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Tag Archives: DLB: Dementia with Lewy Bodies
Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)
Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading →
Posted in Alzheimer’s Research UK, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Personalisation, Quick Insights, Systematic Reviews, UK, Universal Interest
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Tagged 18F-florbetaben, 18F-flutemetamol, 18Fflorbetapir, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Alzheimer’s Research UK (ARUK), Amyloid and Tau PET, APOE e4 (Apolipoprotein E e4), Apolipoprotein E (APOE) e4 Allele, Behavioural Biomarkers, Beta-Amyloid PET Imaging, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Canonical Syndromes of Primary Progressive Aphasia: Non-Fluent / Agrammatic Variant (nfvPPA), Canonical Syndromes of Primary Progressive Aphasia: Semantic Variant (svPPA), Carbon-11 Pittsburgh Compound-B (C-PIB) Radioisotope Tracer, Cerebral Metabolic Rate for Glucose (CMRgl), Cerebrospinal Fluid (CSF) Biomarkers, Cerebrospinal Fluid and Serum MHPG, CMRgl Decline, Corticobasal Degeneration (CBD), CSF 3-methoxy-4-hydrox-yphenylglycol (MHPG), Dementia With Lewy Bodies (DLB), Differential Diagnosis, DLB: Dementia with Lewy Bodies, Docosahexaenoic Acid (DHA), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Eicosapentaenoic Acid (EPA), Frontotemporal Dementia (FTD), α-Synuclein, Journal of Geriatric Care and Research (JGCR), Lewy Body Dementia (LBD), Magnetic Resonance Imaging (MRI), Medial Temporal Lobe Atrophy (MTA), Medial Temporal Lobes (MTL), Metabolic Syndrome (MetS), MRI Brain Imaging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroimaging, Neuroimaging in Dementia Diagnosis, Non-Invasive Biomarkers, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Primary Progressive Aphasia (PPA), Progressive Supranuclear Palsy (PSP), Rapid Screening, Screening for Dementia, Sea Hero Quest (SHQ) Game, Sea Hero Quest VR, Tau PET, Timely Diagnosis, VaD: Vascular Dementia, Variants of Primary Progressive Aphasia (PPA), Vascular Dementia, [18F]THK5351
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Hallucinations and Delusions in Dementia With Lewy Bodies (Behavioural Neurology)
Summary Hallucinations and delusions are common in Dementia with Lewy Bodies (DLB). A study shows that DLB patients who experience delusional symptoms tend to have poorer cognitive function and more severe BPSD. Oddly, DLB patients with diabetes appear to be less … Continue reading →
Posted in For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, Universal Interest
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Tagged Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Behavioural Neurology (Journal), China Medical University Hospital, China Medical University Hospital (Taiwan), Cognitive Symptoms, Delusions, Delusions and Other Neuropsychiatric Symptoms, Delusions of Other Persons Stealing, Dementia With Lewy Bodies (DLB), Department of Internal Medicine: China Medical University Hospital, Department of Neurology: Show Chwan Memorial Hospital, Department of Neurology: Tainan Municipal Hospital, Division of Endocrinology and Metabolism: China Medical University Hospital, DLB, DLB Comorbid With Diabetes, DLB Patients With Diabetes, DLB: Dementia with Lewy Bodies, Family Plans to Abandon Him / Her (Delusional), Fluctuating Cognition, Fluctuations, Hallucinations, Hallucinations and Delusions in Dementia With Lewy Bodies, House Not His / Her Home (Delusional), Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Media Persons in House (Delusional), Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neuropsychiatric Disturbances, Neuropsychiatric Symptoms, Other Persons Stealing (Delusional), Others Not Whom They Claim (Delusional), Parkinsonism, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, Self in Danger (Delusional), Show Chwan Medical Care Corporation, Show Chwan Memorial Hospital (Taiwan), Spouse Having Affair (Delusional), Tainan Municipal Hospital (Taiwan), Taiwan, Unwelcome Guest in House (Delusional), Visual Hallucinations
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Dementia With Lewy Bodies and Parkinson’s Disease Dementia: Compared and Contrasted (BMC Medicine)
Summary The authors of this review consider whether Dementia With Lewy Bodies (DLB) and Parkinson’s Disease Dementia (PDD) are actually two distinct conditions, as the official “Diagnostic and Statistical Manual of Mental Disorders” 5th Edition (DSM–5) would suggest, or whether … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Quick Insights, Universal Interest
