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- Updates Relating to the Lancet Commission on Dementia Prevention, Intervention, and Care (Lancet / Alzheimer’s Research and Therapy / Alzheimer’s and Dementia)
- A Brief Review of How the COVID-19 Pandemic Relates to Elderly Care and Research (JGCR)
- Some Speculated / Potential Benefits of COVID-19 (JGCR / BBC Radio 4’s Rethink / BGS)
- Timeless Good Advice? (Action for Happiness)
- The Diversionary Value of Music Playlists for Patients With Dementia in Accident and Emergency Settings (Nurses.co.uk / BBC News)
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Tag Archives: Harvard University
Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)
Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest
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Tagged Amnestic MCI, Australia, Austria, Bazian, BBC Health News, Behind the Headlines, Brain (Journal), Central Clinical School Faculty of Medicine and Health (Sydney Australia), Clinical and Neurocognitive Features of LATE, Consensus Guidelines for LATE-NC Staging, Consensus Proposed LATE-NC TDP-43 Stages, Dementia-Related Misdiagnosis, Differential Diagnosis, Drug Trials, Drug Trials Failure Rate, Emory University (Atlanta), FTLD-TDP: Frontotemporal Lobar Degeneration With TDP-43 Proteinopathy, Harvard University, Hippocampal Atrophy, Illinois Institute of Technology, Institute of Neurology: Medical University of Vienna, Japan, LATE Biomarkers, LATE Neuropathological Change (LATE-NC), LATE Working Group, Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), Mayo Clinic (Jacksonville), Mayo Clinic: Rochester, Medical University of Vienna, Misdiagnosis, Misdiagnosis (Potential), Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NHS Digital (Formerly NHS Choices), Oldest Old, Oldest Old Age, Oldest People With Dementia, Prevalence of Dementia in Oldest Old, Public Health Impact of LATE, Recommendations for Routine Autopsy Evaluation and Classification of LATE-NC, Rush University Medical Center, Stanford University, Subtypes of Dementia, Sweden, TDP-43 Protein, TDP-43 Proteinopathy, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, United States, University of California, University of Cambridge, University of Kentucky, University of Minnesota, University of Pennsylvania, University of Southern California, University of Sydney Brain and Mind Centre, University of Texas Southwestern Medical Center, University of Washington, Uppsala University, USA
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Probiotics For the Alleviation of Symptoms in Advanced Alzheimer’s Disease? (NHS Choices / Frontiers in Aging Neuroscience / BioResearch Open Access)
Summary Iranian researchers appear to have discovered minor improvements in the symptoms of elderly people with severe Alzheimer’s Disease, associated with the regular consumption of probiotic drinks. The effects of probiotics on biomarkers for inflammation and metabolism were also investigated. … Continue reading →
Posted in For Researchers (mostly), In the News, International, Management of Condition, NHS Digital (Previously NHS Choices), Non-Pharmacological Treatments, Nutrition, Quick Insights, Universal Interest
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Tagged Advanced Dental Associates of New England (Massachusetts), Association Between Gut Health and Brain Function, Bazian, Behind the Headlines, Bifidobacterium bifidum, Biomarkers, Biomarkers for Inflammation and Metabolism, BioResearch Open Access (Journal), Boston University, Boston University School of Medicine, Cancer Research Center: Boston University School of Medicine, Consulate General of Greece in Boston (Massachusetts), Department of Anatomy: Boston University School of Medicine, Department of Chemistry: McGill University, Department of Health Sciences: Boston University, Department of Medicine: Boston University School of Medicine, Department of Neurology: Kashan University of Medical Sciences, Department of Pharmaceutical Chemistry: University of California San Francisco, Dietary Interventions, Dietary Supplements, Double-Blind Randomised Controlled Trials, Frontiers in Aging Neuroscience, Harvard University, hs-CRP, Improving Cognitive Functioning, Iran, Kashan University of Medical Sciences (Iran), Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus fermentum, Markers of Insulin Metabolism, McGill University, MDA, Micro Biota-Gut-Brain Axis, Microbiota-Induced Epigenetics, Mini Mental State Examination (MMSE), PhenoMatriX Inc. (Boston Massachusetts), Physiology Research Center: Kashan University of Medical Sciences, Probiotic Drinks, Probiotic Milk, Probiotic Supplementation, Probiotic Supplementation and Cognitive Function Alzheimer's Disease, Probiotic Supplementation and Metabolic Status in Alzheimer's Disease, Probiotic Supplements and Cognitive Function in Advanced Alzheimer's Disease, Probiotic Treatments, Probiotics, Probiotics in Advanced Alzheimer’s Disease, Randomised Controlled Trials: Appraisal, Research Center for Biochemistry and Nutrition in Metabolic Diseases: Kashan University of Medical Sciences, School of Medicine: Kashan University of Medical Sciences, School of Pharmacy: University of California San Francisco, Triglycerides Levels, University of California San Francisco, Weatherhead Center for International Affairs: Harvard University, Yoghurt
