Tag Archives: Apolipoprotein E (APOE) Gene

Dementia Researchers Recognised and Rewarded (BBC News / Lundbeck Foundation)

Summary Four dementia researchers share the 2018 (€1 million Euro) Brain Prize (bestowed by the Lundbeck Foundation), in recognition of their joint work on the underlying neuropathological mechanisms thought to cause of Alzheimer’s Disease. Full Text Link Reference Roberts, M. … Continue reading

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DDT (Pesticide): Potential Link with Alzheimer’s Disease (BBC News / JAMA Neurology)

Summary Exposure to the pesticide DDT, which was used commonly after WW2, may increase the risk of developing Alzheimer’s Disease, according to research published in JAMA Neurology. Patients with Alzheimer’s Disease, statistically, had four times more residual DDT lingering in … Continue reading

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Bapineuzumab Trials Results in Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)

Summary Bapineuzumab is an anti-amyloid-beta monoclonal antibody, which had shown promise for the treatment of Alzheimer’s Disease. Two double-blind, randomised, placebo-controlled, phase 3 trials have been conducted, involving 2204 patients with mild-to-moderate Alzheimer’s disease. One trial involved 1121 carriers of … Continue reading

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Alzheimer’s Disease: Genetics Research Breakthrough (BBC News / NHS Choices / Nature Genetics)

Summary An international collaboration of geneticists from 145 academic institutions investigating Alzheimer’s Disease have performed a meta-analysis of data about the DNA of 17,000 patients and 37,000 healthy people. Their analysis of genome-wide association studies (GWAS) has identified 21 genetic … Continue reading

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Hormone Replacement Therapy to Slow Dementia Onset? (NHS Choices / PLoS One)

Summary This NHS Choices critical appraisal examines press coverage of recent research which investigated the relationship between the genetic variant APOE-e4 (which increases the risk of developing Alzheimer’s Disease), hormone replacement therapy (HRT) and telomere length (an indicator of cell … Continue reading

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The Role of the APOE Gene in the Neuropsychiatric Symptoms of Late-Onset Alzheimer’s Disease

Summary Neuropsychiatric symptoms, commonly termed behavioural and psychological symptoms of dementia, occur frequently in Alzheimer’s Disease. This article reviews evidence on the likely role of the apolipoprotein E (APOE) gene in the development of neuropsychiatric symptoms in Alzheimer’s Disease, paying … Continue reading

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