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Tag Archives: Frontotemporal Dementia (FTD)
Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)
Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading →
Posted in Alzheimer’s Research UK, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Personalisation, Quick Insights, Systematic Reviews, UK, Universal Interest
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Tagged 18F-florbetaben, 18F-flutemetamol, 18Fflorbetapir, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Alzheimer’s Research UK (ARUK), Amyloid and Tau PET, APOE e4 (Apolipoprotein E e4), Apolipoprotein E (APOE) e4 Allele, Behavioural Biomarkers, Beta-Amyloid PET Imaging, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Canonical Syndromes of Primary Progressive Aphasia: Non-Fluent / Agrammatic Variant (nfvPPA), Canonical Syndromes of Primary Progressive Aphasia: Semantic Variant (svPPA), Carbon-11 Pittsburgh Compound-B (C-PIB) Radioisotope Tracer, Cerebral Metabolic Rate for Glucose (CMRgl), Cerebrospinal Fluid (CSF) Biomarkers, Cerebrospinal Fluid and Serum MHPG, CMRgl Decline, Corticobasal Degeneration (CBD), CSF 3-methoxy-4-hydrox-yphenylglycol (MHPG), Dementia With Lewy Bodies (DLB), Differential Diagnosis, DLB: Dementia with Lewy Bodies, Docosahexaenoic Acid (DHA), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Eicosapentaenoic Acid (EPA), Frontotemporal Dementia (FTD), α-Synuclein, Journal of Geriatric Care and Research (JGCR), Lewy Body Dementia (LBD), Magnetic Resonance Imaging (MRI), Medial Temporal Lobe Atrophy (MTA), Medial Temporal Lobes (MTL), Metabolic Syndrome (MetS), MRI Brain Imaging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroimaging, Neuroimaging in Dementia Diagnosis, Non-Invasive Biomarkers, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Primary Progressive Aphasia (PPA), Progressive Supranuclear Palsy (PSP), Rapid Screening, Screening for Dementia, Sea Hero Quest (SHQ) Game, Sea Hero Quest VR, Tau PET, Timely Diagnosis, VaD: Vascular Dementia, Variants of Primary Progressive Aphasia (PPA), Vascular Dementia, [18F]THK5351
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Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)
Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading →
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Pharmacological Treatments, Quick Insights, UK, Universal Interest
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Tagged Abnormal Prion Protein, Alzheimer's Disease, Alzheimer's Research UK, Alzheimer’s Drug Discovery Foundation, Alzheimer’s Research UK (ARUK), Alzheimer’s Research UK Drug Discovery Institute, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, BBC Health News, Behind the Headlines, Brain (Journal), Centre for Analytical Bioscience: University of Nottingham, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Clinical Neurosciences: University of Cambridge, Dibenzoylmethane, Dibenzoylmethane (DBM): Potential Anti-Cancer Drug, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr David Dexter: Parkinson's UK, Dr Doug Brown: Director of Research and Development at Alzheimer's Society, Drug Discovery Programmes, eIF2a-P-Mediated Translational Repression (Pathway of Neurodegeneration), Frontotemporal Dementia (FTD), Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council’s (MRC) Toxicology Unit, Microscopic Worms, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, MRC: Medical Research Council, Multiple Sclerosis, National Institute for Neurological Disorders and Stroke, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Parkinson's, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Prion Diseases, Prion Protein (PrP(C)), Prion-Infected Mice, Prof. Giovanna Mallucci, Professor Giovanna Mallucci: Associate Drector of UK Dementia Research Institute, Protein Misfolding, Rare Prion Diseases, Repurposing of Drugs, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Trazodone, Trazodone Hydrochloride (Antidepressant), UK Dementia Research Institute, UK Dementia Research Institute (UK DRI), Unfolded Protein Response (UPR), University of Cambridge, University of Leicester, University of Nottingham, Worms: C. elegans
