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Tag Archives: Neurodegenerative Disorders
More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)
Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Association of British Neurologists, Bazian, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Behind the Headlines, Biomarker Development, Biomarkers, Biomarkers for Inflammation, Brain (Journal), Brain Autopsies, Brain Inflammation, C-PK-11195, C-PK-11195 (Biomarker for Inflammation), Cambridge Brain Bank, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Foundation Trust, Consiglio Nazionale delle Ricerche (CNR), Critical Appraisals, Degenerative Tauopathy, Department of Clinical Neurosciences: Cambridge University, Department of Neurology: Walton Centre (Liverpool), Department of Pathology: Cambridge University Hospitals NHS Foundation Trust, Department of Psychiatry: University of Cambridge, Division of Anaesthesia: University of Cambridge, Early-Onset Dementia, F-AV-1451, F-AV-1451 (Biomarker for Protein Clusters), Fronto-Temporal Dementia (FTD), Frontotemporal Dementia, Frontotemporal Dementia (FTD), FTD: Fronto-Temporal Dementia, FTLD-Pick’s, FTLD-TDP (A), FTLD-TDP (C), FTLD-TDP (Types A and C), FTLD-TDP-43, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM): Consiglio Nazionale delle Ricerche (CNR), Italy, Lundbeck Foundation (Denmark), Medical Research Council (MRC), Medical Research Council Cognition and Brain Sciences Unit: University of Cambridge, Microglia, Monoamine Oxidase (MAO), National Institute of Health Research, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Neuroinflammation and Frontotemporal Dementia, Neuroinflammation and Protein Aggregation, Neuromelanin, NIHR Dementias and Neurodegenerative Diseases Research Network, Non-Amyloid-β Protein Aggregation, Non-Fluent Variant Primary Progressive Aphasia (nfvPPA), Patrick Berthoud Charitable Trust, PET Scans, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Protein Aggregation, Protein Clusters, Semantic Variant Primary Progressive Aphasia (svPPA), Tauopathy, TDP-43, TDP-43 Pathology, TDP-43 Protein, TDP-43 Proteinopathy, University of Cambridge, Variants of Primary Progressive Aphasia (PPA), Wellcome Trust, Wolfson Brain Imaging Centre: University of Cambridge
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Cerebral Amyloid Angiopathy (JGCR)
Summary Cerebral Amyloid Angiopathy (CAA) is characterised mainly by impaired perceptual speed, episodic memory, semantic memory, attention and executive function. It has much in common with global cognitive impairment, and diagnosis may overlap with that for Alzheimer’s Disease or other … Continue reading
Posted in Depression, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Quick Insights, Universal Interest
Tagged Ageing Population, Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Boston Radiological Criteria for Probable CAA, Cerebral Amyloid Angiopathy, Cerebral Amyloid Angiopathy (CAA), Cerebral Amyloid Angiopathy (CAA): Clinical Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychiatric Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychopathology, Cerebral Amyloid Angiopathy: Neuropsychiatric Patterns, Cerebral Amyloid Angiopathy: Psychiatric Presentations in Old Age, Cognitive Impairment, Computed Tomography (CT) Scan, Dementia and Cognitive Impairment, Differential Diagnosis, Impulsivity, Journal of Geriatric Care and Research (JGCR), Magnetic Resonance Imaging (MRI) Scan, Neurodegenerative Diseases, Neurodegenerative Disorders, New Zealand, Waitemata District Health Board (Auckland)
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Football and Dementia Risk: Mortality From Neurodegenerative Disease Higher in Former Professional Soccer Players (BBC News / Drake Foundation / NEJM / Bazian)
Summary The Football’s InfluencE on Lifelong health and Dementia risk (FIELD) study, based at Glasgow University and supported by The Football Association and The Professional Footballers’ Association, found that former Scottish professional football players tend to be over 3.5 times more … Continue reading
Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Scotland, Statistics, UK, Universal Interest
Tagged Alan Shearer, Bazian, BBC Health News, BBC News Hampshire and Isle of Wight, BBC Sport, Behind the Headlines, Chronic Traumatic Encephalopathy (CTE), Concussion Action Programme, Dementia in Retired Association Football (Soccer) Players, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Department of Neuropathology: Queen Elizabeth University Hospital (Glasgow), Drake Foundation, Epidemiology, Epidemiology and Statistics, Football Association, Football Association (FA), Football Brain Injury Research, Football Headers, Football’s InfluencE on Lifelong health and Dementia risk (FIELD) Study, Former Professional Soccer Players, Giffnock Soccer Centre, Glasgow Brain Injury Research Group, Glasgow University, Hampden Sports Clinic: Hampden Stadium (Glasgow), Heading Footballs Associated With Dementia / CTE: a New Category of Industrial Injury?, Heading Heavy Leather Footballs, HEADING Study (Health and Ageing Data IN the Game of football), Heading the Ball, Inside Out South (BBC), Institute of Cardiovascular and Medical Sciences: University of Glasgow, Institute of Health and Wellbeing: University of Glasgow, Institute of Neuroscience and Psychology: University of Glasgow, Iwan Roberts: Former Wales and Norwich City Footballer, Lifestyle Risk Factors, Modifiable Risk Factors, Neurodegenerative Disease Mortality in Former Professional Soccer Players, Neurodegenerative Disorders, Neurodegenerative Research, Neuropathology, New England Journal of Medicine, Norwich City, Professional Footballers, Professional Footballers' Association (PFA), Queen Elizabeth University Hospital (Glasgow), Repetitive Mild Traumatic Brain Injury (rTBI), Retired Soccer Players With Dementia, SCORES Project, SCORES Study: Screening Cognitive Outcomes After REpetitive Head Impact in Sport, Scottish Football Association, Scottish Football Association (Proposed Ban on Under-12s Heading Balls in Football Training), Soccer Heading, Sports Medicine, Sub-Concussive Head Impacts, Traumatic Brain Injury, University of East Anglia (UEA), University of East Anglia (UEA) Health and Social Care Partners, University of Glasgow
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More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)
Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading
Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged APP or PSEN Mutations, Australia, Basel, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Columbia University Medical Center, Dementia Research Centre, Dementia Research Centre: University College London, Department of Biomedical Sciences: Macquarie University, Department of Cellular Neurology: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration: Queen Square Institute of Neurology, Department of Neurology: Columbia University Medical Center, Department of Neurology: Keck School of Medicine at USC, Department of Neurology: Ludwig-Maximilians-Universität München, Department of Neurology: Massachusetts General Hospital, Department of Neurology: Mayo Clinic Jacksonville, Department of Neurology: Washington University School of Medicine, Department of Neuroscience: Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Psychotherapy: University of Tübingen, Department of Radiology: Washington University School of Medicine, Departments of Medicine Biomedicine and Clinical Research: University Hospital Basel, Division of Biostatistics: Washington University School of Medicine, Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN), Dominantly Inherited Alzheimer's Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Edith Cowan University: Western Australia, Florey Institute of Neuroscience and Mental Health: University of Melbourne, German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Germany, Harvard Medical School, Hereditary Alzheimer's Disease, Hertie Institute for Clinical Brain Research, Icahn School of Medicine at Mount Sinai (New York), Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Indiana University School of Medicine, Ludwig-Maximilians-Universität München, Macquarie University, Macquarie University (New South Wales), Massachusetts General Hospital, National Institute on Aging, National Institute on Aging (NIA), National Institute on Aging (US), Nature Medicine, Neurodegeneration Division: The Florey Institute of Neuroscience and Mental Health, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NfC), Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Neurologic Clinic and Policlinic: University Hospital Basel, Neuroscience Research Australia, Non-Invasive Biomarkers, Plasma Biomarkers, Preclinical Alzheimer's Disease, Preclinical Biomarkers and Dementia, Preclinical Biomarkers in Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, School of Medical Health and Sciences: Edith Cowan University, School of Medical Sciences: University of New South Wales, Serum Neurofilament Light Chain Protein, Switzerland, Taub Institute for Research on Alzheimer's Disease and the Aging Brain: Columbia University Medical Center, United States, University College London, University Hospital Basel, University of Basel, University of Melbourne, University of New South Wales, University of Tübingen, US National Institute on Aging, USA, Warren Alpert Medical School of Brown University, Washington University School of Medicine
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Dementia Research Centre in Wales (BBC News)
Summary A brief piece, from BBC News, on the work and aims of the £20 million Dementia Research Institute at Cardiff University. Full Text Link Reference Clarke, O. (2018). Fruit flies’ brains studied to help crack dementia. London: BBC Health … Continue reading
Posted in BBC News, For Researchers (mostly), In the News, National, Quick Insights, UK, Universal Interest, Wales
Tagged BBC Health News, BBC Wales News, Biomarkers Research Programmes, Bioscience Careers, Brain Research Imaging Centre at Cardiff University (CUBRIC), Cardiff University, Dementia Action Plan for Wales: 2018-2022, Dementia Research, Dementia Research Careers, Dementia Research Institute (Cardiff), Dementia Research Institute (DRI), Dementia Research Institute at Cardiff University, Drosophila melanogaster, Fruit Flies, Genetic Research, Immune Pathways and Stem Cell (iPSC) Models of Neurodegenerative Disease, Immunology, Inflammation, Inflammatory Response, National Dementia Vision for Wales, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurodevelopmental Disorders: Abnormal Brain Development, Neuroinflammation, Neuroinflammation Research Cluster, Neuroscience, Research and Development, Research and Innovation, Research Careers, Research Commitment, Research Culture, Research Funding, Transgenic Drosophila, Vaughan Gething: Welsh Health Secretary, Welsh Government, Welsh Government Dementia Oversight of Implementation and Impact Group (DOIIG)
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Pre-Eclampsia and Risk of Dementia (BMJ)
Summary Danish research indicates that pre-eclampsia is associated with a subsequent increased risk of dementia in later life, particularly with vascular dementia. Full Text Link Reference Basit, S. Wohlfahrt, J. [and] Boyd, HA. (2018). Pre-eclampsia and risk of dementia later … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, Universal Interest
Tagged BMJ Publishing Group Ltd, British Medical Journal (BMJ), Cardiovascular System Disorders, Cognitive Impairment (Potential Risk Factors), Danish Civil Registration System, Dementia Risk Factors, Denmark, Department of Epidemiology Research: Statens Serum Institut, Epidemiology, Epidemiology and Statistics, Neurocognitive Disorders, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurological Disorders, Obstetrics and Gynaecology, Overlapping Risk Factors, Pre-Eclampsia, Pre-Eclampsia and Risk of Dementia, Risk Factors, Statens Serum Institut (Copenhagen), STOX1 Gene, Vascular Consequences of Pre-Eclampsia, Vascular Dementia, Vascular Risk Factors
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