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Hospital Re-Admission Risks Alter Over Time After Discharge? (Nursing Times / Annals of Internal Medicine)
Summary The risk factors for hospital re-admissions may change over a 30-day period following discharge from hospital, according to US research. There appears to be two distinct phases of re-admission risk; one up to eight days and one up to … Continue reading →
Posted in Acute Hospitals, Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Integrated Care, International, Management of Condition, Person-Centred Care, Quick Insights, Statistics, Universal Interest
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Tagged Acute Care, Acute Hospital Care, Acute Hospitals, Annals of Internal Medicine, Avoidable Acute Hospital Admission in Older People, Avoidable Hospital Admissions, Early Versus Late Readmissions, Emergency Readmissions, Harvard Catalyst, Harvard University, Health Resources and Services Administration: National Institute on Aging, Hospital Re-Admission Risks, Hospital Re-Admission Risks: Time After Discharge, Hospital Re-Admission Risks: Time of Day at Discharge, Hospital Readmission Risk Factors, National Institute on Aging, National Institutes of Health, Nursing Times, Readmissions, Reducing Early Hospital Readmissions, United States, USA
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UK Genomes Project: Genomics England (BBC News / NHS England / HEE / Nature Genetics)
Summary A revolution in medicine is in progress at research centres across the UK, based on unlocking the genetic bases of cancer and other diseases. The UK could become a world leader in genetic research, targeted therapies and personalised medicine. … Continue reading →
Posted in BBC News, Department of Health, Health Education England (HEE), In the News, International, National, NHS, NHS England, Personalisation, Quick Insights, UK, Universal Interest
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Tagged 100000 Genome Project: NHS Genomic Medicine Centres, 100000 Genomes Project, Aarhus University, Akureyri Hospital (Iceland), Astra Zeneca, BBC Health News, Bioinformatics Research Centre: Aarhus University, Biological Treatments, Biotechnology Companies, Birmingham, Broad Institute / Whitehead Institute (Massachusetts), Bubble-Boy Syndrome (Immune Disorders), Call for Global Moratorium on Clinical Uses of Human Germline Editing, Cambridge, Cambridge University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Cancer Research UK (CRUK), Cas9 (Crispr-Associated Protein 9) Enzyme, Cell and Gene Therapy at Institute of Child Health (ICH), Central Manchester University Hospitals NHS Foundation Trust: Genomics Medicines Centre, Chief Scientific Officer Bulletin, Chief Scientific Officer Bulletin (July 2014), Children's Hospital: Landspitali University Hospital (Reykjavik Iceland), Cleveland Clinic, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), Collaborative Projects, Collaborative Working, Crispr, Crispr-Cas9, CRISPR-Cas9 Genome Editing System, Crisprs (Clustered Regularly Interspaced Short Palindromic Repeats), Cross-Sector Partnerships, David Cameron, deCODE Genetics, deCODE Genetics /Amgen Inc., Decoding Inherited Disorders, Dementia Research, Denmark, Department of Human Genetics: University of Leuven, Department of Internal Medicine: Akureyri Hospital (Iceland), Dilated Cardiomyopathy, Division of Cardiovascular Diseases: Mayo Clinic, DNA Extraction, Dr Francis Collins: Director of National Institutes of Health (USA), Dr Marcy Darnovsky: Center for Genetics and Society (USA), Drugs Targeted at Specific Mutations, Duke University, East Anglian Medical Genetics Service: Cambridge University Hospitals NHS Foundation Trust, East of England, East of England NHS GMC: Cambridge University Hospitals NHS Foundation Trust, Elimination of Porcine Endogenous Retroviruses Using Crispr, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Ethical Considerations, Ethical Dilemmas, European Bioinformatics Institute, European Bioinformatics Institute: Wellcome Trust Genome