Tag Archives: Genetically Engineered Mice

Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)

Posted on February 5, 2017 by Dementia and Elderly Care News

Summary NHS Choices’ Behind the Headlines covers Chinese and Canadian research, based on both humans and animals, indicating potential associations between Vitamin A deficiency and later development of Alzheimer’s Disease. “ …vitamin A deficiency is a problem in the developing … Continue reading →

Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Quick Insights, Universal Interest | Tagged Acta Neuropathologica, Aβ-Plaques, Alzheimer's Disease Pathogenesis, Amyloid Beta, Amyloid Precursor Protein (APP), Amyloid-β (Aβ), Amyloid-β Protein, Behind the Headlines, Beta-Amyloid Plaques, Beta-Site Amyloid-Beta Precursor Protein-Cleaving Enzyme 1 (BACE1), Canada, Canadian Institutes of Health Research (CIHR), Children's Hospital of Chongqing Medical University, Children's Nutrition Research Center, China, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Chongqing, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Critical Appraisals, Department of Psychiatry: University of British Columbia, Genetically Engineered Mice, Marginal Vitamin A Deficiency (MVAD), Mice, Ministry of Education Key Laboratory of Child Development and Disorders, National Natural Science Foundation of China, Townsend Family Laboratories: University of British Columbia, University of British Columbia, Vitamin A, Vitamin A Deficiency, Vitamin A Supplementation, Vitamin Supplements, Vitamins | Leave a comment

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Posted on December 5, 2016 by Dementia and Elderly Care News

Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading →

Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA | Leave a comment

Early Indications Suggest Zika Virus Might Damage Adult Brains Resulting in Long-Term Neurological Conditions (NHS Choices / Cell Stem Cell)

Posted on August 20, 2016 by Dementia and Elderly Care News

Summary The Zika virus has been linked with microcephaly in human babies, and has also – more tentatively – been linked to Guillain-Barre Syndrome (GBS), but until now was not thought likely to affect the adult population beyond minor short-term … Continue reading →

Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Aging and Stem Cell Regeneration: Sanford Burnham Prebys Discovery Institute, Apoptosis and Reduced Cellular Proliferation, Apoptotic Neural Cell Death, Behind the Headlines, California Institute of Regenerative Medicine, Caribbean Countries, Cell Stem Cell (Journal), Central America, Central Nervous System Abnormalities, CNS Infections, Del. E. Webb Center for Neuroscience: Sanford Burnham Prebys Discovery Institute, Dementia Risk Factors, Dengue Virus, Department of Neurosciences: University of California, Division of Inflammation Biology: La Jolla Institute for Allergy and Immunology, Environmental Risk Factors, Flaviviruses, Genetically Engineered Mice, Guillain-Barré Syndrome, Guillain-Barre Syndrome (GBS), Hippocampus, Hippocampus-Based Cognitive Processes, Howard Hughes Medical Institute, Howard Hughes Medical Institute: Rockefeller University, Infection, Infection and Infectious Diseases, La Jolla Institute for Allergy and Immunology, La Jolla Institute for Genomic Medicine, Laboratory for Pediatric Brain Diseases: Howard Hughes Medical Institute, Long Term Neurological Conditions, Microcephaly, National Institutes of Health (NIH), National Institutes of Health (US), Neural Progenitor Cells (NPCs), Neurobiology of ZIKV and Potential Neuropsychiatric Manifestations, Neurogenesis, Neurological Complications, Neurological Conditions, Neurological Disease, Neurological Disorders, Pathogenesis, Rady Children’s Institute for Genomic Medicine: University of California, Risk Factors, Risks to Immunocompromised Adults, Rockefeller University, Sanford Burnham Prebys Discovery Institute, Simons Foundation of Autism Research Initiative, South America, Subgranular Zone (SGZ) of Hippocampus, Subventricular Zone (SVZ) of Anterior Forebrain, Systemic ZIKV Can Infect Neural Progenitor Cells in the Adult Brain, The Americas, TKO Mice (Mice With Immune Cells Knocked Out), United States, University of California, USA, World Health Organization (WHO): Zika Public Health Emergency of International Concern, Zika Fever, Zika Infection Leading to Neural Cell Death and Reduced Cell Division, Zika Virus, Zika Virus (ZIKV) Infection, Zika Virus Epidemiology and Recent Epidemics, Zika Virus Infection: Public Health Issues, Zika Virus Outbreaks in the Americas, ZIKV Pandemic | Leave a comment

