Tag Archives: Genetic Variants

Further Confirmation of the Benefits of Education for Cognitive Reserve? (NHS Choices / BMJ)

Posted on December 22, 2017 by Dementia and Elderly Care News

Summary A detailed investigation into modifiable risk factors for Alzheimer’s Disease provides further confirmation that levels of educational attainment are associated with a reduced risk of developing Alzheimer’s Disease. The following NHS Choices Behind the Headlines critical appraisal provides a … Continue reading →

Posted in Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Non-Pharmacological Treatments, Quick Insights, Statistics, Universal Interest | Tagged Access to Education, Additional Year of Education Associated With an 11% Reduction in Risk of Alzheimer's Disease, Alzheimer’s Disease Genetics Consortium (ADGC), Bazian, Behind the Headlines, Benefits of Education, BMJ, BMJ Publishing Group Ltd, Cognitive Reserve, Cognitive Reserve Hypothesis, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), CoSTREAM Consortium, Dementia Risk Factors, Department of Clinical Neurosciences: University of Cambridge, Department of Public Health and Primary Care: University of Cambridge, Educational Attainment, Epidemiology, Epidemiology and Statistics, European Alzheimer's Disease Initiative (EADI), European Union's Horizon 2020, Formal Education and Complex Work (Cognitive Reserve), Genetic and Environmental Risk in Alzheimer’s Disease Consortium (GERAD), Genetic Risk Factors, Genetic Variants, German Centre for Neurodegenerative Diseases, German Centre for Neurodegenerative Diseases (DZNE), Germany, Institute for Stroke and Dementia Research: Klinikum der Universität München, Institute of Environmental Medicine: Karolinska Institutet (Sweden), International Genomics of Alzheimer's Project (IGAP), International Genomics of Alzheimer’s Project, Karolinska Institute, Karolinska Institutet, Klinikum der Universität München, Ludwig-Maximilian University, Ludwig-Maximilians University ( Munich), Mendelian Randomisation, Modifiable Risk Factors, MRC Biostatistics Unit: University of Cambridge, Munich, Munich Cluster for Systems Neurology (SyNergy): Germany, Overlapping Risk Factors, Potentially Modifiable Socio-Environmental Risk Factors, Potentially Modifiable Socio-Environmental Risk Factors for Dementia, Risk Factors for Alzheimer's Diseease, Socio-Environmental Risk Factors, Socio-Environmental Risk Factors for Dementia, Stroke Research Group: University of Cambridge, Sweden, Sweden; Karolinska Institutet, Swedish Brain Foundation, Unit of Nutritional Epidemiology: Karolinska Institutet (Sweden), University of Cambridge | Leave a comment

One More Genetic Link in the Longevity Enigma? (BBC News / Sanger Institute / Nature Communications)

Posted on May 29, 2017 by Dementia and Elderly Care News

Summary People living in the isolated Greek villages of Zoniana and Anogia have a noted tendency to live well into old age. They have a lower than expected incidence of cardiovascular disease, including heart problems, heart attacks and stroke. It … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Stroke, Universal Interest | Tagged 100000 Genomes Project, 100000 Genomes Project Haplotypes, Anogia, Anogia Medical Centre (Greece), APOE, APOE Gene, Array Genotyping, BBC Health News, BMI: Body Mass Index, Body Fat, Body Mass Index (BMI), Cardiometabolic Associations, Cardiovascular Disease (CVD), Cardiovascular Fitness, Cardiovascular Risk, Cardiovascular System Disorders, CDKN2A/B, Cholesterol (HDL), CHRNA3/5, Churchill Hospital (Oxford), Cigarettes, Cretan-Isolated Populations, CVD: Cardiovascular Disease, Department of Nutrition and Dietetics: Harokopio University (Athens), Echinos Medical Centre (Xanthi: Greece), Educational Attainment, Epidemiology, Extra Year in Education Extends Lifespan by 11 months (DNA Study Assertion), FOXO3A, Genetic Correlations: Lifespan and Mortality, Genetic Profiling, Genetic Research, Genetic Variant rs145556679, Genetic Variants, Genetics, Genetics Versus Environment as Determinants of Longevity, Genetics Versus Lifestyle as Determinants of Longevity, Genome-Wide Association Meta-Analysis (GWAMA), Genome-Wide Association Studies, Genome-Wide Association Studies (GWAS), Greece, Greek Villagers, Harokopio University (Athens), HDL-Cholesterol, Heart Disease, HELIC (Hellenic Isolated Cohorts), HELIC MANOLIS Sequencing, High Density Lipoproteins (HDL), High-Density Lipoprotein (HDL) Cholesterol Levels, HLA-DQA1/DRB1, Human Longevity, Insulin Resistance, Isolated Greek Villages, Isolated Populations, Isolated Populations Research, Lifespan, Longevity, Low Density Lipoprotein Cholesterol (LDL-C), Low Density Lipoproteins (LDL), LPA, Lung Cancer, Medical School: University of Exeter, Mendelian Randomisation, METACARPA, Microarrays, Molecular Pathological Epidemiology, Mylopotamos (MANOLIS) and Pomak Villages Cohorts, Mylopotamos: Northern Crete, Nature Communications, Northern Crete, Obesity, Openness to New Experiences, Oxford Centre for Diabetes Endocrinology and Metabolism University of Oxford, Pomak Region of Northern Greece, Population Isolates, Radcliffe Department of Medicine: University of Oxford, Sanger Institute, Saturated Fats, School of Health Science and Education: Harokopio University (Athens), SH2B3, Smoking, Susceptibility to Coronary Artery Disease (CAD), Triglycerides, UK Biobank, Unexpected Genetic Heroes, University of Exeter, University of Exeter Medical School, University of Oxford, Usher Institute of Population Health Sciences and Informatics: University of Edinburgh, Very Low Density Lipoprotein cholesterol (VLDL), Wellbeing and Longevity, Wellcome Trust Centre for Human Genetics: University of Oxford, Wellcome Trust Sanger Institute, Wellcome Trust Sanger Institute: Human Genetics, WGS Haplotypes, Whole Genome Sequencing (WGS), Whole Genome Sequencing and Imputation, Zoniana | Leave a comment

