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Tag Archives: Genetic Profiling
One More Genetic Link in the Longevity Enigma? (BBC News / Sanger Institute / Nature Communications)
Summary People living in the isolated Greek villages of Zoniana and Anogia have a noted tendency to live well into old age. They have a lower than expected incidence of cardiovascular disease, including heart problems, heart attacks and stroke. It … Continue reading →
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Stroke, Universal Interest
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Tagged 100000 Genomes Project, 100000 Genomes Project Haplotypes, Anogia, Anogia Medical Centre (Greece), APOE, APOE Gene, Array Genotyping, BBC Health News, BMI: Body Mass Index, Body Fat, Body Mass Index (BMI), Cardiometabolic Associations, Cardiovascular Disease (CVD), Cardiovascular Fitness, Cardiovascular Risk, Cardiovascular System Disorders, CDKN2A/B, Cholesterol (HDL), CHRNA3/5, Churchill Hospital (Oxford), Cigarettes, Cretan-Isolated Populations, CVD: Cardiovascular Disease, Department of Nutrition and Dietetics: Harokopio University (Athens), Echinos Medical Centre (Xanthi: Greece), Educational Attainment, Epidemiology, Extra Year in Education Extends Lifespan by 11 months (DNA Study Assertion), FOXO3A, Genetic Correlations: Lifespan and Mortality, Genetic Profiling, Genetic Research, Genetic Variant rs145556679, Genetic Variants, Genetics, Genetics Versus Environment as Determinants of Longevity, Genetics Versus Lifestyle as Determinants of Longevity, Genome-Wide Association Meta-Analysis (GWAMA), Genome-Wide Association Studies, Genome-Wide Association Studies (GWAS), Greece, Greek Villagers, Harokopio University (Athens), HDL-Cholesterol, Heart Disease, HELIC (Hellenic Isolated Cohorts), HELIC MANOLIS Sequencing, High Density Lipoproteins (HDL), High-Density Lipoprotein (HDL) Cholesterol Levels, HLA-DQA1/DRB1, Human Longevity, Insulin Resistance, Isolated Greek Villages, Isolated Populations, Isolated Populations Research, Lifespan, Longevity, Low Density Lipoprotein Cholesterol (LDL-C), Low Density Lipoproteins (LDL), LPA, Lung Cancer, Medical School: University of Exeter, Mendelian Randomisation, METACARPA, Microarrays, Molecular Pathological Epidemiology, Mylopotamos (MANOLIS) and Pomak Villages Cohorts, Mylopotamos: Northern Crete, Nature Communications, Northern Crete, Obesity, Openness to New Experiences, Oxford Centre for Diabetes Endocrinology and Metabolism University of Oxford, Pomak Region of Northern Greece, Population Isolates, Radcliffe Department of Medicine: University of Oxford, Sanger Institute, Saturated Fats, School of Health Science and Education: Harokopio University (Athens), SH2B3, Smoking, Susceptibility to Coronary Artery Disease (CAD), Triglycerides, UK Biobank, Unexpected Genetic Heroes, University of Exeter, University of Exeter Medical School, University of Oxford, Usher Institute of Population Health Sciences and Informatics: University of Edinburgh, Very Low Density Lipoprotein cholesterol (VLDL), Wellbeing and Longevity, Wellcome Trust Centre for Human Genetics: University of Oxford, Wellcome Trust Sanger Institute, Wellcome Trust Sanger Institute: Human Genetics, WGS Haplotypes, Whole Genome Sequencing (WGS), Whole Genome Sequencing and Imputation, Zoniana
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Eleven Genomics Medicine Centres Planned for England (BBC News / Department of Health / NHS England)
Summary The NHS has announced further steps in a genetics project, which will involve 11 Genomics Medicine Centres being created in English hospitals to gather DNA information. The aim is to support the 100,000 Genomes Project in research towards the … Continue reading →
Posted in Acute Hospitals, BBC News, Commissioning, Department of Health, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Integrated Care, National, NHS, NHS England, Person-Centred Care, Personalisation, Pharmacological Treatments, Quick Insights, Standards, UK, Universal Interest
