Tag Archives: Frontotemporal Dementia (FTD)

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Posted on April 20, 2017 by Dementia and Elderly Care News

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Prion Protein, Alzheimer's Disease, Alzheimer's Research UK, Alzheimer’s Drug Discovery Foundation, Alzheimer’s Research UK (ARUK), Alzheimer’s Research UK Drug Discovery Institute, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, BBC Health News, Behind the Headlines, Brain (Journal), Centre for Analytical Bioscience: University of Nottingham, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Clinical Neurosciences: University of Cambridge, Dibenzoylmethane, Dibenzoylmethane (DBM): Potential Anti-Cancer Drug, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr David Dexter: Parkinson's UK, Dr Doug Brown: Director of Research and Development at Alzheimer's Society, Drug Discovery Programmes, eIF2a-P-Mediated Translational Repression (Pathway of Neurodegeneration), Frontotemporal Dementia (FTD), Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council’s (MRC) Toxicology Unit, Microscopic Worms, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, MRC: Medical Research Council, Multiple Sclerosis, National Institute for Neurological Disorders and Stroke, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Parkinson's, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Prion Diseases, Prion Protein (PrP(C)), Prion-Infected Mice, Prof. Giovanna Mallucci, Professor Giovanna Mallucci: Associate Drector of UK Dementia Research Institute, Protein Misfolding, Rare Prion Diseases, Repurposing of Drugs, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Trazodone, Trazodone Hydrochloride (Antidepressant), UK Dementia Research Institute, UK Dementia Research Institute (UK DRI), Unfolded Protein Response (UPR), University of Cambridge, University of Leicester, University of Nottingham, Worms: C. elegans | Leave a comment

Driving With Dementia or Mild Cognitive Impairment (EBMH / The Mental Elf / Canadian Geriatrics Journal)

Posted on January 8, 2017 by Dementia and Elderly Care News

Summary A review the current guidelines and evidence relating to driving and dementia (and driving with mild cognitive impairment) which is intended to help clinicians offer advice and make decisions about driving safety. The assessment tools / strategies available are … Continue reading →

Posted in Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), Management of Condition, Mental Health, Patient Information, Personalisation, Practical Advice, Quick Insights, Standards, UK, Universal Interest | Tagged Ageing, Ageing and Dementia, Ageing Population, BMJ Publishing Group Ltd, Canada, Centre for Family Medicine Memory Clinic (Kitchener Ontario), Centre for the Health of the Elderly: Northumberland, Cognitive Assessments / Screening Tools, Combinations of On-Road Tests With Clinical and Neuropsychological Assessments, Dementia and Driving Guidance, Department of Family Medicine: McMaster University, Department of Medicine Division of Geriatrics: Ottawa Hospital, Department of Psychiatry: University of Oxford, Depressive Mood Disorders, Difficult Conversations, Driver and Vehicle Licensing Agency (DVLA), Drivers With Dementia, Driving, Driving and Dementia, Driving Assessment Centres, Driving Cessation, Driving in Dementia: Useful Links, Driving Mobility Approved Assessment Centres: for Independent Assessments, DVLA, DVLA Guidelines on Dementia and Mild Cognitive Impairment, Ethical Considerations, Ethical Dilemmas, Ethical Issues of Dementia Care, Evidence Based Mental Health (EBMH), Evidence Based Mental Health (Journal), Factors Determining Decisions to Stop Driving, Faculty of Health Science: University of Ottawa, Faculty of Medicine: Ottawa Hospital, Frontotemporal Dementia (FTD), Hamilton, Impaired Neck Mobility, Loss of Driving Licence: Patient Impact, McMaster University, Medical Fitness-to-Drive Decisions, Montreal Cognitive Assessment (MoCA), Motor Vehicle Drivers With Dementia, Northumberland, Office of Continuing Professional Development: University of Ottawa, Older People's Services: Oxford Health NHS Foundation Trust, Ottawa Hospital, Oxford Health NHS Foundation Trust, Potential Loss of Driving Licence: Patient Impact Sensitivity, Sensitivity Concerning Patient Impact, The Mental Elf, Tyne and Wear NHS Foundation Trust, University of Ottawa, University of Oxford, Use of Cognitive Tests to Assess Driving Ability, Visual Impairment | Leave a comment

