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Tag Archives: Inflammation
More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)
Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Association of British Neurologists, Bazian, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Behind the Headlines, Biomarker Development, Biomarkers, Biomarkers for Inflammation, Brain (Journal), Brain Autopsies, Brain Inflammation, C-PK-11195, C-PK-11195 (Biomarker for Inflammation), Cambridge Brain Bank, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Foundation Trust, Consiglio Nazionale delle Ricerche (CNR), Critical Appraisals, Degenerative Tauopathy, Department of Clinical Neurosciences: Cambridge University, Department of Neurology: Walton Centre (Liverpool), Department of Pathology: Cambridge University Hospitals NHS Foundation Trust, Department of Psychiatry: University of Cambridge, Division of Anaesthesia: University of Cambridge, Early-Onset Dementia, F-AV-1451, F-AV-1451 (Biomarker for Protein Clusters), Fronto-Temporal Dementia (FTD), Frontotemporal Dementia, Frontotemporal Dementia (FTD), FTD: Fronto-Temporal Dementia, FTLD-Pick’s, FTLD-TDP (A), FTLD-TDP (C), FTLD-TDP (Types A and C), FTLD-TDP-43, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM): Consiglio Nazionale delle Ricerche (CNR), Italy, Lundbeck Foundation (Denmark), Medical Research Council (MRC), Medical Research Council Cognition and Brain Sciences Unit: University of Cambridge, Microglia, Monoamine Oxidase (MAO), National Institute of Health Research, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Neuroinflammation and Frontotemporal Dementia, Neuroinflammation and Protein Aggregation, Neuromelanin, NIHR Dementias and Neurodegenerative Diseases Research Network, Non-Amyloid-β Protein Aggregation, Non-Fluent Variant Primary Progressive Aphasia (nfvPPA), Patrick Berthoud Charitable Trust, PET Scans, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Protein Aggregation, Protein Clusters, Semantic Variant Primary Progressive Aphasia (svPPA), Tauopathy, TDP-43, TDP-43 Pathology, TDP-43 Protein, TDP-43 Proteinopathy, University of Cambridge, Variants of Primary Progressive Aphasia (PPA), Wellcome Trust, Wolfson Brain Imaging Centre: University of Cambridge
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Dementia Research Centre in Wales (BBC News)
Summary A brief piece, from BBC News, on the work and aims of the £20 million Dementia Research Institute at Cardiff University. Full Text Link Reference Clarke, O. (2018). Fruit flies’ brains studied to help crack dementia. London: BBC Health … Continue reading
Posted in BBC News, For Researchers (mostly), In the News, National, Quick Insights, UK, Universal Interest, Wales
Tagged BBC Health News, BBC Wales News, Biomarkers Research Programmes, Bioscience Careers, Brain Research Imaging Centre at Cardiff University (CUBRIC), Cardiff University, Dementia Action Plan for Wales: 2018-2022, Dementia Research, Dementia Research Careers, Dementia Research Institute (Cardiff), Dementia Research Institute (DRI), Dementia Research Institute at Cardiff University, Drosophila melanogaster, Fruit Flies, Genetic Research, Immune Pathways and Stem Cell (iPSC) Models of Neurodegenerative Disease, Immunology, Inflammation, Inflammatory Response, National Dementia Vision for Wales, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurodevelopmental Disorders: Abnormal Brain Development, Neuroinflammation, Neuroinflammation Research Cluster, Neuroscience, Research and Development, Research and Innovation, Research Careers, Research Commitment, Research Culture, Research Funding, Transgenic Drosophila, Vaughan Gething: Welsh Health Secretary, Welsh Government, Welsh Government Dementia Oversight of Implementation and Impact Group (DOIIG)
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Preventative Treatment to Reduce Risk of Alzheimer’s Disease, Using Non-Steroidal Anti-Inflammatory Drugs? (NHS Choices / Journal of Alzheimer’s Disease)
Summary A recent article suggests that use of nonsteroidal anti-inflammatory drugs (NSAIDs) might help to reduce the risk of developing Alzheimer’s Disease, if prescription were to be commenced years before clinical signs were to develop. An NHS Choices Behind the … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Aβ42, Alzheimer Disease Anti-Inflammatory Prevention, Alzheimer’s Disease Biomarkers, Amyloid Beta (Aβ42), Amyloid Beta Protein, Amyloid Cascade Inflammatory Hypothesis, Amyloid-β (Aβ), Amyloidogenic and Inflammatory Pathways, Aurin Biotech, Aurin Biotech Inc. Ltd. (Vancouver), ß-amyloid, Bazian, Behind the Headlines, Biomarkers, Canada, Critical Appraisals, Dementia Risk Reduction and Prevention, Dementia Saliva Testing (Pilot Study), Diagnosis of Alzheimer's Disease Based on Salivary Amyloid-β Protein 42 Levels, ELISA Method to Determine Aβ42 Levels in Saliva, Fluid Biomarker Analysis, Ibuprofen, Ibuprofen and the Reduced Risk of Alzheimer’s Disease Link, Inflammation, Journal of Alzheimer's Disease, Long-Term Ibuprofen Use, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroinflammation, Non-Invasive Biomarkers, Non-Steroidal Anti-Inflammatory Drugs (NSAIDS), NSAIDS: Non-Steroidal Anti-Inflammatory Drugs, Preclinical Biomarkers in Alzheimer's Disease, Preventative Interventions, Prevention, Saliva Tests, Salivary Amyloid-β Protein 42 Levels, Salivary Biomarkers
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Animal Study Explores the Potential of a Novel Diabetes Drug for Reducing Memory Loss in Dementia – In Mice (NHS Choices / Brain Research)
Summary Early animal research indicates that a new drug designed for the future treatment of diabetes may (one day) have an alternative re-use for reducing the memory-loss symptoms of Alzheimer’s Disease. Mice given a modified version of a so-called triple … Continue reading