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Tagged 100000 Genome Project: NHS Genomic Medicine Centres, 100000 Genomes Project, Academic Health Science Networks (AHSNs), Advanced Therapies Facility (QEH), Advanced Therapies Facility: Birmingham NIHR / Wellcome Trust Clinical Research Facility (CRF), BBC Health News, BBC Wales News, Birmingham, Birmingham (UK), Birmingham and the Black Country (Dudley Sandwell Walsall and Wolverhampton), Birmingham CDRC, Birmingham Centre for Clinical Haematology, Birmingham Centre for Clinical Trials (BCCT), Birmingham Children’s Hospital, Birmingham City Council, Birmingham City Deal, Birmingham Experimental Arthritis Treatment Centre for Rheumatoid Arthritis (BEAT-RA), Birmingham Health Partners, Birmingham MRC Centre for Immune Regulation, Birmingham NIHR Liver Biomedical Research Unit (BRU), Cambridge, Cambridge University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Cancer Research UK Centre, Cancer Research UK's Stratified Medicine Programme, Cardiff University’s MRC Centre for Neuropsychiatric Genetics and Genomics (MRC CNGG), Central Manchester University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Centre for Clinical Haematology (CCH), Centre for Endocrinology Diabetes and Metabolism (CEDAM), Centre for Obesity Research, Centre for Translational Inflammation (CTIR), Centre for Translational Inflammation Research (QEH), Chronic Disease Resource Centre (CDRC), City of Sandwell and West Birmingham NHS Foundation Trust, Clinical Research Facility (QEH), Decoding Inherited Disorders, Dementia Research, DNA Extraction, Dudley Group of Hospitals, East of England, East of England NHS GMC: Cambridge University Hospitals NHS Foundation Trust, Exeter, Experimental Cancer Medicine Centre (ECMC), Genetic Disorders and Genomics, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genomic Computing, Genomic Medicine, Genomic Medicine Centres, Genomic Medicine Centres (GMCs), Genomic Technologies, Genomics, Genomics England, Genomics in the NHS, Genomics Medicine Centres, Genomics-Based Medicine, Genotyping, George Freeman: Former Life Sciences Minister, Great Ormond Street Hospital NHS Foundation Trust: Genomics Medicines Centre, Greater Manchester, Greater Manchester NHS GMC: Central Manchester University Hospitals NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust: Genomics Medicines Centre London, Health Research Bus (HRB), Health Research Trauma Management Healthcare Technology Co-operative (NIHR Trauma Management HTC), Henry Wellcome Building for Nuclear Magnetic Resonance Facility (HWB-NMR), Herceptin, Human Biomaterials Resource Centre (HBRC), Illumina, Imperial College Health Partners NHS GMC: Imperial College Healthcare NHS Trust, Imperial College Healthcare NHS Trust: Genomics Medicines Centre, Inflammation Research Facility (IRF): NIHR / Wellcome Trust Clinical Research Facility, Innovation, Innovation and Improvement, Innovation in Bioinformatics, Innovation in Biotechnology, Innovation in Genetics, Institute for Translational Medicine in Birmingham, Institute of Translational Medicine (ITM), Institute of Translational Medicine: University of Birmingham, Liverpool Women's NHS Foundation Trust: Genomics Medicines Centre, London, Medical Director of NHS England: Professor Sir Bruce Keogh, Microarrays, MRC ARUK Centre for Healthy Ageing, MRC Centre for Neuropsychiatric Genetics and Genomics (MRC CNGG), Multidisciplinary Assessment of Technology Centre for Healthcare (MATCH), National Institute for Health Research (NIHR), National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre (NIHR SRMRC), Networks, Networks and Alliances, Newcastle upon Tyne Hospitals NHS Foundation Trust: Genomics Medicines Centre, Next-Generation Sequencing (NGS), NHS Five Year Forward View, NHS Five Year Forward View (5YFV), NHS Genomic Medicine Centres, NHS Genomic Medicine Centres Prospectus, NHS Genomics Medicine Centres, NHS Workforce, NIHR / Wellcome Trust Birmingham Clinical Research Facility (WTCRF), NIHR Clinical Research Facility, NIHR Collaborations for Leadership in Applied Health