Genetic Mutation Which Delays Alzheimer’s Disease? (NHS Choices / Molecular Psychiatry)

Posted on January 4, 2016 by Dementia and Elderly Care News

Summary A study of 71 persons from an extended family (comprising around 5,000 people) in northern Colombia, who carry a mutation in a gene called PSEN1 (the so-called the Paisa mutation, which causes a rare, severe form of early-onset Alzheimer’s disease), … Continue reading →

Genetic / Biological Foundations of Mental Processing Speed Discovered? (BBC News / Molecular Psychiatry)

Posted on April 24, 2015 by Dementia and Elderly Care News

Summary A large international epidemiological study of data from 30,000 people may have identified underlying genetic variants linked to individual differences in the ability to process information. Genetic differences might explain why some people are quicker thinkers in middle age … Continue reading →

Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, Scotland, UK, Universal Interest | Tagged Australia, BBC Health News, CADM2 Gene, Cell Adhesion Molecule Two (CADM2) Gene, CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium, Croatia, Digit Symbol Substitution Test (DSST), DTNBP1, Edinburgh University, Executive Function and Processing Speed, Finland, Gamma-Aminobutyric Acid (GABA) Transport, Genetic / Biological Foundations of Mental Processing Speed, Genetic Research, Genetic Variants, Genetics, Genome-Wide Association Studies (GWAS), Glutamate Signalling, Holland, Letter Digit Coding Test (LDCT), Letter-Digit Substitution Task (LDST), Mental Processing Speed, Molecular Psychiatry (Journal), Neuron Cell-Cell Adhesion, Quick Thinkers, Scotland, Single Nucleotide Polymorphisms (SNPs), Stroop Card 2 (Colour Card), Stroop Card 3 (Colour Word Card), Symbol Digit Modalities Test (SDMT), Thinking Efficiency, Thinking Speed, Trail Making Test Part A (Trail A), Trail Making Test Part B (Trail B), TRIB3, WDR72 Gene | Leave a comment

Eleven Genomics Medicine Centres Planned for England (BBC News / Department of Health / NHS England)

Posted on December 22, 2014 by Dementia and Elderly Care News

Summary The NHS has announced further steps in a genetics project, which will involve 11 Genomics Medicine Centres being created in English hospitals to gather DNA information. The aim is to support the 100,000 Genomes Project in research towards the … Continue reading →

Recent Systematic Reviews and Meta-Analyses Concerning Genetic Research

Posted on August 9, 2014 by Dementia and Elderly Care News

Some of the following articles may be available freely where indicated (depending on local circumstances). Access to the full-text of the other articles will require a suitable Athens password, a journal subscription or payment. The Bibliographic Citations Wang, XB. Cui, … Continue reading →

Posted in For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews, UK | Tagged Alzheimer's Disease Genetic Consortium, Alzheimer's Disease Susceptibility Genes, Amyotrophic Lateral Sclerosis, Angiotensin-Converting Enzyme Gene Polymorphisms, Biomarker Assessments in Alzheimer’s Disease, Biomarkers, C4D Consortium, C9orf72, CARDIoGRAM Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology, CYP2D6 Polymorphisms, Diabetes Mellitus, Dominantly Inherited Alzheimer Network, ESR1 Gene, European Alzheimer's Disease Initiative (EADI), Familial Alzheimer's Disease, Framingham Heart Study, Frontotemporal Dementia, Genetic and Environmental Risk in Alzheimer's Disease, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genome-Wide Association Studies (GWAS), Genomics, Genomics and Randomized Trials Network, International Stroke Genetics Consortium, METASTROKE Consortium, miRNA Regulatory Pathways in Alzheimer's Disease, miRNAs, Novel Susceptibility Loci (Alzheimer's Disease), Presenilin 2 Mutations, Progranulin Polymorphism rs5848, Recent Systematic Reviews and Meta-Analyses, Risk Factors, rs5848, Systematic Reviews and Meta-Analyses, Type 2 Diabetes, UNC13A | Leave a comment

UK Genomes Project: Genomics England (BBC News / NHS England / HEE / Nature Genetics)

Posted on August 1, 2014 by Dementia and Elderly Care News

Summary A revolution in medicine is in progress at research centres across the UK, based on unlocking the genetic bases of cancer and other diseases. The UK could become a world leader in genetic research, targeted therapies and personalised medicine. … Continue reading →

Tag Archives: Genetic Variants

Further Confirmation of the Benefits of Education for Cognitive Reserve? (NHS Choices / BMJ)

One More Genetic Link in the Longevity Enigma? (BBC News / Sanger Institute / Nature Communications)

Genetic Mutation Which Delays Alzheimer’s Disease? (NHS Choices / Molecular Psychiatry)

Genetic / Biological Foundations of Mental Processing Speed Discovered? (BBC News / Molecular Psychiatry)

Eleven Genomics Medicine Centres Planned for England (BBC News / Department of Health / NHS England)

Recent Systematic Reviews and Meta-Analyses Concerning Genetic Research

UK Genomes Project: Genomics England (BBC News / NHS England / HEE / Nature Genetics)

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