Tag Archives: Neurodegenerative Diseases

Early Research on Stress and Social Disadvantage as Potential Risk Factors (BBC News / AAIC)

Posted on July 20, 2017 by Dementia and Elderly Care News

Summary Early research findings presented at the Alzheimer’s Association International Conference in London suggest that stressful life events, and more generally the chronic stress of enduring social deprivation life-long, may age the brain. The researchers claim that extremely stressful experiences … Continue reading →

Posted in BBC News, Charitable Bodies, Community Care, For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, International, Quick Insights, UK, Universal Interest | Tagged 2017 Alzheimer’s Association International Conference (AAIC®2017), African Americans, Alzheimer’s Association AAIC Press Office, Alzheimer’s Association International Conference (AAIC®2017), Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Dementia Risk Reduction and Prevention, Environmental Risk Factors, Epidemiology, Epidemiology and Statistics, Ethnicity, Health Determinants, Health Improvement, Health Inequalities, Health Policy, Immune System, Immune System and Neurodegenerative Diseases, Improving Local Public Health, Improving Public Health, Inflammation, Inflammation and Neurodegenerative Diseases, Inflammatory Response, Lifestyle Risk Factors, Modifiable Risk Factors, Necroptosis, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Overlapping Risk Factors, Potentially Modifiable Socio-Environmental Risk Factors, Prevention, Prevention Agenda, Prevention of Dementia, Reducing Health Inequalities, Risk Factors, Social Epidemiology, Socio-Environmental Risk Factors, Stressful Life Experiences, University of Wisconsin School of Medicine, University of Wisconsin-Milwaukee | Leave a comment

Dementia with Lewy Bodies: Updated DLB Consortium Diagnosis and Management Consensus Report (Neurology)

Posted on July 13, 2017 by Dementia and Elderly Care News

Summary The Dementia with Lewy Bodies (DLB) Consortium has published an updated set of recommendations on diagnosis and management of DLB. Clinical features and diagnostic biomarkers are covered, with guidance on their interpretation. Previously omitted aspects of Lewy-related pathology are … Continue reading →

Posted in Antipsychotics, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, UK | Tagged Abnormal Proteins (Alpha-Synuclein), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Alternatives to Antipsychotics, Antipsychotics Limitation in Dementia, Antipsychotics: Neuroleptic Sensitivity, Assessment and Diagnosis, Australia, Autonomic System Dysfunction, Banner Sun Health Research Institute, Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blackouts, Brain and Mind Centre: University of Sydney, Brain Stimulation, Center for Neurodegenerative Disease Research: University of Pennsylvania, Centre for Age-Related Diseases: Stavanger University Hospital, Cognitive Decline (DLB vs. Alzheimer's), Cognitive Symptoms, Comparison of Cognitive Decline (DLB vs. AD), Deep Brain Stimulation for the Treatment of Dementia, Delusions, Dementia With Lewy Bodies (DLB), Dementia With Lewy Bodies (DLB) Consortium, Department of Laboratory Medicine and Pathology: Mayo Clinic, Department of Neurology: Mayo Clinic, Department of Neurology: Mayo Clinic (Rochester), Department of Neurology: University of Pennsylvania, Department of Neuroscience and Neuropathology Laboratory: Mayo Clinic, Department of Neuroscience Imaging and Clinical Sciences: University G. d'Annunzio of Chieti-Pescara, Department of Neuroscience: Mayo Clinic, Department of Psychiatry and Psychology: Mayo Clinic, Department of Veterans Affairs, Departments of Radiology and Neurology: University of Michigan, Diagnosis and Management of Dementia with Lewy Bodies, Diagnosis and Screening: Dementia with Lewy Bodies, Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), Differential Diagnosis, Dizziness, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Drooling, DSM-5, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease and DLB, Fainting, Florida Atlantic University, Fluctuating Cognition, Fluctuations, Fourth Consensus Report of DLB Consortium, Hallucinations, Handwriting, ICube Laboratory, Institute for Healthy Aging and Lifespan Studies (I-HeAL): Florida Atlantic University, Institute of Neuroscience: Newcastle University, Institute of Psychiatry Psychology and Neuroscience: King’s College London, Italy, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Kings College London, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Lewy Body Society, Medical School: University of Exeter; University of Exeter, Misdiagnosis, Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neurology (Journal), Norway, Parkinson's Disease and Mental Illness Research Education and Clinical Centers (PADRECC and MIRECC): Philadelphia Veterans Affairs Medical Center, Parkinson’s-Like Symptoms, Perelman School of Medicine: University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Postural Instability, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Repeated Falls, Severe Neuroleptic Sensitivity, Severe Sensitivity to Antipsychotic Agents, Shuffling Walk, Sleep Disorders Center: Mayo Clinic, Stavanger University Hospital, Stavanger University Hospital; Norway, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, Transient Loss of Consciousness, Underlying Mechanisms of DLB Pathogenesis, United States, University G. d'Annunzio of Chieti-Pescara, University Hospital of Strasbourg, University of Michigan, University of Pennsylvania, University of Strasbourg, University of Sydney | Leave a comment

Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Posted on July 6, 2017 by Dementia and Elderly Care News

Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, National, NHS Choices, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Abnormal Proteins (Tau), Alzheimer’s Disease, Amyloid and Tau Imaging, Atomic Structure of Tau Filaments, BBC Health News, Behind the Headlines, Cryo-Electron Microscopy (Cryo-EM), Cryo-EM Structures of PHFs and SFs, Cryo-EM Structures of Tau Filaments, Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Drug Trials Failure Rate, European Union, Indiana University, Indiana University School of Medicine, Laboratory of Molecular Biology (LMB) Neuroscience Division, Medical Research Council (MRC), Misfolded Proteins, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology (LMB), MRC Laboratory of Molecular Biology: Cambridge, MRC: Medical Research Council, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Research, Neurofibrillary Tangles, Neurofibrillary Tangles (NFTs), Neuropathologic Disorders, Neuropathology, Novel Targets in Neurodegeneration, Paired Helical Filaments (PHFs) and Straight Filaments (SFs), Protein Misfolding, Protofilament Interface in PHFs and SFs, Tau, Tau Aggregation, Tau Filaments, Tau Pathogenesis, Tau Pathology, Tau Protein, Tauopathy, Ultrastructural Polymorphs, United States, US National Institutes of Health, USA | Leave a comment

Earlier Diagnosis Research: the Deep and Frequent Phenotyping Study (BBC News / GtR)

Posted on June 28, 2017 by Dementia and Elderly Care News

Summary The Deep and Frequent Phenotyping Study aims to discover new ways of diagnosing dementia, ideally decades before the symptoms become apparent in order to give future drug treatments the best chance of working. The Deep and Frequent Phenotyping Study … Continue reading →