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Driving With Dementia or Mild Cognitive Impairment (EBMH / The Mental Elf / Canadian Geriatrics Journal)
Summary A review the current guidelines and evidence relating to driving and dementia (and driving with mild cognitive impairment) which is intended to help clinicians offer advice and make decisions about driving safety. The assessment tools / strategies available are … Continue reading →
Posted in Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), Management of Condition, Mental Health, Patient Information, Personalisation, Practical Advice, Quick Insights, Standards, UK, Universal Interest
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Tagged Ageing, Ageing and Dementia, Ageing Population, BMJ Publishing Group Ltd, Canada, Centre for Family Medicine Memory Clinic (Kitchener Ontario), Centre for the Health of the Elderly: Northumberland, Cognitive Assessments / Screening Tools, Combinations of On-Road Tests With Clinical and Neuropsychological Assessments, Dementia and Driving Guidance, Department of Family Medicine: McMaster University, Department of Medicine Division of Geriatrics: Ottawa Hospital, Department of Psychiatry: University of Oxford, Depressive Mood Disorders, Difficult Conversations, Driver and Vehicle Licensing Agency (DVLA), Drivers With Dementia, Driving, Driving and Dementia, Driving Assessment Centres, Driving Cessation, Driving in Dementia: Useful Links, Driving Mobility Approved Assessment Centres: for Independent Assessments, DVLA, DVLA Guidelines on Dementia and Mild Cognitive Impairment, Ethical Considerations, Ethical Dilemmas, Ethical Issues of Dementia Care, Evidence Based Mental Health (EBMH), Evidence Based Mental Health (Journal), Factors Determining Decisions to Stop Driving, Faculty of Health Science: University of Ottawa, Faculty of Medicine: Ottawa Hospital, Frontotemporal Dementia (FTD), Hamilton, Impaired Neck Mobility, Loss of Driving Licence: Patient Impact, McMaster University, Medical Fitness-to-Drive Decisions, Montreal Cognitive Assessment (MoCA), Motor Vehicle Drivers With Dementia, Northumberland, Office of Continuing Professional Development: University of Ottawa, Older People's Services: Oxford Health NHS Foundation Trust, Ottawa Hospital, Oxford Health NHS Foundation Trust, Potential Loss of Driving Licence: Patient Impact Sensitivity, Sensitivity Concerning Patient Impact, The Mental Elf, Tyne and Wear NHS Foundation Trust, University of Ottawa, University of Oxford, Use of Cognitive Tests to Assess Driving Ability, Visual Impairment
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Altered Humour Predicts Behavioural Variant Frontotemporal Dementia? (BBC News / MRC / JAD / Cortex)
Summary Researchers at University College London are interested in whether sense of humour changes might help predict frontotemporal dementia (FTD). Their latest paper suggests that changes in sense of humour can be an early sign of this type of dementia, … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Quick Insights, UK, Universal Interest
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Tagged Altered Humour, Altered Sense of Humour, Alzheimer's Research UK, BBC Health News, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), BV-FTD, Canadian Institutes of Health Research, Changes in Humour, Cortex (Journal), Dementia Research Centre: University College London, Dementia Research Centre: University College London: UCL Institute of Neurology: University College London, Frankly Inappropriate Humour Responses, Fronto-Temporal Dementia (FTD), Frontotemporal Dementia (FTD), Frontotemporal Lobar Degeneration, Frontotemporal Lobar Degeneration (FTLD), FTLD: Frontotemporal Lobar Degeneration, Humour in Dementia, Humour Processing in Frontotemporal Lobar Degeneration, JAD, Journal of Alzheimer's Disease, Medical Research Council (MRC), MRC, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurology, NIHR Queen Square Dementia Biomedical Research Unit, Semantic Dementia, UCL Institute of Neurology: University College London, University College London, Wellcome Trust
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Non-Alzheimer’s Dementias: Three Reviews (Lancet)
