Tag Archives: APOE

One More Genetic Link in the Longevity Enigma? (BBC News / Sanger Institute / Nature Communications)

Posted on May 29, 2017 by Dementia and Elderly Care News

Summary People living in the isolated Greek villages of Zoniana and Anogia have a noted tendency to live well into old age. They have a lower than expected incidence of cardiovascular disease, including heart problems, heart attacks and stroke. It … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Stroke, Universal Interest | Tagged 100000 Genomes Project, 100000 Genomes Project Haplotypes, Anogia, Anogia Medical Centre (Greece), APOE, APOE Gene, Array Genotyping, BBC Health News, BMI: Body Mass Index, Body Fat, Body Mass Index (BMI), Cardiometabolic Associations, Cardiovascular Disease (CVD), Cardiovascular Fitness, Cardiovascular Risk, Cardiovascular System Disorders, CDKN2A/B, Cholesterol (HDL), CHRNA3/5, Churchill Hospital (Oxford), Cigarettes, Cretan-Isolated Populations, CVD: Cardiovascular Disease, Department of Nutrition and Dietetics: Harokopio University (Athens), Echinos Medical Centre (Xanthi: Greece), Educational Attainment, Epidemiology, Extra Year in Education Extends Lifespan by 11 months (DNA Study Assertion), FOXO3A, Genetic Correlations: Lifespan and Mortality, Genetic Profiling, Genetic Research, Genetic Variant rs145556679, Genetic Variants, Genetics, Genetics Versus Environment as Determinants of Longevity, Genetics Versus Lifestyle as Determinants of Longevity, Genome-Wide Association Meta-Analysis (GWAMA), Genome-Wide Association Studies, Genome-Wide Association Studies (GWAS), Greece, Greek Villagers, Harokopio University (Athens), HDL-Cholesterol, Heart Disease, HELIC (Hellenic Isolated Cohorts), HELIC MANOLIS Sequencing, High Density Lipoproteins (HDL), High-Density Lipoprotein (HDL) Cholesterol Levels, HLA-DQA1/DRB1, Human Longevity, Insulin Resistance, Isolated Greek Villages, Isolated Populations, Isolated Populations Research, Lifespan, Longevity, Low Density Lipoprotein Cholesterol (LDL-C), Low Density Lipoproteins (LDL), LPA, Lung Cancer, Medical School: University of Exeter, Mendelian Randomisation, METACARPA, Microarrays, Molecular Pathological Epidemiology, Mylopotamos (MANOLIS) and Pomak Villages Cohorts, Mylopotamos: Northern Crete, Nature Communications, Northern Crete, Obesity, Openness to New Experiences, Oxford Centre for Diabetes Endocrinology and Metabolism University of Oxford, Pomak Region of Northern Greece, Population Isolates, Radcliffe Department of Medicine: University of Oxford, Sanger Institute, Saturated Fats, School of Health Science and Education: Harokopio University (Athens), SH2B3, Smoking, Susceptibility to Coronary Artery Disease (CAD), Triglycerides, UK Biobank, Unexpected Genetic Heroes, University of Exeter, University of Exeter Medical School, University of Oxford, Usher Institute of Population Health Sciences and Informatics: University of Edinburgh, Very Low Density Lipoprotein cholesterol (VLDL), Wellbeing and Longevity, Wellcome Trust Centre for Human Genetics: University of Oxford, Wellcome Trust Sanger Institute, Wellcome Trust Sanger Institute: Human Genetics, WGS Haplotypes, Whole Genome Sequencing (WGS), Whole Genome Sequencing and Imputation, Zoniana | Leave a comment

Alzheimer’s Disease: Genetics Research Breakthrough (BBC News / NHS Choices / Nature Genetics)

Posted on October 28, 2013 by Dementia and Elderly Care News

Summary An international collaboration of geneticists from 145 academic institutions investigating Alzheimer’s Disease have performed a meta-analysis of data about the DNA of 17,000 patients and 37,000 healthy people. Their analysis of genome-wide association studies (GWAS) has identified 21 genetic … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Alzheimer's Gene (APOE4 Gene), Alzheimer's Research UK, APOE, APOE Gene, Apolipoprotein E (APOE) Gene, BBC Health News, Behind the Headlines, Boston University School of Medicine, Boston University School of Public Health, Broca Hospital, Cardiff University, Centre d'Etude du Polymorphisme Humain (CEPH), Centre for Neuropsychiatric Genetics & Genomics: Cardiff University, Centre National de Génotypage, Cholesterol, Collaborative Projects, Collaborative Working, Columbia University, Commissariat à l'Energie Atomique, Critical Appraisals, DNA, Eidgenössische Technische Hochschule, Endocytosis, Erasmus MC University Medical Center: Rotterdam, Fondation Jean Dausset, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genome-Wide Association Studies (GWAS), Gertrude H. Sergievsky Center: Columbia University, Immune System, Innovation in Genetics, INSERM, Institut Génomique, Institut Pasteur de Lille, International Collaborations, Late-Onset Alzheimer's Disease (LOAD), Medical Research Council (MRC), Medical University of Graz, Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Nature Genetics, Netherlands Consortium for Healthy Aging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Perelman School of Medicine: University of Pennsylvania, Research and Innovation, Research Consortia, Single Nucleotide Polymorphisms (SNPs), Systematic Reviews and Meta-Analyses, Taub Institute on Alzheimer's Disease and the Aging Brain, Université Lille 2, University College London Institute of Neurology, University of Bonn, University of Iceland, University of Miami, University of Pennsylvania, University of Washington, University Paris Descartes, Wellcome Trust | Leave a comment

