Tag Archives: Neurodegeneration

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading

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Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading

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Optometric and Ophthalmological Tests for Visual Symptoms of Posterior Cortical Atrophy (BMJ Open)

Summary Research by the College of Optometrists on Posterior Cortical Atrophy (PCA) has investigated the suitability of certain vision assessment tests to help differentiate between cortical and optical / ocular causes of visual impairment. An awareness of PCA helps to … Continue reading

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Hippocampal Neurogenesis Life-Long (BBC News / Nature Medicine)

Summary Contrary to popular belief, the creation of new brain cells persists throughout life (in the hippocampus at least); although the rate of neurogenesis may decline with old age, and fall massively in Alzheimer’s Disease. Full Text Link Reference Gallagher, … Continue reading

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Smell Test for Early Detection of Parkinson’s Disease (BBC News)

Summary Parkinson’s Disease has a distinctive odour for certain gifted individuals, which has been analysed chemically and may now be replicated for automated detection by machine. This may, in future, permit earlier diagnosis and open the possibilities for timely treatments … Continue reading

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Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

Summary Further discussion about the possibilities of using inexpensive eye tests to detect Alzheimer’s Disease, perhaps years before symptoms appear. This particular technique involves the examination of blood vessels and blood flow in the retina, as detected by Octa (Optical … Continue reading

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Summary of Recent Progress in Alzheimer’s Disease Prevention Trials (CTAD / JPAD)

Summary The following article summarises a round-up of present understanding and developments reflected in current and planned prevention trials, as discussed at a EU / US / Clinical Trials in Alzheimer’s Disease (CTAD) Task Force meeting, as of December 2016-7. … Continue reading

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