Tag Archives: Mice

Further Evidence on the Association Between Poor Oral Health and the Risk of Developing Alzheimer’s Disease. New Possibilities for Treatment? (BBC News / Science Advances)

Posted on January 25, 2019 by Dementia and Elderly Care News

Summary Analysis of brain tissue, spinal fluid, and saliva from persons with Alzheimer’s Disease indicates the presence of Porphyromonas gingivalis (the bacterium associated with chronic gum disease) in the brain and central nervous system. Animal research using mice indicates that … Continue reading →

Posted in Animal Studies, BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Alzheimer's Disease and Chronic Periodontitis, Alzheimer's Disease Causation and Possible Treatments, Alzheimer’s Disease, Amyloid Beta, Amyloid Beta Protein, Arginine-Gingipain A (RgpA), Arginine-Gingipain B (RgpB), Australia, Bazian, Behind the Headlines, Beta-Amyloid Plaques, Chronic Gum Disease, Chronic Periodontitis, Common Oral Problems and Risk Factors, COR271, COR388, Cortexyme, Dementia Risk Factors, Dental Healthcare, Dental Hygiene, Evidence for Risk Factors of Dementia, Gingipain, Gingipain Inhibitors, Gum Disease, Gum Disease (Periodontitis), Gum Disease Bacteria, Harvard University School of Dental Medicine, β-Amyloid Plaques, Jagiellonian University (Poland), Lysine-Gingipain (Kgp), Mice, Modifiable Risk Factors, Neuroprotective Agents, New Zealand, Oral Health in Older Adults, Oral Healthcare, Oral Hygiene, P. gingivalis, Periodontitis, Periodontitis and Risk of Developing Alzheimer’s Disease, Poland, Porphyromonas gingivalis, Porphyromonas Gingivalis in Alzheimer’s Disease, Risk Factors, Science Advances (Journal), Small-Molecule Gingipain Inhibitors: Possibly Neuroprotective, Tau Tangles, Transgenic Mice, University of Auckland, University of California, University of Louisville School of Dentistry, University of Melbourne | Leave a comment

Vitamin D May Not Offer Protection Against Neurological Diseases? (NHS Choices / Nutritional Neuroscience / BJPsych Open)

Posted on July 14, 2018 by Dementia and Elderly Care News

Summary A recent systematic review of studies into the role of Vitamin D exposure levels / deficiency or supplementation in four neurodegenerative diseases (Alzheimer’s Disease, Motor Neurone Disease, Multiple Sclerosis (MS) and Parkinson’s Disease) found little conclusive evidence for any … Continue reading →

Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Systematic Reviews, Universal Interest | Tagged 25-Dihydroxyvitamin D Levels, Adelaide Centre for Neuroscience Research: University of Adelaide, Adelaide Medical School: University of Adelaide, ALS: Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Australia, Australian Research Council Centre of Excellence for Nanoscale BioPhotonics: University of Adelaide, Bazian, Behind the Headlines, BJPsych Open (Journal), Canada, Critical Appraisals, Cumming School of Medicine: University of Calgary, Department of Family Medicine: University of Calgary, Department of Family Medicine: University of Newcastle, Diet and Dementia, Dietary Interventions, Dietary Risk Factors, Dietary Supplements, Endogenous Vitamin D From UV Exposure, Exogenously Derived Vitamin D From Supplementation, Faculty of Medicine: University of Newcastle (Australia), Mice, Motor Neurone Disease (MND), Mouse Model of Alzheimer's Disease, Multiple Sclerosis, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurological Disorders, Neuroprotection, Neuroprotection Research, Neuroprotective Agents, Neuroprotective Diets, Neuroprotective Lifestyles, Northern Clinical School: University of Sydney, Nutritional and Metabolic Disorders, Nutritional Neuroscience, Rehabilitation Studies Unit: University of Sydney, School of Medicine and Public Health: University of Newcastle (Australia), School of Psychology: University of South Australia, Social Work and Social Policy: University of South Australia, Sun Exposure, Sunlight Exposure, Sunridge Family Medicine Teaching Centre: University of Calgary, Supplementation (Dietary), Sydney Medical School: University of Sydney, Systematic Reviews and Meta-Analyses, Ultraviolet (UV) Exposure, Ultraviolet (UV) Radiation, University of Adelaide, University of Calgary, University of Newcastle (Australia), University of South Australia, University of Sydney, Vitamin D, Vitamin D Deficiency, Vitamin D Supplementation, Vitamin D Supplements | Leave a comment

Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)

Posted on February 5, 2017 by Dementia and Elderly Care News

Summary NHS Choices’ Behind the Headlines covers Chinese and Canadian research, based on both humans and animals, indicating potential associations between Vitamin A deficiency and later development of Alzheimer’s Disease. “ …vitamin A deficiency is a problem in the developing … Continue reading →

Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Quick Insights, Universal Interest | Tagged Acta Neuropathologica, Aβ-Plaques, Alzheimer's Disease Pathogenesis, Amyloid Beta, Amyloid Precursor Protein (APP), Amyloid-β (Aβ), Amyloid-β Protein, Behind the Headlines, Beta-Amyloid Plaques, Beta-Site Amyloid-Beta Precursor Protein-Cleaving Enzyme 1 (BACE1), Canada, Canadian Institutes of Health Research (CIHR), Children's Hospital of Chongqing Medical University, Children's Nutrition Research Center, China, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Chongqing, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Critical Appraisals, Department of Psychiatry: University of British Columbia, Genetically Engineered Mice, Marginal Vitamin A Deficiency (MVAD), Mice, Ministry of Education Key Laboratory of Child Development and Disorders, National Natural Science Foundation of China, Townsend Family Laboratories: University of British Columbia, University of British Columbia, Vitamin A, Vitamin A Deficiency, Vitamin A Supplementation, Vitamin Supplements, Vitamins | Leave a comment

Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)

Posted on December 12, 2016 by Dementia and Elderly Care News

Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading →

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Posted on December 5, 2016 by Dementia and Elderly Care News

Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading →

Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA | Leave a comment

Memories Lost in Alzheimer’s Disease: Potentially Retrievable? (NHS Choices / Nature)

Posted on April 3, 2016 by Dementia and Elderly Care News

Summary Research on transgenic mice suggests that memories are not destroyed irretrievably by Alzheimer’s Disease; there appears to be problems recalling these lost memories. Lost memories may be retrievable, under experimental conditions, by exposing “Engram Cells” with bright blue light … Continue reading →

Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Contextual Fear Conditioning: Test Of Memory in Animals (Mice For Example), Current Opinion in Neurobiology, Dentate Gyrus Engram Cells, Department of Biology and Department of Brain and Cognitive Sciences: Massachusetts Institute of Technology, Direct Optogenetic Activation of Hippocampal Memory Engram Cells, Engram Cells, Episodic Memory, Freeze Response: Contextual Fear Conditioning Test of Memory in Animals (Mice For Example), Genetically Engineered Mice, Hippocampus, Hippocampus-Based Cognitive Processes, Hippocampus-Dependent Memory Deficits, Howard Hughes Medical Institute, Howard Hughes Medical Institute: Massachusetts Institute of Technology, Induced Fear Responses, JPB Foundation, Massachusetts Institute of Technology (MIT), Mechanisms of Memory Retrieval, Memory Consolidation, Memory Engram Cells, Memory Retrieval by Activating Engram Cells, Mice, Mouse Model of Alzheimer's Disease, Mouse Models of Alzheimer's Disease, Nature, Nerve Cell Spine Density, Neurobiology, Neurobiology of Memory Storage, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Rehebbilitating Memory (sic), Retrieval Rather Than Storage-Related Memory Impairments, RIKEN Brain Science Institute, RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory: Massachusetts Institute of Technology, Specific Memory Engrams in Particular Brain Regions, Spine Density in Engram Cells, Transgenic Mice, Use of Blue Light to Stimulate Brain Cells Associated With Memory (Engram Cells) | Leave a comment

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Posted on January 10, 2016 by Dementia and Elderly Care News

Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading →

Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK | Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton | Leave a comment

Tag Archives: Mice

Further Evidence on the Association Between Poor Oral Health and the Risk of Developing Alzheimer’s Disease. New Possibilities for Treatment? (BBC News / Science Advances)

Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)

Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

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