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- Dementia-Friendly Communities Provision, Viewed as a Social Determinant of Health (JGCR / NHS England / WHO)
- International Perspectives on the Possible Impact of the COVID-19 Pandemic and Lockdown on Abuse of the Elderly (JGCR / American Journal of Geriatric Psychiatry / JAGS)
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Tag Archives: Nature
New Uncertainties Around Irreversible Brain Cell Death Following Oxygen Deprivation? (BBC News / Nature)
Summary Conventional medical wisdom holds that brain cells and working brain circuitry are prone to irreversible damage following merely minutes of interrupted blood flow and disrupted oxygen supply. Researchers at Yale University used an extracorporeal pulsatile-perfusion system to restore circulation in … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
Tagged Anoxia, BBC Health News, Boston University School of Medicine, Brain Cell Death, Brain Damage, BRAIN Initiative (US), Cellular Neuroscience Neurodegeneration and Repair, Center for Neuroscience and Regeneration Research: Yale School of Medicine, Department of Anatomy and Neurobiology: Boston University School of Medicine, Department of Biology and Biotechnology L. Spallanzani: University of Pavia, Department of Comparative Medicine: Yale University, Department of Genetics: Yale School of Medicine, Department of Internal Medicine: Yale School of Medicine, Department of Neurology: University of Pittsburgh, Department of Neurology: Yale School of Medicine, Department of Neuroscience: Yale School of Medicine, Department of Psychiatry: Yale School of Medicine, Department of Radiology and Biomedical Imaging: Yale School of Medicine, Ethical Considerations, Ethical Dilemmas, Extracorporeal Pulsatile-Perfusion, Interdisciplinary Center for Bioethics: Yale University, Italy, Kavli Institute for Neuroscience: Yale School of Medicine, Medical Scientist Training Program: Yale School of Medicine, Nature, Post-Mortem Brain Tissue, Post-Mortem Brains, Post-Mortem Brains (Porcine), Post-Mortem Pig Brains, Program in Cellular Neuroscience Neurodegeneration and Repair: Yale School of Medicine, Recovery From Anoxia, Rehabilitation Research Center: VA Connecticut Healthcare System, Section of Cardiovascular Medicine: Yale School of Medicine, U.S. BRAIN Initiative, United States, University of Pavia, University of Pittsburgh, USA, VA Connecticut Healthcare System, Yale Child Study Center: Yale School of Medicine, Yale School of Medicine, Yale School of Medicine (New Haven)
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Blood Test for Pre-Symptomatic Alzheimer’s Disease Likely to Arrive Soon? (BBC News / Nature)
Summary A blood test developed by researchers in Australia and Japan appears to be able to predict the risk of developing Alzheimer’s Disease, with 90% accuracy. Detection of amyloid beta in the blood may be taken as a biomarker for … Continue reading
Posted in BBC News, Diagnosis, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
Tagged Alzheimer’s Disease, Amyloid Beta, Amyloid-β (Aβ), Austin Health: Australia, Australia, ß-amyloid, BBC Health News, Beta-Amyloid, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Center for Development of Advanced Medicine for Dementia:: National Center for Geriatrics and Gerontology (Japan), Conversion to Dementia From Prodromal Disease, CSIRO (Brisbane), Edith Cowan University: Western Australia, Florey Institute: University of Melbourne, Health and Biosecurity: CSIRO (Brisbane), Japan, Koichi Tanaka Mass Spectrometry Research Laboratory: Shimadzu Corporation, Koichi Tanaka Mass Spectrometry Research Laboratory: Shimadzu Corporation (Kyoto), Laboratory of Neuropathology and Neuroscience: University of Tokyo, National Center for Geriatrics and Gerontology (Japan), Nature, Non-Invasive Biomarkers, Plasma Amyloid-β Biomarkers for Alzheimer’s Disease, Plasma Biomarkers, Preclinical Biomarkers in Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Shimadzu Corporation, Shimadzu Corporation (Kyoto), Tokyo Metropolitan Institute of Gerontology, University of Melbourne, University of Tokyo
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Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)
Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, National, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Abnormal Proteins (Tau), Alzheimer’s Disease, Amyloid and Tau Imaging, Atomic Structure of Tau Filaments, BBC Health News, Behind the Headlines, Cryo-Electron Microscopy (Cryo-EM), Cryo-EM Structures of PHFs and SFs, Cryo-EM Structures of Tau Filaments, Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Drug Trials Failure Rate, European Union, Indiana University, Indiana University School of Medicine, Laboratory of Molecular Biology (LMB) Neuroscience Division, Medical Research Council (MRC), Misfolded Proteins, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology (LMB), MRC Laboratory of Molecular Biology: Cambridge, MRC: Medical Research Council, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Research, Neurofibrillary Tangles, Neurofibrillary Tangles (NFTs), Neuropathologic Disorders, Neuropathology, Novel Targets in Neurodegeneration, Paired Helical Filaments (PHFs) and Straight Filaments (SFs), Protein Misfolding, Protofilament Interface in PHFs and SFs, Tau, Tau Aggregation, Tau Filaments, Tau Pathogenesis, Tau Pathology, Tau Protein, Tauopathy, Ultrastructural Polymorphs, United States, US National Institutes of Health, USA
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Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)
Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading
Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA
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The Reproducibilty Problem / Replication Crisis in Science: a Pervasive Issue in Medicine? (BBC News / Nature / Elife)
Summary It has been estimated that between 65% and 90% of researchers typically fail to reproduce fellow scientists’ research results. The Reproducibility Project: Cancer Biology has raised awareness of the prevalence of this problem in biomedical science. The issues are … Continue reading
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Non-Pharmacological Treatments, Pharmacological Treatments, Quick Insights, Standards, Statistics, Universal Interest
