Tag Archives: Cerebrospinal Fluid

Brain and Immune System: Not Unconnected? (NHS Choices / Nature)

Summary Researchers have discovered previously unsuspected lymphatic vessels in the outer layers of the brain. The brain and central nervous system were not previously thought to be connected to the lymphatic system, so this discovery may pave the way for … Continue reading

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Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

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Early Diagnosis of Alzheimer’s Disease Using Spinal Fluid? (NHS Choices / Cell Reports)

Summary A recent diagnostic study has investigated the possibility of diagnosing Alzheimer’s Disease, years before disease onset, using cerebrospinal fluid (CSF). The technique for identifying people with Alzheimer’s Disease would be based on detecting very small amounts of abnormal (misfolded) … Continue reading

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Biomarkers Predicting Cognitive Decline and Alzheimer’s Disease

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 2 Issue 3, October 2011]. Summary The process of developing Alzheimer’s Disease is known to begin years before the formal diagnosis of clinical dementia. The concept … Continue reading

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Caffeine for Cognitive Protection?

Abstract Compromised function of the choroid plexus and defective cerebrospinal fluid production (resulting in diminished clearance of β-amyloid protein) is widely thought to play an important role in late-onset version of Alzheimer’s Disease. The authors of this article speculate that … Continue reading

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A Test for the Early Detection / Diagnosis of Alzheimer’s Disease?

[This article first appeared in: Dementia Newsletter RWHT Volume 1 Issue 6 January 2011]. Abstract Researchers are looking at many drugs and treatments under development, but it is difficult to test how well these work currently because dementia is usually diagnosed … Continue reading

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