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Tag Archives: Critical Appraisals
More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)
Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Association of British Neurologists, Bazian, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Behind the Headlines, Biomarker Development, Biomarkers, Biomarkers for Inflammation, Brain (Journal), Brain Autopsies, Brain Inflammation, C-PK-11195, C-PK-11195 (Biomarker for Inflammation), Cambridge Brain Bank, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Foundation Trust, Consiglio Nazionale delle Ricerche (CNR), Critical Appraisals, Degenerative Tauopathy, Department of Clinical Neurosciences: Cambridge University, Department of Neurology: Walton Centre (Liverpool), Department of Pathology: Cambridge University Hospitals NHS Foundation Trust, Department of Psychiatry: University of Cambridge, Division of Anaesthesia: University of Cambridge, Early-Onset Dementia, F-AV-1451, F-AV-1451 (Biomarker for Protein Clusters), Fronto-Temporal Dementia (FTD), Frontotemporal Dementia, Frontotemporal Dementia (FTD), FTD: Fronto-Temporal Dementia, FTLD-Pick’s, FTLD-TDP (A), FTLD-TDP (C), FTLD-TDP (Types A and C), FTLD-TDP-43, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM): Consiglio Nazionale delle Ricerche (CNR), Italy, Lundbeck Foundation (Denmark), Medical Research Council (MRC), Medical Research Council Cognition and Brain Sciences Unit: University of Cambridge, Microglia, Monoamine Oxidase (MAO), National Institute of Health Research, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Neuroinflammation and Frontotemporal Dementia, Neuroinflammation and Protein Aggregation, Neuromelanin, NIHR Dementias and Neurodegenerative Diseases Research Network, Non-Amyloid-β Protein Aggregation, Non-Fluent Variant Primary Progressive Aphasia (nfvPPA), Patrick Berthoud Charitable Trust, PET Scans, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Protein Aggregation, Protein Clusters, Semantic Variant Primary Progressive Aphasia (svPPA), Tauopathy, TDP-43, TDP-43 Pathology, TDP-43 Protein, TDP-43 Proteinopathy, University of Cambridge, Variants of Primary Progressive Aphasia (PPA), Wellcome Trust, Wolfson Brain Imaging Centre: University of Cambridge
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Optimal Timing of Blood Pressure Medication: Insight Into Chronotherapy for Cardiovascular Disease Risk Reduction (BBC News / EHJ / Bazian)
Summary Results from the Hygia Chronotherapy Trial suggest that blood pressure medicines may be more effective at lowering blood pressure, and reducing the risk of heart attacks and / or stroke, when taken at bedtime. Full Text Link Reference Roberts, M. (2019). Blood … Continue reading
Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Hypertension, In the News, International, Management of Condition, NHS Digital (Previously NHS Choices), Person-Centred Care, Pharmacological Treatments, Quick Insights, Stroke, Universal Interest
Tagged Asleep Blood Pressure, Atlantic Research Center for Information and Communication Technologies (AtlantTIC), Bazian, BBC Health News, Bedtime Hypertension, Bioengineering and Chronobiology Laboratories: University of Vigo, Blood Pressure, Blood Pressure Medications, Blood Pressure Medications (Timing), Body Clock, Cardiovascular Disease, Cardiovascular Disease (CVD), Cardiovascular Disease Risk Reduction, Chronotherapy, Circadian Cycles, Circadian Factors, Circadian Rhythms, Complejo Hospitalario Universitario, Critical Appraisals, CVD: Cardiovascular Disease, Estructura de Xestión Integrada de Ourense, Estructura de Xestión Integrada de Santiago de Compostela: Servicio Galego de Saúde (SERGAS), Estructura de Xestión Integrada de Vigo: Servicio Galego de Saúde (SERGAS), European Heart Journal, Heart Failure, High Blood Pressure, Human Circadian Clock, Hygia Project Investigators, Hygia Chronotherapy Trial, Hypertension, Myocardial Infarction, NCT03457168, Servicio de Nefrología: Complejo Hospitalario Universitario, Servicio Galego de Saúde (SERGAS), Spain, Stroke Risk Factor Modification, University of Vigo, University of Vigo (Spain)
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Optimism Linked to Longevity (BBC News / PNAS / Bazian)
Summary Researchers in the United States, using data from the Nurses’ Health Study and the Veterans’ Health Study, have confirmed that optimists tend to live longer and are more likely to achieve “exceptional longevity” i.e. live to an age of … Continue reading
Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest
Tagged Bazian, BBC Health News, BBC UGC Hub, Behavioural Risk Factors, Behind the Headlines, Boston University School of Medicine, Boston University School of Public Health, Brigham and Women's Hospital, Channing Division of Network Medicine: Brigham and Women’s Hospital, Critical Appraisals, Department of Epidemiology: Boston University School of Public Health, Department of Epidemiology: Harvard T.H. Chan School of Public Health, Department of Population Medicine: Harvard Medical School, Department of Psychiatry: Boston University School of Medicine, Department of Social and Behavioral Sciences: Harvard T.H. Chan School of Public Health, Epidemiology, Epidemiology and Statistics, Exceptional Longevity, Fonds de Recherche en Santé–Quebec, Harvard Medical School, Harvard Pilgrim Health Care Institute, Harvard T.H. Chan School of Public Health, Human Longevity, Lee Kum Sheung Center for Health and Happiness: Harvard T.H. Chan School of Public Health, Life Orientation Test – Revised, Lifestyle