Tagged BBC Radio 4 Today, BBC Radio 4: Today Programme, BBC Science and Environment News, BBC Science News, Belief and Culture, Biomedical Research, Canada, Cancer Research, Cancer Research in the UK, Center for Open Science (Charlottesville USA), Culture and Leadership, Culture Change, Culture of Impact Over Scientific Substance / Rigour (Alleged), Dame Ottoline Leyser: Director of Sainsbury Laboratory at the University of Cambridge, Dementia Research and Drug Development, Elife, Evidence Uncertainties, Learning Culture, Living With Uncertainty, Making Sense of Uncertainty, McGill University in Montreal, Nature, Replicability, Replication, Reproducibility Project: Cancer Biology, Reproducibilty, Reproducibilty Crisis (sic), Research and Innovation, Research Culture, Research Culture Good Practice, Sainsbury Laboratory at the University of Cambridge, Uncertainty, United States, University of Edinburgh, University of Virginia, University of Virginia's Centre for Open Science, USA, Wasted Resources
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Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)
Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Non-Pharmacological Treatments, Quick Insights, Universal Interest
Tagged 40 Hz Light-Flickering Regime, Amyloid, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid Deposits, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Amyloid-β Protein, BBC Health News, Broad Institute of Harvard and MIT, Department of Brain and Cognitive Sciences: Massachusetts Institute of Technology, Departments of Biological Engineering and Brain and Cognitive Sciences: Massachusetts Institute of Technology, Flashing Light Therapy, Gamma Frequency Entrainment: Attenuation of Amyloid Load, Gamma Frequency Light, Gamma Light Oscillations (20-50 Hz), Gamma Rhythms, Immune Cells (Microglia), Institute of Medical Engineering and Sciences: Massachusetts Institute of Technology, Light Therapy, Light Therapy for Dementia, Massachusetts General Hospital (Boston), Massachusetts Institute of Technology, Massachusetts Institute of Technology (MIT), McGovern Institute for Brain Research: Massachusetts Institute of Technology, Mice, Microglia, MIT Media Lab: Massachusetts Institute of Technology, Nature, Non-Invasive 40 Hz Light-Flickering Regime, Picower Institute for Learning and Memory: Massachusetts Institute of Technology, Rodents, Strobe Light Therapy, Transgenic Mice, United States, USA
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A Natural Limit to Human Life Expectancy? (BBC News / Nature)
Summary Despite recent historical trends in the seemingly endless increase in human life expectancy, researchers analysing global demographic data believe they may have detected signs that the maximum lifespan may be limited to around 115 years “Our results strongly suggest … Continue reading
Posted in BBC News, In the News, International, Quick Insights, Statistics, Universal Interest
Tagged Ageing, Ageing Population, Ageing Research, Albert Einstein College of Medicine, BBC Health News, Centenarians, Department of Genetics: Albert Einstein College of Medicine, Department of Ophthalmology and Visual Sciences: Albert Einstein College of Medicine, Diminishing Gains in Reduction of Late-Life Mortality, Female Life Expectancy, Gerontological Research Group (GRG), Human Mortality Database, Human Mortality Database (HMD), INED, Jeanne Calment (Former Supercentenarian), Life Expectancy, Life Expectancy and Causes of Death, Life Expectancy Gaps, Life Expectancy Over Time: Trends Since 1900, Male Life Expectancy, Max Planck Institute for Demographic Research, Maximum Reported Age at Death (MRAD), Mortality, Mortality Statistics, Natural Limit to Human Lifespan (Postulated), Nature, Proportion of Population Surviving to Old Age Among Females in 40 Countries and Territories, Proportion of Population Surviving to Old Age Among Males in 40 Countries and Territories, Reported Age at Death of Supercentenarians, Super-Centenarians, Supercentenarians, UCL Institute of Healthy Ageing, United States, University of California, USA
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Potential Risk of Alzheimer’s Disease Transmission (BBC News / NHS Choices / Nature / MRC)
Summary There may be a theoretical risk of Alzheimer’s Disease being transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). This hypothesis has arisen as a result of the examination of the brains of eight patients who had … Continue reading
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease and Blood Transfusion, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-Beta Deposition in APP Transgenic Mice, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Behind the Headlines, Brain Deposition of Amyloid, Brain-Derived Human Growth Hormone (HGH), Cadaver-Derived Growth Hormone, Cerebral Amyloid Angiopathy, Coexistence of Alzheimer-Type Neuropathology in Creutzfeldt-Jakob Disease, Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Contaminated Surgical Instruments, Contamination of Injections, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, Decontamination of Surgical Instruments, Department of Neurodegenerative Disease: UCL Institute of Neurology, Exogenous Induction of Cerebral β-Amyloidogenesis, Grey Matter and Vascular Amyloid-β (Aβ) Pathology, Human Pituitary-Derived Growth Hormone, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract, Medical Research Council, Medical Research Council (MRC), Medical Research Council Prion Unit, Misfolded Proteins, MRC Clinical Trials Unit at University College London, National Institute of Health Research (NIHR), National Prion Clinic: National Hospital for Neurology and Neurosurgery, National Prion Monitoring Cohort Study, Nature, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Neuropathologic Assessment of Alzheimer’s Disease, NHS National Prion Clinic (NPC) in London, Peripheral Administration of Tau Aggregates Triggers Intracerebral Tauopathy in Transgenic Mice, Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Seeded β-Amyloid in APP Transgenic Mice, Surgical Transmission of Prions, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible and Non-Transmissible Amyloidoses, UCLH / UCL Biomedical Research Centre, UCLH / UCL Dementia Biomedical Research Unit, University College London (UCL)
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