Campus, Exeter, Familial Adenomatous Polyposis (FAP), Foetal Stem Cells, Four Ps of Personalised Medicine: Participatory Role for Patients, Four Ps of Personalised Medicine: Precise Diagnoses, Four Ps of Personalised Medicine: Prediction and Prevention of Disease, Four Ps of Personalised Medicine: Targeted and Personalised Interventions, Francis Crick Institute, Fred and Pamela Buffett Cancer Centre (Omaha), Gene Editing in Mice With Duchenne Muscular Dystrophy, Genetic Disorders and Genomics, Genetic Engineering (Pandora's Box), Genetic Modification of Cells: HIV Treatment Strategy, Genetic Profiling, Genetic Research, Genetic Susceptibility Loci, Genetic Triggers, Genetic Variants, Genetics of Alzheimer's Disease, Genome Campus (Wellcome Trust), Genome Sequencing, Genomic Computing, Genomic Medicine, Genomic Medicine Centres, Genomic Medicine Centres (GMCs), Genomics, Genomics Education Programme, Genomics Education Programme (HEE), Genomics England, Genomics England’s Ethics Advisory Committee, Genomics in the NHS, Genomics-Based Medicine, Genotyping, Germline Alterations (Suggested for DMD Huntington's Disease or Cystic Fibrosis), Germline Editing, Germline Gene Editing, Germline Modification, GM Babies, Great Ormond Street Hospital, Great Ormond Street Hospital (GOSH), Great Ormond Street Hospital NHS Foundation Trust: Genomics Medicines Centre, Greater Manchester, Greater Manchester NHS GMC: Central Manchester University Hospitals NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust: Genomics Medicines Centre London, Harvard University, Health Education England's Genomics Education Programme, HEE: Health Education England, Herceptin, Hinxton Group, Housekeeping Proteins, Human Embryos Edited (August 2017), Human Genetic Disorders, Human Germline Editing, Human Protein Atlas, Hypertrophic Cardiomyopathy, IBM Watson Health, IBM's Watson Supercomputer, Iceland, Icelandic Medical Center (Laeknasetrid), IL2RG Gene, Illumina, Imperial College Health Partners NHS GMC: Imperial College Healthcare NHS Trust, Imperial College Healthcare NHS Trust: Genomics Medicines Centre, Improved Prevention Based on Underlying Predisposition, In Utero Stem Cell Therapy, Innovation in Biotechnology, Innovation in Genetics, Innovative Genomics Initiative (University of California in Berkeley / University of California in San Francisco), Institute of Child Health (ICH), International Summit on Human Gene Editing, Introducing Genomics in Healthcare (Health Education England Video), Knowledge Networks, Knowledge Translation, Knut & Alice Wallenberg Foundation, Knut and Alice Wallenberg Foundation, Laboratory in Mjodd (RAM) Iceland, Landscape of Mutations in Breast Cancer Whole-Genome Sequences, Landspitali University Hospital (Iceland), Large DNA Banks, Large-Scale Whole-Genome Sequencing, Large-Scale Whole-Genome Sequencing (Iceland), Liverpool Women's NHS Foundation Trust: Genomics Medicines Centre, London, Lund University, Mayo Clinic (Rochester Minnesota), McDonnell Genome Institute: Washington University (St. Louis), Medical Director of NHS England: Professor Sir Bruce Keogh, Medical Research Council (MRC), Microarrays, Moratorium on Heritable Genome Editing, Mutational Signatures, Mutational Signatures in Breast Cancer, Networks, Networks and Alliances, Newcastle upon Tyne Hospitals NHS Foundation Trust: Genomics Medicines Centre, Next-Generation Sequencing (NGS), NHS Genomic Medicine Centres, NHS Genomic Medicine Centres (NHS GMCs), NHS Genomic Medicine Centres Prospectus, NHS Genomics Medicine Centres, NHS Workforce, North East, North East and North Cumbria NHS GMC: Newcastle upon Tyne Hospitals NHS Foundation Trust, North Thames Genomic Medicine Centre, North Thames NHS Genomic Medicine Centre (NHS GMC), North West Coast NHS GMC: Liverpool Women’s NHS Foundation Trust, North West London Healthcare Trust, Nuffield Council on Bioethics, OHSU Knight Cardiovascular Institute, Osteogenesis Imperfecta, Oxford, Oxford NHS GMC: Oxford University Hospitals Foundation Trust, Oxford University Hospitals Foundation Trust: Genomics Medicines Centre, Partnership, Partnership and Collaboration, Partnership Working, Personalised Health Care for Cancer, Personalised Medicine, Personalised Medicine Strategy (NHS England), Personalised Medicine Strategy Board, Personalised Medicine Strategy for the NHS, Personalised Medicine: Improving Outcomes, Peter Grainger: Patient and Public Involvement Representative at St Mark’s Hospital (North West London Healthcare Trust), Pharmaceutical Industry, PHG Foundation, Prof Peter Braude: King's College London, Professor Ian Cumming OBE: HEE Chief Executive, Professor Sir Bruce Keogh, Professor Sue Hill: Chief Scientific Officer for England, Profiling Individual