Tag Archives: INSERM

Heavy Drinking: an Under-Appreciated Dementia Risk Factor? (BBC News / Lancet Public Health)

Summary Research based in France has discovered an association between alcohol use disorders and dementia risk, particularly regarding the risk of developing early-onset dementia (i.e. with onset at an age less than 65 years). Full Text Link Reference Alcohol and … Continue reading

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Updated Projections for the Dementia Time-Bomb in England and Wales to 2040 (BMJ)

Summary A recent study by researchers University College London (UCL) and the University of Liverpool attempting to assess the future societal burden of dementia (sometimes termed the “Dementia Timebomb”) predicts the number of people living with dementia in England and Wales could … Continue reading

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Physical Activity in Midlife May Not Reduce Risk of Developing Dementia: No Harm in Trying (BMJ)

Summary The general consensus in the literature has tended to suggest that mid-life physical activity is typically beneficial, in part as a lifestyle choice which is likely to contribute to a reduced risk of developing cognitive decline and / or … Continue reading

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Huntington’s Disease: a Blood Test “Speedometer”? (BBC News / Lancet Neurology)

Summary Early research shows promise that a protein biomarker in the blood, called neurofilament light chain (NFL), which is released from damaged brain cells in Huntington’s Disease, may be the basis for a blood test able to predict whether people … Continue reading

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Urine Test for Creutzfeldt-Jakob Disease (CJD)? (BBC News / MRC / JAMA Neurology / NEJM)

Summary It may one day be possible to use a non-invasive diagnostic urine test to discover whether or not patients have sporadic Creutzfeldt-Jakob Disease (sCJD). Full Text Link Reference A urine test for Creutzfeldt-Jakob Disease may be possible. London: Medical … Continue reading

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Use of Benzodiazepines and Increased Risk of Alzheimer’s Disease (BBC News / BMJ)

Summary Long-term use of benzodiazepines, often prescribed for anxiety and sleep problems, appears to be linked to an increased risk of developing Alzheimer’s Disease. A French-Canadian team of researchers have found a cumulative dose-effect association between exposure to benzodiazepines (over … Continue reading

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Alzheimer’s Disease Genetics Research: Two New Susceptibility Genes (PloS One)

Summary An international collaboration of geneticists investigating susceptibility genes for Alzheimer’s Disease has identified two additional genes (chromosome 8 TP53INP1 and chromosome 14 IGHV1-67). These two genetic susceptibility loci appear to be involved in energy metabolism, protein degradation and the … Continue reading

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Early Menopause and Cognitive Decline (NHS Choices / BJOG)

Summary French research into the impact of a premature menopause (≤40 years) on cognitive function in later life indicates that premature surgical menopause and premature ovarian failure are associated with long-term negative effects on cognitive function. These effects are not … Continue reading

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Systematic Review of Blood Biomarkers for Alzheimer’s Disease Onset and Progression (Journal of Alzheimer’s Disease)

Summary Blood-based protein biomarkers to predict the onset and progression of Alzheimer’s Disease (AD) would assist in timely diagnosis and would also be beneficial for clinical trials in helping with the selection of subjects for preventative trials. This systematic review … Continue reading

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Alzheimer’s Disease: Genetics Research Breakthrough (BBC News / NHS Choices / Nature Genetics)

Summary An international collaboration of geneticists from 145 academic institutions investigating Alzheimer’s Disease have performed a meta-analysis of data about the DNA of 17,000 patients and 37,000 healthy people. Their analysis of genome-wide association studies (GWAS) has identified 21 genetic … Continue reading

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