Posted in Alzheimer's Society, Animal Studies, Charitable Bodies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Alzheimer's Society, Alzheimer’s Disease and Diabetes, Amyloid Plaque Load, APP/PS1 Transgenic Mouse Model, Bazian, BDNF Levels in Hippocampus of APP/PS1 Mice, BDNF: Brain-Derived Neurotrophic Factor, Behind the Headlines, Biomedical and Life Science: Lancaster University, Brain Research, Brain Research (Journal), Brain-Derived Neurotrophic Factor (BDNF), China, Critical Appraisals, Department of Human Anatomy: Shaoyang University, Diabetes Drugs, Faculty of Health and Medicine: Lancaster University, GIP Receptor Agonists, GLP-1/GIP Dual Agonists, Glucagon-Like Peptide-1 (GLP-1) Analogs, Incretin Hormones, Incretin Mimetics, Inflammation, β-Amyloid Plaques, Key Laboratory of Cellular Physiology: Shanxi Medical University, Lancaster University, Medical College: Shaoyang University, Memory Loss, Ministry of Human Resources and Social Security (Shanxi Scholarship Council of China), Morris Water Maze Test, Mouse Model of Alzheimer’s Disease, Mouse Models of Alzheimer's Disease, Neuroprotection, Neuroprotection Research, Neuroprotective Agents, Neuroprotective Effects of Triple GLP-1/GIP/Glucagon Receptor Agonist, Novel GLP-1/GIP/Gcg Receptor Agonist, Off-Label Drug Repurposing Trials, Oxidative Stress, People's Republic of China, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Repurposing GLP-1 Agonists, Repurposing of Drugs, Second Hospital Neurology Department: Shanxi Medical University, Shanxi Medical University, Shanxi Medical University (China), Shanxi Scholarship Council of China, Shaoyang University, Shaoyang University (China), Synaptophysin (SYN) Levels, Transgenic Mice, Triple GLP-1/GIP/Glucagon Receptor Agonist, Triple GLP-1/GIP/Glucagon Receptor Agonists, Triple Receptor Agonist (TA) Drugs, Type 2 Diabetes, Type 2 Diabetes Drugs Development and Re-Purposing, Type 2 Diabetes Mellitus (T2DM), Water Maze Test
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Septicaemia Associated with Increased Dementia Risk (Oncotarget)
Summary There appears to be a statistically significant association between septicemia and a subsequent increased risk of developing dementia (of the non-Alzheimer’s Disease varieties). Full Text Link Reference Chou, CH. Lee, JT. [and] Lin, CC. [et al] (2017). Septicemia is … Continue reading
Posted in Statistics, Universal Interest
Tagged Acute Sepsis, Blood Infections, China, China Medical University (Taiwan), China Medical University Hospital (Taiwan), China Medical University: China Medical University (Taiwan), Cognitive Impairment, Dementia Risk Factors, Dementia Risk Reduction, Department of Internal Medicine: China Medical University (Taiwan), Department of Neurology: Tri-Service General Hospital (Taiwan), Department of Nuclear Medicine China Medical University (Taiwan) China Medical University (Taiwan), Diseases and Medical Conditions Associated With Dementia Risk, Division of Kidney Disease: China Medical University (Taiwan), Epidemiology, Epidemiology and Statistics, Evidence for Risk Factors of Dementia, Graduate Institute of Clinical Medical Science: China Medical University (Taiwan), Graduate Institute of Medical Sciences: National Defense Medical Center (Taiwan), Infection Induced Immune Activation, Inflammation, Inflammatory Response, Institute of Population Health Sciences: National Health Research Institutes, LHID: Longitudinal Health Insurance Database (Taiwan), Longitudinal Health Insurance Database (LHID), Management Office for Health Data: China Medical University Hospital, National Defense Medical Center (Taiwan), National Health Research Institutes (Taiwan), Overlapping Risk Factors, People's Republic of China, Risk Factors, Sepsis, Septicaemia, Septicemia, Systemic Infection and Cognitive Impairment, Taiwan, Tri-Service General Hospital: National Defense Medical Center (Taiwan)
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Early Research on Stress and Social Disadvantage as Potential Risk Factors (BBC News / AAIC)
Summary Early research findings presented at the Alzheimer’s Association International Conference in London suggest that stressful life events, and more generally the chronic stress of enduring social deprivation life-long, may age the brain. The researchers claim that extremely stressful experiences … Continue reading
Posted in BBC News, Charitable Bodies, Community Care, For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, International, Quick Insights, UK, Universal Interest
Tagged 2017 Alzheimer’s Association International Conference (AAIC®2017), African Americans, Alzheimer’s Association AAIC Press Office, Alzheimer’s Association International Conference (AAIC®2017), Centre for the Study of Social Cohesion: University of Oxford, Cortisol, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Dementia Risk Reduction and Prevention, Environmental Risk Factors, Epidemiology, Epidemiology and Statistics, Ethnicity, Health Determinants, Health Improvement, Health Inequalities, Health Policy, Immune System, Immune System and Neurodegenerative Diseases, Improving Local Public Health, Improving Public Health, Inflammation, Inflammation and Neurodegenerative Diseases, Inflammatory Response, Lifestyle Risk Factors, Modifiable Risk Factors, Necroptosis, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Overlapping Risk Factors, Potentially Modifiable Socio-Environmental Risk Factors, Prevention, Prevention Agenda, Prevention of Dementia, Reducing Health Inequalities, Risk Factors, Social Epidemiology, Socio-Environmental Risk Factors, Stressful Life Experiences, University of Wisconsin School of Medicine, University of Wisconsin-Milwaukee
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