Posted in Alzheimer's Society, BBC News, Commissioning, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Mental Health, Models of Dementia Care, National, NIHR, Quick Insights, UK, Universal Interest | Tagged Ageing Population, Alterations in Movement and Walking (“Gait”) Assessments, Alzheimer's Disease: Early Detection by Brain Scan, Alzheimer’s Disease Biomarkers, Amnestic Mild Cognitive Impairment (a-MCI), Amnestic Mild Cognitive Impairment (aMCI), Applications of Big Data, BBC Radio, BBC Radio 4, BBC's World At One Programme, Big Data Analytics, Big Data Funding and Research, Biomarker Assessments in Alzheimer’s Disease, Biomarker Assessments in Alzheimer’s Disease Clinical Trials, Biomarker Assessments in Clinical Trials, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Biomarkers Research Programmes, Blood and Urine Biomarkers, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Scans, Cambridge Neuropsychological Test Automated Battery (CANTAB), Cerebrospinal Fluid (CSF) Biomarkers, Clinical Assessments, Cognitive Assessments / Screening Tools, Conversion to Dementia From Prodromal Disease, CSF Biomarkers, Deep and Frequent Phenotyping Study, Deep and Frequent Phenotyping Study (DFP), Deep and Frequent Phenotyping; Combinatorial Biomarkers of Dementia, Dementia Research, Dementia Research Funding, Dementias Platform UK, Dementias Platform UK (DPUK), Dementias Platform UK: MRC, DFP Study Team, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, DPUK: Dementias Platform UK, Drug Trials Failure Rate, Early Detection of Alzheimer’s Disease, Early Detection of Preclinical Disease, EEG: Electroencephalography, Effectiveness of Early Detection and Treatment, Electroencephalogram (EEG) Brain Scans, Electroencephalography (EEG), Gait and Cognition, Gait Changes, Gateway to Research (GtR), Global Dementia Research, Global Leadership, Hypothetical Prodromes of Dementia, Imanova, Imperial College London, Join Dementia Research, Join Dementia Research: Clinical Trials Matchmaker Service, Join Dementia Research: Recruitment Onto Dementia Studies, Kings College London, Magnetic Resonance Imaging (MRI) Scan, Magnetoencephalography (MEG), Medical Research Council (MRC), Medical Research Council (UK), National Institute of Health Research (NIHR), Neurobiology of Aging (Journal), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Newcastle University, Non-Invasive Biomarkers, Ocular Manifestations in Neurodegenerative Diseases, Open Data and Big Data, Ophthalmological Assessments, Participation in Research, Participation in Research Studies, Partnership and Collaboration, Patient and Public Participation, PharmaCog Consortium, Positron Emission Tomography (PET), Pre-Clinical Genotype-Phenotype Predictors of Alzheimer's Disease, Prodromal Alzheimer's Disease, Professor Clare Mackay: Imaging Neuroscience at the University of Oxford, Professor Lynn Rochester: Clinical Ageing Research Unit at Newcastle University, Professor Simon Lovestone: Lead Researcher and Professor of Translational Neuroscience at University of Oxford, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Proteomic Analysis, Proteomics, Public Participation in Research, Publicly-Funded UK Big Data Research, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Funding, Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Changes as Surrogate Biomarker for Alzheimer's Disease, Retinal Ganglion Cells (RGCs), Retinal Manifestations of Alzheimer's Disease, Screening Tools for Amnestic Mild Cognitive Impairment (a-MCI), Surrogate Biomarkers of Neurodegeneration, Translational Research, University College London, University of Cambridge, University of Edinburgh, University of Manchester, University of Oxford, Volunteers, Walking Pattern (Gait), Wearable Devices, Wearables (Technology) | Leave a comment

Unresolved Issues of Means-Testing in the Payment For Social Care: a Recent History of the Dementia Tax (House of Commons Library)

Posted on June 24, 2017 by Dementia and Elderly Care News

Summary A recent House of Commons Library briefing paper presents an overview of policy proposals and actual policies, from different Governments since 1997, concerning for how individuals with assets must pay for social care. Unlike health services provided by the NHS, social … Continue reading →

Posted in Commissioning, Community Care, For Carers (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Integrated Care, Management of Condition, National, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, Scotland, Standards, Statistics, UK, Universal Interest | Tagged Adult Social Care, Adult Social Care Funding, Adult Social Care in England, Adult Social Care Services, Ageing and Dementia, Ageing and Society, Ageing Policy in the UK, Ageing Population, Barriers to Integration: NHS Services Free Versus Means-Tested Social Care, Care Costs: Cap and Means Test, Care Funding, Care Home Costs, Care Home Fees, Care Tax (So-Called Dementia Tax), Caring and Family Finances, Catastrophic Care Costs, Changes Since UK Devolution, Commission on the Funding of Care and Support (2012 Report), Conservative Government 2017 U-Turn Over Cap on Social Care Costs, Conservative Manifesto (2017), Conservative Manifesto (2017): Forward Together – Our Plan for a Stronger Britain and a Prosperous Future, Conservative Manifesto on Social Care (2017), Conservative Party’s 2017 Election Manifesto, Cost of Social Care for Older People, Dementia Tax, Dementia Tax (Alzheimer's Society), Devolution, Devolved Decision-Making, Dilnot Commission Recommendations, Dilnot Commission Report on Funding of Care and Support, Financial Constraints, Financial Context, Financial Issues, Financial Planning, Four-Year Cap on Paying Social Care Charges (Historical Unadopted Policy Proposal), Free Personal Care in Scotland, Funding of Care and Support (Dilnot Commission), Health and Social Care Services, Home and Community Care Services, Home Care, Home Care Services, House of Commons, House of Commons Library, House of Commons Library Briefing Paper CBP-8000, Labour Government’s 2010 Proposal for Free Social Care (Unfulfilled), Labour Governments and Conservative Governments: Surprising Historical Commonalities, Long-Term Care (LTC), Long-Term Care and Support, Long-Term Conditions (LTCs), Means Test, National Care Service (Historical Proposals), Neurodegenerative Diseases, Neurodegenerative Disorders, Parliament, Payment For Social Care: a Brief History of Policy (House of Commons Library), Professor Sir Stuart Sutherland (Royal Commission on Long-Term Care for the Elderly), Property and Capital: Means-Test (Care Home Residents), Property and Capital: Means-Test (Home Care Proposals 2017), Queen's Speech 2017, Royal Commission on Long Term Care, Royal Commission on Long Term Care for Older People, Royal Commission on Long Term Care of Older People, Scottish Executive, Securing Good Care for Older People (2006), Self-Funders, Self-Funders Cross-Subsidising Everyone Else, Self-Funders Cross-Subsidising Non-Savers, Self-Funders Subsidising the Social Care System, Self-Funding, Sir Andrew Dilnot, Sir Derek Wanless’s (2006) Report Proposing Partnership Funding for Social Care, Social Care Crisis, Social Care: Government Reviews and Policy Proposals on Paying For Care, Social Care: Timeline of Government Reviews and Policy Proposals re: Paying For Care, State Funded Social Care, Stealth Death Tax: Chargable Against Families' Property Assets, Stealth Taxes, Sustainability, Tariff Income, Theresa May Social Care U-Turn (2017), Tory Social Care Plans (2017), UK Parliament, Upper and Lower Capital Limits of Means-Test, What is Classed as Capital: Means-Test | Leave a comment

