Tag Archives: Neurodegenerative Diseases

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Posted on October 24, 2019 by Dementia and Elderly Care News

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading →

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Aducanumab, Aducanumab (Biogen), Aducanumab: Recombinant Human Monoclonal Antibody, Aβ, Aβ Accumulation, Aβ-Plaques, Aβopathy, Amyloid Beta, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, Amyloid-Related Imaging Abnormalities-Edema (ARIA-E), Amyloidopathy, Antibody-Based Immunotherapy Against Aβ, ARIA-E Episodes, Beta-Amyloid, Beta-Amyloid Plaques, Biogen, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Drug Side-Effects, Drug Trials Failure Rate, Drugs for Cognitive Symptoms of Cognitive Decline and Dementia, Drugs for Treatment of Alzheimer’s Disease, Edema, β-Amyloid (Aβ) Accumulation, β-amyloid Deposition, Monoclonal Antibodies, Neurimmune, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Oedema, Phase 3 EMERGE Study, Phase 3 ENGAGE Study, Slowing of Cognitive Decline, Treatment of Alzheimer's Disease | Leave a comment

Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Posted on June 17, 2019 by Dementia and Elderly Care News

Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading →

Posted in Alzheimer’s Research UK, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Personalisation, Quick Insights, Systematic Reviews, UK, Universal Interest | Tagged 18F-florbetaben, 18F-flutemetamol, 18Fflorbetapir, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Alzheimer’s Research UK (ARUK), Amyloid and Tau PET, APOE e4 (Apolipoprotein E e4), Apolipoprotein E (APOE) e4 Allele, Behavioural Biomarkers, Beta-Amyloid PET Imaging, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Canonical Syndromes of Primary Progressive Aphasia: Non-Fluent / Agrammatic Variant (nfvPPA), Canonical Syndromes of Primary Progressive Aphasia: Semantic Variant (svPPA), Carbon-11 Pittsburgh Compound-B (C-PIB) Radioisotope Tracer, Cerebral Metabolic Rate for Glucose (CMRgl), Cerebrospinal Fluid (CSF) Biomarkers, Cerebrospinal Fluid and Serum MHPG, CMRgl Decline, Corticobasal Degeneration (CBD), CSF 3-methoxy-4-hydrox-yphenylglycol (MHPG), Dementia With Lewy Bodies (DLB), Differential Diagnosis, DLB: Dementia with Lewy Bodies, Docosahexaenoic Acid (DHA), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Eicosapentaenoic Acid (EPA), Frontotemporal Dementia (FTD), α-Synuclein, Journal of Geriatric Care and Research (JGCR), Lewy Body Dementia (LBD), Magnetic Resonance Imaging (MRI), Medial Temporal Lobe Atrophy (MTA), Medial Temporal Lobes (MTL), Metabolic Syndrome (MetS), MRI Brain Imaging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroimaging, Neuroimaging in Dementia Diagnosis, Non-Invasive Biomarkers, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Primary Progressive Aphasia (PPA), Progressive Supranuclear Palsy (PSP), Rapid Screening, Screening for Dementia, Sea Hero Quest (SHQ) Game, Sea Hero Quest VR, Tau PET, Timely Diagnosis, VaD: Vascular Dementia, Variants of Primary Progressive Aphasia (PPA), Vascular Dementia, [18F]THK5351 | Leave a comment

Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)

Posted on May 1, 2019 by Dementia and Elderly Care News

Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Amnestic MCI, Australia, Austria, Bazian, BBC Health News, Behind the Headlines, Brain (Journal), Central Clinical School Faculty of Medicine and Health (Sydney Australia), Clinical and Neurocognitive Features of LATE, Consensus Guidelines for LATE-NC Staging, Consensus Proposed LATE-NC TDP-43 Stages, Dementia-Related Misdiagnosis, Differential Diagnosis, Drug Trials, Drug Trials Failure Rate, Emory University (Atlanta), FTLD-TDP: Frontotemporal Lobar Degeneration With TDP-43 Proteinopathy, Harvard University, Hippocampal Atrophy, Illinois Institute of Technology, Institute of Neurology: Medical University of Vienna, Japan, LATE Biomarkers, LATE Neuropathological Change (LATE-NC), LATE Working Group, Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), Mayo Clinic (Jacksonville), Mayo Clinic: Rochester, Medical University of Vienna, Misdiagnosis, Misdiagnosis (Potential), Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NHS Digital (Formerly NHS Choices), Oldest Old, Oldest Old Age, Oldest People With Dementia, Prevalence of Dementia in Oldest Old, Public Health Impact of LATE, Recommendations for Routine Autopsy Evaluation and Classification of LATE-NC, Rush University Medical Center, Stanford University, Subtypes of Dementia, Sweden, TDP-43 Protein, TDP-43 Proteinopathy, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, United States, University of California, University of Cambridge, University of Kentucky, University of Minnesota, University of Pennsylvania, University of Southern California, University of Sydney Brain and Mind Centre, University of Texas Southwestern Medical Center, University of Washington, Uppsala University, USA | Leave a comment

Optometric and Ophthalmological Tests for Visual Symptoms of Posterior Cortical Atrophy (BMJ Open)