Memories Lost in Alzheimer’s Disease: Potentially Retrievable? (NHS Choices / Nature)

Posted on April 3, 2016 by Dementia and Elderly Care News

Summary Research on transgenic mice suggests that memories are not destroyed irretrievably by Alzheimer’s Disease; there appears to be problems recalling these lost memories. Lost memories may be retrievable, under experimental conditions, by exposing “Engram Cells” with bright blue light … Continue reading →

Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Contextual Fear Conditioning: Test Of Memory in Animals (Mice For Example), Current Opinion in Neurobiology, Dentate Gyrus Engram Cells, Department of Biology and Department of Brain and Cognitive Sciences: Massachusetts Institute of Technology, Direct Optogenetic Activation of Hippocampal Memory Engram Cells, Engram Cells, Episodic Memory, Freeze Response: Contextual Fear Conditioning Test of Memory in Animals (Mice For Example), Genetically Engineered Mice, Hippocampus, Hippocampus-Based Cognitive Processes, Hippocampus-Dependent Memory Deficits, Howard Hughes Medical Institute, Howard Hughes Medical Institute: Massachusetts Institute of Technology, Induced Fear Responses, JPB Foundation, Massachusetts Institute of Technology (MIT), Mechanisms of Memory Retrieval, Memory Consolidation, Memory Engram Cells, Memory Retrieval by Activating Engram Cells, Mice, Mouse Model of Alzheimer's Disease, Mouse Models of Alzheimer's Disease, Nature, Nerve Cell Spine Density, Neurobiology, Neurobiology of Memory Storage, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Rehebbilitating Memory (sic), Retrieval Rather Than Storage-Related Memory Impairments, RIKEN Brain Science Institute, RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory: Massachusetts Institute of Technology, Specific Memory Engrams in Particular Brain Regions, Spine Density in Engram Cells, Transgenic Mice, Use of Blue Light to Stimulate Brain Cells Associated With Memory (Engram Cells) | Leave a comment

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Posted on January 10, 2016 by Dementia and Elderly Care News

Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading →

Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK | Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton | Leave a comment

Novel Approach to Prevention of Alzheimer’s Disease Explored in Laboratory (Express / PloS One)

Posted on May 4, 2015 by Dementia and Elderly Care News

Summary Researchers at the University of California, San Diego, have explored a different approach to mainstream research into the prevention of Alzheimer’s Disease. It is believed that Alzheimer’s Disease develops when amyloid precursor protein (APP) gets cut-up by enzymes and … Continue reading →

Posted in Animal Studies, For Doctors (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights | Tagged Aβ40, Aβ42, Alzheimer's Disease, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid Precursor Protein, ß-amyloid, Beta-Amyloid, Binding Affinity Measurement by Biolayer Interferometry, Candidate Drugs for Alzheimer's Disease, Confocal Microscopy, Cultured Jurkat Cells, Department of Biology: University of California San Diego, Department of Medicine: University of California San Diego, Department of Neuroscience Imaging Core: University of California San Diego, Department of Neurosciences: University of California-San Diego, Disease Modifying Treatment by 2025 (Aim), Experimental Therapeutic Approaches to Reduce ß-Amyloid (Alzheimer’s Disease), Express (Newspaper), FortéBio, Genetically Engineered Mice, Human Neuroblastoma Cell-Line IMR-32 (ATCC CCL-127), β-Amyloid (Aβ) Accumulation, β-Amyloid Precursor Protein (APP), Mouse Model of Alzheimer's Disease, Notch Intracellular Domain (NICD), P4 and P8: Protein Site-Specific Small Peptides to Reduce Aβ Production, Pall Corporation, Peptides of Presenilin-1, Peptides P1 Through P10, PLoS One, Presenilin, Specific Binding of P4 and P8 to APP, Transgenic Mice, United States; Cenna Biosciences Incorporated, University of California, University of California San Diego, USA | Leave a comment

Stroke Brain Damage Reversed by Brain Stimulation? (BBC News / PNAS)

Posted on August 19, 2014 by Dementia and Elderly Care News

Summary Research at Stanford University School of Medicine, on mice, indicates that stimulation of the brain regions which control movement may help recovery from strokes. They investigated whether brain stimulation aided recovery and discovered that those animals receiving brain stimulation … Continue reading →

