Tag Archives: CSF Aβ

Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

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Early Diagnosis of Alzheimer’s Disease Using Spinal Fluid? (NHS Choices / Cell Reports)

Summary A recent diagnostic study has investigated the possibility of diagnosing Alzheimer’s Disease, years before disease onset, using cerebrospinal fluid (CSF). The technique for identifying people with Alzheimer’s Disease would be based on detecting very small amounts of abnormal (misfolded) … Continue reading

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Biomarker Assessments in Alzheimer’s Disease Clinical Trials (Quintiles / Frontiers in Aging Neuroscience)

Summary Accurate and sensitive tools are required for the early detection / diagnosis of Alzheimer’s Disease, particularly to assist research. Alzheimer’s Disease clinical trials make increasing use of biomarkers, particularly neuroimaging markers and cerebrospinal fluid (CSF) biomarkers obtained via invasive … Continue reading

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Brain Scans Distinguish Between Dementia Types (BBC News / Neurology)

Summary Scientists at the University of Pennsylvania believe they may have discovered how to distinguish between different types of dementia without the need for invasive lumbar puncture tests to obtain cerebrospinal fluid (csf).  Alzheimer’s and frontotemporal dementia share similar features and symptoms and can … Continue reading

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Early-Onset Alzheimer’s Gene Studied in Young Adults (NHS Choices / Lancet Neurology)

Summary This is another critical appraisal from the NHS Choices “Behind the Headlines” service, released during 2012, on elderly care and dementia-related topics appearing in the news. Full Text Link (a) Reference Early-Onset Alzheimer’s gene explored in teens. London: NHS … Continue reading

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People Likely to Develop Alzheimer’s Disease are Potentially Identifiable Ten Years Earlier (Department of Health, Dementia)

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 2 Issue 7, February 2012]. Summary People at risk of developing Alzheimer’s Disease (AD) could be pre-diagnosed ten years before the disease becomes manifest, according to a … Continue reading

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