Tag Archives: Clearance of Amyloid Beta Protein

BBC iWonder Guide: How Close Are We to Stopping Alzheimer’s Disease? (BBC News)

Summary The BBC’s iWonder Guides provide “thought-provoking answers to the questions sparked by everyday life”. This particular collection of brief digestible articles, animations and videos covers: A frightening prospect (epidemiological statistics). How the disease affects your brain cells (an interactive … Continue reading

Posted in Animal Studies, BBC News, In the News, Non-Pharmacological Treatments, Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)

Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading

Posted in BBC News, For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Metal Protein Attenuating Compounds for Alzheimer’s Disease (Cochrane Database)

Summary This systematic review evaluates the efficacy of metal protein attenuating compounds (MPACs) for the treatment of cognitive impairment in Alzheimer’s dementia. Earlier experimentation and mouse model studies had indicated that MPACs might promote the dissolution and clearance of beta-amyloid … Continue reading

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Pharmacological Treatments, Systematic Reviews, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Biomarker Assessments in Alzheimer’s Disease Clinical Trials (Quintiles / Frontiers in Aging Neuroscience)

Summary Accurate and sensitive tools are required for the early detection / diagnosis of Alzheimer’s Disease, particularly to assist research. Alzheimer’s Disease clinical trials make increasing use of biomarkers, particularly neuroimaging markers and cerebrospinal fluid (CSF) biomarkers obtained via invasive … Continue reading

Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Quick Insights | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Copper Disrupts Brain Amyloid-β Production and Clearance? (NHS Choices / PNAS)

Summary This NHS Choices “Behind the Headlines” critical appraisal of recent research in the news is about a laboratory study carried out on mice and human brain cells, investigating whether copper may reduce the capacity of the brain to get … Continue reading

Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Proposed for Next Newsletter, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Alzheimer’s Disease and the Clearance of Amyloid Beta Protein

[This article first appeared in: Dementia Newsletter RWHT Volume 1 Issue 6 January 2011]. Abstract Amyloid beta is normally released in the brain and cleared, but in Alzheimer’s disease the protein accumulates in the brain and causes cell death. The brains … Continue reading

Posted in For Researchers (mostly), In the News, Universal Interest | Tagged , , , | Leave a comment