Posted in Acute Hospitals, Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Stroke, Universal Interest | Tagged Acute Ischaemic Stroke, BBC Health News, BDNF: Brain-Derived Neurotrophic Factor, Brain Plasticity: Brain Stimulation-Induced, Brain Stimulation, Brain-Derived Neurotrophic Factor (BDNF), Channelrhodopsin 2, Cracking the Neural Code (CNC) Program, Deep Brain Stimulation for the Treatment of Strokes, Functional Recovery (Post-Stroke), Genetic Research, Genetically Engineered Mice, Howard Hughes Medical Institute, Ipsilesional Primary Motor Cortex (iM1), Laboratory of Synthetic Perceptive Emotive and Cognitive Systems: Pompeu Fabra University, Motor Cortex, Nerve Growth Factor, Neuronal Stimulation, Neurotrophin 3, Neurotrophins, Optogenetic Neuronal Stimulation, Optogenetic Stimulation, Optogenetics, Physical Rehabilitation, Plasticity Marker Growth-Associated Protein 43, PNAS, Pompeu Fabra University, Poststroke Rehabilitation, Potential Drug Targets for Stroke Treatment, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Recovery, Rehabilitation, Selective Neuronal Stimulations, Spain, Stanford Stroke Center: Stanford University School of Medicine, Stanford University, Stanford University School of Medicine, Stroke Rehabilitation, Stroke Therapy, Synaptic Plasticity, United States, USA, Virtual Reality in Post-Stroke Recovery, Virtuous Circle in Post-Stroke Recovery | Leave a comment

Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)

Posted on May 15, 2014 by Dementia and Elderly Care News

Summary Recent research into transgenic mice (and early, small-scale investigations with people) suggests that the anti-depressant citalopram could be used to slow the onset of Alzheimer’s Disease. This work in the United States appears to show that citalopram may counteract … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Amyloid Beta, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Antidepressants, Antidepressive Agents, Avid Radiopharmaceuticals, BBC Health News, Beta-Amyloid, Beta-Amyloid Plaques, Citalopram, CSF Aβ Production, Department of Neurology: Washington University, Department of Neurology: Washington University School of Medicine, Eli Lilly Inc., Genetically Engineered Mice, Hope Center for Neurological Disorders: Washington University, Hope Center for Neurological Disorders: Washington University School of Medicine, β-amyloid, Knight Alzheimer's Disease Research Center, Knight Alzheimer's Disease Research Center: Washington University Medical Center, Mice, Mouse Model of Alzheimer's Disease, Off-Label Drug Repurposing Trials, Pittsburgh Compound B (PIB), PNAS, Positron Emission Tomography (PET), Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Protein Plaques, Repurposing of Drugs, Science Translational Medicine, Selective Serotonin Reuptake Inhibitors (SSRIs), SSRIs: Selective Serotonin Reuptake Inhibitors, Transgenic Mice, United States, University of Pennsylvania, University of Washington, USA, Washington University Medical Center, Washington University School of Medicine | Leave a comment

Protein Involved in Old-Age Memory Loss? (BBC News / Science Translational Medicine)

Posted on September 5, 2013 by Dementia and Elderly Care News

Summary US researchers working with the donated brains of eight dead people and also performing experiments on mice have discovered indications that low levels of a protein in the brain (called RbAp48) may be responsible for memory loss. This discovery might, one day, lead to treatments … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Age-Related Memory Loss, Ageing, BBC Health News, Columbia University, Columbia University Medical Centre, Dentate Gyrus, Department of Neuroscience: Columbia University, Entorhinal Cortex, Genetically Engineered Mice, Hippocampal Subregions and Cognitive Ageing, Hippocampus-Dependent Memory Deficits, Histone Acetylation, Histone-Binding Protein RbAp48, Inhibition of RbAp48, Memory Loss, Memory Problems, Morris Water Maze Test, New York, Old-Age Memory Loss, RbAp48 Protein, Science Translational Medicine, Transgenic Mice, USA | Leave a comment

Tag Archives: Genetically Engineered Mice

Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Early Indications Suggest Zika Virus Might Damage Adult Brains Resulting in Long-Term Neurological Conditions (NHS Choices / Cell Stem Cell)

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Novel Approach to Prevention of Alzheimer’s Disease Explored in Laboratory (Express / PloS One)

Stroke Brain Damage Reversed by Brain Stimulation? (BBC News / PNAS)

Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)

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