Summary The Lancet has published a series of three up-to-date reviews concerning non-Alzheimer’s dementia. Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access). Reference Dementia – not all about Alzheimer’s. [Editorial]. … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Patient Care Pathway, Person-Centred Care, Pharmacological Treatments, Quick Insights, Statistics, Systematic Reviews, UK, Universal Interest
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Tagged Akershus University Hospital and University of Oslo, Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC), Alzheimer's Disease With Cardiovascular Disease, APOE e4 (Apolipoprotein E e4), ApoE e4 Allele, Association of RBD with Synucleinopathies, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Biomarkers, Brain Imaging, BV-FTD, C677T, C9orf72 MAPT and GRN Genes, Cambridge Biomedical Campus, Campus for Ageing and Vitality: Newcastle upon Tyne, Center for Sleep Medicine: Mayo Clinic, Center for Sleep Medicine: Mayo Clinic College of Medicine, Centre for Age-Related Diseases: Stavanger University Hospital, Cerebrovascular Disease, CeVD: Cerebrovascular Disease, Clinical Symptoms Characteristic of Frontotemporal Dementia, Cognitive Assessments / Screening Tools, Constipation, Delirium and Dementia With Lewy Bodies, Dementia with Lewy Bodies, Dementia With Lewy Bodies (DLB), Dementia with Lewy Bodies Symptoms, Department of Geriatric Psychiatry: Akershus University Hospital, Department of Neurology: Mayo Clinic College of Medicine, Department of Psychiatry: University of Cambridge, Diagnosis of Vascular Dementia, Differential Diagnosis, Differential Diagnosis of Memory Problems, Division of Psychiatry: University College London, DLB: Dementia with Lewy Bodies, Dopamine Transporter Single Photon Emission CT, Early Diagnosis, Epidemiology, Epidemiology and Statistics, Epidemiology of Frontotemporal Dementia, Epidemiology of Major Neurological Disorders, Fluctuating Cognition, Fluctuations, Fluorodeoxyglucose PET, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Frontotemporal Dementia Symptoms, Frontotemporal Dementia With Motor Neurone Disease (FTD-MND), Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Lobar Degeneration FUS, FTLD: Frontotemporal Lobar Degeneration, Genetic and Pathological Correlation in FTLD, Genetics, Genetics of DLB, Haemorrhagic Dementia, Hallucinations, Hallucinations and Delusions in Parkinson's Disease, Hallucinations in People with Dementia, Hereditary Vascular Dementia (CADASIL), Hypoperfusion Dementia, Imaging, Increased Salivation, Institute of Neuroscience and Newcastle University Institute for Ageing: Newcastle University, Lancet, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Management of Vascular Dementia, Mayo Clinic College of Medicine (USA), Memory and Aging Center: University of California, Mental Health Unit: St Margaret's Hospital (Epping), Mild Cognitive Impairment in Parkinson's Disease (MCI-PD), MTHFR, Multi-Infarct Dementia (Cortical Vascular Dementia), National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN), Neurological Disease, Neurological Disorders, Neuropathological Features, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NFV-PPA, Non-Alzheimer’s Dementia, Non-Fluent Variant Primary Progressive Aphasia, Nondegenerative Neurological Diseases (NNDs), North Essex Partnership University NHS Foundation Trust, Norway, Norway Stavanger University Hospital, Nosology of Vascular Dementia, Olfactory Dysfunction, Parkinson’s Disease Dementia, Parkinsonism, Pathological Staging, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Prevalence of Cerebrovascular Disease, Prevalence of Neurological Disorders, Prodromal Dementia With Lewy Bodies, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, Sandler Neurosciences Center (San Francisco), Semantic Variant Primary Progressive Aphasia, Single Photon Emission Computed Tomography (SPECT), Small Vessel Arteriosclerosis, Small Vessel Dementia (Subcortical Vascular Dementia), SNCA and LRRK2 Genes, SPECT (Single Photon Emission Computed Tomography), Stavanger University Hospital, Stavanger University Hospital; Norway, Strategic Infarct Dementia, Subtypes of Vascular Dementia, SV-PPA, Systematic Reviews and Meta-Analyses, Timely Diagnosis, Treatments for Dementia With Lewy Bodies and Parkinson's Disease Dementia, United States, University College London, University of California, University of California: San Francisco School of Medicine, University of Cambridge, USA, VaD: Vascular Dementia, Vascular Dementia Symptoms, Visual Hallucinations
