Tag Archives: Early Diagnosis of Alzheimer’s Disease

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

Summary Research published in the Neurology journal claims a significant breakthrough in the development of a blood test (for plasma Aβ42/Aβ40) which may be able to predict Alzheimer’s Disease onset with 94% accuracy. Due caution: “But it’s important to note … Continue reading

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Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading

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Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

Summary Further discussion about the possibilities of using inexpensive eye tests to detect Alzheimer’s Disease, perhaps years before symptoms appear. This particular technique involves the examination of blood vessels and blood flow in the retina, as detected by Octa (Optical … Continue reading

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More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading

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Earlier Diagnosis of Alzheimer’s Disease Using Saliva Test? (NHS Choices / JAD)

Summary Pilot research indicates that a chemical in the saliva can be used to differentiate, with relatively high accuracy, between persons who are currently healthy, those with mild cognitive impairment (MCI), and others with Alzheimer’s Disease. Potentially, salivary biomarkers could … Continue reading

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Earlier Diagnosis of Glaucoma – and Possibly Many Neurodegenerative Diseases – By Retinal Examination? (BBC News / NHS Choices / Brain)

Summary A fluorescent dye injected into the bloodstream may, in future, provide a convenient method of detecting glaucoma earlier – perhaps a decade before more overt symptoms and damage have had the opportunity to develop – by identifying changes in … Continue reading

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Under-Diagnosis of Dementia in the Community: an International Review (BMJ Open / JGCR)

Summary A literature review and meta-analysis of 23 international studies on the under-detection (i.e. the failure to achieve a diagnosis) of dementia identified a pooled rate of undetected dementia assessed to be 61.7%. The rate of under-detection was higher in … Continue reading

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