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Recent Posts
- Dementia-Friendly Communities Provision, Viewed as a Social Determinant of Health (JGCR / NHS England / WHO)
- International Perspectives on the Possible Impact of the COVID-19 Pandemic and Lockdown on Abuse of the Elderly (JGCR / American Journal of Geriatric Psychiatry / JAGS)
- Updates Relating to the Lancet Commission on Dementia Prevention, Intervention, and Care (Lancet / Alzheimer’s Research and Therapy / Alzheimer’s and Dementia)
- A Brief Review of How the COVID-19 Pandemic Relates to Elderly Care and Research (JGCR)
- Some Speculated / Potential Benefits of COVID-19 (JGCR / BBC Radio 4’s Rethink / BGS)
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Tag Archives: INSERM
Updated Projections for the Dementia Time-Bomb in England and Wales to 2040 (BMJ)
Summary A recent study by researchers University College London (UCL) and the University of Liverpool attempting to assess the future societal burden of dementia (sometimes termed the “Dementia Timebomb”) predicts the number of people living with dementia in England and Wales could … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, National, Quick Insights, Statistics, UK, Universal Interest, Wales
Tagged BMJ, BMJ Publishing Group Ltd, British Medical Journal (BMJ), Burden of Dementia, Burden of Dementia (Statistics), Centre for Dementia Prevention: University of Edinburgh, Centre for Research in Epidemiology and Public Health: Hôpital Paul Brousse, Clinicum, Dementia Incidence Projections: England and Wales to 2040, Dementia Prevalence, Dementia Time-Bomb, Department of Epidemiology and Public Health (University College London), Department of Epidemiology and Public Health: University College, Department of Prevention and Medical Education: Medical University of Gdansk, Department of Public Health and Policy: University of Liverpool, English Longitudinal Study of Ageing (ELSA), Epidemiology, Epidemiology and Statistics, Faculty of Medicine: University of Helsinki, Finland, France, Hôpital Paul Brousse, IMPACT-BAM (IMPACT-Better Ageing Model), IMPACT-Better Ageing Model (IMPACT-BAM), INSERM, Medical University of Gdansk, Poland, Prevalence of Dementia, University College London, University of Edinburgh, University of Helsinki, University of Liverpool, Wider Societal Burden
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Physical Activity in Midlife May Not Reduce Risk of Developing Dementia: No Harm in Trying (BMJ)
Summary The general consensus in the literature has tended to suggest that mid-life physical activity is typically beneficial, in part as a lifestyle choice which is likely to contribute to a reduced risk of developing cognitive decline and / or … Continue reading
Posted in For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Non-Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest
Tagged Active Lifestyle, Ageing Population, Association Between Physical Activity and Cognitive Function and / or Dementia, BMJ, British Medical Journal (BMJ), British Medical Journal Publishing Group Limited: Data Release (HSCIC), Centre for Research in Epidemiology and Population Health: Hôpital Paul Brousse, Centre for Research in Epidemiology and Population Health: Université Paris-Saclay, Civil Service Departments in London: Whitehall II Study, Cognitive Decline, Cognitive Decline Studies, Conventional Wisdom, Department of Epidemiology and Public Health (University College London), Environmental and Lifestyle Factors, Epidemiology, Epidemiology and Statistics, France, Hôpital Paul Brousse, Healthy Behaviours, Healthy Lifestyles, Healthy Living, INSERM, INSERM U1219: University of Bordeaux, Lifestyle Factors, Lifestyle Risk Factors, MCI: Mild Cognitive Impairment, Mild Cognitive Impairment (MCI), Moderate Exercise, Modifiable Risk Factors, Myth-Busting, Neuroprotective Lifestyles, Physical Activity and Health Benefits, Physical Activity Before Dementia, Physical Activity for Persons With Dementia, Physical Activity Programmes, Physical Activity Programs for Improvement of Dementia Symptoms, Physical Exercise, Physical Exercise Programmes, Physical Inactivity, Physical Therapy, Possible Myths or Misconceptions: Dementia and Activity (Reverse Causation Fallacy), Preclinical Dementia and Associated Lifestyle Changes, Preclinical Phase of Dementia, Received Wisdom, Sedentary Lifestyles, Trajectories of Physical Activity Before Dementia, Unhealthy Lifestyles, Université Paris-Saclay, University College London, University of Bordeaux, Vascular and Lifestyle Factors, Whitehall II Study, Whitehall Study
