Tag Archives: Beta-Amyloid

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Blood Test for Pre-Symptomatic Alzheimer’s Disease Likely to Arrive Soon? (BBC News / Nature)

Summary A blood test developed by researchers in Australia and Japan appears to be able to predict the risk of developing Alzheimer’s Disease, with 90% accuracy. Detection of amyloid beta in the blood may be taken as a biomarker for … Continue reading

Posted in BBC News, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Early Signs of a Historic Breakthrough in the Treatment of Alzheimer’s Disease? (BBC News / Nature)

Summary Early results, based on small numbers of patients in a Phase I trial, indicate unprecedented progress in the development of a pharmacological treatment of Alzheimer’s Disease. The drug Aducanumab appears to combat (and reverse) the build-up of amyloid protein … Continue reading

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Models of Dementia Care, Pharmacological Treatments, Quick Insights, Scotland, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Dietary Exposure to Environmental Toxin Triggers Neurodegeneration? (BBC News / Royal Society Proceedings B Journal)

Summary Exposure to a toxin, Beta-N-methylamino-L-alanine (BMAA), from algae may be linked to dementia. This finding could offer fresh clues for the possible causes of the condition and potential future treatments. Research suggests that provision of L-serine in the diet … Continue reading

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Repurposing of Existing Drugs to Prevent Dementia? (BBC News / Science Advances /Alzheimer’s Research UK)

Summary A number of drugs, already approved as safe for the treatment of other conditions, and which could help protect against Alzheimer’s Disease, are said to have been detected and short-listed for further investigation. Full Text Link Reference Alzheimer’s preventative … Continue reading

Posted in Alzheimer's Society, Alzheimer’s Research UK, Animal Studies, BBC News, Charitable Bodies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Novel Approach to Prevention of Alzheimer’s Disease Explored in Laboratory (Express / PloS One)

Summary Researchers at the University of California, San Diego, have explored a different approach to mainstream research into the prevention of Alzheimer’s Disease. It is believed that Alzheimer’s Disease develops when amyloid precursor protein (APP) gets cut-up by enzymes and … Continue reading

Posted in Animal Studies, For Doctors (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Promoting Awareness of Current Trials and Encouraging Public Engagement in Dementia Research (NIHR / Join Dementia Research)

Summary The “Join Dementia Research” website has been designed to assist people to learn more about dementia research which is ongoing, whether in their local areas or across the UK. This service offers the public opportunities to get involved in … Continue reading

Posted in Alzheimer's Society, Alzheimer’s Research UK, Charitable Bodies, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Social Workers (mostly), Local Interest, Management of Condition, Models of Dementia Care, National, NIHR, Non-Pharmacological Treatments, Northern Ireland, Parkinson's Disease, Patient Care Pathway, Patient Information, Pharmacological Treatments, Practical Advice, Quick Insights, UK, Universal Interest, Wales | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

More on the Cognitive Reserve Hypothesis (BBC News / Nature Neuroscience)

Summary A small study based at the University of California suggests some people’s brains may have the ability to resist early damage arising in the initial stages of Alzheimer’s Disease. In elderly subjects asked to memorise a series of pictures … Continue reading

Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

Posted in Charitable Bodies, Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment