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- Dementia-Friendly Communities Provision, Viewed as a Social Determinant of Health (JGCR / NHS England / WHO)
- International Perspectives on the Possible Impact of the COVID-19 Pandemic and Lockdown on Abuse of the Elderly (JGCR / American Journal of Geriatric Psychiatry / JAGS)
- Updates Relating to the Lancet Commission on Dementia Prevention, Intervention, and Care (Lancet / Alzheimer’s Research and Therapy / Alzheimer’s and Dementia)
- A Brief Review of How the COVID-19 Pandemic Relates to Elderly Care and Research (JGCR)
- Some Speculated / Potential Benefits of COVID-19 (JGCR / BBC Radio 4’s Rethink / BGS)
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Tag Archives: Early Detection of Preclinical Disease
Digital Technology for Early Detection of Neurodegenerative Disease (BBC News / EDoN)
Summary The Early Detection of Neurodegenerative Diseases (EDoN) initiative, with backing from Alzheimer’s Research UK, is working to develop wearable devices which will collect data to help detect the early stages of Alzheimer’s Disease and other neurodegenerative diseases. Full Text … Continue reading →
Posted in Alzheimer’s Research UK, BBC News, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, UK, Universal Interest
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Tagged Accelerating Detection of Disease Programme, Alan Turing Institute, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Research UK (ARUK), Artificial Intelligence (AI), ARUK: Alzheimer’s Research UK, Asymptomatic Alzheimer’s Disease, Automatic Speech Analysis, BBC Health News, BBC Technology News, Behavioural Biomarkers, Benefits of Early Detection, Big Data, Bill and Melinda Gates Foundation, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, CrawfordWorks, David Cameron, David Cameron: Former Prime Minister, Digital Biomarkers, Digital Diagnostic Tools, Digital Fingerprints, Digital Technology, Digital Technology and Innovation, Early Detection of Alzheimer’s Disease, Early Detection of Disease, Early Detection of Neurodegenerative Diseases, Early Detection of Neurodegenerative Diseases (EDoN), Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Diagnosis of Dementia, Early Recognition of Alzheimer’s Disease Using Digital Technology, Early Recognition of Neurodegenerative Diseases Using Digital Technology, EDoN Clinical Support Group, EDoN Cohorts and Biomarkers Working Group, EDoN Digital Platform Working Group, EDoN Digital Support Group, EDoN Digital Toolkit, EDoN Digital Tools Working Group, EDoN Fingerprint Analytics Working Group, EDoN White Paper, Ethical Considerations, Ethical Sharing of Data Between Organisations, Fingerprint Analytics, Gait: an Integrative Measure of Health, Heart Rate, Iceland Foods Charitable Foundation, Information Technology, International and Independent External Advisory Board, Investment in Information Technology, Machine Learning Models, Medopad, Mild Cognitive Impairment (MCI), Mindstrong Health, MRC Harwell Institute, National Hospital for Neurology and Neurosurgery: University College London, National Physical Laboratory, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Newcastle University, Non-Invasive Biomarkers, Optimising Benefits of Digital Technology, Preclinical Alzheimer's Disease, Preclinical Biomarkers and Dementia, Preclinical Biomarkers in Alzheimer's Disease, Preclinical Dementia and Associated Lifestyle Changes, Preclinical Indicators and Dementia, Preclinical Indicators in Alzheimer's Disease, Preclinical Phase of Dementia, Prodromal Alzheimer's Disease, Prodromal Dementia, Rates of Conversion From Mild Cognitive Impairment to Dementia, Research Informatics, Sleep Patterns, Smart Phone apps, Smart Sensors, Smart Watches, Target Discovery and Preclinical Validation, Tencent, The Rt Hon David Cameron: Chair of EDoN Board, The Rt Hon David Cameron: President of Alzheimer’s Research UK, Timely / Preclinical Neurodegenerative Diseases Diagnosis, Timely Screening / Preclinical Neurodegenerative Disease, University College London, University of Cambridge, University of Exeter, University of Oxford Big Data Institute, Walking Speed: a Behavioural Biomarker for Neurocognitive and Physical Decline, Wearable Devices, Wearable Monitoring Equipment, Wearable Sensors, Wearable Technology, Wearables (Technology)
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Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)
Summary Research published in the Neurology journal claims a significant breakthrough in the development of a blood test (for plasma Aβ42/Aβ40) which may be able to predict Alzheimer’s Disease onset with 94% accuracy. Due caution: “But it’s important to note … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
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Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Early Screening, Amyloid, Amyloid and Tau PET, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood Test for Brain Amyloidosis: Validated Using Amyloid PET and CSF p-tau181/Aβ42 as Reference Standards, Blood Tests, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Imaging, Brain Research, Case Finding, Conversion to Dementia From Prodromal Disease, Dementia Diagnosis, Dementia Innovation, Dementia Research, Dementia Screening, Department of Neurology: Washington University, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostic Imaging, Division of Biostatistics: Washington University, Drug Development for Alzheimer's Disease, Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Hope Center for Neurological Disorders: Washington University, Knight Alzheimer's Disease Research Center: Washington University, Mallinckrodt Institute of Radiology: Washington University, Neurology (Journal), Non-Invasive Biomarkers, Plasma Biomarkers, Plasma β-Amyloid 42/40, Plasma Protein Markers of MRI Measures in Asymptomatic Individuals, Preclinical Alzheimer's Disease, Preclinical Biomarkers in Alzheimer's Disease, Predictive Ability (of Tests), Prodromal Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Rapid Screening, Recruitment Onto Dementia Clinical Trials, SAP (Protein), SAP: Serum Amyloid Protein, Screening, Screening for Dementia, Washington University School of Medicine
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More on the NHS Long Term Plan (DHSC / NHS England / BBC News / NAO / King’s Fund)
Summary The NHS Long Term Plan was released earlier this week. The plan is backed by the commitment of an extra £20.5 billion funding for the NHS per year. “The 10-year plan includes measures to prevent 150,000 heart attacks, strokes … Continue reading →
Posted in Acute Hospitals, BBC News, Commissioning, Community Care, Department of Health, Department of Health and Social Care (DHSC), Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, King's Fund, Management of Condition, Mental Health, National, National Audit Office, NHS, NHS England, Non-Pharmacological Treatments, Person-Centred Care, Personalisation, Quick Insights, Standards, Statistics, UK, Universal Interest
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Tagged Academic Health Science Networks (AHSNs), Accelerated Turnaround Process (ATP), Access to Personal Health Records Online, Access to Primary Care, Advisory Committee on Resource Allocation: Adjustment to Funding Formulae for Health Inequalities, Ageing Population, Air Pollution, Alcohol Abuse, Alcohol and Drug Consumption, Alcohol Care Teams, Alcohol Consumption, Alcohol Drugs and Tobacco, Alcohol Misuse, Alcohol or Tobacco Withdrawal, Alcohol-Related Activity in Hospitals, Alcohol-Related Admissions to Hospital, Alcohol-Related Burden on the NHS, Alcohol-Related Harm, Andy Bell: Centre for Mental Health, Antimicrobial Resistance (AMR), Antipsychotics Limitation in Dementia, Back Pain, BBC Health News, BBC Reality Check Team, Benefits of Detection and Early Intervention, Benefits of Early Detection, Berkshire, Blackpool, Bradford City, Cambridge, Cambridge University Hospitals NHS Foundation Trust, Cancer Survival, Cancer Survival Rates in England, Carer Support, Carers: Greater Recognition and Support, Case Studies Illustrating Aspects of the NHS Long Term Plan, Celia Ingham Clark: NHS England’s National Director for Reducing Premature Deaths, Chief Clinical Information Officer (CCIO), Chief Information Officer (CIO), Childhood Obesity, Children and Young People's Health Services, Choice and Control, Choice and Control Over Decisions, Community First Responders – Making a Difference, Community Multidisciplinary Teams, Community Resilience, Community-Based Care, Community-Based Interventions, Community-Based Services, Community-Based Support, Control and Independence, CVDPREVENT: National Primary Care Audit, Dame Donna Kinnair: Royal College of Nursing, Delayed Transfers of Care, Delivering Enhanced Care Across the Whole System - Dementia ‘Virtual Ward’, Dementia Diagnosis Rate, Dementia Risk Reduction and Prevention, Dementia Virtual Wards, Detentions Under the Mental Health Act: Reduced by Street Triage Teams, Developing People: Improving Care, DHSC Health White Paper (2021): Integration and Innovation - Working Together to Improve Health and Social Care For All, Diabetes, Diabetes Prevention, Diabetes Prevention Programme, Diagnosing Lung Cancer Earlier in Manchester, Diet, Diet and Exercise, Diet-Related Ill Health, Dietary Risk Factors, Digital Enablement, Digital Health Innovations, Digital Health Services, Digital Innovation, Digital Innovation Hubs, Digital Innovations in Health, Digital Service Transformation, Digital Services, Digital Services for Patients, Digital Technology, Digital Technology and Innovation, Digital-First Primary Care, Digitally-Enabled Access to Care, Digitally-Enabled Care, Digitally-Enabled Primary and Outpatient Care, Dr Jennifer Dixon CBE (Health Foundation), Dr Ron Daniels: Chief Executive of UK Sepsis Trust, Dr Simon Eccles: Chief Clinical Information Officer at NHSX, Dr Simon Eccles: Chief Clinical Information Officer for Health and Care at NHS England, Dr Tim Nutbeam: Clinical Advisor for UK Sepsis Trust, E-Sepsis: Early Detection and Treatment Helping to Save Lives, Early Detection of Disease, Early Detection of Preclinical Disease, Early Intervention in Psychosis Service - Support to Children And Young People, Early Recognition and Treatment of Delirium Using Digital Technology, Early Recognition and Treatment of Pre-existing Mental Health History Using Digital Technology, Early Recognition and Treatment of Sepsis Using Digital Technology, Economic Sustainability, Efficiencies and Productivity Gains, Efficiency and Effectiveness, Efficiency Opportunities, Efficiency Savings, Elective Care Transformation Programme, Elective Care Transformation Programme Team, Electronic Care Record (ECR), Electronic Health Records, Electronic Health Records (EHRs), Electronic Patient Record (EPR), Electronic Patient Record Systems, Emergency Mental Health Support, Enabling Self-management and Coping with Arthritic Pain Through Exercise (ESCAPE-Pain), Enhanced Health in Care Homes (EHCH) Vanguards, Financial Recovery Fund (FRF), First Contact Practitioners (FCPs), Former Prime Minster: Rt Hon Theresa May MP, GDE Blueprints, Genetic Testing, Genomics and Personalised Medicine, Getting It Right First Time (GIRFT), Global Burden of Disease Study, Global Digital Exemplar (GDE), Global Digital Exemplar Community Platform, Gloucestershire Hospitals NHS Foundation Trust, GoodSAM app, Growing the Medical Workforce, Health Centre Makeover Helps People With A Learning Disability And Dementia, Health Information Technology, Health Innovation, Healthier Fleetwood - Transforming Care For Patients, Healthier You: NHS Diabetes Prevention Programme Delivers Fast Results, Healthy Ageing, Healthy Behaviours, Healthy Communities, Healthy Lifestyles, Heart Patient Receives Life-Saving Support, High in Fat Salt and Sugar (HFSS), Homefirst Scheme, Horizon-Scanning, Hospital Stays for Alcohol-Related Harm (Adults’ Health and Lifestyle), Ian Dalton: Chief Executive of NHS Improvement, Improving Access to Psychological Therapies (IAPT), Improving Population Health, Increasing Personal Independence Through a New Personalised Budget, Information Technology, Informed Choices About Health and Social Care, Informed Decision-Making, Innovative Approach to Intermediate Care in Doncaster, Innovative Children’s Hospital App Transforms Patient Care, Integrated Care Systems (ICSs), Integrated Mental Health Care is Helping to Boost Employment Prospects, Integrated Out-of-Hospital Care, Integrated Prevention Approaches, Integration and Innovation: Working Together to Improve Health and Social Care For All, International Recruitment, IPS Services, Joint Care From Community Stroke Team and Stroke Association’s Reablement Service - 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Prevention: Central to the NHS Long Term Plan (BBC News / NHS Egland)
Summary Early announcements concerning the NHS Long Term Plan, previously billed as the “NHS Ten Year Plan”, indicate an even greater emphasis on the prevention agenda. This will involve, among other related schemes, the provision for problem drinkers and smokers … Continue reading →
Posted in Acute Hospitals, BBC News, Commissioning, Community Care, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Integrated Care, Management of Condition, Mental Health, National, NHS, NHS England, Non-Pharmacological Treatments, Patient Care Pathway, Patient Information, Person-Centred Care, Personalisation, Quick Insights, Royal College of Physicians, Standards, Statistics, UK, Universal Interest
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Tagged Access to Personal Health Records Online, Access to Primary Care, Ageing Population, Alcohol Abuse, Alcohol and Drug Consumption, Alcohol Care Teams, Alcohol Consumption, Alcohol Drugs and Tobacco, Alcohol Misuse, Alcohol or Tobacco Withdrawal, Alcohol-Related Activity in Hospitals, Alcohol-Related Admissions to Hospital, Alcohol-Related Burden on the NHS, Alcohol-Related Harm, BBC Health News, Benefits of Detection and Early Intervention, Benefits of Early Detection, Cancer Survival, Cancer Survival Rates in England, Childhood Obesity, Choice and Control, Choice and Control Over Decisions, Community Resilience, Community-Based Care, Community-Based Interventions, Community-Based Services, Community-Based Support, Control and Independence, Deborah Arnott: Chief Executive of ASH (Health Charity), Dementia Risk Reduction and Prevention, Diabetes, Diabetes Prevention, Diet, Diet and Exercise, Diet-Related Ill Health, Dietary Risk Factors, Digital Health Innovations, Digital Innovation, Digital Innovations in Health, Digital Service Transformation, Digital Services, Digital Services for Patients, Digital Technology and Innovation, Duncan Selbie: Chief Executive of Public Health England, Early Detection of Disease, Early Detection of Preclinical Disease, Economic Sustainability, Efficiencies and Productivity Gains, Efficiency and Effectiveness, Efficiency Opportunities, Efficiency Savings, Electronic Care Record (ECR), Electronic Health Records, Electronic Health Records (EHRs), Electronic Patient Record (EPR), Electronic Patient Record Systems, Former Prime Minster: Rt Hon Theresa May MP, Health Information Technology, Health Innovation, Healthy Ageing, Healthy Behaviours, Healthy Communities, Healthy Lifestyles, Hospital Stays for Alcohol-Related Harm (Adults’ Health and Lifestyle), Information Technology, Informed Choices About Health and Social Care, Informed Decision-Making, Integrated Prevention Approaches, Lifestyle Risk Factors, Long-Term Funding Settlement for NHS, Maternal Health and Wellbeing, Maternal Mental Health, Maternity Services, Matt Hancock: Secretary of State for Health and Social Care, National Childhood Obesity Strategy, NHS Long Term Plan (2019), NHS Long-Term Plan, NHS Sustainability, NHS Ten Year Plan, NHS Workforce, Optimising Benefits of Digital Technology, Optimising Patient Outcomes Using Digital Technology, Optimising Use of Digital Technology, Personal Budgets (PBs), Personal Budgets for Older People, Preventative Care, Preventative Services, Preventing Avoidable Emergency Admissions, Prevention, Prevention Agenda, Prevention Agenda Linking Dementia and Other Non-Communicable Diseases, Prevention and Self Care, Prevention Programmes, Preventive Care, Preventive Services, Professor Andrew Goddard: President of Royal College of Physicians, Recruitment, Recruitment and Retention, Reducing Alcohol-Related Harm, Reducing Unnecessary Admissions, Reducing Unscheduled Admissions, Reducing Waste in the NHS, Royal College of Physicians (RCP), Rt Hon Matt Hancock MP, Rt Hon Theresa May MP (Former Prime Minster), Self-Care, Self-Determination, Self-Management Support, Service User Involvement, Simon Stevens: Chief Executive of NHS England, Smoking, Smoking Cessation, Specialist Alcohol Care Teams Trials, Support for Self-Care, Supporting Healthy Lifestyles, Sustainability, Theresa May's Mental Health Reforms, Tobacco, Tobacco Advisory Group: Royal College of Physicians, Tobacco Consumption, Tobacco Dependency, Tobacco Smoking, Transformational Technologies, Transformative Health Technology, Transformative Technology, Treating Patients Closer to Home, UK Cancer Survival Rates, Unhealthy Lifestyles, Use of Technology to Predict Illnesses and Target Advice, Workforce Competencies, Workforce Development, Workforce Issues
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Investigations Into the Early Signs, Symptoms and Family Experiences of Alzheimer’s Disease (BMJ Open / International Psychogeriatrics)
Summary A literature review analyses the sequence / timing of the early signs and symptoms of Alzheimer’s Disease. The authors distinguish between the early signs of late-onset Alzheimer’s Disease (LOAD) and those of early-onset Alzheimer’s Disease (EOAD). Full Text Link … Continue reading →
Posted in Community Care, Depression, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), International, Mental Health, Models of Dementia Care, Quick Insights, Systematic Reviews, UK, Universal Interest
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Tagged Aberrant Motor Behaviour, Acalculia, Agitation, Alexia, Anomia, Anosognosia, Anxiety, Apathy, Australia, BMJ Open, BMJ Publishing Group Ltd, Box Hill Hospital (Victoria), Cognitive Impairment, Conversion to Dementia From Prodromal Disease, Disinhibition, Early Detection of Preclinical Disease, Early Signs and Symptoms of Alzheimer's Disease, Early-Onset Alzheimer’s Disease (EOAD), Early-Onset Dementia, Eastern Cognitive Disorders Clinic: Box Hill Hospital, Experiences, Experiences of the Transition to Dementia, Family and Caregiver Experiences, Family Members' Experiences of Pre-Diagnostic Phase of Dementia, Hallucination, Initial Onset and Diagnosis, Institute for Health Research: University of Bedfordshire, International Psychogeriatrics, Irritability, Late Onset Dementia, Late-Onset Alzheimer's Disease, Late-Onset Alzheimer's Disease (LOAD), Melbourne School of Psychological Sciences: University of Melbourne, Neuroscience Department: Box Hill Hospital, Olfactory Disturbances, Patient and Carer Experiences, Patient Experiences, Pre-Diagnostic Phase of Dementia, Preclinical Alzheimer's Disease, Preclinical Indicators in Alzheimer's Disease, Preclinical Phase of Dementia, Prodromal Alzheimer's Disease, School of Life Sciences: University of Hull, Signs and Symptoms of Alzheimer's Disease, University of Bedfordshire, University of Hull, University of Melbourne, Weight Loss, Young Onset Dementia (YOD), Young-Onset Dementia
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Earlier Diagnosis Research: the Deep and Frequent Phenotyping Study (BBC News / GtR)
Summary The Deep and Frequent Phenotyping Study aims to discover new ways of diagnosing dementia, ideally decades before the symptoms become apparent in order to give future drug treatments the best chance of working. The Deep and Frequent Phenotyping Study … Continue reading →
Posted in Alzheimer's Society, BBC News, Commissioning, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Mental Health, Models of Dementia Care, National, NIHR, Quick Insights, UK, Universal Interest
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Tagged Ageing Population, Alterations in Movement and Walking (“Gait”) Assessments, Alzheimer's Disease: Early Detection by Brain Scan, Alzheimer’s Disease Biomarkers, Amnestic Mild Cognitive Impairment (a-MCI), Amnestic Mild Cognitive Impairment (aMCI), Applications of Big Data, BBC Radio, BBC Radio 4, BBC's World At One Programme, Big Data Analytics, Big Data Funding and Research, Biomarker Assessments in Alzheimer’s Disease, Biomarker Assessments in Alzheimer’s Disease Clinical Trials, Biomarker Assessments in Clinical Trials, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Biomarkers Research Programmes, Blood and Urine Biomarkers, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Scans, Cambridge Neuropsychological Test Automated Battery (CANTAB), Cerebrospinal Fluid (CSF) Biomarkers, Clinical Assessments, Cognitive Assessments / Screening Tools, Conversion to Dementia From Prodromal Disease, CSF Biomarkers, Deep and Frequent Phenotyping Study, Deep and Frequent Phenotyping Study (DFP), Deep and Frequent Phenotyping; Combinatorial Biomarkers of Dementia, Dementia Research, Dementia Research Funding, Dementias Platform UK, Dementias Platform UK (DPUK), Dementias Platform UK: MRC, DFP Study Team, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, DPUK: Dementias Platform UK, Drug Trials Failure Rate, Early Detection of Alzheimer’s Disease, Early Detection of Preclinical Disease, EEG: Electroencephalography, Effectiveness of Early Detection and Treatment, Electroencephalogram (EEG) Brain Scans, Electroencephalography (EEG), Gait and Cognition, Gait Changes, Gateway to Research (GtR), Global Dementia Research, Global Leadership, Hypothetical Prodromes of Dementia, Imanova, Imperial College London, Join Dementia Research, Join Dementia Research: Clinical Trials Matchmaker Service, Join Dementia Research: Recruitment Onto Dementia Studies, Kings College London, Magnetic Resonance Imaging (MRI) Scan, Magnetoencephalography (MEG), Medical Research Council (MRC), Medical Research Council (UK), National Institute of Health Research (NIHR), Neurobiology of Aging (Journal), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Newcastle University, Non-Invasive Biomarkers, Ocular Manifestations in Neurodegenerative Diseases, Open Data and Big Data, Ophthalmological Assessments, Participation in Research, Participation in Research Studies, Partnership and Collaboration, Patient and Public Participation, PharmaCog Consortium, Positron Emission Tomography (PET), Pre-Clinical Genotype-Phenotype Predictors of Alzheimer's Disease, Prodromal Alzheimer's Disease, Professor Clare Mackay: Imaging Neuroscience at the University of Oxford, Professor Lynn Rochester: Clinical Ageing Research Unit at Newcastle University, Professor Simon Lovestone: Lead Researcher and Professor of Translational Neuroscience at University of Oxford, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Proteomic Analysis, Proteomics, Public Participation in Research, Publicly-Funded UK Big Data Research, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Funding, Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Changes as Surrogate Biomarker for Alzheimer's Disease, Retinal Ganglion Cells (RGCs), Retinal Manifestations of Alzheimer's Disease, Screening Tools for Amnestic Mild Cognitive Impairment (a-MCI), Surrogate Biomarkers of Neurodegeneration, Translational Research, University College London, University of Cambridge, University of Edinburgh, University of Manchester, University of Oxford, Volunteers, Walking Pattern (Gait), Wearable Devices, Wearables (Technology)
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Developments in Dementia Research: From the Horses’ Mouths (NHS England / NIHR)
Summary Professor Alistair Burns (NHS England’s National Clinical Director for Dementia and Older Peoples’ Mental Health), and Professor Martin Rossor (NIHR National Director for Dementia Research), discuss current issues and new approaches in dementia research, touching briefly upon some of … Continue reading →
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Models of Dementia Care, National, NHS England, NIHR, Pharmacological Treatments, Quick Insights, UK, Universal Interest
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Tagged 100000 Genomes Project, A4 Study, Alistair Burns: Honorary Consultant Old Age Psychiatrist in the Manchester Mental Health and Social Care Trust (MMHSCT), Alistair Burns: NHS England’s National Clinical Director for Older People’s Mental Health, Alistair Burns: Professor of Old Age Psychiatry at University of Manchester, Alzheimer's Prevention Initiative, Alzheimer’s Disease Biomarkers, Alzheimer’s Prevention Initiative Study, Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study), APP and Presenilin, Asymptomatic Alzheimer’s Disease, Banner Alzheimer's Institute, Biomarkers, Chance Genetic Mutations, Colombia, Colombian Alzheimer's Prevention Initiative Registry in Medellín Antioquia, DIAN-TU Study, DIAN-TU Trial, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), Early Detection of Alzheimer’s Disease, Early Detection of Preclinical Disease, Genentech, Genomics, Genomics England, Genomics in the NHS, Genomics-Based Medicine, Global Outlook, Identification of People At Risk of Dementia, International Collaborations, International Programmes, International Research, Medellin (Colombia), Monoclonal Antibodies, MRC Neurochemical Pharmacology Unit, Mutational Signatures, National Clinical Director for Dementia, National Institute for Health Research (NIHR), National Institutes of Health (NIH), National Institutes of Health (US), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, NIHR Clinical Research Network, NIHR Dementia Translational Research Collaboration, NIHR National Director for Dementia Research, NIHR Translational Research Collaboration, Overcoming Barriers, Participation in Research, Participation in Research Studies, Preclinical Alzheimer's Disease, Presenilin, Prodromal Alzheimer's Disease, Professor Alistair Burns, Professor Martin Rossor: Director of the NIHR Queen Square Dementia Biomedical Research Unit, Professor Martin Rossor: Former Director of the NIHR Dementia and Neurodegenerative Disease Research Network (DeNDRoN), Professor Martin Rossor: Former President of the Association of British Neurologists (2011-2013), Professor Martin Rossor: Honorary Consultant Neurologist at National Hospital for Neurology and Neurosurgery, Professor Martin Rossor: National Hospital (Queen Square), Professor Martin Rossor: NIHR National Director for Dementia Research, Professor Martin Rossor: UCL Institute of Neurology, Promisary Science, Reducing Downstream Effects of Disease, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Mapping, Research Networks, Research Promotion, Sharing Knowledge and Information, Slowing Progression of Disease (Stabilisation), Solanezumab (Sola or Solab), Solanezumab: Humanised Monoclonal Antibody, Therapeutic Nihilism (Avoiding), Translational Research, UK Genomes Project: Genomics England, University of Southern California’s Alzheimer’s Therapeutic Research Institute, Washington University School of Medicine
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Deep and Frequent Phenotyping Study: Dementia Early Detection and Biomarkers Research Programme (MRC / NIHR)
Summary The Deep and Frequent Phenotyping Study will explore improvements in biomarker research and the development of tests to detect Alzheimer’s Disease early on. This research programme will be funded by the National Institute of Health Research (NIHR) and the … Continue reading →
Posted in Alzheimer's Society, Charitable Bodies, Commissioning, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NIHR, Quick Insights, UK, Universal Interest
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Tagged Alterations in Movement and Walking (“Gait”) Assessments, Alzheimer's Disease: Early Detection by Brain Scan, Alzheimer’s Disease Biomarkers, Aridhia, AstraZeneca / MedImmune, Berry Consultants, Biomarker Assessments in Alzheimer’s Disease, Biomarker Assessments in Alzheimer’s Disease Clinical Trials, Biomarker Assessments in Clinical Trials, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Biomarkers Research Programmes, Blood and Urine Biomarkers, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Scans, Cambridge Cognition, Cerebrospinal Fluid (CSF) Biomarkers, Clinical Assessments, Cognitive Assessments / Screening Tools, Conversion to Dementia From Prodromal Disease, CSF Biomarkers, Deep and Frequent Phenotyping Study, Dementia Research, Dementia Research Funding, Dementias Platform UK, Dementias Platform UK (DPUK), Dementias Platform UK: MRC, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, DPUK: Dementias Platform UK, Dr Rob Buckle: Director of Science Programmes at MRC, Drug Trials Failure Rate, Early Detection of Alzheimer’s Disease, Early Detection of Preclinical Disease, EEG: Electroencephalography, Effectiveness of Early Detection and Treatment, Electroencephalogram (EEG) Brain Scans, Electroencephalography (EEG), Exprodo, Gait and Cognition, Gait Changes, Global Dementia Research, Global Leadership, Hypothetical Prodromes of Dementia, Imanova, Imperial College London, IXICO, Kings College London, Magnetic Resonance Imaging (MRI) Scan, Magnetoencephalography (MEG), Medical Research Council (MRC), Medical Research Council (UK), National Institute of Health Research (NIHR), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Newcastle University, Non-Invasive Biomarkers, Ocular Manifestations in Neurodegenerative Diseases, Ophthalmological Assessments, Optos, Participation in Research, Participation in Research Studies, Partnership and Collaboration, Patient and Public Participation, Positron Emission Tomography (PET), Pre-Clinical Genotype-Phenotype Predictors of Alzheimer's Disease, Prodromal Alzheimer's Disease, Professor Chris Whitty: Chief Scientific Adviser at Department of Health, Professor Simon Lovestone: Lead Researcher and Professor of Translational Neuroscience at University of Oxford, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Proteomic Analysis, Proteomics, Public Participation in Research, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Funding, Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Changes as Surrogate Biomarker for Alzheimer's Disease, Retinal Ganglion Cells (RGCs), Retinal Manifestations of Alzheimer's Disease, Sage Bionetworks, Surrogate Biomarkers of Neurodegeneration, Translational Research, TrialSpark, University College London, University of Cambridge, University of Edinburgh, University of Manchester, University of Oxford, Volunteers, Walking Pattern (Gait), Wearable Devices, Wearables (Technology), West London Mental Health Trust / Imperial College London
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European Medicines Agency Consultation on Pharmacological Treatments for Dementia (EMA)
Summary The European Medicines Agency (EMA) has released an updated draft guideline on medicines for the treatment of Alzheimer’s Disease and other types of dementia, for consultative feedback. Full Text Link Reference Consultation on revised guideline on medicines to treat … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Pharmacological Treatments, Quick Insights, Standards
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Tagged Accelerating Alzheimer's Research and Drug Development, Alzheimer’s Disease Biomarkers, Behavioural and Psychiatric Symptoms of Dementia, Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarker Assessments in Alzheimer’s Disease, Biomarker Assessments in Alzheimer’s Disease Clinical Trials, Biomarker Assessments in Clinical Trials, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, BPSD: Behavioral and Psychological Symptoms of Dementia, Cardiovascular Adverse Events, Clinical Diagnostic Criteria, Committee for Medicinal Products for Human Use (CHMP), Comparison IWG and NIA-AA Criteria for Clinical Diagnosis of Alzheimer´s Disease, Diagnostic Tests, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Drug Development for Alzheimer's Disease, Drug