Altered Humour Predicts Behavioural Variant Frontotemporal Dementia? (BBC News / MRC / JAD / Cortex)

Posted on November 12, 2015 by Dementia and Elderly Care News

Summary Researchers at University College London are interested in whether sense of humour changes might help predict frontotemporal dementia (FTD). Their latest paper suggests that changes in sense of humour can be an early sign of this type of dementia, … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Quick Insights, UK, Universal Interest | Tagged Altered Humour, Altered Sense of Humour, Alzheimer's Research UK, BBC Health News, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), BV-FTD, Canadian Institutes of Health Research, Changes in Humour, Cortex (Journal), Dementia Research Centre: University College London, Dementia Research Centre: University College London: UCL Institute of Neurology: University College London, Frankly Inappropriate Humour Responses, Fronto-Temporal Dementia (FTD), Frontotemporal Dementia (FTD), Frontotemporal Lobar Degeneration, Frontotemporal Lobar Degeneration (FTLD), FTLD: Frontotemporal Lobar Degeneration, Humour in Dementia, Humour Processing in Frontotemporal Lobar Degeneration, JAD, Journal of Alzheimer's Disease, Medical Research Council (MRC), MRC, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurology, NIHR Queen Square Dementia Biomedical Research Unit, Semantic Dementia, UCL Institute of Neurology: University College London, University College London, Wellcome Trust | Leave a comment

Non-Alzheimer’s Dementias: Three Reviews (Lancet)

Posted on October 24, 2015 by Dementia and Elderly Care News

Summary The Lancet has published a series of three up-to-date reviews concerning non-Alzheimer’s dementia. Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access). Reference Dementia – not all about Alzheimer’s. [Editorial]. … Continue reading →

Cognitive Reserve: the Benefits of Mentally Challenging Occupations and Bilingualism (Daily Mail / Neurology / CMAJ / Neuropsychology)

Posted on May 6, 2015 by Dementia and Elderly Care News

Summary Research published in the Neurology journal suggests that having a challenging occupation can potentially halve the rate of decline in memory and thinking capacity in later life, compared to pursuing mentally undemanding work. Workers performing complex jobs (such as … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Statistics, UK, Universal Interest | Tagged Active and Healthy Ageing, Ageing Well, Bilingual Advantage, Bilingual People, Bilingualism, Bilingualism and Later-Life Cognition, Center for Public Mental Health (Austria), CMAJ, CMAJ: Canadian Medical Association Journal, Cognitive Activity and Cognitive Decline, Cognitive Decline, Cognitive Exercises, Cognitive Impairment, Cognitive Inactivity, Cognitive Performance, Cognitive Reserve, Cognitive Reserve Hypothesis, Cognitive Stimulation, Cognitive Stimulation at Work, Daily Mail, Department of Biostatistics and Epidemiology: University of Pennsylvania, Department of Neurology: University of Pennsylvania, Department of Psychology: University of Iowa, Department of Public Health and Clinical and Molecular Medicine: University of Cagliari, Enriched Environments at Work, Epidemiology, Epidemiology and Statistics, Frontotemporal Degeneration Center: University of Pennsylvania, Frontotemporal Dementia (FTD), Frontotemporal Lobar Degeneration (FTLD), Germany, Healthy Lifestyles, Institute of Social Medicine: University of Leipzig, Interesting Jobs, Interesting Work, Italy, Learning Two Languages, Leipzig Longitudinal Study of the Aged, LIFE-Leipzig Research Center for Civilization Diseases: University of Leipzig, Lifelong Bilingualism, Mentally Challenging Occupations, Mentally Undemanding Work, Mini Mental State Examination (MMSE), Multilingualism, Neurology, Neurology (Journal), Neuropsychology (Journal), O*NET Job Descriptor Database, Occupational Attainment, Occupational Health and Public Health: University of Leipzig, Pennsylvania State University, Perelman School of Medicine: University of Pennsylvania, University Medical Center Hamburg-Eppendorf (Germany), University of Cagliari, University of Iowa, University of Leipzig; Department of Health Economics and Health Services Research, University of Pennsylvania, Using Two Languages | Leave a comment

