Tag Archives: Drug Development for Alzheimer’s Disease

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

Posted on August 3, 2019 by Dementia and Elderly Care News

Summary Research published in the Neurology journal claims a significant breakthrough in the development of a blood test (for plasma Aβ42/Aβ40) which may be able to predict Alzheimer’s Disease onset with 94% accuracy. Due caution: “But it’s important to note … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Early Screening, Amyloid, Amyloid and Tau PET, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood Test for Brain Amyloidosis: Validated Using Amyloid PET and CSF p-tau181/Aβ42 as Reference Standards, Blood Tests, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Imaging, Brain Research, Case Finding, Conversion to Dementia From Prodromal Disease, Dementia Diagnosis, Dementia Innovation, Dementia Research, Dementia Screening, Department of Neurology: Washington University, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostic Imaging, Division of Biostatistics: Washington University, Drug Development for Alzheimer's Disease, Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Hope Center for Neurological Disorders: Washington University, Knight Alzheimer's Disease Research Center: Washington University, Mallinckrodt Institute of Radiology: Washington University, Neurology (Journal), Non-Invasive Biomarkers, Plasma Biomarkers, Plasma β-Amyloid 42/40, Plasma Protein Markers of MRI Measures in Asymptomatic Individuals, Preclinical Alzheimer's Disease, Preclinical Biomarkers in Alzheimer's Disease, Predictive Ability (of Tests), Prodromal Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Rapid Screening, Recruitment Onto Dementia Clinical Trials, SAP (Protein), SAP: Serum Amyloid Protein, Screening, Screening for Dementia, Washington University School of Medicine | Leave a comment

Summary of Recent Progress in Alzheimer’s Disease Prevention Trials (CTAD / JPAD)

Posted on October 1, 2018 by Dementia and Elderly Care News

Summary The following article summarises a round-up of present understanding and developments reflected in current and planned prevention trials, as discussed at a EU / US / Clinical Trials in Alzheimer’s Disease (CTAD) Task Force meeting, as of December 2016-7. … Continue reading →

AAIC’s Curated Round-Up of Publications Related to the 2016 Alzheimer’s Association International Conference (Alzheimer’s Association International Conference / Alzheimer’s and Dementia)

Posted on July 30, 2016 by Dementia and Elderly Care News

Summary Not everyone will have been able to attend the Alzheimer’s Association International Conference in Toronto last week. The Alzheimer’s Association AAIC Press Office has been kind enough to provide a curated collection of associated publications, relating to the 2016 … Continue reading →