Cancer Genomes (Personalised Medicine), Protein-Coding Cancer Genes, Radboud University, Regional Genetic Laboratories, Research and Development, Research and Innovation, Research Commitment, Research Consortia, Research Culture, Research Into Aging, Research Networks, Researcher Access to Data, Resources for Researchers, Royal Devon and Exeter NHS Foundation Trust: Genomics Medicines Centre, Royal Institute of Technology in Sweden, Sanger Institute, School of Engineering and Natural Sciences, Science Working Group: Cancer, Science Working Group: Infectious Diseases, Science Working Group: Rare Diseases, Small and Medium Enterprises (SMEs), SMEs, Somatic Genetic Basis of Breast Cancer, South London NHS GMC: Guy’s and St Thomas’ NHS Foundation Trust, South West Peninsula, South West Peninsula NHS GMC: Royal Devon and Exeter NHS Foundation Trust, Southampton, St Mark’s Hospital, Sun Yat-sen University in Guangdong (China), Talens, Targeted Drugs, Targeted Therapies, Testes, Thermo Fisher Scientific (Massachusetts), Transformational Elements of NHS Genomic Medicine Centres, UK Genomes Project: Genomics England, UK Research and Life Science Sector, University College London Partners NHS GMC: Great Ormond Street Hospital NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust: Genomics Medicines Centre, University Hospitals Birmingham NHS Foundation Trust: Genomics Medicines Centre, University of Iceland, University of Texas MD Anderson Cancer Center, USA, Viv Parry OBE (Science Broadcaster), Wellcome Trust, Wellcome Trust Sanger Institute, Wessex NHS GMC: University Hospital Southampton NHS Foundation Trust, West Midlands, West Midlands NHS GMC: University Hospitals Birmingham NHS Foundation Trust, Whole Genome Sequencing, Workforce Competencies, Workforce Development, Workforce Training, Xenotransplantation: Avoiding Shortage of Human Donor Organs, Yale Cancer Centre, Zinc fingers
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Exposure of Aged Mice to Young Blood Plasma Improves Age-Related Cognitive Impairment? (BBC News / NHS Choices / Nature Medicine / Science)
Summary Researchers at Stanford University believe they might have discovered a novel method of slowing, or even reversing, a range of ageing processes (mental and physical). Their work, based on mice so far, involved injecting the blood of young mice … Continue reading →
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
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Tagged AfaSci Research Laboratory: California, Age and Ageing, Age-Related Cognitive Impairment, Age-Related Neurodegenerative and Neurovascular Diseases, Aged Mice: Exposure to Young Blood Plasma, Ageing, BBC Health News, Behind the Headlines, Blood Plasma, Blood Transfusions, Brigham and Women's Hospital: Boston, Cardiovascular Division: Brigham and Women's Hospital, Cellular Ageing, Center for Systems Biology and Department of Radiology: Massachusetts General Hospital, Center for Tissue Regeneration Repair and Restoration: VA Palo Alto Health Care System, Cognitive Decline, Cognitive Decline Studies, Cognitive Impairment, Contextual Fear Conditioning, Critical Appraisals, Department of Anatomy: University of California San Francisco, Department of Neurology and Neurological Sciences: Stanford University School of Medicine, Department of Stem Cell and Regenerative Biology: Harvard University, Developmental and Stem Cell Biology Graduate Program: University of California San Francisco, Disease-Modifying Therapies for Dementia, Dr Tony Wyss-Coray: Stanford University School of Medicine, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research: San Francisco, GDF11, Harvard Medical School, Harvard Stem Cell Institute, Harvard University, Hippocampus, Hippocampus-Based Cognitive Processes, Hippocampus-Dependent Memory Deficits, Howard Hughes Medical Institute, Joslin Diabetes Center and the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Late-Life Cognitive Decline, Massachusetts General Hospital, Mice, Nature Medicine, Neurodegeneration, Neurodegenerative Disease Research, Neurogenesis, Neurogenic Rejuvenation of the Aging Mouse Brain (Blood Plasma), Neuroscience Graduate Program: Stanford University School of Medicine, Rejuvenation of Synaptic Plasticity, Rejuvenation of the Aging Mouse Brain (Blood Plasma), Spatial Learning and Memory, Stanford University School of Medicine, Stanford [California], Synaptic Plasticity, Translational Research, United States, University of California San Francisco, USA, VA Palo Alto Health Care System, Vascular and Neurogenic Rejuvenation, Vascular Rejuvenation of the Aging Mouse Brain (Blood Plasma), Young Blood (Rejuvenating Effects)
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