Tag Archives: Critical Appraisals

More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Posted on March 22, 2020 by Dementia and Elderly Care News

Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest | Tagged Association of British Neurologists, Bazian, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Behind the Headlines, Biomarker Development, Biomarkers, Biomarkers for Inflammation, Brain (Journal), Brain Autopsies, Brain Inflammation, C-PK-11195, C-PK-11195 (Biomarker for Inflammation), Cambridge Brain Bank, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Foundation Trust, Consiglio Nazionale delle Ricerche (CNR), Critical Appraisals, Degenerative Tauopathy, Department of Clinical Neurosciences: Cambridge University, Department of Neurology: Walton Centre (Liverpool), Department of Pathology: Cambridge University Hospitals NHS Foundation Trust, Department of Psychiatry: University of Cambridge, Division of Anaesthesia: University of Cambridge, Early-Onset Dementia, F-AV-1451, F-AV-1451 (Biomarker for Protein Clusters), Fronto-Temporal Dementia (FTD), Frontotemporal Dementia, Frontotemporal Dementia (FTD), FTD: Fronto-Temporal Dementia, FTLD-Pick’s, FTLD-TDP (A), FTLD-TDP (C), FTLD-TDP (Types A and C), FTLD-TDP-43, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM): Consiglio Nazionale delle Ricerche (CNR), Italy, Lundbeck Foundation (Denmark), Medical Research Council (MRC), Medical Research Council Cognition and Brain Sciences Unit: University of Cambridge, Microglia, Monoamine Oxidase (MAO), National Institute of Health Research, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Neuroinflammation and Frontotemporal Dementia, Neuroinflammation and Protein Aggregation, Neuromelanin, NIHR Dementias and Neurodegenerative Diseases Research Network, Non-Amyloid-β Protein Aggregation, Non-Fluent Variant Primary Progressive Aphasia (nfvPPA), Patrick Berthoud Charitable Trust, PET Scans, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Protein Aggregation, Protein Clusters, Semantic Variant Primary Progressive Aphasia (svPPA), Tauopathy, TDP-43, TDP-43 Pathology, TDP-43 Protein, TDP-43 Proteinopathy, University of Cambridge, Variants of Primary Progressive Aphasia (PPA), Wellcome Trust, Wolfson Brain Imaging Centre: University of Cambridge | Leave a comment

Optimal Timing of Blood Pressure Medication: Insight Into Chronotherapy for Cardiovascular Disease Risk Reduction (BBC News / EHJ / Bazian)

Posted on October 26, 2019 by Dementia and Elderly Care News

Summary Results from the Hygia Chronotherapy Trial suggest that blood pressure medicines may be more effective at lowering blood pressure, and reducing the risk of heart attacks and / or stroke, when taken at bedtime. Full Text Link Reference Roberts, M. (2019). Blood … Continue reading →

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Hypertension, In the News, International, Management of Condition, NHS Digital (Previously NHS Choices), Person-Centred Care, Pharmacological Treatments, Quick Insights, Stroke, Universal Interest | Tagged Asleep Blood Pressure, Atlantic Research Center for Information and Communication Technologies (AtlantTIC), Bazian, BBC Health News, Bedtime Hypertension, Bioengineering and Chronobiology Laboratories: University of Vigo, Blood Pressure, Blood Pressure Medications, Blood Pressure Medications (Timing), Body Clock, Cardiovascular Disease, Cardiovascular Disease (CVD), Cardiovascular Disease Risk Reduction, Chronotherapy, Circadian Cycles, Circadian Factors, Circadian Rhythms, Complejo Hospitalario Universitario, Critical Appraisals, CVD: Cardiovascular Disease, Estructura de Xestión Integrada de Ourense, Estructura de Xestión Integrada de Santiago de Compostela: Servicio Galego de Saúde (SERGAS), Estructura de Xestión Integrada de Vigo: Servicio Galego de Saúde (SERGAS), European Heart Journal, Heart Failure, High Blood Pressure, Human Circadian Clock, Hygia Project Investigators, Hygia Chronotherapy Trial, Hypertension, Myocardial Infarction, NCT03457168, Servicio de Nefrología: Complejo Hospitalario Universitario, Servicio Galego de Saúde (SERGAS), Spain, Stroke Risk Factor Modification, University of Vigo, University of Vigo (Spain) | Leave a comment

Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Early Promising Results? (JAD / Bazian)