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Posted on June 23, 2017 by Dementia and Elderly Care News

Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading →

Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA | Leave a comment

Huntington’s Disease: a Blood Test “Speedometer”? (BBC News / Lancet Neurology)

Posted on June 12, 2017 by Dementia and Elderly Care News

Summary Early research shows promise that a protein biomarker in the blood, called neurofilament light chain (NFL), which is released from damaged brain cells in Huntington’s Disease, may be the basis for a blood test able to predict whether people … Continue reading →

Posted in BBC News, Diagnosis, For Researchers (mostly), In the News, International, Quick Insights, UK, Universal Interest | Tagged BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blood Tests, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Huntington’s Disease, Blood-Based NfL, Canada, Carver College of Medicine: University of Iowa, Cath Stanley: Chief Executive of Hungtington's Disease Association, Centre for Molecular Medicine and Therapeutics: University of British Columbia, CHDI Foundation, Department of Neurology: Leiden University, Department of Psychiatry and Neurochemistry: Sahlgrenska Academy; University of Gothenburg, Department of Psychiatry: University of Iowa, European Research Council, France, Genetics Department: Pitié-Salpêtrière University Hospital, HTT, HTT Mutation Carriers, Huntington Disease, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, INSERM, Institut du Cerveau et de la Moelle épinière (ICM), Institute of Neuroscience and Physiology: Sahlgrenska Academy (University of Gothenburg), Institute of Neuroscience and Physiology: Sahlgrenska Academy at University of Gothenburg, Knut and Alice Wallenberg Foundation, Lancet Neurology, Leiden University, Leonard Wolfson Experimental Neurology Centre: University College London, Medical Research Council (MRC), Mutant Huntingtin (mHTT), National Hospital for Neurology and Neurosurgery, National Institute for Health Research UCL Hospitals Biomedical Research Centre, Netherlands, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Huntington's Disease, Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Non-Invasive Biomarkers, Pitié-Salpêtrière University Hospital (Paris), Plasma Biomarkers, Plasma Neurofilament Light Chain, Preclinical Biomarkers in Huntington's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital (Sweden), Serum Neurofilament Light Chain Protein, Sorbonne Universités, Surrogate Biomarkers of Neurodegeneration, Sweden; Clinical Neurochemistry Laboratory: Sahlgrenska University Hospital, Swedish Research Council, Torsten Söderberg Foundation, Transforming Research and Clinical Knowledge in Huntington's Disease (TRACK-HD), UCL Institute of Neurology, University College London (UCL), University of British Columbia, University of Gothenburg, University of Iowa, UPMC University Paris 06: INSERM | Leave a comment

Tag Archives: Neurodegenerative Diseases

Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Earlier Diagnosis Research: the Deep and Frequent Phenotyping Study (BBC News / GtR)

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Huntington’s Disease: a Blood Test “Speedometer”? (BBC News / Lancet Neurology)

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