Tag Archives: Neurodegenerative Disorders

More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Posted on March 22, 2020 by Dementia and Elderly Care News

Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest | Tagged Association of British Neurologists, Bazian, Behavioural Frontotemporal Dementia (bvFTD), Behavioural Variant Frontotemporal Dementia (bvFTD), Behind the Headlines, Biomarker Development, Biomarkers, Biomarkers for Inflammation, Brain (Journal), Brain Autopsies, Brain Inflammation, C-PK-11195, C-PK-11195 (Biomarker for Inflammation), Cambridge Brain Bank, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Foundation Trust, Consiglio Nazionale delle Ricerche (CNR), Critical Appraisals, Degenerative Tauopathy, Department of Clinical Neurosciences: Cambridge University, Department of Neurology: Walton Centre (Liverpool), Department of Pathology: Cambridge University Hospitals NHS Foundation Trust, Department of Psychiatry: University of Cambridge, Division of Anaesthesia: University of Cambridge, Early-Onset Dementia, F-AV-1451, F-AV-1451 (Biomarker for Protein Clusters), Fronto-Temporal Dementia (FTD), Frontotemporal Dementia, Frontotemporal Dementia (FTD), FTD: Fronto-Temporal Dementia, FTLD-Pick’s, FTLD-TDP (A), FTLD-TDP (C), FTLD-TDP (Types A and C), FTLD-TDP-43, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM): Consiglio Nazionale delle Ricerche (CNR), Italy, Lundbeck Foundation (Denmark), Medical Research Council (MRC), Medical Research Council Cognition and Brain Sciences Unit: University of Cambridge, Microglia, Monoamine Oxidase (MAO), National Institute of Health Research, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroinflammation, Neuroinflammation and Frontotemporal Dementia, Neuroinflammation and Protein Aggregation, Neuromelanin, NIHR Dementias and Neurodegenerative Diseases Research Network, Non-Amyloid-β Protein Aggregation, Non-Fluent Variant Primary Progressive Aphasia (nfvPPA), Patrick Berthoud Charitable Trust, PET Scans, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Protein Aggregation, Protein Clusters, Semantic Variant Primary Progressive Aphasia (svPPA), Tauopathy, TDP-43, TDP-43 Pathology, TDP-43 Protein, TDP-43 Proteinopathy, University of Cambridge, Variants of Primary Progressive Aphasia (PPA), Wellcome Trust, Wolfson Brain Imaging Centre: University of Cambridge | Leave a comment

Cerebral Amyloid Angiopathy (JGCR)

Posted on March 5, 2020 by Dementia and Elderly Care News

Summary Cerebral Amyloid Angiopathy (CAA) is characterised mainly by impaired perceptual speed, episodic memory, semantic memory, attention and executive function. It has much in common with global cognitive impairment, and diagnosis may overlap with that for Alzheimer’s Disease or other … Continue reading →

Posted in Depression, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Quick Insights, Universal Interest | Tagged Ageing Population, Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Boston Radiological Criteria for Probable CAA, Cerebral Amyloid Angiopathy, Cerebral Amyloid Angiopathy (CAA), Cerebral Amyloid Angiopathy (CAA): Clinical Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychiatric Manifestations, Cerebral Amyloid Angiopathy (CAA): Psychopathology, Cerebral Amyloid Angiopathy: Neuropsychiatric Patterns, Cerebral Amyloid Angiopathy: Psychiatric Presentations in Old Age, Cognitive Impairment, Computed Tomography (CT) Scan, Dementia and Cognitive Impairment, Differential Diagnosis, Impulsivity, Journal of Geriatric Care and Research (JGCR), Magnetic Resonance Imaging (MRI) Scan, Neurodegenerative Diseases, Neurodegenerative Disorders, New Zealand, Waitemata District Health Board (Auckland) | Leave a comment

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Posted on October 24, 2019 by Dementia and Elderly Care News

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading →

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Aducanumab, Aducanumab (Biogen), Aducanumab: Recombinant Human Monoclonal Antibody, Aβ, Aβ Accumulation, Aβ-Plaques, Aβopathy, Amyloid Beta, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, Amyloid-Related Imaging Abnormalities-Edema (ARIA-E), Amyloidopathy, Antibody-Based Immunotherapy Against Aβ, ARIA-E Episodes, Beta-Amyloid, Beta-Amyloid Plaques, Biogen, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Drug Side-Effects, Drug Trials Failure Rate, Drugs for Cognitive Symptoms of Cognitive Decline and Dementia, Drugs for Treatment of Alzheimer’s Disease, Edema, β-Amyloid (Aβ) Accumulation, β-amyloid Deposition, Monoclonal Antibodies, Neurimmune, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Oedema, Phase 3 EMERGE Study, Phase 3 ENGAGE Study, Slowing of Cognitive Decline, Treatment of Alzheimer's Disease | Leave a comment