Research and Care for Birmingham and the Black Country (NIHR CLAHRC-BBC), NIHR Horizon Scanning Centre, NIHR Translational Research Partnerships (TRPs), North East, North East and North Cumbria NHS GMC: Newcastle upon Tyne Hospitals NHS Foundation Trust, North West Coast NHS GMC: Liverpool Women’s NHS Foundation Trust, Oxford, Oxford NHS GMC: Oxford University Hospitals Foundation Trust, Oxford University Hospitals Foundation Trust: Genomics Medicines Centre, Partnership, Partnership and Collaboration, Partnership Working, Personalised Medicine, Pharmaceutical Industry, Professor David Adams: Dean of Medicine at University of Birmingham Medical School, Professor Mark Caulfield: Chief Scientist at Genomics England, Professor Sir Bruce Keogh, Professor Sue Hill: Chief Scientific Officer for England, QMM: the Student Magazine of the University of Birmingham College of Medical and Dental Sciences, Queen Elizabeth Hospital, Research and Development, Research and Innovation, Research Commitment, Research Consortia, Research Culture, Research Into Aging, Research Networks, Researcher Access to Data, Resources for Researchers, Royal Devon and Exeter NHS Foundation Trust: Genomics Medicines Centre, Shape of Training Report, Shape Of Training Review, Sir John Chisholm: Executive Chair of Genomics England, South London NHS GMC: Guy’s and St Thomas’ NHS Foundation Trust, South West Peninsula, South West Peninsula NHS GMC: Royal Devon and Exeter NHS Foundation Trust, Southampton, Stem Cell Translational Medicine, STXBP1, Targeted Therapies, Translational Research, UK Genomes Project: Genomics England, UK Research and Life Science Sector, University College London Partners NHS GMC: Great Ormond Street Hospital NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust: Genomics Medicines Centre, University Hospitals Birmingham NHS Foundation Trust, University Hospitals Birmingham NHS Foundation Trust: Genomics Medicines Centre, University Hospitals Birmingham: Cancer Clinical Specialties, University of Birmingham, University of Birmingham Medical School, Wales Infants and Children’s Genome Service (Wings), Wellcome Trust Clinical Research Facility, Welsh Government's Genomics for Precision Medicine Strategy (2017), Wessex NHS GMC: University Hospital Southampton NHS Foundation Trust, West Midlands, West Midlands Academic Health Network, West Midlands NHS GMC: University Hospitals Birmingham NHS Foundation Trust, West Midlands RDS: NIHR Research Design Service (RDS), Whole Genome Sequencing
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UK Genomes Project: Genomics England (BBC News / NHS England / HEE / Nature Genetics)
Summary A revolution in medicine is in progress at research centres across the UK, based on unlocking the genetic bases of cancer and other diseases. The UK could become a world leader in genetic research, targeted therapies and personalised medicine. … Continue reading →
Posted in BBC News, Department of Health, Health Education England (HEE), In the News, International, National, NHS, NHS England, Personalisation, Quick Insights, UK, Universal Interest
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Tagged 100000 Genome Project: NHS Genomic Medicine Centres, 100000 Genomes Project, Aarhus University, Akureyri Hospital (Iceland), Astra Zeneca, BBC Health News, Bioinformatics Research Centre: Aarhus University, Biological Treatments, Biotechnology Companies, Birmingham, Broad Institute / Whitehead Institute (Massachusetts), Bubble-Boy Syndrome (Immune Disorders), Call for Global Moratorium on Clinical Uses of Human Germline Editing, Cambridge, Cambridge University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Cancer Research UK (CRUK), Cas9 (Crispr-Associated Protein 9) Enzyme, Cell and Gene Therapy at Institute of Child Health (ICH), Central Manchester University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Chief Scientific Officer Bulletin, Chief Scientific Officer Bulletin (July 2014), Children's Hospital: Landspitali University Hospital (Reykjavik Iceland), Cleveland