Posted on September 25, 2019 by Dementia and Elderly Care News

Summary Transcranial Electromagnetic Treatment (TEMT) for persons with mild / moderate Alzheimer’s Disease, delivered ia a bathing cap-style head device called the MemorEM, appears to bring about various statistically significant improvements without any observable adverse effects. Benefits are said to include: “ …cognitive enhancement, changes to CSF / … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, NHS Digital (Previously NHS Choices), Non-Pharmacological Treatments, Quick Insights, Universal Interest | Tagged 2DG-PET, ADAS-Cog: Alzheimer’s Disease Assessment Scale - Cognitive Subscale, Adverse Event Assessment, Aβ Accumulation, Aβ-Plaques, Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog), Alzheimer’s Disease Biomarkers, Alzheimer’s Disease Cooperative Study - Activities of Daily Living, Angel Investor Forum, Bazian, Behind the Headlines, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Byrd Alzheimer's Institute (Tampa Florida), Cerebral Metabolic Rate for Glucose (Via 2DG-PET), Cerebrospinal Fluid (CSF), Cerebrospinal Fluid (CSF) Biomarkers, Clock Drawing Test, College of Pharmacy: University of South Florida, Critical Appraisals, CSF Biomarkers, Czech Republic, Department of Neurology: Charles University (Prague), Diffusion Tensor Imaging (DTI), Digit Span, FDG-PET Imaging, fMRI, Functional Magnetic Resonance Imaging (fMRI), Glass Charitable Foundation, Invicro (Boston USA), Journal of Alzheimer's Disease, Journal of Alzheimer’s Disease (JAD), Left Coast Engineering (Escondido California), MemorEM (Transcranial Electromagnetic Stimulation), Motol University Hospital (Prague), MRI Scans, National Institute of Neurological Disorders and Stroke (NINDS), NeuroEM Therapeutics Inc. (Phoenix Arizona), Ocotillo Electromagnetics Inc. (Chandler Arizona), olumbia Suicide Severity Rating Scale, Plasma Biomarkers, Rey Auditory Verbal Learning Test (Rey AVLT), Rey AVLT, RF Exposure Laboratory (San Marcos California), School of Aging Studies: University of South Florida, Transcranial Brain Stimulation, Transcranial Electromagnetic Treatment (TEMT), United States, University Diagnostic Institute (Tampa Florida), University of South Florida, University of South Florida Health / Byrd Alzheimer's Institute, USA | Leave a comment

Optimism Linked to Longevity (BBC News / PNAS / Bazian)

Posted on August 27, 2019 by Dementia and Elderly Care News

Summary Researchers in the United States, using data from the Nurses’ Health Study and the Veterans’ Health Study, have confirmed that optimists tend to live longer and are more likely to achieve “exceptional longevity” i.e. live to an age of … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest | Tagged Bazian, BBC Health News, BBC UGC Hub, Behavioural Risk Factors, Behind the Headlines, Boston University School of Medicine, Boston University School of Public Health, Brigham and Women's Hospital, Channing Division of Network Medicine: Brigham and Women’s Hospital, Critical Appraisals, Department of Epidemiology: Boston University School of Public Health, Department of Epidemiology: Harvard T.H. Chan School of Public Health, Department of Population Medicine: Harvard Medical School, Department of Psychiatry: Boston University School of Medicine, Department of Social and Behavioral Sciences: Harvard T.H. Chan School of Public Health, Epidemiology, Epidemiology and Statistics, Exceptional Longevity, Fonds de Recherche en Santé–Quebec, Harvard Medical School, Harvard Pilgrim Health Care Institute, Harvard T.H. Chan School of Public Health, Human Longevity, Lee Kum Sheung Center for Health and Happiness: Harvard T.H. Chan School of Public Health, Life Orientation Test – Revised, Lifestyle Risk Factors, Longevity, Massachusetts Veterans Epidemiology Research and Information Center: Veterans Affairs Boston Healthcare System, Mental and Physical Health, Modifiable Risk Factors, National Center for Posttraumatic Stress Disorder: Veterans Affairs Boston Healthcare System, National Institutes of Health, National Institutes of Health (NIH), National Institutes of Health: Clinical Science Research and Development Service, Nurses’ Health Study, Nurses’ Health Study (NHS), Optimism, Optimism Associated With Longevity, Optimists, Physical Impacts of Mood, Positive Outlook, Positive Psychology, Positive Psychosocial Factors, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Psychosocial Protective and Risk Factors, Reducing the Divide Between Mental and Physical Healthcare, Revised Optimism–Pessimism Scale from the Minnesota Multiphasic Personality Inventory-2, United States, US Department of Veterans Affairs, USA, User-Generated Content: the BBC UGC Hub, Veterans Affairs Boston Healthcare System, Veterans Affairs Normative Aging Study, Veterans Affairs Normative Aging Study (NAS), Wellbeing and Longevity | Leave a comment