Risk Factors, Longevity, Massachusetts Veterans Epidemiology Research and Information Center: Veterans Affairs Boston Healthcare System, Mental and Physical Health, Modifiable Risk Factors, National Center for Posttraumatic Stress Disorder: Veterans Affairs Boston Healthcare System, National Institutes of Health, National Institutes of Health (NIH), National Institutes of Health: Clinical Science Research and Development Service, Nurses’ Health Study, Nurses’ Health Study (NHS), Optimism, Optimism Associated With Longevity, Optimists, Physical Impacts of Mood, Positive Outlook, Positive Psychology, Positive Psychosocial Factors, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Psychosocial Protective and Risk Factors, Reducing the Divide Between Mental and Physical Healthcare, Revised Optimism–Pessimism Scale from the Minnesota Multiphasic Personality Inventory-2, United States, US Department of Veterans Affairs, USA, User-Generated Content: the BBC UGC Hub, Veterans Affairs Boston Healthcare System, Veterans Affairs Normative Aging Study, Veterans Affairs Normative Aging Study (NAS), Wellbeing and Longevity
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Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)
Summary Further discussion about the possibilities of using inexpensive eye tests to detect Alzheimer’s Disease, perhaps years before symptoms appear. This particular technique involves the examination of blood vessels and blood flow in the retina, as detected by Octa (Optical … Continue reading
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Assessment and Diagnosis, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Central Subfield Thickness (CST), Cognitive Impairment, Critical Appraisals, Dementia Case Finding, Dementia Diagnosis, Dementia Screening, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostics, Duke University in North Carolina, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Treatment Diabetic Retinopathy Study, Eye Examinations, Foveal Avascular Zone (FAZ) Area, Karen L. Wrenn Alzheimer's Disease Award, Macular Ganglion Cell-Inner Plexiform Layer (GC-IPL), MCI: Mild Cognitive Impairment, Mild Cognitive Impairment, National Institutes of Health, National Institutes of Health (NIH), National Institutes of Health (US), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS Digital (Formerly NHS Choices), Non-Invasive Biomarkers, Octa: Optical Coherence Tomography Angiography, Ophthalmology Retina, Optical Coherence Tomography, Optical Coherence Tomography Angiography (OCTA), Preclinical Alzheimer's Disease, Rapid Screening, Research to Prevent Blindness Inc. (New York), Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Examination in Neurodegenerative Diseases, Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease, Retinal Microvascular and Neurodegenerative Changes in Mild Cognitive Impairment, Retinal Vessel Density (VD), Screening, Screening for Dementia, Timely Diagnosis, US National Institutes of Health (NIH), USA
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Brain Training in Later Life: Limited Value for Prevention of Cognitive Decline? (BBC News / BMJ / NHS Digital)
Summary A Scottish study indicates that self-reported intellectual engagement (in the form of performing puzzles, crosswords and other problem-solving activities) during later life has little influence on the trajectory of decline of memory or mental processing speed. The cognitive reserve … Continue reading
Posted in Alzheimer’s Research UK, BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Non-Pharmacological Treatments, Quick Insights, Scotland, UK, Universal Interest
Tagged Aberdeen Birth Cohort Studies, Alzheimer's Research UK, Bazian, BBC Health News, Behind the Headlines, Biology and Biotechnology Science Research Council, BMJ, BMJ Publishing Group Ltd, Brain Training, British Medical Journal (BMJ), Cognitive Decline, Cognitive Decline Studies, Cognitive Impairment, Cognitive Impairment (Potential Risk and Protective Factors), Cognitive Interventions, Cognitive Reserve, Cognitive Reserve Hypothesis, Cognitive Stimulation, Cognitive Training, Cognitive Training Exercises, Cognitively Stimulating Activities, Critical Appraisals, Curiosity (Openness), Dementia Risk Reduction and Prevention, Department of Psychology: National University of Ireland, Department of Psychology: University of Aberdeen, Engage Your Brain: GCBH Recommendations on Cognitively Stimulating Activities, Enjoyment and General Engagement, Global Council on Brain Health (GCBH), Healthy Ageing, Healthy Behaviours, Healthy Lifestyles, Healthy Living, Henry Smith Charity, Hobbies and Interests, Institute of Applied Health Sciences: University of Aberdeen, Intellectual Engagement (Self-Reported), Ireland, Lifelong Learning, Meaningful Activity, Meaningful Activity and Occupation, Meaningful Occupation, Medical Research Council, Mentally Challenging Occupations, Mild Cognitive Impairment, Mild Cognitive Impairment (MCI), Modifiable Risk Factors, National University of Ireland (Galway), Neuroprotective Lifestyles, NHS Grampian (Aberdeen), Positive Engagement, Problem-Solving Skills, Progression of Mild Cognitive Impairment, Rates of Conversion From Mild Cognitive Impairment to Dementia, Scottish Government Health Department, Scottish Mental Health Survey of 1947, Skills and Hobbies, Slowing of Cognitive Decline, University of Aberdeen, Use It or Lose It Hypothesis, Use It or Lose It Hypothesis: Benefit of Cognitively Stimulating Activity, Wellcome Trust
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