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Tag Archives: Genetically Engineered Mice
Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)
Summary NHS Choices’ Behind the Headlines covers Chinese and Canadian research, based on both humans and animals, indicating potential associations between Vitamin A deficiency and later development of Alzheimer’s Disease. “ …vitamin A deficiency is a problem in the developing … Continue reading
Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Quick Insights, Universal Interest
Tagged Acta Neuropathologica, Aβ-Plaques, Alzheimer's Disease Pathogenesis, Amyloid Beta, Amyloid Precursor Protein (APP), Amyloid-β (Aβ), Amyloid-β Protein, Behind the Headlines, Beta-Amyloid Plaques, Beta-Site Amyloid-Beta Precursor Protein-Cleaving Enzyme 1 (BACE1), Canada, Canadian Institutes of Health Research (CIHR), Children's Hospital of Chongqing Medical University, Children's Nutrition Research Center, China, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Chongqing, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Critical Appraisals, Department of Psychiatry: University of British Columbia, Genetically Engineered Mice, Marginal Vitamin A Deficiency (MVAD), Mice, Ministry of Education Key Laboratory of Child Development and Disorders, National Natural Science Foundation of China, Townsend Family Laboratories: University of British Columbia, University of British Columbia, Vitamin A, Vitamin A Deficiency, Vitamin A Supplementation, Vitamin Supplements, Vitamins
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Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)
Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA
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Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)
Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading
Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK
Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton
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Stroke Brain Damage Reversed by Brain Stimulation? (BBC News / PNAS)
Summary Research at Stanford University School of Medicine, on mice, indicates that stimulation of the brain regions which control movement may help recovery from strokes. They investigated whether brain stimulation aided recovery and discovered that those animals receiving brain stimulation … Continue reading
Posted in Acute Hospitals, Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Stroke, Universal Interest
Tagged Acute Ischaemic Stroke, BBC Health News, BDNF: Brain-Derived Neurotrophic Factor, Brain Plasticity: Brain Stimulation-Induced, Brain Stimulation, Brain-Derived Neurotrophic Factor (BDNF), Channelrhodopsin 2, Cracking the Neural Code (CNC) Program, Deep Brain Stimulation for the Treatment of Strokes, Functional Recovery (Post-Stroke), Genetic Research, Genetically Engineered Mice, Howard Hughes Medical Institute, Ipsilesional Primary Motor Cortex (iM1), Laboratory of Synthetic Perceptive Emotive and Cognitive Systems: Pompeu Fabra University, Motor Cortex, Nerve Growth Factor, Neuronal Stimulation, Neurotrophin 3, Neurotrophins, Optogenetic Neuronal Stimulation, Optogenetic Stimulation, Optogenetics, Physical Rehabilitation, Plasticity Marker Growth-Associated Protein 43, PNAS, Pompeu Fabra University, Poststroke Rehabilitation, Potential Drug Targets for Stroke Treatment, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Recovery, Rehabilitation, Selective Neuronal Stimulations, Spain, Stanford Stroke Center: Stanford University School of Medicine, Stanford University, Stanford University School of Medicine, Stroke Rehabilitation, Stroke Therapy, Synaptic Plasticity, United States, USA, Virtual Reality in Post-Stroke Recovery, Virtuous Circle in Post-Stroke Recovery
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Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)
Summary Recent research into transgenic mice (and early, small-scale investigations with people) suggests that the anti-depressant citalopram could be used to slow the onset of Alzheimer’s Disease. This work in the United States appears to show that citalopram may counteract … Continue reading
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
Tagged Amyloid Beta, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Antidepressants, Antidepressive Agents, Avid Radiopharmaceuticals, BBC Health News, Beta-Amyloid, Beta-Amyloid Plaques, Citalopram, CSF Aβ Production, Department of Neurology: Washington University, Department of Neurology: Washington University School of Medicine, Eli Lilly Inc., Genetically Engineered Mice, Hope Center for Neurological Disorders: Washington University, Hope Center for Neurological Disorders: Washington University School of Medicine, β-amyloid, Knight Alzheimer's Disease Research Center, Knight Alzheimer's Disease Research Center: Washington University Medical Center, Mice, Mouse Model of Alzheimer's Disease, Off-Label Drug Repurposing Trials, Pittsburgh Compound B (PIB), PNAS, Positron Emission Tomography (PET), Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Protein Plaques, Repurposing of Drugs, Science Translational Medicine, Selective Serotonin Reuptake Inhibitors (SSRIs), SSRIs: Selective Serotonin Reuptake Inhibitors, Transgenic Mice, United States, University of Pennsylvania, University of Washington, USA, Washington University Medical Center, Washington University School of Medicine
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