Blood Test Could Assist Early Diagnosis of Alzheimer’s Disease (BBC News)

Posted on March 11, 2013 by Dementia and Elderly Care News

Summary Researchers at the University of Nottingham are developing a quick and easy blood test to detect proteins linked strongly with Alzheimer’s Disease, such as amyloid and APOE, in combination with other markers linked to inflammation. The test has not been fully validated yet, and could be … Continue reading →

Posted in Acute Hospitals, Alzheimer’s Research UK, BBC News, Community Care, Diagnosis, For Researchers (mostly), In the News, Quick Insights, UK, Universal Interest | Tagged Alzheimer's Gene (APOE4 Gene), Alzheimer’s Early Screening, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid-β (Aβ), APOE, ApoE and Genetics of Alzheimer's Disease, ApoE e4 Allele, APOE4 Gene, Apolipoprotein E (APOE) e4 Allele, BBC Health News, Beta-Amyloid, Beta-Amyloid Plaques, Biomarkers, Blood Tests, Case Finding for Patients with Dementia, Common Genetic Risk Factor Links Alzheimer’s Disease and Type 2 Diabetes (SorCS1), Dementia Case Finding, Diagnostic Markers, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Screening, Effective Diagnostics, Genetic Profiling, Genetics of Alzheimer's Disease, Inflammation, β-amyloid, Nottingham Trent University’s John van Geest Cancer Research Centre, Rapid Screening, Screening, Screening for Dementia, Targeted Screening for Dementia, University of Nottingham, University of Nottingham’s School of Molecular Medical Sciences | Leave a comment

Alzheimer’s Brain Plaques Cleared Rapidly by Cancer Drug in Mice (BBC News / NHS Choices)

Posted on February 15, 2012 by Dementia and Elderly Care News

Summary Clumps of a protein called beta-amyloid are a feature of Alzheimer’s Disease. The clearance of these plaques is widely thought to be a promising target for Alzheimer’s research. It has now been found that the destructive plaques found in the … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Proposed for Next Newsletter, Quick Insights, Universal Interest | Tagged Aβ-Plaques, Animal Model, Animal Research, APOE, ApoE e4 Allele, Apolipoprotein E, Beta-Amyloid, Bexarotene (Targretin), Blanchette Hooker Rockefeller Fund, Case Western Reserve University, β-amyloid, Murine Model of Alzheimer's Disease, Peroxisome Proliferator Activated Receptor (PPARγ), Protein Plaques, Retinoid X Receptors (RXR), Roby and Taft Funds for Alzheimer’s, RXR Agonist, Skin Cancer Drug (Targretin), Thome Foundation | Leave a comment

Genes Involved in Late-Onset Alzheimer’s Disease Identified (Genome-Wide Association Studies)

Posted on April 18, 2011 by Dementia and Elderly Care News

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 1 Issue 10, May 2011]. Abstract Five further genes which increase the risk of developing late-onset Alzheimer’s Disease have been identified, taking the number of identified … Continue reading →

Posted in Acute Hospitals, Alzheimer's Society, Community Care, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged ABCA7, Alzheimer’s Association, Alzheimer’s Disease Genetics Consortium (ADGC), APOE, BIN1, Case-Control Studies, CD2AP, CD33, CLU, CR1, EPHA1, Genome-Wide Association Studies, Innovation in Genetics, Medical Research Council (UK), MS4A4E, MS4A6A, National Institutes of Health (US), PICALM, Wellcome Trust | Leave a comment

Tag Archives: APOE

One More Genetic Link in the Longevity Enigma? (BBC News / Sanger Institute / Nature Communications)

Alzheimer’s Disease: Genetics Research Breakthrough (BBC News / NHS Choices / Nature Genetics)

Blood Test Could Assist Early Diagnosis of Alzheimer’s Disease (BBC News)

Genes Involved in Late-Onset Alzheimer’s Disease Identified (Genome-Wide Association Studies)

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