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Tagged Aβ Deposition in DLB, Atypical Parkinsonism (AP), Austria, BMC Medicine, Corticobasal Syndrome (CBS), Dementia With Lewy Bodies (DLB), Department of Laboratory Medicine Nijmegen: Radboud University Medical Center, Department of Neurology: Radboud University Medical Center, Department of Radiology and Nuclear Medicine: Radboud University Medical Center, Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM–5), Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), Differential Diagnosis, DLB, DLB: Dementia with Lewy Bodies, Donders Institute for Brain Cognition and Behaviour: Radboud University Medical Center, DSM-5, Early Diagnosis of Parkinson’s Disease and DLB, Fourth Consensus Report of DLB Consortium, Institute of Clinical Neurobiology (Alberichgasse Vienna), Israel, Multiple System Atrophy (MSA), Netherlands, Parkinson's Disease Diagnostic Observations (PADDO) Study, Parkinson’s Dementia, Parkinson’s Disease Dementia (PDD), Progressive Supranuclear Palsy (PSP), Radboud University Medical Center, Sackler Faculty of Medicine: Tel-Aviv University, Tel Aviv University, Underlying Mechanisms of DLB Pathogenesis, Vascular Parkinsonism (VP)
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Dementia with Lewy Bodies: Updated DLB Consortium Diagnosis and Management Consensus Report (Neurology)
Summary The Dementia with Lewy Bodies (DLB) Consortium has published an updated set of recommendations on diagnosis and management of DLB. Clinical features and diagnostic biomarkers are covered, with guidance on their interpretation. Previously omitted aspects of Lewy-related pathology are … Continue reading →
Posted in Antipsychotics, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, UK
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Tagged Abnormal Proteins (Alpha-Synuclein), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Alternatives to Antipsychotics, Antipsychotics Limitation in Dementia, Antipsychotics: Neuroleptic Sensitivity, Assessment and Diagnosis, Australia, Autonomic System Dysfunction, Banner Sun Health Research Institute, Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blackouts, Brain and Mind Centre: University of Sydney, Brain Stimulation, Center for Neurodegenerative Disease Research: University of Pennsylvania, Centre for Age-Related Diseases: Stavanger University Hospital, Cognitive Decline (DLB vs. Alzheimer's), Cognitive Symptoms, Comparison of Cognitive Decline (DLB vs. AD), Deep Brain Stimulation for the Treatment of Dementia, Delusions, Dementia With Lewy Bodies (DLB), Dementia With Lewy Bodies (DLB) Consortium, Department of Laboratory Medicine and Pathology: Mayo Clinic, Department of Neurology: Mayo Clinic, Department of Neurology: Mayo Clinic (Rochester), Department of Neurology: University of Pennsylvania, Department of Neuroscience and Neuropathology Laboratory: Mayo Clinic, Department of Neuroscience Imaging and Clinical Sciences: University G. d'Annunzio of Chieti-Pescara, Department of Neuroscience: Mayo Clinic, Department of Psychiatry and Psychology: Mayo Clinic, Department of Veterans Affairs, Departments of Radiology and Neurology: University of Michigan, Diagnosis and Management of Dementia with Lewy Bodies, Diagnosis and Screening: Dementia with Lewy Bodies, Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), Differential Diagnosis, Dizziness, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Drooling, DSM-5, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease and DLB, Fainting, Florida Atlantic University, Fluctuating Cognition, Fluctuations, Fourth Consensus Report of DLB Consortium, Hallucinations, Handwriting, ICube Laboratory, Institute for Healthy Aging and Lifespan Studies (I-HeAL): Florida Atlantic University, Institute of Neuroscience: Newcastle University, Institute of Psychiatry Psychology and Neuroscience: King’s College London, Italy, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Kings College London, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Lewy Body Society, Medical School: University of Exeter; University of Exeter, Misdiagnosis, Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neurology (Journal), Norway, Parkinson's Disease and Mental Illness Research Education and Clinical Centers (PADRECC and MIRECC): Philadelphia Veterans Affairs Medical Center, Parkinson’s-Like Symptoms, Perelman School of Medicine: University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Postural Instability, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Repeated Falls, Severe Neuroleptic Sensitivity, Severe Sensitivity to Antipsychotic Agents, Shuffling Walk, Sleep Disorders Center: Mayo Clinic, Stavanger University Hospital, Stavanger University Hospital; Norway, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, Transient Loss of Consciousness, Underlying Mechanisms of DLB Pathogenesis, United States, University G. d'Annunzio of Chieti-Pescara, University Hospital of Strasbourg, University of Michigan, University of Pennsylvania, University of Strasbourg, University of Sydney
