Tag Archives: Apolipoprotein E (APOE) e4 Allele

Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading

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On “SuperAgers”: People Who Avoid Age-Related Memory Problems (BBC News / Journal of Neuroscience / Journal of Cognitive Neuroscience / JINS)

Summary Researchers have been studying “SuperAgers”, and the associated phenomenon of SuperAging, to discover possible physiological and genetic mechanisms behind the fortuitous preservation of superior memory into old age. Full Text Link Reference ‘Super agers’ offer clue to keeping a … Continue reading

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Genetic Mutation Which Delays Alzheimer’s Disease? (NHS Choices / Molecular Psychiatry)

Summary A study of 71 persons from an extended family (comprising around 5,000 people) in northern Colombia, who carry a mutation in a gene called PSEN1 (the so-called the Paisa mutation, which causes a rare, severe form of early-onset Alzheimer’s disease), … Continue reading

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Deaf Awareness Week 2015: Plus Articles on Hearing Loss and Cognitive Impairment / Dementia (UK Council on Deafness / BBC News / Various)

Summary Deaf Awareness Week falls between May 4th – 10th 2015. The UK Council on Deafness has produced posters in support of the event. Full Text Link Reference Connect and Communicate: Deaf Awareness Week 2015. [Online]: The UK Council on … Continue reading

Posted in BBC News, Charitable Bodies, Depression, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Mental Health, Quick Insights, Systematic Reviews, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

DDT (Pesticide): Potential Link with Alzheimer’s Disease (BBC News / JAMA Neurology)

Summary Exposure to the pesticide DDT, which was used commonly after WW2, may increase the risk of developing Alzheimer’s Disease, according to research published in JAMA Neurology. Patients with Alzheimer’s Disease, statistically, had four times more residual DDT lingering in … Continue reading

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Bapineuzumab Trials Results in Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)

Summary Bapineuzumab is an anti-amyloid-beta monoclonal antibody, which had shown promise for the treatment of Alzheimer’s Disease. Two double-blind, randomised, placebo-controlled, phase 3 trials have been conducted, involving 2204 patients with mild-to-moderate Alzheimer’s disease. One trial involved 1121 carriers of … Continue reading

Posted in For Doctors (mostly), For Researchers (mostly), International, Pharmacological Treatments | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Blood Test Could Assist Early Diagnosis of Alzheimer’s Disease (BBC News)

Summary Researchers at the University of Nottingham are developing a quick and easy blood test to detect proteins linked strongly with Alzheimer’s Disease, such as amyloid and APOE, in combination with other markers linked to inflammation. The test has not been fully validated yet, and could be … Continue reading

Posted in Acute Hospitals, Alzheimer’s Research UK, BBC News, Community Care, Diagnosis, For Researchers (mostly), In the News, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Hormone Replacement Therapy to Slow Dementia Onset? (NHS Choices / PLoS One)

Summary This NHS Choices critical appraisal examines press coverage of recent research which investigated the relationship between the genetic variant APOE-e4 (which increases the risk of developing Alzheimer’s Disease), hormone replacement therapy (HRT) and telomere length (an indicator of cell … Continue reading

Posted in For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Universal Interest | Tagged , , , , , , , , , , , , , , , , , | Leave a comment

Exposure to Statins in Early Old Age May Lower Risk of Alzheimer’s Disease

[This abstract first appeared in: Dementia: the Latest Evidence Newsletter RWHT Volume 1 Issue 7 February 2011]. Abstract This US prospective cohort study looked into whether statins (simvastatin, lovastatin, pravastatin and atorvastatin) reduce the risk of Alzheimer’s Disease (AD), and investigated the influence … Continue reading

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