Discovery Programmes, Drug Identification, Drug Target Validation, Drug-Development Pipeline, Drugs for Treatment of Alzheimer’s Disease, Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Diagnostic Criteria, EMA Central Nervous System Working Party, EMA: European Medicines Agency, Enrichment of Study Populations, European Medicines Agency, European Medicines Agency (EMA), Genetic Testing, Genetic Triggers, Genetics of Alzheimer's Disease, Guideline on Clinical Investigation of Medicines for Alzheimer’s Disease and Other Dementias, Guideline on Medicinal Products for the Treatment of Alzheimer’s Disease and Nine Other Dementias, International Organisations, International Programmes, International Working Group (IWG), Long-Term Efficacy and Safety Studies, Medical Research, Medicines Development, Medicines Mechanism of Action, National Institutes of Health (NIH), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurological Adverse Events, Neurological Disorders, Novel Targets in Neurodegeneration, Ordering of Alzheimer's Disease Biomarkers, Pharmaceutical Industry, Pharmacological Research, Preclinical Alzheimer's Disease, Preclinical Biomarkers in Alzheimer's Disease, Preclinical Indicators and Dementia, Preclinical Indicators in Alzheimer's Disease, Prodromal Alzheimer's Disease, Psychiatric Adverse Events, Research and Development, Research and Innovation, Research Commitment, Research Consortia, Research Culture, Research Networks, Research Programmes, Safety and Efficacy Markers, Stratification of Subgroups (Clinical Trials), Target Discovery and Preclinical Validation, Therapeutic Target(s): Identification, Timely Diagnosis
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Spatial Navigation Tests For Disorientation May Identify Preclinical Alzheimer’s Disease? (BBC News / Science / JGCR / Brain)
Summary A German study indicates that persons with a high genetic risk of developing Alzheimer’s Disease might be identified early by monitoring their performance in tests involving navigation through a virtual maze. Full Text Link Reference Virtual reality maze ‘predicts … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
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Tagged APOE e4 Carriers, APOE-4 Allele, Apoe-ε4 Allele, APOE-ε4 Carriers, Apolipoprotein E (APOE) e4 Allele, Apolipoprotein E (Apoe)-ε4 Genotype, At-Genetic-Risk Alzheimer's Disease, BBC Health News, Behavioural Biomarkers, Big Data, Bonn, Brain (Journal), Center for Economics and Neuroscience: University of Bonn, Computer Games, Conversion to Dementia From Prodromal Disease, Dementia, Dementia Research, Department of Clinical Educational and Health Psychology: University College London, Department of Clinical Neurosciences: University of Cambridge, Department of Electrical Engineering: University College London, Department of Epileptology: University of Bonn, Department of Neuropsychology: Ruhr-University Bochum, Department of Psychiatry: University of Cambridge, Department of Psychology: Ulm University, Department of Psychology: University of Bonn, Diagnosis, Differential Diagnosis, Digital Diagnostic Tools, Disorientation, Donders Institute for Brain Cognition and Behaviour: Radboud University, Early Detection of Preclinical Disease, Early-Onset Alzheimer's Gene, Early-Onset Dementia, Entorhinal Cortex, Entorhinal Dysfunction in Adults at Genetic Risk for Alzheimer’s Disease, Gamification, German Center for Neurodegenerative Diseases (DZNE), German Centre for Neurodegenerative Diseases (Bonn), Germany, Germany. Department of Epileptology: University of Bonn, Grid-Cell-Like Representations, Grid-Cell-Like Representations in Adults at Genetic Risk for Alzheimer’s Disease, HTC Vive iVR Equipment, Information Technology, Institute of Cognitive Neuroscience: Ruhr-University Bochum, Institute of Cognitive Neuroscience: University College London, Journal of Geriatric Care and Research (JGCR), MRC Cognition and Brain Sciences Unit: University of Cambridge, Netherlands, Neurodegenerative Disease, Non-Invasive Biomarkers, Pre-Dementia (MCI), Preclinical Alzheimer's Disease, Preclinical Indicators and Dementia, Preclinical Indicators in Alzheimer's Disease, Prodromal Alzheimer's Disease, Radboud University, Risk Factors, Ruhr-University Bochum, Science (American Association for the Advancement of Science), Science Journal, Sea Hero Quest (SHQ) Game, Spatial Disorientation, Spatial Navigation Benchmarks, Spatial Navigation Tests of Disorientation, Ulm University, University College London, University of Bonn, University of Cambridge, Virtual Mazes
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