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Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)
Summary Research at the University of Edinburgh indicates that test for synuclein, which measures how sticky this protein molecule has become (i.e. alpha-synuclein aggregation), might be the key to diagnosing accurately the early stages of both Parkinson’s Disease and Dementia … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Scotland, UK, Universal Interest
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Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synuclein RT-QuIC, Alpha-Synucleinopathies, Annals of Clinical and Translational Neurology, BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Brain Bank Network (MRC), Brains for Dementia Research (BDR), Centre for Clinical Brain Sciences: Western General Hospital, Cerebrospinal Fluid Biomarkers for Parkinson's Disease Diagnosis, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, CSF Biomarkers, Dementia With Lewy Bodies (DLB), Department of Physiology Anatomy and Genetics: University of Oxford, Diagnosis, Diagnosis and Screening: Dementia with Lewy Bodies, Differential Diagnosis, DLB: Dementia with Lewy Bodies, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease, Early Diagnosis of Parkinson’s Disease and DLB, Edinburgh Brain Bank, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, John Radcliffe Hospital, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Medical Research Council (MRC), Michael J Fox Foundation, Misfolded Proteins, Monument Trust Discovery Award (Parkinson's UK), MRC Brain Bank, National CJD Research and Surveillance Unit (NCJDRSU), National CJD Surveillance Unit: Western General Hospital: Data Release (HSCIC), National Institute for Health Research (NIHR), National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NCJDRSU: National CJD Research and Surveillance Unit, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Nuffield Department of Clinical Neurosciences: University of Oxford, OPDC Discovery Cohort, OPTIMA Cohort, OPTIMA Cohort (Oxford Project to Investigate Memory and Ageing), Oxford Brain Bank, Oxford Parkinson's Disease Centre, Oxford Parkinson's Disease Centre (OPDC) Discovery Study, Oxford Parkinson's Disease Centre: University of Oxford, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Real-Time Quaking-Induced Conversion (RT-QuIC) Based Assay, Scottish Government's Chief Scientists Office, Sporadic Creutzfeldt-Jakob Disease, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, UK Brain Banks Network, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, Underlying Mechanisms of DLB Pathogenesis, University of Edinburgh, University of Oxford, Western General Hospital: Edinburgh
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Non-Alzheimer’s Dementias: Three Reviews (Lancet)
Summary The Lancet has published a series of three up-to-date reviews concerning non-Alzheimer’s dementia. Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access). Reference Dementia – not all about Alzheimer’s. [Editorial]. … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Patient Care Pathway, Person-Centred Care, Pharmacological Treatments, Quick Insights, Statistics, Systematic Reviews, UK, Universal Interest
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Tagged Akershus University Hospital and University of Oslo, Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC), Alzheimer's Disease With Cardiovascular Disease, APOE e4 (Apolipoprotein E e4), ApoE e4 Allele, Association of RBD with Synucleinopathies, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Biomarkers, Brain Imaging, BV-FTD, C677T, C9orf72 MAPT and GRN Genes, Cambridge Biomedical Campus, Campus for Ageing and Vitality: Newcastle upon Tyne, Center for Sleep Medicine: Mayo Clinic, Center for Sleep Medicine: Mayo Clinic College of Medicine, Centre for Age-Related Diseases: Stavanger University Hospital, Cerebrovascular Disease, CeVD: Cerebrovascular Disease, Clinical Symptoms Characteristic of Frontotemporal Dementia, Cognitive Assessments / Screening Tools, Constipation, Delirium and Dementia With Lewy Bodies, Dementia with Lewy Bodies, Dementia With Lewy Bodies (DLB), Dementia with Lewy Bodies Symptoms, Department of Geriatric Psychiatry: Akershus University Hospital, Department of Neurology: Mayo Clinic College of Medicine, Department of Psychiatry: University of Cambridge, Diagnosis of Vascular Dementia, Differential Diagnosis, Differential Diagnosis of Memory Problems, Division of Psychiatry: University College London, DLB: Dementia with Lewy Bodies, Dopamine Transporter Single Photon Emission CT, Early Diagnosis, Epidemiology, Epidemiology and