Frontotemporal Dementia: Basic Disease Processes Uncovered? (Alzheimer’s Society / Journal of Cell Biology)

Posted on April 1, 2015 by Dementia and Elderly Care News

Summary Researchers studying the connections between neurons in fruit flies may have identified mechanisms which are involved neurodegeneration in Frontotemporal Dementia (FTD). FTD affects the frontal and temporal lobes (in human brains). A protein called CHMP2B can cause neuronal connections … Continue reading →

Posted in Alzheimer's Society, Animal Studies, Charitable Bodies, For Doctors (mostly), For Researchers (mostly), International, Quick Insights, UK, Universal Interest | Tagged Activator Protein-1), Age-Related Neurodegenerative and Neurovascular Diseases, c-Jun N-terminal kinase (JNK), CHMP2B, Disease Modifying Treatment by 2025 (Aim), Drosophila melanogaster, Endosomal JNK-Scaffold POSH (Plenty-of-SH3s), ESCRT-III Dysfunction, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Fruit Flies, Fruit Fly Model of Frontotemporal Dementia, JCB: Journal of Cell Biology, Journal of Cell Biology, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurology, Novel Targets in Neurodegeneration, Pick’s Disease (Frontotemporal Dementia), POSH (Plenty-of-SH3s), Potential Drug Targets, RAB8 Deficiency, Rab8 POSH and TAK1 (Regulation of Synaptic Growth), RAB8 Protein, Synaptic Overgrowth and Endosomal Dysfunction, Transgenic Drosophila | Leave a comment

Further Dementia Diagnostic Test Accuracy Systematic Review Protocols (Cochrane Database)