Football and Dementia Risk: Mortality From Neurodegenerative Disease Higher in Former Professional Soccer Players (BBC News / Drake Foundation / NEJM / Bazian)

Posted on October 23, 2019 by Dementia and Elderly Care News

Summary The Football’s InfluencE on Lifelong health and Dementia risk (FIELD) study, based at Glasgow University and supported by The Football Association and The Professional Footballers’ Association, found that former Scottish professional football players tend to be over 3.5 times more … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Scotland, Statistics, UK, Universal Interest | Tagged Alan Shearer, Bazian, BBC Health News, BBC News Hampshire and Isle of Wight, BBC Sport, Behind the Headlines, Chronic Traumatic Encephalopathy (CTE), Concussion Action Programme, Dementia in Retired Association Football (Soccer) Players, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Department of Neuropathology: Queen Elizabeth University Hospital (Glasgow), Drake Foundation, Epidemiology, Epidemiology and Statistics, Football Association, Football Association (FA), Football Brain Injury Research, Football Headers, Football’s InfluencE on Lifelong health and Dementia risk (FIELD) Study, Former Professional Soccer Players, Giffnock Soccer Centre, Glasgow Brain Injury Research Group, Glasgow University, Hampden Sports Clinic: Hampden Stadium (Glasgow), Heading Footballs Associated With Dementia / CTE: a New Category of Industrial Injury?, Heading Heavy Leather Footballs, HEADING Study (Health and Ageing Data IN the Game of football), Heading the Ball, Inside Out South (BBC), Institute of Cardiovascular and Medical Sciences: University of Glasgow, Institute of Health and Wellbeing: University of Glasgow, Institute of Neuroscience and Psychology: University of Glasgow, Iwan Roberts: Former Wales and Norwich City Footballer, Lifestyle Risk Factors, Modifiable Risk Factors, Neurodegenerative Disease Mortality in Former Professional Soccer Players, Neurodegenerative Disorders, Neurodegenerative Research, Neuropathology, New England Journal of Medicine, Norwich City, Professional Footballers, Professional Footballers' Association (PFA), Queen Elizabeth University Hospital (Glasgow), Repetitive Mild Traumatic Brain Injury (rTBI), Retired Soccer Players With Dementia, SCORES Project, SCORES Study: Screening Cognitive Outcomes After REpetitive Head Impact in Sport, Scottish Football Association, Scottish Football Association (Proposed Ban on Under-12s Heading Balls in Football Training), Soccer Heading, Sports Medicine, Sub-Concussive Head Impacts, Traumatic Brain Injury, University of East Anglia (UEA), University of East Anglia (UEA) Health and Social Care Partners, University of Glasgow | Leave a comment

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

Posted on September 20, 2019 by Dementia and Elderly Care News

Summary Terazosin, a drug developed originally to treat benign prostatic hyperplasia (BPH), may slow the progression of Parkinson’s Disease. It is thought that Terazosin may help by activating an enzyme (PGK1) which prevents cell death in the relevant brain regions. … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged BBC Health News, Beihang University (Beijing), Beijing Advanced Innovation Center for Big Data-Based Precision Medicine: Beihang University, Beijing Institute for Brain Disorders: Capital Medical University, Bellvitge University Hospital-IDIBEL, Benign Prostatic Hyperplasia (BPH), Capital Medical University (Beijing), Carver College of Medicine: University of Iowa, Center of Regenerative Medicine in Barcelona (CMRB), Center of Stroke: Beijing Institute for Brain Disorders, China, Department of Molecular and Translational Medicine: University of Brescia, Department of Pathology and Experimental Therapeutics: Bellvitge University Hospital-IDIBELL, Departments of Pharmaceutical Care and Neurology: University of Iowa, Disease-Modifying Treatments for Parkinson's Disease, Drugs Development and Re-Purposing, Hospital Duran i Reynals, Hospitalet de Llobregat (Barcelona), Hospitalet de Llobregat and Institute of Biomedicine of the University of Barcelona (IBUB), Howard Hughes Medical Institute: University of Iowa, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institute of Hypoxia Medicine: Xuanwu Hospital, Italy, Journal of Clinical Investigation, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education (China), Loss of Dopaminergic Neurons in pars compacta of Substantia Nigra (SNpc), Networking Biomedical Research Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Neurodegenerative Disorders, Neurodegenerative Research, Off-Label Drug Repurposing Trials, Peking University, PGK1, Phosphoglycerate Kinase 1 (PGK1), Potential Repurposing of Drugs to Slow Progression of Parkinson’s Disease, Repurposing of Drugs, School of Life Sciences: Peking University, Spain, State Key Laboratory of Membrane Biology: Peking University, Substantia Nigra, Terazosin, United States, University of Brescia, University of Iowa, USA, Xuanwu Hospital (China) | Leave a comment

Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)

Posted on May 1, 2019 by Dementia and Elderly Care News

Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Amnestic MCI, Australia, Austria, Bazian, BBC Health News, Behind the Headlines, Brain (Journal), Central Clinical School Faculty of Medicine and Health (Sydney Australia), Clinical and Neurocognitive Features of LATE, Consensus Guidelines for LATE-NC Staging, Consensus Proposed LATE-NC TDP-43 Stages, Dementia-Related Misdiagnosis, Differential Diagnosis, Drug Trials, Drug Trials Failure Rate, Emory University (Atlanta), FTLD-TDP: Frontotemporal Lobar Degeneration With TDP-43 Proteinopathy, Harvard University, Hippocampal Atrophy, Illinois Institute of Technology, Institute of Neurology: Medical University of Vienna, Japan, LATE Biomarkers, LATE Neuropathological Change (LATE-NC), LATE Working Group, Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), Mayo Clinic (Jacksonville), Mayo Clinic: Rochester, Medical University of Vienna, Misdiagnosis, Misdiagnosis (Potential), Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NHS Digital (Formerly NHS Choices), Oldest Old, Oldest Old Age, Oldest People With Dementia, Prevalence of Dementia in Oldest Old, Public Health Impact of LATE, Recommendations for Routine Autopsy Evaluation and Classification of LATE-NC, Rush University Medical Center, Stanford University, Subtypes of Dementia, Sweden, TDP-43 Protein, TDP-43 Proteinopathy, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, United States, University of California, University of Cambridge, University of Kentucky, University of Minnesota, University of Pennsylvania, University of Southern California, University of Sydney Brain and Mind Centre, University of Texas Southwestern Medical Center, University of Washington, Uppsala University, USA | Leave a comment

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Posted on January 28, 2019 by Dementia and Elderly Care News

Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged APP or PSEN Mutations, Australia, Basel, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Columbia University Medical Center, Dementia Research Centre, Dementia Research Centre: University College London, Department of Biomedical Sciences: Macquarie University, Department of Cellular Neurology: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration: Queen Square Institute of Neurology, Department of Neurology: Columbia University Medical Center, Department of Neurology: Keck School of Medicine at USC, Department of Neurology: Ludwig-Maximilians-Universität München, Department of Neurology: Massachusetts General Hospital, Department of Neurology: Mayo Clinic Jacksonville, Department of Neurology: Washington University School of Medicine, Department of Neuroscience: Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Psychotherapy: University of Tübingen, Department of Radiology: Washington University School of Medicine, Departments of Medicine Biomedicine and Clinical Research: University Hospital Basel, Division of Biostatistics: Washington University School of Medicine, Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN), Dominantly Inherited Alzheimer's Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Edith Cowan University: Western Australia, Florey Institute of Neuroscience and Mental Health: University of Melbourne, German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Germany, Harvard Medical School, Hereditary Alzheimer's Disease, Hertie Institute for Clinical Brain Research, Icahn School of Medicine at Mount Sinai (New York), Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Indiana University School of Medicine, Ludwig-Maximilians-Universität München, Macquarie University, Macquarie University (New South Wales), Massachusetts General Hospital, National Institute on Aging, National Institute on Aging (NIA), National Institute on Aging (US), Nature Medicine, Neurodegeneration Division: The Florey Institute of Neuroscience and Mental Health, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NfC), Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Neurologic Clinic and Policlinic: University Hospital Basel, Neuroscience Research Australia, Non-Invasive Biomarkers, Plasma Biomarkers, Preclinical Alzheimer's Disease, Preclinical Biomarkers and Dementia, Preclinical Biomarkers in Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, School of Medical Health and Sciences: Edith Cowan University, School of Medical Sciences: University of New South Wales, Serum Neurofilament Light Chain Protein, Switzerland, Taub Institute for Research on Alzheimer's Disease and the Aging Brain: Columbia University Medical Center, United States, University College London, University Hospital Basel, University of Basel, University of Melbourne, University of New South Wales, University of Tübingen, US National Institute on Aging, USA, Warren Alpert Medical School of Brown University, Washington University School of Medicine | Leave a comment

Tag Archives: Neurodegenerative Disorders

More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Cerebral Amyloid Angiopathy (JGCR)

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

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