Clinic, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), Collaborative Projects, Collaborative Working, Crispr, Crispr-Cas9, CRISPR-Cas9 Genome Editing System, Crisprs (Clustered Regularly Interspaced Short Palindromic Repeats), Cross-Sector Partnerships, David Cameron, deCODE Genetics, deCODE Genetics /Amgen Inc., Decoding Inherited Disorders, Dementia Research, Denmark, Department of Human Genetics: University of Leuven, Department of Internal Medicine: Akureyri Hospital (Iceland), Dilated Cardiomyopathy, Division of Cardiovascular Diseases: Mayo Clinic, DNA Extraction, Dr Francis Collins: Director of National Institutes of Health (USA), Dr Marcy Darnovsky: Center for Genetics and Society (USA), Drugs Targeted at Specific Mutations, Duke University, East Anglian Medical Genetics Service: Cambridge University Hospitals NHS Foundation Trust, East of England, East of England NHS GMC: Cambridge University Hospitals NHS Foundation Trust, Elimination of Porcine Endogenous Retroviruses Using Crispr, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Ethical Considerations, Ethical Dilemmas, European Bioinformatics Institute, European Bioinformatics Institute: Wellcome Trust Genome Campus, Exeter, Familial Adenomatous Polyposis (FAP), Foetal Stem Cells, Four Ps of Personalised Medicine: Participatory Role for Patients, Four Ps of Personalised Medicine: Precise Diagnoses, Four Ps of Personalised Medicine: Prediction and Prevention of Disease, Four Ps of Personalised Medicine: Targeted and Personalised Interventions, Francis Crick Institute, Fred and Pamela Buffett Cancer Centre (Omaha), Gene Editing in Mice With Duchenne Muscular Dystrophy, Genetic Disorders and Genomics, Genetic Engineering (Pandora's Box), Genetic Modification of Cells: HIV Treatment Strategy, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genome Campus (Wellcome Trust), Genome Sequencing, Genomic Computing, Genomic Medicine, Genomic Medicine Centres, Genomic Medicine Centres (GMCs), Genomics, Genomics Education Programme, Genomics Education Programme (HEE), Genomics England, Genomics England’s Ethics Advisory Committee, Genomics in the NHS, Genomics-Based Medicine, Genotyping, Germline Alterations (Suggested for DMD Huntington's Disease or Cystic Fibrosis), Germline Editing, Germline Gene Editing, Germline Modification, GM Babies, Great Ormond Street Hospital, Great Ormond Street Hospital (GOSH), Great Ormond Street Hospital NHS Foundation Trust: Genomics Medicines Centre, Greater Manchester, Greater Manchester NHS GMC: Central Manchester University Hospitals NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust: Genomics Medicines Centre London, Harvard University, Health Education England's Genomics Education Programme, HEE: Health Education England, Herceptin, Heritable Human Genome Editing (HHGE), Hinxton Group, Housekeeping Proteins, Human Embryos Edited (August 2017), Human Genetic Disorders, Human Germline Editing, Human Germline Genome Editing (HGGE), Human Protein Atlas, Hypertrophic Cardiomyopathy, IBM Watson Health, IBM's Watson Supercomputer, Iceland, Icelandic Medical Center (Laeknasetrid), IL2RG Gene, Illumina, Imperial College Health Partners NHS GMC: Imperial College Healthcare NHS Trust, Imperial College Healthcare NHS Trust: Genomics Medicines Centre, Improved Prevention Based on Underlying Predisposition, In Utero Stem Cell Therapy, Innovation in Biotechnology, Innovation in Genetics, Innovative Genomics Initiative (University of California in Berkeley / University of California in San Francisco), Institute of Child Health (ICH), International Commission on the Clinical Use of Human Germline Genome Editing, International Summit on Human Gene Editing, Introducing Genomics in Healthcare (Health Education England Video), Knowledge Networks, Knowledge Translation, Knut & Alice Wallenberg Foundation, Knut and Alice Wallenberg Foundation, Laboratory in Mjodd (RAM) Iceland, Landscape of Mutations in Breast Cancer Whole-Genome Sequences, Landspitali University Hospital (Iceland), Large DNA Banks, Large-Scale Whole-Genome