Posted on August 29, 2014 by Dementia and Elderly Care News

Summary This is an additional list of diagnostic testing-related protocols, further to the Cochrane Dementia and Cognitive Improvement Group (CDCIG) Diagnostic Test Accuracy (DTA) protocols and protocol templates listed earlier in Generic Protocol(s) for Diagnostic Test Accuracy Reviews in Dementia … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Models of Dementia Care, NIHR, Systematic Reviews, UK | Tagged 11C-PIB-PET, 18FDG-PET, 6-Item Cognitive Impairment Test (6-CIT), Abbreviated Mental Test (AMT), Addenbrooke's Cognitive Exaination-Revised (ACE-R), ALOIS: the Cochrane Dementia and Cognitive Improvement Group, APOE e4 (Apolipoprotein E e4), APOE-4 Allele, Asymptomatic Alzheimer’s Disease, Blessed Information-Memory-Concentration Test (Blessed I-M-C), Brain Imaging, Bristol University, Canada, CDCIG: Cochrane Dementia and Cognitive Improvement Group, Central and North West London NHS Foundation Trust, China, China Medical University, Clinical Cooperation Unit Nuclear Medicine (Heidelberg), Clock Drawing Test (CDT), Cochrane Dementia and Cognitive Improvement Group (CDCIG), Cochrane Diagnostic Test Accuracy (DTA) Dementia Reviews, Cochrane Diagnostic Test Accuracy (DTA) Reviews, Cochrane Diagnostic Test Accuracy Review Unit (DTA Unit), Cognitive Assessments / Screening Tools, CSF (Cerebrospinal Fluid Analysis of Amyloid Beta and Tau), CSF Tau, CSF Tau / ABeta Ratio, Department of Neurology: VU University Medical Centre Amsterdam, Devon, Diagnostic Test Accuracy (DTA) Handbook, Diagnostic Test Accuracy Reviews, Differential Diagnosis, Differential Diagnosis of Alzheimer’s Disease, Dopamine Transporter Imaging, Dopamine Transporter Imaging (for Diagnosis of DLB), DTA Handbook, Early Differential Diagnosis, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta: Neuroepidemiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, FP-CIT (Fluoropropyl-Carbomethoxy-3b-(4-Iodophenyl)Tropane), Frenchay Hospital (Bristol), Frontotemporal Dementia (FTD), Generic Protocols for Cross-Sectional and Delayed-Verification Studies, German Cancer Research Center: Medical PET Group - Biological Imaging, Germany, Glasgow Royal Infirmary, GP-Cog, Imaging, Imperial College London, Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Institute of Cardiovascular and Medical Sciences: Glasgow, Institute of Cardiovascular and Medical Sciences: University of Glasgow, Institute of Health Research: Exeter, Institute of Public Health (Cambridge UK), Institute of Public Health (IPH), Institute of Public Health: Cambridge, IRCCS Fatebenefratelli (Brescia), Italy, John Radcliffe Hospital, LITA Polo Universitario, Maastricht University, Maastricht University: Department of Psychiatry and Neuropsychology, Mini-Cog, Modified Mini-Mental State Examination (3-MS), MRI, MRI Brain Imaging, MRI Scans, National Institute for Health Research (NIHR) Cochrane Collaboration Programme, Netherlands, Neuroimaging in Dementia Diagnosis, Neuropsychological Tests for Alzheimer’s Disease Diagnosis, Neuropsychological Tests for Dementia Diagnosis, North Bristol NHS Trust, Nuffield Department of Clinical Neurosciences (Oxford), Nuffield Department of Clinical Neurosciences: University of Oxford, Nuffield Department of Medicine (Oxford), Older People and Healthy Ageing Service Line (London), OPTIMA (Oxford Project to Investigate Memory and Ageing), OPTIMA (Oxfordshire UK), Ospedale Luigi Sacco, Oxford, Oxford Health NHS Foundation Trust, Oxford University Hospitals NHS Trust, Oxford University Medical School, PenCLAHRC, Peninsula CLAHRC, Peninsula Technology Assessment Group (PenTAG), PET-FDG (Positron Emission Tomography F-Fluorodeoxyglucose), PET-PiB (Positron Emission Tomography-Pittsburgh Compound B), Plasma and Cerebrospinal Fluid (CSF) Abeta42, Positron Emission Tomography (PET), Protocols, Public Health Epidemiology and Biostatistics: Birmingham, Queen's University (Canada), Radcliffe Department of Medicine, ratio, rCBF SPECT, Research Protocol, School for Mental Health and Neuroscience: Maastricht University, Shengjing Hospital, sMRI (Structural Magnetic Resonance Imaging), SPECT (Single Photon Emission Computed Tomography), St Louis University Mental Status Examination (SLUMS), Study Protocol, Sunnybrook Health Sciences Centre (Toronto), Systematic Reviews and Meta-Analyses, Test Your Memory (TYM), University Hospitals Bristol, University of Birmingham, University of Bristol, University of Cambridge, University of Exeter, University of Exeter Medical School, University of Glasgow, University of Milan, University of Oxford, University of Toronto, VU University (Netherlands), VU University Medical Centre | Leave a comment

Tag Archives: Frontotemporal Dementia (FTD)

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Altered Humour Predicts Behavioural Variant Frontotemporal Dementia? (BBC News / MRC / JAD / Cortex)

Further Dementia Diagnostic Test Accuracy Systematic Review Protocols (Cochrane Database)

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