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Huntington’s Disease: a Blood Test “Speedometer”? (BBC News / Lancet Neurology)
Summary Early research shows promise that a protein biomarker in the blood, called neurofilament light chain (NFL), which is released from damaged brain cells in Huntington’s Disease, may be the basis for a blood test able to predict whether people … Continue reading
Posted in BBC News, Diagnosis, For Researchers (mostly), In the News, International, Quick Insights, UK, Universal Interest
Tagged BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blood Tests, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Huntington’s Disease, Blood-Based NfL, Canada, Carver College of Medicine: University of Iowa, Cath Stanley: Chief Executive of Hungtington's Disease Association, Centre for Molecular Medicine and Therapeutics: University of British Columbia, CHDI Foundation, Department of Neurology: Leiden University, Department of Psychiatry and Neurochemistry: Sahlgrenska Academy; University of Gothenburg, Department of Psychiatry: University of Iowa, European Research Council, France, Genetics Department: Pitié-Salpêtrière University Hospital, HTT, HTT Mutation Carriers, Huntington Disease, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, INSERM, Institut du Cerveau et de la Moelle épinière (ICM), Institute of Neuroscience and Physiology: Sahlgrenska Academy (University of Gothenburg), Institute of Neuroscience and Physiology: Sahlgrenska Academy at University of Gothenburg, Knut and Alice Wallenberg Foundation, Lancet Neurology, Leiden University, Leonard Wolfson Experimental Neurology Centre: University College London, Medical Research Council (MRC), Mutant Huntingtin (mHTT), National Hospital for Neurology and Neurosurgery, National Institute for Health Research UCL Hospitals Biomedical Research Centre, Netherlands, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Huntington's Disease, Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Non-Invasive Biomarkers, Pitié-Salpêtrière University Hospital (Paris), Plasma Biomarkers, Plasma Neurofilament Light Chain, Preclinical Biomarkers in Huntington's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital (Sweden), Serum Neurofilament Light Chain Protein, Sorbonne Universités, Surrogate Biomarkers of Neurodegeneration, Sweden; Clinical Neurochemistry Laboratory: Sahlgrenska University Hospital, Swedish Research Council, Torsten Söderberg Foundation, Transforming Research and Clinical Knowledge in Huntington's Disease (TRACK-HD), UCL Institute of Neurology, University College London (UCL), University of British Columbia, University of Gothenburg, University of Iowa, UPMC University Paris 06: INSERM
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Use of Benzodiazepines and Increased Risk of Alzheimer’s Disease (BBC News / BMJ)
Summary Long-term use of benzodiazepines, often prescribed for anxiety and sleep problems, appears to be linked to an increased risk of developing Alzheimer’s Disease. A French-Canadian team of researchers have found a cumulative dose-effect association between exposure to benzodiazepines (over … Continue reading
Posted in Acute Hospitals, BBC News, Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Mental Health, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Statistics, Universal Interest
