Tag Archives: Apolipoprotein E

Postural (Orthostatic) Hypotension and Risk of Dementia? (BBC News / PLoS Medicine / NHS Choices)

Summary It appears that people who experience frequent drops in blood pressure or dizziness when standing up suddenly may be at increased risk of dementia, perhaps due to a decreased flow of blood to the brain. Full Text Link Reference … Continue reading

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On “SuperAgers”: People Who Avoid Age-Related Memory Problems (BBC News / Journal of Neuroscience / Journal of Cognitive Neuroscience / JINS)

Summary Researchers have been studying “SuperAgers”, and the associated phenomenon of SuperAging, to discover possible physiological and genetic mechanisms behind the fortuitous preservation of superior memory into old age. Full Text Link Reference ‘Super agers’ offer clue to keeping a … Continue reading

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Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

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Systematic Review of Blood Biomarkers for Alzheimer’s Disease Onset and Progression (Journal of Alzheimer’s Disease)

Summary Blood-based protein biomarkers to predict the onset and progression of Alzheimer’s Disease (AD) would assist in timely diagnosis and would also be beneficial for clinical trials in helping with the selection of subjects for preventative trials. This systematic review … Continue reading

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DDT (Pesticide): Potential Link with Alzheimer’s Disease (BBC News / JAMA Neurology)

Summary Exposure to the pesticide DDT, which was used commonly after WW2, may increase the risk of developing Alzheimer’s Disease, according to research published in JAMA Neurology. Patients with Alzheimer’s Disease, statistically, had four times more residual DDT lingering in … Continue reading

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Bapineuzumab Trials Results in Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)

Summary Bapineuzumab is an anti-amyloid-beta monoclonal antibody, which had shown promise for the treatment of Alzheimer’s Disease. Two double-blind, randomised, placebo-controlled, phase 3 trials have been conducted, involving 2204 patients with mild-to-moderate Alzheimer’s disease. One trial involved 1121 carriers of … Continue reading

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