementia, Hallucinations, Hallucinations and Delusions in Parkinson's Disease, Hallucinations in People with Dementia, Hereditary Vascular Dementia (CADASIL), Hypoperfusion Dementia, Imaging, Increased Salivation, Institute of Neuroscience and Newcastle University Institute for Ageing: Newcastle University, Lancet, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Management of Vascular Dementia, Mayo Clinic College of Medicine (USA), Memory and Aging Center: University of California, Mental Health Unit: St Margaret's Hospital (Epping), Mild Cognitive Impairment in Parkinson's Disease (MCI-PD), MTHFR, Multi-Infarct Dementia (Cortical Vascular Dementia), National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN), Neurological Disease, Neurological Disorders, Neuropathological Features, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NFV-PPA, Non-Alzheimer’s Dementia, Non-Fluent Variant Primary Progressive Aphasia, Nondegenerative Neurological Diseases (NNDs), North Essex Partnership University NHS Foundation Trust, Norway, Norway Stavanger University Hospital, Nosology of Vascular Dementia, Olfactory Dysfunction, Parkinson’s Disease Dementia, Parkinsonism, Pathological Staging, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Prevalence of Cerebrovascular Disease, Prevalence of Neurological Disorders, Prodromal Dementia With Lewy Bodies, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, Sandler Neurosciences Center (San Francisco), Semantic Variant Primary Progressive Aphasia, Single Photon Emission Computed Tomography (SPECT), Small Vessel Arteriosclerosis, Small Vessel Dementia (Subcortical Vascular Dementia), SNCA and LRRK2 Genes, SPECT (Single Photon Emission Computed Tomography), Stavanger University Hospital, Stavanger University Hospital; Norway, Strategic Infarct Dementia, Subtypes of Vascular Dementia, SV-PPA, Systematic Reviews and Meta-Analyses, Timely Diagnosis, Treatments for Dementia With Lewy Bodies and Parkinson's Disease Dementia, United States, University College London, University of California, University of California: San Francisco School of Medicine, University of Cambridge, USA, VaD: Vascular Dementia, Vascular Dementia Symptoms, Visual Hallucinations
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Further Dementia Diagnostic Test Accuracy Systematic Review Protocols (Cochrane Database)
Summary This is an additional list of diagnostic testing-related protocols, further to the Cochrane Dementia and Cognitive Improvement Group (CDCIG) Diagnostic Test Accuracy (DTA) protocols and protocol templates listed earlier in Generic Protocol(s) for Diagnostic Test Accuracy Reviews in Dementia … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Models of Dementia Care, NIHR, Systematic Reviews, UK
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Tagged 11C-PIB-PET, 18FDG-PET, 6-Item Cognitive Impairment Test (6-CIT), Abbreviated Mental Test (AMT), Addenbrooke's Cognitive Exaination-Revised (ACE-R), ALOIS: the Cochrane Dementia and Cognitive Improvement Group, APOE e4 (Apolipoprotein E e4), APOE-4 Allele, Asymptomatic Alzheimer’s Disease, Blessed Information-Memory-Concentration Test (Blessed I-M-C), Brain Imaging, Bristol University, Canada, CDCIG: Cochrane Dementia and Cognitive Improvement Group, Central and North West London NHS Foundation Trust, China, China Medical University, Clinical Cooperation Unit Nuclear Medicine (Heidelberg), Clock Drawing Test (CDT), Cochrane Dementia and Cognitive Improvement Group (CDCIG), Cochrane Diagnostic Test Accuracy (DTA) Dementia Reviews, Cochrane Diagnostic Test Accuracy (DTA) Reviews, Cochrane Diagnostic Test Accuracy Review Unit (DTA Unit), Cognitive Assessments / Screening Tools, CSF (Cerebrospinal Fluid Analysis of Amyloid Beta and Tau), CSF Tau, CSF Tau / ABeta Ratio, Department of Neurology: VU University Medical Centre Amsterdam, Devon, Diagnostic Test Accuracy (DTA) Handbook, Diagnostic Test Accuracy Reviews, Differential Diagnosis, Differential Diagnosis of Alzheimer’s Disease, Dopamine Transporter Imaging, Dopamine Transporter Imaging (for Diagnosis of DLB), DTA Handbook, Early Differential Diagnosis, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta: Neuroepidemiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, FP-CIT (Fluoropropyl-Carbomethoxy-3b-(4-Iodophenyl)Tropane), Frenchay Hospital (Bristol), Frontotemporal Dementia (FTD), Generic Protocols for Cross-Sectional and Delayed-Verification Studies, German Cancer Research Center: Medical PET Group - Biological Imaging, Germany, Glasgow Royal Infirmary, GP-Cog, Imaging, Imperial College London, Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Institute of Cardiovascular and Medical Sciences: Glasgow, Institute of Cardiovascular and Medical Sciences: University of Glasgow, Institute of Health Research: Exeter, Institute of Public Health (Cambridge UK), Institute of Public Health (IPH), Institute of Public Health: Cambridge, IRCCS Fatebenefratelli (Brescia), Italy, John Radcliffe Hospital, LITA Polo Universitario, Maastricht University, Maastricht University: Department of Psychiatry and