Tag Archives: Misfolded Prion Protein (PrP)

Possible Future Treatment of CJD? (BBC News)

Summary University College London Hospitals NHS Foundation Trust (UCLH)’s National Prion Clinic has been granted the go-ahead to test the use of a man-made antibody treatment (PRN100), with a view to halting or slowing the progression of sporadic CJD. “We … Continue reading

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No Room For Complacency Regarding Population Subclinical vCJD? (PLoS Pathogens)

Summary After a near-miss mini-epidemic of Variant Creutzfeldt-Jakob Disease (vCJD) in the 1990s, experts caution that: “It is essential that we do not become complacent and continue both surveillance and risk management strategies in both human and animal prion diseases”. … Continue reading

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Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading

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Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)

Summary A natural human mutation (called V127) in the gene encoding prion protein may offer resistance to CJD. A study using mice with this genetic mutation appears to confirm resistance to prion diseases. This finding may in future help in … Continue reading

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Risks of Variant Creutzfeldt-Jakob Disease: UK Blood Safety (Department of Health)

Summary This document presents the Government’s response to the Science and Technology Select Committee’s “After the Storm?” report on blood safety. It sets out the government’s commitment to evidence-based and cost effective ways to reduce risks of infection from blood transfusions, … Continue reading

Posted in Acute Hospitals, Community Care, Department of Health, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS, Non-Pharmacological Treatments, Patient Care Pathway, Quick Insights, Standards, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Potential Transmission of vCJD (BBC News / House of Commons Science and Technology Committee / SaBTO)

Summary The House of Commons Science and Technology Committee has asserted that the government has a too casual approach to the human form of mad cow disease. Roughly one in 2,000 people in the UK could be a carrier of … Continue reading

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Blood Donation and Transmission of vCJD: Inquiry Required? (BBC News)

Summary The Commons Science and Technology Committee has called for an independent inquiry to check the safety of donor blood arising from the hidden risk of infection from variant CJD (the human form of “mad cow disease”). A recent study revealed one in 2,000 Britons … Continue reading

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