Posted on April 5, 2019 by Dementia and Elderly Care News

Summary Research by the College of Optometrists on Posterior Cortical Atrophy (PCA) has investigated the suitability of certain vision assessment tests to help differentiate between cortical and optical / ocular causes of visual impairment. An awareness of PCA helps to … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Quick Insights, UK | Tagged Acalculia, Agraphia, Balint’s Syndrome, BMJ Open, BMJ Publishing Group Ltd, College of Optometrists, Dementia Research Centre: University College London, Department of Research: College of Optometrists, Fragmented Images or Letters, Fragmented Letters Test, Gerstmann’s Syndrome, Identification of Cortical Perceptual Problems, Institute of Neurology: University College London, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Oculomotor Apraxia, Optometric and Ophthalmological Tests for Posterior Cortical Atrophy, Posterior Cortical Atrophy, Posterior Cortical Atrophy (PCA), Progressive Visual Dysfunction, Queen Square Screening Test for Cognitive Deficits (The Green Book), Queen Square Screening Test for Visual Deficits, Queen Square Screening Test for Visual Deficits (The Blue Book), Rare Dementia Support (London), Rare Dementia Support PCA Support Group, Rare Dementias, Reduced Effective Field of Vision, Simultanagnosia, Snellen Letter Chart, UCL PCA Support Group, University College London (UCL), University College London’s Queen Square Neurology Centre, Vision Assessment Tests, Visual Dysfunction in Posterior Cortical Atrophy, Visual Symptoms of Posterior Cortical Atrophy | Leave a comment

Hippocampal Neurogenesis Life-Long (BBC News / Nature Medicine)

Posted on March 27, 2019 by Dementia and Elderly Care News

Summary Contrary to popular belief, the creation of new brain cells persists throughout life (in the hippocampus at least); although the rate of neurogenesis may decline with old age, and fall massively in Alzheimer’s Disease. Full Text Link Reference Gallagher, … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Adult Hippocampal Neurogenesis (AHN), Alzheimer’s Disease, BBC Health News, CBMSO: Centro de Biología Molecular 'Severo Ochoa' (Madrid), Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), CIEN Foundation (Madrid), Department of Molecular Biology: Universidad Autónoma de Madrid, Department of Molecular Neuropathology: Centro de Biología Molecular 'Severo Ochoa', Faculty of Biomedical and Health Sciences: Universidad Europea de Madrid, Hippocampal Neurogenesis, Hippocampus, Hippocampus-Dependent Cognitive Decline, Hippocampus-Dependent Memory Deficits, Memory Problems, Nature Medicine, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Creation, Neuronal Loss, Neuropathology Department: CIEN Foundation, New Neurons in Brain, Spain, Universidad Autónoma de Madrid, Universidad Europea de Madrid | Leave a comment

Smell Test for Early Detection of Parkinson’s Disease (BBC News)

Posted on March 21, 2019 by Dementia and Elderly Care News

Summary Parkinson’s Disease has a distinctive odour for certain gifted individuals, which has been analysed chemically and may now be replicated for automated detection by machine. This may, in future, permit earlier diagnosis and open the possibilities for timely treatments … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, Scotland, UK, Universal Interest | Tagged ACS Central Science (Journal), Anatune (Cambridge UK), BBC Health News, BBC Scotland News, Biomarkers, Biomarkers Predicting Parkinson's Disease, Department of Biochemistry: University of Liverpool, Department of Neurology: Salford Royal Foundation Trust, Early Diagnosis, Early Diagnosis of Parkinson’s Disease, Edinburgh University, Eicosane, Hyperosmic Super Smeller, Institute for Stem Cell Research: University of Edinburgh, Institute of Integrative Biology: University of Liverpool, Joy Milne, Les Milne, Manchester Academic Health Science Centre: University of Manchester, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Non-Invasive Biomarkers, Odour, Parkinson's Disease Smell Test, Parkinson’s Disease Sebum Volatilome, Parkinson’s UK, Perillic Aldehyde, Rapid Screening, Salford Royal Foundation Trust, School of Biological Sciences: University of Edinburgh, Sebum, Smell Test for Parkinson's Disease Diagnosis, Timely / Preclinical Parkinson's Disease Diagnosis, Timely Diagnosis, University of Edinburgh, University of Liverpool, University of Manchester, Volatile Biomarkers of Parkinson’s Disease, Volatilome | Leave a comment

Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

Posted on March 20, 2019 by Dementia and Elderly Care News

Summary Further discussion about the possibilities of using inexpensive eye tests to detect Alzheimer’s Disease, perhaps years before symptoms appear. This particular technique involves the examination of blood vessels and blood flow in the retina, as detected by Octa (Optical … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Assessment and Diagnosis, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Central Subfield Thickness (CST), Cognitive Impairment, Critical Appraisals, Dementia Case Finding, Dementia Diagnosis, Dementia Screening, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostics, Duke University in North Carolina, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Treatment Diabetic Retinopathy Study, Eye Examinations, Foveal Avascular Zone (FAZ) Area, Karen L. Wrenn Alzheimer's Disease Award, Macular Ganglion Cell-Inner Plexiform Layer (GC-IPL), MCI: Mild Cognitive Impairment, Mild Cognitive Impairment, National Institutes of Health, National Institutes of Health (NIH), National Institutes of Health (US), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS Digital (Formerly NHS Choices), Non-Invasive Biomarkers, Octa: Optical Coherence Tomography Angiography, Ophthalmology Retina, Optical Coherence Tomography, Optical Coherence Tomography Angiography (OCTA), Preclinical Alzheimer's Disease, Rapid Screening, Research to Prevent Blindness Inc. (New York), Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Examination in Neurodegenerative Diseases, Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease, Retinal Microvascular and Neurodegenerative Changes in Mild Cognitive Impairment, Retinal Vessel Density (VD), Screening, Screening for Dementia, Timely Diagnosis, US National Institutes of Health (NIH), USA | Leave a comment

Tag Archives: Neurodegenerative Diseases

Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Optometric and Ophthalmological Tests for Visual Symptoms of Posterior Cortical Atrophy (BMJ Open)

Hippocampal Neurogenesis Life-Long (BBC News / Nature Medicine)

Smell Test for Early Detection of Parkinson’s Disease (BBC News)

Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

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