Neuropsychology, Mini-Cog, Modified Mini-Mental State Examination (3-MS), MRI, MRI Brain Imaging, MRI Scans, National Institute for Health Research (NIHR) Cochrane Collaboration Programme, Netherlands, Neuroimaging in Dementia Diagnosis, Neuropsychological Tests for Alzheimer’s Disease Diagnosis, Neuropsychological Tests for Dementia Diagnosis, North Bristol NHS Trust, Nuffield Department of Clinical Neurosciences (Oxford), Nuffield Department of Clinical Neurosciences: University of Oxford, Nuffield Department of Medicine (Oxford), Older People and Healthy Ageing Service Line (London), OPTIMA (Oxford Project to Investigate Memory and Ageing), OPTIMA (Oxfordshire UK), Ospedale Luigi Sacco, Oxford, Oxford Health NHS Foundation Trust, Oxford University Hospitals NHS Trust, Oxford University Medical School, PenCLAHRC, Peninsula CLAHRC, Peninsula Technology Assessment Group (PenTAG), PET-FDG (Positron Emission Tomography F-Fluorodeoxyglucose), PET-PiB (Positron Emission Tomography-Pittsburgh Compound B), Plasma and Cerebrospinal Fluid (CSF) Abeta42, Positron Emission Tomography (PET), Protocols, Public Health Epidemiology and Biostatistics: Birmingham, Queen's University (Canada), Radcliffe Department of Medicine, ratio, rCBF SPECT, Research Protocol, School for Mental Health and Neuroscience: Maastricht University, Shengjing Hospital, sMRI (Structural Magnetic Resonance Imaging), SPECT (Single Photon Emission Computed Tomography), St Louis University Mental Status Examination (SLUMS), Study Protocol, Sunnybrook Health Sciences Centre (Toronto), Systematic Reviews and Meta-Analyses, Test Your Memory (TYM), University Hospitals Bristol, University of Birmingham, University of Bristol, University of Cambridge, University of Exeter, University of Exeter Medical School, University of Glasgow, University of Milan, University of Oxford, University of Toronto, VU University (Netherlands), VU University Medical Centre
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Generic Protocol(s) for Diagnostic Test Accuracy Reviews in Dementia (Cochrane Database)
Summary The Cochrane Dementia and Cognitive Improvement Group (CDCIG) is working – in collaboration with the Cochrane Diagnostic Test Accuracy Review Unit (DTA Unit) and the Institute of Public Health (IPH) – on a series of Cochrane Diagnostic Test Accuracy … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, NIHR, Systematic Reviews, UK
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Tagged 6-Item Cognitive Impairment Test (6-CIT), Abbreviated Mental Test (AMT), Addenbrooke's Cognitive Exaination-Revised (ACE-R), ALOIS: the Cochrane Dementia and Cognitive Improvement Group, APOE e4 (Apolipoprotein E e4), Asymptomatic Alzheimer’s Disease, Avon and Wiltshire Mental Health Partnership NHS Trust, Blessed Information-Memory-Concentration Test (Blessed I-M-C), Bristol, Bristol University: Academic Unit of Psychiatry, Bristol University: Addiction and Suicide Research, Bristol University: Centre for Mental Health, Bristol University: School of Community Medicine, CDCIG: Cochrane Dementia and Cognitive Improvement Group, Clock Drawing Test (CDT), Cochrane Dementia and Cognitive Improvement Group (CDCIG), Cochrane Dementia and Cognitive Improvement Group: Oxford University, Cochrane Diagnostic Test Accuracy (DTA) Dementia Reviews, Cochrane Diagnostic Test Accuracy (DTA) Reviews, Cochrane Diagnostic Test Accuracy Review Unit (DTA Unit), Cognitive Assessments / Screening Tools, CSF (Cerebrospinal Fluid Analysis of Amyloid Beta and Tau), Diagnostic Test Accuracy (DTA) Handbook, Diagnostic Test Accuracy Reviews, DTA Handbook, Exeter, FP-CIT (Fluoropropyl-Carbomethoxy-3b-(4-Iodophenyl)Tropane), Generic Protocols for Cross-Sectional and Delayed-Verification Studies, Glasgow, GP-Cog, Institute of Public Health (IPH), Institute of Public Health: Cambridge, Mini Mental State Examination (MMSE), Mini-Cog, Modified Mini-Mental State Examination (3-MS), Montreal Cognitive Assessment (MoCA), National Institute for Health Research (NIHR) Cochrane Collaboration Programme, Neuropsychological Tests for Alzheimer’s Disease Diagnosis, Neuropsychological Tests for Dementia Diagnosis, Oxford, Peninsula Technology Assessment Group (PenTAG), PET-FDG (Positron Emission Tomography F-Fluorodeoxyglucose), PET-PiB (Positron Emission Tomography-Pittsburgh Compound B), Protocols, Research Protocol, School of Community Medicine: Bristol University, School of Social and Community Medicine: Bristol University, Severn Deanery (Bristol UK), sMRI (Structural Magnetic Resonance Imaging), SPECT (Single Photon Emission Computed Tomography), St Louis University Mental Status Examination (SLUMS), Study Protocol, Systematic Reviews and Meta-Analyses, Test Your Memory (TYM), University of Bristol, University of Bristol: School of Social and Community Medicine, University of Cambridge, University of Cambridge: Department of Public Health and Primary Care: Cambridge, University of Exeter, University of Exeter Medical School, University of Glasgow, University of Oxford, University of Oxford: Radcliffe Department of Medicine
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