Sequencing, Large-Scale Whole-Genome Sequencing (Iceland), Liverpool Women's NHS Foundation Trust: Genomics Medicines Centre, London, Lund University, Mayo Clinic (Rochester Minnesota), McDonnell Genome Institute: Washington University (St. Louis), Medical Director of NHS England: Professor Sir Bruce Keogh, Medical Research Council (MRC), Microarrays, Moratorium on Heritable Genome Editing, Mutational Signatures, Mutational Signatures in Breast Cancer, Networks, Networks and Alliances, Newcastle upon Tyne Hospitals NHS Foundation Trust: Genomics Medicines Centre, Next-Generation Sequencing (NGS), NHS Genomic Medicine Centres, NHS Genomic Medicine Centres (NHS GMCs), NHS Genomic Medicine Centres Prospectus, NHS Genomics Medicine Centres, NHS Workforce, North East, North East and North Cumbria NHS GMC: Newcastle upon Tyne Hospitals NHS Foundation Trust, North Thames Genomic Medicine Centre, North Thames NHS Genomic Medicine Centre (NHS GMC), North West Coast NHS GMC: Liverpool Women’s NHS Foundation Trust, North West London Healthcare Trust, Nuffield Council on Bioethics, OHSU Knight Cardiovascular Institute, Osteogenesis Imperfecta, Oxford, Oxford NHS GMC: Oxford University Hospitals Foundation Trust, Oxford University Hospitals Foundation Trust: Genomics Medicines Centre, Partnership, Partnership and Collaboration, Partnership Working, Personalised Health Care for Cancer, Personalised Medicine, Personalised Medicine Strategy (NHS England), Personalised Medicine Strategy Board, Personalised Medicine Strategy for the NHS, Personalised Medicine: Improving Outcomes, Peter Grainger: Patient and Public Involvement Representative at St Mark’s Hospital (North West London Healthcare Trust), Pharmaceutical Industry, PHG Foundation, Prof Peter Braude: King's College London, Professor Ian Cumming OBE: HEE Chief Executive, Professor Sir Bruce Keogh, Professor Sue Hill: Chief Scientific Officer for England, Profiling Individual Cancer Genomes (Personalised Medicine), Protein-Coding Cancer Genes, Radboud University, Regional Genetic Laboratories, Research and Development, Research and Innovation, Research Commitment, Research Consortia, Research Culture, Research Into Aging, Research Networks, Researcher Access to Data, Resources for Researchers, Royal Devon and Exeter NHS Foundation Trust: Genomics Medicines Centre, Royal Institute of Technology in Sweden, Sanger Institute, School of Engineering and Natural Sciences, Science Working Group: Cancer, Science Working Group: Infectious Diseases, Science Working Group: Rare Diseases, Small and Medium Enterprises (SMEs), SMEs, Somatic Genetic Basis of Breast Cancer, South London NHS GMC: Guy’s and St Thomas’ NHS Foundation Trust, South West Peninsula, South West Peninsula NHS GMC: Royal Devon and Exeter NHS Foundation Trust, Southampton, St Mark’s Hospital, Sun Yat-sen University in Guangdong (China), Talens, Targeted Drugs, Targeted Therapies, Testes, Thermo Fisher Scientific (Massachusetts), Transformational Elements of NHS Genomic Medicine Centres, UK Genomes Project: Genomics England, UK Research and Life Science Sector, University College London Partners NHS GMC: Great Ormond Street Hospital NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust: Genomics Medicines Centre, University Hospitals Birmingham NHS Foundation Trust: Genomics Medicines Centre, University of Iceland, University of Texas MD Anderson Cancer Center, USA, Viv Parry OBE (Science Broadcaster), Wellcome Trust, Wellcome Trust Sanger Institute, Wessex NHS GMC: University Hospital Southampton NHS Foundation Trust, West Midlands, West Midlands NHS GMC: University Hospitals Birmingham NHS Foundation Trust, Whole Genome Sequencing, Workforce Competencies, Workforce Development, Workforce Training, Xenotransplantation: Avoiding Shortage of Human Donor Organs, Yale Cancer Centre, Zinc fingers
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Alzheimer’s Disease Genetics Research: Two New Susceptibility Genes (PloS One)