Healthy Lifestyles May Partially Help Offset Genetic Risk Factors for Dementia (BBC News / JAMA / Bazian)

Posted on July 17, 2019 by Dementia and Elderly Care News

Summary Persons in the UK Biobank study were followed over time to discover whether pursuing a healthy lifestyle (not smoking, regular physical activity, healthy diet and moderate alcohol consumption) might be associated with lower risk of developing dementia regardless of predisposing genetic risk factors. Statistically, favourable (“healthy”) lifestyles … Continue reading →

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Non-Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged Active Lifestyle, Ageing Population, Alan Turing Institute, Albertinen-Haus Centre for Geriatrics and Gerontology: University of Hamburg, Alzheimer’s Association International Conference (AAIC®2019), Association Between Physical Activity and Cognitive Function and / or Dementia, Association of Lifestyle and Genetic Risk Factors With Incidence of Dementia, Australia, Australian Centre for Precision Health: University of South Australia, Bazian, BBC Health News, Behind the Headlines, Cigarette Smoking, Clinical Trial Service Unit and Epidemiological Studies Unit: University of Oxford, Cognitive Impairment (Potential Risk and Protective Factors), Cognitive Impairment (Potential Risk Factors), Critical Appraisals, Cumulative Benefit of Reducing Risk Factors, Dementia and Geriatric Cognitive Disorders, Dementia Prevention, Dementia Risk Factors, Dementia Risk Reduction and Prevention, Department of Health Economics and Health Services Research: Hamburg Center for Health Economics, Division of General Medicine: University of Michigan, Epidemiology, Epidemiology and Statistics, Genetic Risk Factors, Genetic Risk Factors for Alzheimer’s Disease, Germany, Great Ormond Street Institute of Child Health, Hamburg Center for Health Economics, Healthy Behaviours, Healthy Diet, Healthy Lifestyle Score: Based on Four Established Dementia Risk Factors (Smoking Physical Activity Diet and Alcohol Consumption), Healthy Lifestyles, Healthy Living, Institute for Healthcare Policy and Innovation: University of Michigan, Institute for Social Research: University of Michigan, JAMA, Journal of the American Medical Association (JAMA), Later Life, Life-Course Approach to Healthy and Active Ageing, Lifestyle Factors, Lifestyle Risk Factors, Mild Cognitive Impairment (MCI), Moderate Alcohol Consumption, Moderate Exercise, Modifiable Risk Factors, Neurological Disorders, Neuroprotective Lifestyles, NIHR CLAHRC South West Peninsula (PenCLAHRC), Nuffield Department of Population Health: University of Oxford, Nutritional and Metabolic Disorders, Obesity Risk Factor, Overlapping Risk Factors, Physical Activity and Health Benefits, Physical Activity Before Dementia, Physical Exercise, Physical Exercise Programmes, Physical Inactivity, Polygenic Risk Score: Individual’s Load of Common Genetic Variants Associated with Alzheimer's Disease and Dementia Risk, Population Policy and Practice: University College London, Potentially Modifiable Socio-Environmental Risk Factors for Dementia, Prevention, Prevention Agenda, Prevention Better Than Cure, Prevention of Dementia, Preventive Care, Psychosocial and Lifestyle-Related Risk Factors, Psychosocial Protective and Risk Factors, Reducing the Incidence of Dementia, Regular Physical Activity, Risk Factors, Risk Factors and Preventive Interventions for Cognitive Impairment, Risk Factors and Preventive Interventions for Dementia, Risk Reduction of Cognitive Decline and Dementia, Scientific Department: University of Hamburg, Smoking, Smoking Cessation, Social Epidemiology, South Australia, Staying Healthy for Longer, Tobacco Consumption, UK Biobank, Unhealthy Lifestyles, United States, University College London, University of Exeter, University of Exeter Medical School, University of Hamburg, University of Michigan, University of Oxford, University of South Australia, University of South Australia Cancer Research Institute, USA, Veterans Affairs Center for Clinical Management Research in Michigan, Veterans Affairs Center for Clinical Management Research: Michigan | Leave a comment

Consumption of Sugary Drinks Associated With Higher Cancer Risk? (BBC News / BMJ / Bazian)