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Cognitive Reserve: the Benefits of Mentally Challenging Occupations and Bilingualism (Daily Mail / Neurology / CMAJ / Neuropsychology)
Summary Research published in the Neurology journal suggests that having a challenging occupation can potentially halve the rate of decline in memory and thinking capacity in later life, compared to pursuing mentally undemanding work. Workers performing complex jobs (such as … Continue reading →
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Statistics, UK, Universal Interest
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Tagged Active and Healthy Ageing, Ageing Well, Bilingual Advantage, Bilingual People, Bilingualism, Bilingualism and Later-Life Cognition, Center for Public Mental Health (Austria), CMAJ, CMAJ: Canadian Medical Association Journal, Cognitive Activity and Cognitive Decline, Cognitive Decline, Cognitive Exercises, Cognitive Impairment, Cognitive Inactivity, Cognitive Performance, Cognitive Reserve, Cognitive Reserve Hypothesis, Cognitive Stimulation, Cognitive Stimulation at Work, Daily Mail, Department of Biostatistics and Epidemiology: University of Pennsylvania, Department of Neurology: University of Pennsylvania, Department of Psychology: University of Iowa, Department of Public Health and Clinical and Molecular Medicine: University of Cagliari, Enriched Environments at Work, Epidemiology, Epidemiology and Statistics, Frontotemporal Degeneration Center: University of Pennsylvania, Frontotemporal Dementia (FTD), Frontotemporal Lobar Degeneration (FTLD), Germany, Healthy Lifestyles, Institute of Social Medicine: University of Leipzig, Interesting Jobs, Interesting Work, Italy, Learning Two Languages, Leipzig Longitudinal Study of the Aged, LIFE-Leipzig Research Center for Civilization Diseases: University of Leipzig, Lifelong Bilingualism, Mentally Challenging Occupations, Mentally Undemanding Work, Mini Mental State Examination (MMSE), Multilingualism, Neurology, Neurology (Journal), Neuropsychology (Journal), O*NET Job Descriptor Database, Occupational Attainment, Occupational Health and Public Health: University of Leipzig, Pennsylvania State University, Perelman School of Medicine: University of Pennsylvania, University Medical Center Hamburg-Eppendorf (Germany), University of Cagliari, University of Iowa, University of Leipzig; Department of Health Economics and Health Services Research, University of Pennsylvania, Using Two Languages
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Frontotemporal Dementia: Basic Disease Processes Uncovered? (Alzheimer’s Society / Journal of Cell Biology)
Summary Researchers studying the connections between neurons in fruit flies may have identified mechanisms which are involved neurodegeneration in Frontotemporal Dementia (FTD). FTD affects the frontal and temporal lobes (in human brains). A protein called CHMP2B can cause neuronal connections … Continue reading →
Posted in Alzheimer's Society, Animal Studies, Charitable Bodies, For Doctors (mostly), For Researchers (mostly), International, Quick Insights, UK, Universal Interest
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Tagged Activator Protein-1), Age-Related Neurodegenerative and Neurovascular Diseases, c-Jun N-terminal kinase (JNK), CHMP2B, Disease Modifying Treatment by 2025 (Aim), Drosophila melanogaster, Endosomal JNK-Scaffold POSH (Plenty-of-SH3s), ESCRT-III Dysfunction, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Fruit Flies, Fruit Fly Model of Frontotemporal Dementia, JCB: Journal of Cell Biology, Journal of Cell Biology, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurology, Novel Targets in Neurodegeneration, Pick’s Disease (Frontotemporal Dementia), POSH (Plenty-of-SH3s), Potential Drug Targets, RAB8 Deficiency, Rab8 POSH and TAK1 (Regulation of Synaptic Growth), RAB8 Protein, Synaptic Overgrowth and Endosomal Dysfunction, Transgenic Drosophila
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