Posted in Charitable Bodies, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged 2016 Alzheimer’s Association International Conference (AAIC®2016), Aboriginal and Torres Strait Islanders, Accelerating Medicines Partnership (AMP-AD), AD Genetics Consortium (ADGC), AddNeuroMed, ADNI Depression Study, Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) Study, Alzheimer's and Dementia: The Journal of the Alzheimer's Association, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), Alzheimer's Disease Big Data DREAM Challenge 1, Alzheimer's Disease Neuroimaging Initiative, Alzheimer’s Association, Alzheimer’s Association International Conference® (AAIC®) 2016, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Therapy Clinical Trial Results, Alzheimers and Dementia, Argentina ADNI (Arg-ADNI), Australian ADNI, Australian Imaging Biomarkers and Lifestyle Study of Aging (AIBL), Avoidable Hospital Admissions, Avoidable Hospitalizations of People With Alzheimer’s Disease: Cost to Medicare (USA), Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Brain Insulin and Insulin Receptors, Brain Insulin Resistance, Caregiver Burden and Dependence, Causes of Brain Insulin Resistance, China ADNI (C-ADNI), Chronic Traumatic Brain Injury, Clinical Dementia Rating–Sum of Boxes (CDR-SB), Cognitive Training, Critical Path Institute's (C-Path) Coalition Against Major Diseases (CAMD) Initiative, CSF Biomarkers, DADE Investigator Group, DADE Study, Dementia-Related Misdiagnosis, Dementia-Related Misdiagnosis (Male), Department of Defense Alzheimer's Disease Neuroimaging Initiative, Dependence in AD in England (DADE), Dependence Scale (DS), Dialogue on Reverse Engineering Assessment and Methods (DREAM) Project, Dietary Recommendations, Disease Modification, Down Syndrome Biomarker Initiative, DREAM, Drug Development for Alzheimer's Disease, Early Treatment to Reduce Costs and Mortality, EPAD, Estrogen Receptor (ESR), Estrogen Receptor Polymorphisms and Incident Dementia, European ADNI (E-ADNI), European Medical Information Framework (EMIF), Food and Drug Administration (FDA)'s Guidance for Industry Alzheimer’s Disease: Developing Drugs for the Treatment of Early Stage Disease, Formal Education and Complex Work, Framingham Heart Study, Frontotemporal Lobar Degeneration Neuroimaging Initiative, Genetic and Environmental Risk for AD Consortium (GERAD1), Global CEO Initiative for Alzheimer's Disease, Glucagon-Like Peptide-1 (GLP-1) Analogs, Imatinib Inhibition of Amyloid Precursor Protein (APP) In Humans, Imatinib Treatment and Aβ42 (In Humans), Impacts of ADNI, Incretin Mimetics, Innovative Medicine Initiative AD Research Platform, Insulin Receptor Substrate-1 (IRS-1) Signaling Pathway, Italo Monzino Foundation, Japanese ADNI (J-ADNI), Korean ADNI, Laboratory of Neuroimaging (LONI), Leuco-Methylthioninium (LMTM), Liraglutide (Victoza), LMTM Monotherapy, MBI Checklist (MBI-C), Mediterranean and DASH Diets, Mediterranean Diet, Mediterranean-DASH Intervention for Neurodegenerative Delay: MIND, Mediterranean-Dietary Approach to Systolic Hypertension (DASH) Diet, Mediterranean-Dietary Approach to Systolic Hypertension (DASH) Diet Intervention for Neurodegenerative Delay (MIND) Diet Score, Mild Behavioural Impairment (MBI), Mild Cognitive Impairment (MCI), MIND Diet, Monzino, Monzino 80-Plus Study, Neurodegeneration, Neurodegenerative Disease Research, North American Registry for Care and Research in MS, NPS Professional Interest Area (PIA), Parkinson's Progressive Markers Initiative (PPMI), Preclinical Alzheimer's Disease, Prevalence of Dementia in Aboriginal Australians, Prevalence of Dementia in China, Prevalence of Dementia in Oldest Old, Prodromal Alzheimer's Disease, Psychological Symptoms of Dementia (BPSD), Reduction of Systematic Sedation in Dementia Care, Regulation and Drug Development For Early-Stage Alzheimer's Disease, Relationship Between Age and Dementia Prevalence, Research and Development, Research and Innovation, Research Commitment, Resilience, Rush University Medical Center, Sage Bionetworks, Smell Tests For Detection of Memory Decline and Dementia, Streptozotocin (STZ), Taiwan ADNI, TauRx Therapeutics, Toronto, Transforming Research and Clinical Knowledge in Huntington's Disease (TRACK-HD), Translational Research, Translational Research Into Alzheimer's Disease in Europe, Traumatic Brain Injury, Traumatic Brain Injury (TBI), Treating Brain Insulin Resistance, Update of the Alzheimer's Disease Neuroimaging Initiative, Urban and Regional Aboriginal Australians, Urban and Rural Areas of China, Worldwide Alzheimer's Disease Neuroimaging Initiative | Leave a comment

Faintest Hints of Promise From a Recent Dementia Drug Trial? (BBC News / Alzheimer’s Association International Conference)

Posted on July 28, 2016 by Dementia and Elderly Care News

Summary Data from a recent trial involving 891 patients, presented at the Alzheimer’s Association International Conference in Toronto this week, indicates that an experimental new drug (LMTX) appears to slow the death of brain cells and preserve mental function in … Continue reading →

Posted in Alzheimer’s Disease International (ADI), BBC News, Charitable Bodies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Tau), Alzheimer Disease and Related Disorders Research Unit of the McGill University Research Centre for Studies in Aging (Douglas Mental Health University Institute), Alzheimer's Disease Research Unit: McGill University (Canada), Alzheimer’s Association, Alzheimer’s Association International Conference® (AAIC®) 2016, BBC Health News, Degenerative Tauopathy, Dementia Research, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Douglas Mental Health University Institute: McGill University Research Centre for Studies in Aging, Dr Serge Gauthier: Director of Alzheimer's Disease Research Unit at McGill University in Canada, Drug Development for Alzheimer's Disease, Drug Discovery Programmes, Drug Identification, Drug Trials, Drug Trials Failure Rate, Drug-Development Pipeline, Drugs for Treatment of Alzheimer’s Disease, Global Dementia Research, Leuco-methylthioninium-bis (hydromethanesulfonate) (LMTM), Leucomethylthioninium Salts (LMTX), LMTM Monotherapy, LMTX, Ltd., Neurodegeneration, Neurodegenerative Disease Research, Research and Development, Research and Innovation, Research Commitment, Tau, Tau Aggregation, Tau Aggregation Inhibitor Therapy, Tau Aggregation Inhibitors, Tau Pathology, Tau Tangles, Tau-Targeting Drugs, Tauopathy, TauRX, TauRx Therapeutics, Treatment and Prevention of Dementia | Leave a comment

