Tag Archives: BACE1

Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

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More on the Underlying Relationships Between Alzheimer’s Disease and Diabetes? (NHS Choices / Diabetologia)

Summary Further evidence has emerged concerning shared genetic linkages and biological processes underlying potential links between Alzheimer’s Disease and Type 2 Diabetes. Full Text Link Reference Diabetes drugs may be useful for Alzheimer’s, mice research finds. London: NHS Choices Behind … Continue reading

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Exosomes: a Breakthrough in Delivering Gene Therapy to the Brain

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 1 Issue 10, May 2011]. Abstract A new way of delivering drugs to the brain uses the body’s own “transporters”, called exosomes. This technique of drugs … Continue reading

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