Tagged Anxiety, Behind the Headlines, Benzodiazepine Use and Risk of Alzheimer's Disease, Benzodiazepines, BMJ, British Medical Journal (BMJ), Canada Faculty of Pharmacy: University of Montreal, Dose-Response Effect, Epidemiology, French Institute of Public Health Research (IRESP), French Ministry of Health (Direction Générale de la Santé), French National Institute of Health and Medical Research (INSERM), Funding Agency for Health Research of Quebec (Fonds de la Recherche en Santé du Québec) (FRSQ), INSERM, Inserm Research Center for Epidemiology and Biostatistics: Bordeaux, Insomnia, Institute of Health and Medical Research (Inserm), IRESP (Institut de Recherche en Santé Publique), Pharmacoepidemiology, Prescription Sleeping Pills, Quebec Health Insurance Program Database (RAMQ), Research Center of the University of Montreal Hospital Center (CRCHUM), Risk Factors, Risk Factors for Alzheimer's Diseease, Sedatives, Sleeping Pills, Sleeping Problems, Université de Bordeaux, University of Bordeaux: College of Health Sciences, University of Montreal, University of Montreal Hospital Center
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Early Menopause and Cognitive Decline (NHS Choices / BJOG)
Summary French research into the impact of a premature menopause (≤40 years) on cognitive function in later life indicates that premature surgical menopause and premature ovarian failure are associated with long-term negative effects on cognitive function. These effects are not … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest
Tagged Australia, Behind the Headlines, Benton’s Visual Retention Test (BVRT), Bilateral Oophorectomy, BJOG, BJOG: International Journal of Obstetrics and Gynaecology, Bordeaux, Cancer and Disease Epigenetics: Murdoch Children's Research Institute [Melbourne], Centre Memoire Ressources et Recherche in Montpellier (France), CHRU Dijon: Centre Mémoire Ressources et Recherche, CHRU Montpellier: Centre Mémoire Ressources et Recherche, Cognitive Impairment, Department of Paediatrics: University of Melbourne, Dijon, Early Menopause, Early Menopause and Cognitive Decline, France, French Three-City Study, Hormone Replacement Therapy, Hormone Therapy (HT), HRT, Hysterectomy, Imperial College London, INSERM, Isaacs’ Set Test, MCI: Mild Cognitive Impairment, Mental Decline, Mental Speed and Agility, Mild Cognitive Impairment (MCI), Montpellier, Montpellier and Bordeaux Universities, Murdoch Children's Research Institute: Australia, Neuropsychiatry: Epidemiological and Clinical Research (Montpellier), Non-Surgical Loss of Ovarian Function, Ovarian Failure, Ovariectomy, Postmenopausal Hormone Therapy, Premature Bilateral Ovariectomy, Premature Ovarian Failure, Trail Making Tests, Université Montpellier, Verbal Fluency, Visual Memory
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Systematic Review of Blood Biomarkers for Alzheimer’s Disease Onset and Progression (Journal of Alzheimer’s Disease)
Summary Blood-based protein biomarkers to predict the onset and progression of Alzheimer’s Disease (AD) would assist in timely diagnosis and would also be beneficial for clinical trials in helping with the selection of subjects for preventative trials. This systematic review … Continue reading
Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews, UK
Tagged AddNeuroMed (ANM), Alzheimer's Research UK, Apolipoprotein E, Aristotle University, Biological Networks Gene Ontology tool (BINGO), Biomarker Assessments in Alzheimer’s Disease Clinical Trials, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Biomedical Research Unit for Dementia: South London and Maudsley NHS Foundation, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Candidate Blood Proteome Markers, Complement C3, Database for Annotation, Department of Neurobiology: Karolinska Institutet-Stockholm University, France, Gene Ontology (GO), Greece, INSERM, INSERM: University of Toulouse, Institute of Psychiatry: King's College London, Italy, α-1-antitrypsin, α-2-macroglobulin, Journal of Alzheimer's Disease, Karolinska Institutet, King's Health Partners (ARUK/DCR) Research Cohorts, Kings College London, Kuopio University Hospital, Kyoto Encyclopedia of Genes and Genomes (KEGG), Maudsley BRC Dementia Case Registry, Medical University of Lodz, NIHR Biomedical Research Centre for Mental Health, Non-Invasive Biomarkers, Plasma Biomarkers, Poland, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, SomaLogic (Boulder Colorado), SomaLogic's SOMAscan Proteomics, South London and Maudsley NHS Foundation, Sweden, University of Eastern Finland, University of Perugia, USA, Visualization and Integrated Discovery (DAVID)
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