Summary An international collaboration of geneticists investigating susceptibility genes for Alzheimer’s Disease has identified two additional genes (chromosome 8 TP53INP1 and chromosome 14 IGHV1-67). These two genetic susceptibility loci appear to be involved in energy metabolism, protein degradation and the … Continue reading →
Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Mental Health, NHS Digital (Previously NHS Choices), Quick Insights, UK
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Tagged Alzheimer's Disease Susceptibility Genes, BBC Health News, Behind the Headlines, Boston University School of Medicine, Boston University School of Public Health, Brigham Young University, Cardiff University, Case Western Reserve University, Centre de Mémoire de Ressources et de Recherche de Bordeaux, Centre for Neuropsychiatric Genetics & Genomics: Cardiff University, Centre Hospitalier Régional Universitaire de Lille, Chromosome 14 IGHV1-67, Chromosome 8 TP53INP1, Collaborative Projects, Collaborative Working, Energy Metabolism, Erasmus MC University Medical Center, Functional Genomics Center Zurich, Gene-Wide Analytical Approaches, Genes Linked to Schizophrenia, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genetics of Schizophrenia, Genome-Wide Association Dataset, Genome-Wide Association Studies (GWAS), Hospital Universitari Vall d'Hebron - Institut de Recerca, Immune System, Innovation in Genetics, INSERM, Institut Pasteur de Lille, International Genomics of Alzheimer's Project Consortium, Karolinska Institutet, McGill University and Génome Québec Innovation Centre, Medical University Graz, MRC Centre for Neuropsychiatric Genetics & Genomics, Nature, Nature Publishing Group, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Novel Susceptibility Loci (Alzheimer's Disease), Protein Degradation, Research and Innovation, Research Consortia, Schizophrenia, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Single Nucleotide Polymorphisms (SNPs), Université Lille 2, University of Bonn, University of Miami, University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, University of Texas Health Sciences Center at Houston, University of Washington, University of Zurich, US National Institute of Mental Health, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Victor Segalen University
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Alzheimer’s Disease: Genetics Research Breakthrough (BBC News / NHS Choices / Nature Genetics)
Summary An international collaboration of geneticists from 145 academic institutions investigating Alzheimer’s Disease have performed a meta-analysis of data about the DNA of 17,000 patients and 37,000 healthy people. Their analysis of genome-wide association studies (GWAS) has identified 21 genetic … Continue reading →
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
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Tagged Alzheimer's Gene (APOE4 Gene), Alzheimer's Research UK, APOE, APOE Gene, Apolipoprotein E (APOE) Gene, BBC Health News, Behind the Headlines, Boston University School of Medicine, Boston University School of Public Health, Broca Hospital, Cardiff University, Centre d'Etude du Polymorphisme Humain (CEPH), Centre for Neuropsychiatric Genetics & Genomics: Cardiff University, Centre National de Génotypage, Cholesterol, Collaborative Projects, Collaborative Working, Columbia University, Commissariat à l'Energie Atomique, Critical Appraisals, DNA, Eidgenössische Technische Hochschule, Endocytosis, Erasmus MC University Medical Center: Rotterdam, Fondation Jean Dausset, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genome-Wide Association Studies (GWAS), Gertrude H. Sergievsky Center: Columbia University, Immune System, Innovation in Genetics, INSERM, Institut Génomique, Institut Pasteur de Lille, International Collaborations, Late-Onset Alzheimer's Disease (LOAD), Medical Research Council (MRC), Medical University of Graz, Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Nature Genetics, Netherlands Consortium for Healthy Aging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Perelman School of Medicine: University of Pennsylvania, Research and Innovation, Research Consortia, Single Nucleotide Polymorphisms (SNPs), Systematic Reviews and Meta-Analyses, Taub Institute on Alzheimer's Disease and the Aging Brain, Université Lille 2, University College London Institute of Neurology, University of Bonn, University of Iceland, University of Miami, University of Pennsylvania, University of Washington, University Paris Descartes, Wellcome Trust