Posted on July 13, 2019 by Dementia and Elderly Care News

Summary Sugary drinks, including 100% fruit juices and fizzy pops, appear to increase the risk of cancer (very slightly). Full Text Link Reference Gallagher, J. (2019). Are sugary drinks causing cancer? London: BBC Health News, July 11th 2019. This relates … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest | Tagged 100% Fruit Juices: Potential Modifiable Risk Factor for Cancer Prevention, Adiposity, Adiposity and Cancer, Adiposity-Related Cancers, Avicenne Hospital, Bazian, BBC Health News, Behind the Headlines, BMJ, BMJ Publishing Group Ltd, British Medical Journal (BMJ), Cancer Risk Factors, Conservatoire National des Arts et Métiers (CNAM), Critical Appraisals, Diet and Nutrition, Diet and Obesity, Dietary Risk Factors, Epidemiology, Epidemiology and Statistics, Fine and Gray Model, Fondation de France, Framingham Offspring Cohort, Framingham Third Generation Cohort, France, French Ministry of Health, French National Cancer Institute, French National Cause Specific Mortality Registry (CépiDC), French NutriNet-Santé Cohort, French Public Health Agency, Glycaemic Index or Glycaemic Load of Sugary Drinks, Healthy Ageing, Healthy Lifestyles, Lifestyle Factors, Lifestyle Risk Factors, Melbourne Collaborative Cohort Study, Modifiable Risk Factors, National Institute for Agricultural Research (INRA), National Institute for Health and Medical Research (INSERM), NutriNet-Santé Prospective Cohort, Nutrition, Nutritional Epidemiology Research Team (EREN), Nutritional Epidemiology Surveillance Team (ESEN), Obesity, Obesity - Cancer Link, Obesity and Elevated Cancer Risk, Overlapping Risk Factors, Paris 13 University, Public Health Department: Avicenne Hospital, Risk Factors, Santé Publique France: the French Public Health Agency, SNIIRAM Databases, Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS): Inserm U1153, Sugar Consumption, Sugary Drinks, Sugary Drinks: Link to Cancer, Sugary Drinks: Potential Modifiable Risk Factor for Cancer Prevention, Unhealthy Lifestyles, Visceral Adiposity | Leave a comment

Estimated Burden of Alcohol-Related Care in NHS Hospitals (BBC News / Addiction / Bazian)

Posted on July 6, 2019 by Dementia and Elderly Care News

Summary Alcohol-related medical conditions cost the NHS in the UK roughly £3.5 billion per year. One in five UK hospital patients drink alcohol harmfully, according to a recent study. Full Text Link Reference Alcohol abuse affects one in five UK … Continue reading →

Posted in Acute Hospitals, BBC News, Delirium, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Management of Condition, NHS, NHS Digital (Previously NHS Choices), Quick Insights, Systematic Reviews, UK, Universal Interest | Tagged Addiction (Journal), Alcohol Abuse, Alcohol Dependence, Alcohol Intoxication, Alcohol Misuse, Alcohol Withdrawal State, Alcohol Withdrawal State With Delirium, Alcohol-Related Conditions Among Hospital Patients, Alcohol-Related Harm, Alcohol‐Induced Acute Pancreatitis, Alcohol‐Induced Chronic Pancreatitis, Alcohol‐Induced Psychotic Disorder, Alcoholic Cirrhosis of Liver, Alcoholic Gastritis, Alcoholic Hepatic Failure, Alcoholic Hepatitis, Alcoholic Liver Disease (Unspecified), Alcoholic Polyneuropathy, Alcoholism, Bazian, Behind the Headlines, Brighton and Sussex Medical School: University of Brighton, Critical Appraisals, Department of Child and Adolescent Psychiatry: King’s College London, Department of Non-communicable Disease Epidemiology: London School of Hygiene and Tropical Medicine, Department of Psychological Medicine: King's College London, Drinking Culture, Gastrointestinal Disorders Due to Alcohol, Harmful Alcohol Use, Harmful Effects of Drinking (Alcohol), Harmful Use of Alcohol, Institute of Psychiatry Psychology and Neuroscience: King’s College London, Intentional Self‐Poisoning By and Exposure to Alcohol, Kings College London, Liver Disorders Due to Alcohol, London School of Hygiene and Tropical Medicine, Medical Research Council Addiction Research Clinical Fellowship, Mental and Behavioural Disorders Due to Use of Alcohol, National Addiction Centre and the Department of Psychological Medicine: King's College London, NIHR Maudsley Biomedical Research Centre: South London and the Maudsley NHS Foundation Trust, Other Disorders Due to Alcohol, Poisoning Due to Alcohol, Prevalence of Alcohol-Related Care in NHS Hospitals, Prevalence of Alcohol-Related Conditions in UK Hospitals, South London and the Maudsley NHS Foundation Trust, Systematic Reviews and Meta-Analyses, University of Brighton, University of Sussex | Leave a comment

Tag Archives: Critical Appraisals

More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Optimal Timing of Blood Pressure Medication: Insight Into Chronotherapy for Cardiovascular Disease Risk Reduction (BBC News / EHJ / Bazian)

Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Early Promising Results? (JAD / Bazian)

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