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Tag Archives: Mice
Further Evidence on the Association Between Poor Oral Health and the Risk of Developing Alzheimer’s Disease. New Possibilities for Treatment? (BBC News / Science Advances)
Summary Analysis of brain tissue, spinal fluid, and saliva from persons with Alzheimer’s Disease indicates the presence of Porphyromonas gingivalis (the bacterium associated with chronic gum disease) in the brain and central nervous system. Animal research using mice indicates that … Continue reading
Posted in Animal Studies, BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Alzheimer's Disease and Chronic Periodontitis, Alzheimer's Disease Causation and Possible Treatments, Alzheimer’s Disease, Amyloid Beta, Amyloid Beta Protein, Arginine-Gingipain A (RgpA), Arginine-Gingipain B (RgpB), Australia, Bazian, Behind the Headlines, Beta-Amyloid Plaques, Chronic Gum Disease, Chronic Periodontitis, Common Oral Problems and Risk Factors, COR271, COR388, Cortexyme, Dementia Risk Factors, Dental Healthcare, Dental Hygiene, Evidence for Risk Factors of Dementia, Gingipain, Gingipain Inhibitors, Gum Disease, Gum Disease (Periodontitis), Gum Disease Bacteria, Harvard University School of Dental Medicine, β-Amyloid Plaques, Jagiellonian University (Poland), Lysine-Gingipain (Kgp), Mice, Modifiable Risk Factors, Neuroprotective Agents, New Zealand, Oral Health in Older Adults, Oral Healthcare, Oral Hygiene, P. gingivalis, Periodontitis, Periodontitis and Risk of Developing Alzheimer’s Disease, Poland, Porphyromonas gingivalis, Porphyromonas Gingivalis in Alzheimer’s Disease, Risk Factors, Science Advances (Journal), Small-Molecule Gingipain Inhibitors: Possibly Neuroprotective, Tau Tangles, Transgenic Mice, University of Auckland, University of California, University of Louisville School of Dentistry, University of Melbourne
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Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)
Summary NHS Choices’ Behind the Headlines covers Chinese and Canadian research, based on both humans and animals, indicating potential associations between Vitamin A deficiency and later development of Alzheimer’s Disease. “ …vitamin A deficiency is a problem in the developing … Continue reading
Posted in Animal Studies, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Quick Insights, Universal Interest
Tagged Acta Neuropathologica, Aβ-Plaques, Alzheimer's Disease Pathogenesis, Amyloid Beta, Amyloid Precursor Protein (APP), Amyloid-β (Aβ), Amyloid-β Protein, Behind the Headlines, Beta-Amyloid Plaques, Beta-Site Amyloid-Beta Precursor Protein-Cleaving Enzyme 1 (BACE1), Canada, Canadian Institutes of Health Research (CIHR), Children's Hospital of Chongqing Medical University, Children's Nutrition Research Center, China, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Chongqing, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Critical Appraisals, Department of Psychiatry: University of British Columbia, Genetically Engineered Mice, Marginal Vitamin A Deficiency (MVAD), Mice, Ministry of Education Key Laboratory of Child Development and Disorders, National Natural Science Foundation of China, Townsend Family Laboratories: University of British Columbia, University of British Columbia, Vitamin A, Vitamin A Deficiency, Vitamin A Supplementation, Vitamin Supplements, Vitamins
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Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)
Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Non-Pharmacological Treatments, Quick Insights, Universal Interest
Tagged 40 Hz Light-Flickering Regime, Amyloid, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid Deposits, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Amyloid-β Protein, BBC Health News, Broad Institute of Harvard and MIT, Department of Brain and Cognitive Sciences: Massachusetts Institute of Technology, Departments of Biological Engineering and Brain and Cognitive Sciences: Massachusetts Institute of Technology, Flashing Light Therapy, Gamma Frequency Entrainment: Attenuation of Amyloid Load, Gamma Frequency Light, Gamma Light Oscillations (20-50 Hz), Gamma Rhythms, Immune Cells (Microglia), Institute of Medical Engineering and Sciences: Massachusetts Institute of Technology, Light Therapy, Light Therapy for Dementia, Massachusetts General Hospital (Boston), Massachusetts Institute of Technology, Massachusetts Institute of Technology (MIT), McGovern Institute for Brain Research: Massachusetts Institute of Technology, Mice, Microglia, MIT Media Lab: Massachusetts Institute of Technology, Nature, Non-Invasive 40 Hz Light-Flickering Regime, Picower Institute for Learning and Memory: Massachusetts Institute of Technology, Rodents, Strobe Light Therapy, Transgenic Mice, United States, USA
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Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)
Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA
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Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)
Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading
Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK
Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton
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EPPS Clears Amyloid Plaques in Mice: Alzheimer’s Disease Potentially Reversible? (BBC News / NHS Choices / Nature Communications)
Summary Korean researchers have identified a chemical (EPPS) which appears to be capable of clearing amyloid plaques from the brains of transgenic mice. The amount of plaques present in these animals’ brains was reduced in treated mice, and the treated … Continue reading
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), Aβ-Plaques, Amyloid, Amyloid Beta Protein, Amyloid Hypothesis, Amyloid Precursor Protein (APP), Amyloid Proteins, Amyloid-Beta Clearance in APP Transgenic Mice, Amyloid-β Protein, Amyloidopathy, Anti-Amyloid Therapies, APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Beta-Amyloid Plaques, Biological Chemistry Program: Korea University of Science and Technology (UST), Brain Science Institute: Korea Institute of Science and Technology (KIST), Center for Neuro-Medicine: Korea Institute of Science and Technology (KIST), Center for Neuroscience: Korea Institute of Science and Technology (KIST), EPPS Removal of Ab Plaques and Oligomers in APP/PS1 Mice, EPPS Rescues Hippocampus-Dependent Cognitive Deficits (in Mice), GoshenBiotech Inc, Korea, Korea Institute of Science and Technology, Korea Institute of Science and Technology (KIST), Korea University of Science and Technology (UST), Mice, Nature Communications, Neurodegeneration, Neurodegenerative Research, Protein Plaques, Republic of Korea, Research Institute: GoshenBiotech Inc., Transgenic Mice
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