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Quick Insight: United States Perspective on Dementia Research Funding and Progress (Cure Alzheimer’s Fund)
Summary This video gives an overview of the organisations and funding arrangements behind recent collaborative research work on Alzheimer’s Disease, and other form of dementia, in the USA. “Cure Alzheimer’s Fund and the National Institute of Mental Health (NIMH) are … Continue reading →
Posted in Charitable Bodies, For Researchers (mostly), International, Non-Pharmacological Treatments, Pharmacological Treatments, Proposed for Next Newsletter, Quick Insights, Universal Interest
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Tagged Alzheimer's Research, Amyloid Proteins, ApoE and Genetics of Alzheimer's Disease, Big Pharma, Collaboration, Collaborative Innovation Networks, Collaborative Projects, Collaborative Working, Cure Alzheimer's Fund, Cure Alzheimer’s Fund Research Consortium, Dementia Research, FDA, Gene CD33, Genetic Profiling, Genetic Research, Genetic Testing, Genetic Triggers, Genetics of Alzheimer's Disease, Genome Biology, Genome Sequencing, Information Sharing, Innovation in Genetics, Medicare and Medicaid, National Institute of Mental Health (NIMH), Partnership and Collaboration, Pharmaceutical Industry, Philanthropy, Pre-Competitive Collaboration, Protein Plaques, Public-Private Partnerships, Research and Development, Research and Innovation, Research Consortia, Research Funding, Research Networks, Research Spending, Translational Research, USA, Variant Call Format (VCF), Venture Capital (Approach to Research), Venture Funding, Whole Genome Sequencing
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Frontotemporal Dementia (BMJ)
Summary Frontotemporal dementia involves a diverse range of conditions which are a cause of young onset dementia. There is selective brain atrophy in the frontal and temporal lobes, which requires brain magnetic resonance imaging for accurate diagnosis. Approximately one-quarter of … Continue reading →
Posted in Acute Hospitals, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Mental Health, Quick Insights, Universal Interest
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Tagged Arnold Pick, Association for Frontotemporal Degeneration, Behavioural Variant Frontotemporal Dementia (bvFTD), BMJ, Brain Imaging, C9ORF72 Gene, Corticobasal Syndrome (CBS), Dementia Research Centre: UCL Institute of Neurology, Dementia Research Centre: University College London, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Frontotemporal Dementia Support Group, Frontotemporal Dementia With Motor Neurone Disease (FTD-MND), Frontotemporal Lobar Degeneration, Frontotemporal Lobar Dementia (FTD), FUS Protein, Fused in Sarcoma (FUS) Protein, Genetic Profiling, Logopenic Aphasia, Magnetic Resonance Imaging (MRI), Microtubule Associated Protein Tau (MAPT), MRI, MRI Scans, Neurodegeneration, Neurodegenerative Diseases, Neuroimaging, Neurological Disease, Neurology, Pick’s Disease, Progressive Non-Fluent Aphasia (PNFA), Progressive Nonfluent Aphasia, Semantic Dementia, TDP-43, TDP-43 Pathology, Trazodone, UCL Institute of Neurology: University College London, University College London, Valosin Containing Protein (VCP), Young Onset Dementia (YOD)
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Blood Test for Early Detection of Alzheimer’s Disease? (BBC News / Genome Biology)
Summary The degenerative processes causing Alzheimer’s Disease are believed to start often years before clinical symptoms become apparent. Researchers have been investigating ways of detecting the disease earlier. Such tests should help in learning more about how the disease progresses. Tests … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