Statistics, Epidemiology of Frontotemporal Dementia, Epidemiology of Major Neurological Disorders, Fluctuating Cognition, Fluctuations, Fluorodeoxyglucose PET, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Frontotemporal Dementia Symptoms, Frontotemporal Dementia With Motor Neurone Disease (FTD-MND), Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Lobar Degeneration FUS, FTLD: Frontotemporal Lobar Degeneration, Genetic and Pathological Correlation in FTLD, Genetics, Genetics of DLB, Haemorrhagic Dementia, Hallucinations, Hallucinations and Delusions in Parkinson's Disease, Hallucinations in People with Dementia, Hereditary Vascular Dementia (CADASIL), Hypoperfusion Dementia, Imaging, Increased Salivation, Institute of Neuroscience and Newcastle University Institute for Ageing: Newcastle University, Lancet, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Management of Vascular Dementia, Mayo Clinic College of Medicine (USA), Memory and Aging Center: University of California, Mental Health Unit: St Margaret's Hospital (Epping), Mild Cognitive Impairment in Parkinson's Disease (MCI-PD), MTHFR, Multi-Infarct Dementia (Cortical Vascular Dementia), National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN), Neurological Disease, Neurological Disorders, Neuropathological Features, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NFV-PPA, Non-Alzheimer’s Dementia, Non-Fluent Variant Primary Progressive Aphasia, Nondegenerative Neurological Diseases (NNDs), North Essex Partnership University NHS Foundation Trust, Norway, Norway Stavanger University Hospital, Nosology of Vascular Dementia, Olfactory Dysfunction, Parkinson’s Disease Dementia, Parkinsonism, Pathological Staging, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Prevalence of Cerebrovascular Disease, Prevalence of Neurological Disorders, Prodromal Dementia With Lewy Bodies, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, Sandler Neurosciences Center (San Francisco), Semantic Variant Primary Progressive Aphasia, Single Photon Emission Computed Tomography (SPECT), Small Vessel Arteriosclerosis, Small Vessel Dementia (Subcortical Vascular Dementia), SNCA and LRRK2 Genes, SPECT (Single Photon Emission Computed Tomography), Stavanger University Hospital, Stavanger University Hospital; Norway, Strategic Infarct Dementia, Subtypes of Vascular Dementia, SV-PPA, Systematic Reviews and Meta-Analyses, Timely Diagnosis, Treatments for Dementia With Lewy Bodies and Parkinson's Disease Dementia, United States, University College London, University of California, University of California: San Francisco School of Medicine, University of Cambridge, USA, VaD: Vascular Dementia, Vascular Dementia Symptoms, Visual Hallucinations
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Exploring Disease-Modifying Treatments for Lewy-Body Dementia (Frontiers in Neuroscience)
Summary The authors of this review remind readers that there are currently no disease-modifying therapies for Dementia with Lewy bodies (DLB). DLB accounts for perhaps 25% of all dementia cases. This review covers therapeutic directions which have been explored for … Continue reading →
Posted in Acute Hospitals, Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Models of Dementia Care, Quick Insights, Systematic Reviews
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Tagged Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Aging Mind and Brain Initiative: University of Iowa Iowa City, Basal Forebrain Cholinergic Neurons (BFCN), Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Brain Stimulation, Carver College of Medicine: University of Iowa Iowa City, DBS Targeting the Nucleus Basalis of Meynert (NBM), Deep Brain Stimulation, Deep Brain Stimulation (DBS), Deep Brain Stimulation (DBS) of Nucleus Basalis of Meynert (NBM) in Dementia with Lewy Bodies (DLB), Deep Brain Stimulation for the Treatment of Dementia, Dementia With Lewy Bodies (DLB), Department of Neurology: University of Iowa Iowa City, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Disease-Modifying Treatments for Lewy-Body Dementia, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Fibrils, Fluctuating Cognition, Fluctuations, Fornix DBS, Frontiers in Neuroscience, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Misfolded Proteins, NBM DBS, Nerve Growth Factor (NGF) Secretion, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofibrillary Tangles, NFT+/Aβ- Brains (Neurofibrillary Tangles Without Amyloid [Aβ] Plaques), Non-Motor Fluctuations in Parkinson's Disease, Physician Scientist Training Program: University of Iowa Iowa City, Prion-Like Mechanisms, Synucleinopathy, Synucleinopathy Progression, Underlying Mechanisms of DLB Pathogenesis, United States, University of Iowa, USA
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