European Medicines Agency Consultation on Pharmacological Treatments for Dementia (EMA)

Posted on February 3, 2016 by Dementia and Elderly Care News

Summary The European Medicines Agency (EMA) has released an updated draft guideline on medicines for the treatment of Alzheimer’s Disease and other types of dementia, for consultative feedback. Full Text Link Reference Consultation on revised guideline on medicines to treat … Continue reading →

World Alzheimer’s Day (BBC News / ARUK / OHE / NHS Choices)

Posted on September 22, 2015 by Dementia and Elderly Care News

Summary To mark World Alzheimer’s Day, life-expectancy and dementia incidence statistics, commissioned from the Office of Health Economics, have been used to arrive at the projection that perhaps one in three people born in the UK this year could develop … Continue reading →

Posted in Alzheimer’s Research UK, BBC News, Charitable Bodies, Commissioning, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Management of Condition, Models of Dementia Care, NHS Digital (Previously NHS Choices), Patient Care Pathway, Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged Accelerating Alzheimer's Research and Drug Development, Ageing Population, Ageing Society, Alzheimer’s Research UK (ARUK), ARUK: Alzheimer’s Research UK, Behind the Headlines, CFAS I Study, Cognitive Functioning and Ageing Study (CFAS), Costs of Dementia in UK, Delaying Onset: Cost Impact, Delaying Onset: Human Impact, Dementia Innovation, Dementia Research, Dementia Research Champions Group, Disease Modifying Treatment by 2025 (Aim), Disease Progression, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr Matthew Norton: Alzheimer's Research UK, Drug Development for Alzheimer's Disease, Drug-Development Pipeline, Epidemiology, Estimation of Future Cases of Dementia: From Males / Females Born in 2015, Forecasting Life Expectancy, Gender (Sex), Gender Differences in Diagnosis Rates, Incidence Studies, Life Expectancy, Life Table Data, Life Tables, National Life Tables, Office of Health Economics (OHE), OHE Consulting, OHE: Office of Health Economics, Prevalence, Prevalence of Dementia, Progression to Alzheimer's Disease, Slowing Progression: Cost Impact, Slowing Progression: Human Impact, Solanezumab (Eli Lilly), Trajectory of Dementia in the UK | Leave a comment

New Hopes for Disease-Modifying Pharmacological Dementia Treatment (BBC News / AAIC / ARUK)

Posted on July 22, 2015 by Dementia and Elderly Care News

Summary Trials of the drug Solanezumab were abandoned in apparent failure in 2012. More detailed examination of the data has since revealed evidence that this medication may have a role in slowing the pace of progression in Alzheimer’s Disease slightly, … Continue reading →

Posted in Alzheimer’s Research UK, BBC News, Charitable Bodies, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Patient Care Pathway, Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged Accelerating Alzheimer's Research and Drug Development, Alzheimer's Association International Conference (Washington, Alzheimer’s Association International Conference® (AAIC®) 2015, Alzheimer’s Research UK (ARUK), Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, ARUK: Alzheimer’s Research UK, BBC Health News, Big Pharma, Delaying Onset: Cost Impact, Delaying Onset: Human Impact, Disease Modifying Treatment by 2025 (Aim), Disease Progression, Disease-Modifying Therapies for Dementia, Dr Eric Karran: Director of Research at Alzheimer’s Research UK, Drug Development for Alzheimer's Disease, Drug-Development Pipeline, Eli Lilly, EXPEDITION Studies, β-amyloid, July 2015), Misfolded Proteins, Neurofibrillary Tangles, Neuronal Loss, Progression of Mild Cognitive Impairment to Dementia, Progression to Alzheimer's Disease, Slowing Progression: Cost Impact, Slowing Progression: Human Impact, Solanezumab (Eli Lilly), Solanezumab EXPEDITION Trials, Solanezumab for Mild-to-Moderate Alzheimer’s Disease, Solanezumab Trials, Solanezumab: Humanised Monoclonal Antibody | Leave a comment

Tag Archives: Drug Development for Alzheimer’s Disease

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

European Medicines Agency Consultation on Pharmacological Treatments for Dementia (EMA)

New Hopes for Disease-Modifying Pharmacological Dementia Treatment (BBC News / AAIC / ARUK)

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