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Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Early Screening, Assessment and Diagnosis, BBC Health News, Blood Tests, Dementia Diagnosis, Dementia Screening, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostics, Differential Diagnosis, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Differential Diagnosis, Early Screening, Genetic Profiling, Genetic Tests, Genetics of Alzheimer's Disease, Genome Biology, Germany, Innovation in Genetics, microRNA, MicroRNAs, Rapid Screening, Saarland University, Screening, Screening for Dementia
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Blood Test Could Assist Early Diagnosis of Alzheimer’s Disease (BBC News)
Summary Researchers at the University of Nottingham are developing a quick and easy blood test to detect proteins linked strongly with Alzheimer’s Disease, such as amyloid and APOE, in combination with other markers linked to inflammation. The test has not been fully validated yet, and could be … Continue reading →
Posted in Acute Hospitals, Alzheimer’s Research UK, BBC News, Community Care, Diagnosis, For Researchers (mostly), In the News, Quick Insights, UK, Universal Interest
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Tagged Alzheimer's Gene (APOE4 Gene), Alzheimer’s Early Screening, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid-β (Aβ), APOE, ApoE and Genetics of Alzheimer's Disease, ApoE e4 Allele, APOE4 Gene, Apolipoprotein E (APOE) e4 Allele, BBC Health News, Beta-Amyloid, Beta-Amyloid Plaques, Biomarkers, Blood Tests, Case Finding for Patients with Dementia, Common Genetic Risk Factor Links Alzheimer’s Disease and Type 2 Diabetes (SorCS1), Dementia Case Finding, Diagnostic Markers, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Screening, Effective Diagnostics, Genetic Profiling, Genetics of Alzheimer's Disease, Inflammation, β-amyloid, Nottingham Trent University’s John van Geest Cancer Research Centre, Rapid Screening, Screening, Screening for Dementia, Targeted Screening for Dementia, University of Nottingham, University of Nottingham’s School of Molecular Medical Sciences
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Early-Onset Alzheimer’s Gene Studied in Young Adults (NHS Choices / Lancet Neurology)
Summary This is another critical appraisal from the NHS Choices “Behind the Headlines” service, released during 2012, on elderly care and dementia-related topics appearing in the news. Full Text Link (a) Reference Early-Onset Alzheimer’s gene explored in teens. London: NHS … Continue reading →
Posted in For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices)
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Tagged Alzheimer's Prevention Initiative, Amyloid Precursor Protein (APP), Anonymous Foundation, Arizona Alzheimer's Consortium, Autosomal Dominant Alzheimer's Disease, Banner Alzheimer's Institute, Boston University Department of Psychology, Brain Imaging, Cerebrospinal Fluid (CSF), Cerebrospinal Fluid (CSF) Biomarkers, Colciencias, Colombian Alzheimer's Prevention Initiative Registry in Medellín Antioquia, Common Genetic Risk Factor Links Alzheimer’s Disease and Type 2 Diabetes (SorCS1), CSF, CSF Aβ, CSF Aβ(1-42), Department of Psychiatry: University of Arizona, Early-Onset Alzheimer's Gene, Fluid Biomarker Analysis, Forget Me Not Initiative, Genetic Profiling, Genetics of Alzheimer's Disease, Hereditary Form of Early-Onset Alzheimer's Disease, Lancet Neurology, Magnetic Resonance Imaging (MRI), MRI, MRI Scan, Neurogenomics Division: Translational Genomics Research Institute (Phoenix), Nomis Foundation, Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), PSEN1 E280A, State of Arizona, Translational Genomics Research Institute, University of Arizona, US National Institute of Neurological Disorders and Stroke, US National Institute on Aging, Young Onset Dementia (YOD)
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