Tag Archives: Neurodegenerative Disorders

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Posted on October 24, 2019 by Dementia and Elderly Care News

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading →

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged Aducanumab, Aducanumab (Biogen), Aducanumab: Recombinant Human Monoclonal Antibody, Aβ, Aβ Accumulation, Aβ-Plaques, Aβopathy, Amyloid Beta, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, Amyloid-Related Imaging Abnormalities-Edema (ARIA-E), Amyloidopathy, Antibody-Based Immunotherapy Against Aβ, ARIA-E Episodes, Beta-Amyloid, Beta-Amyloid Plaques, Biogen, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Drug Side-Effects, Drug Trials Failure Rate, Drugs for Cognitive Symptoms of Cognitive Decline and Dementia, Drugs for Treatment of Alzheimer’s Disease, Edema, β-Amyloid (Aβ) Accumulation, β-amyloid Deposition, Monoclonal Antibodies, Neurimmune, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Oedema, Phase 3 EMERGE Study, Phase 3 ENGAGE Study, Slowing of Cognitive Decline, Treatment of Alzheimer's Disease | Leave a comment

Football and Dementia Risk: Mortality From Neurodegenerative Disease Higher in Former Professional Soccer Players (BBC News / Drake Foundation / NEJM / Bazian)

Posted on October 23, 2019 by Dementia and Elderly Care News

Summary The Football’s InfluencE on Lifelong health and Dementia risk (FIELD) study, based at Glasgow University and supported by The Football Association and The Professional Footballers’ Association, found that former Scottish professional football players tend to be over 3.5 times more … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Scotland, Statistics, UK, Universal Interest | Tagged Alan Shearer, Bazian, BBC Health News, BBC Sport, Behind the Headlines, Chronic Traumatic Encephalopathy (CTE), Dementia in Retired Association Football (Soccer) Players, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Department of Neuropathology: Queen Elizabeth University Hospital (Glasgow), Drake Foundation, Epidemiology, Epidemiology and Statistics, Football Association, Football Association (FA), Football Brain Injury Research, Football Headers, Football’s InfluencE on Lifelong health and Dementia risk (FIELD) Study, Former Professional Soccer Players, Glasgow Brain Injury Research Group, Glasgow University, Hampden Sports Clinic: Hampden Stadium (Glasgow), Heading Footballs Associated With Dementia / CTE: a New Category of Industrial Injury?, Heading Heavy Leather Footballs, HEADING Study (Health and Ageing Data IN the Game of football), Heading the Ball, Institute of Cardiovascular and Medical Sciences: University of Glasgow, Institute of Health and Wellbeing: University of Glasgow, Institute of Neuroscience and Psychology: University of Glasgow, Lifestyle Risk Factors, Modifiable Risk Factors, Neurodegenerative Disease Mortality in Former Professional Soccer Players, Neurodegenerative Disorders, Neurodegenerative Research, Neuropathology, New England Journal of Medicine, Professional Footballers, Professional Footballers' Association (PFA), Queen Elizabeth University Hospital (Glasgow), Repetitive Mild Traumatic Brain Injury (rTBI), Retired Soccer Players With Dementia, Soccer Heading, Sports Medicine, Sub-Concussive Head Impacts, Traumatic Brain Injury, University of Glasgow | Leave a comment

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

Posted on September 20, 2019 by Dementia and Elderly Care News

Summary Terazosin, a drug developed originally to treat benign prostatic hyperplasia (BPH), may slow the progression of Parkinson’s Disease. It is thought that Terazosin may help by activating an enzyme (PGK1) which prevents cell death in the relevant brain regions. … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged BBC Health News, Beihang University (Beijing), Beijing Advanced Innovation Center for Big Data-Based Precision Medicine: Beihang University, Beijing Institute for Brain Disorders: Capital Medical University, Bellvitge University Hospital-IDIBEL, Benign Prostatic Hyperplasia (BPH), Capital Medical University (Beijing), Carver College of Medicine: University of Iowa, Center of Regenerative Medicine in Barcelona (CMRB), Center of Stroke: Beijing Institute for Brain Disorders, China, Department of Molecular and Translational Medicine: University of Brescia, Department of Pathology and Experimental Therapeutics: Bellvitge University Hospital-IDIBELL, Departments of Pharmaceutical Care and Neurology: University of Iowa, Disease-Modifying Treatments for Parkinson's Disease, Drugs Development and Re-Purposing, Hospital Duran i Reynals, Hospitalet de Llobregat (Barcelona), Hospitalet de Llobregat and Institute of Biomedicine of the University of Barcelona (IBUB), Howard Hughes Medical Institute: University of Iowa, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institute of Hypoxia Medicine: Xuanwu Hospital, Italy, Journal of Clinical Investigation, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education (China), Loss of Dopaminergic Neurons in pars compacta of Substantia Nigra (SNpc), Networking Biomedical Research Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Neurodegenerative Disorders, Neurodegenerative Research, Off-Label Drug Repurposing Trials, Peking University, PGK1, Phosphoglycerate Kinase 1 (PGK1), Potential Repurposing of Drugs to Slow Progression of Parkinson’s Disease, Repurposing of Drugs, School of Life Sciences: Peking University, Spain, State Key Laboratory of Membrane Biology: Peking University, Substantia Nigra, Terazosin, United States, University of Brescia, University of Iowa, USA, Xuanwu Hospital (China) | Leave a comment

Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)

Posted on May 1, 2019 by Dementia and Elderly Care News

Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Amnestic MCI, Australia, Austria, Bazian, BBC Health News, Behind the Headlines, Brain (Journal), Central Clinical School Faculty of Medicine and Health (Sydney Australia), Clinical and Neurocognitive Features of LATE, Consensus Guidelines for LATE-NC Staging, Consensus Proposed LATE-NC TDP-43 Stages, Dementia-Related Misdiagnosis, Differential Diagnosis, Drug Trials, Drug Trials Failure Rate, Emory University (Atlanta), FTLD-TDP: Frontotemporal Lobar Degeneration With TDP-43 Proteinopathy, Harvard University, Hippocampal Atrophy, Illinois Institute of Technology, Institute of Neurology: Medical University of Vienna, Japan, LATE Biomarkers, LATE Neuropathological Change (LATE-NC), LATE Working Group, Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), Mayo Clinic (Jacksonville), Mayo Clinic: Rochester, Medical University of Vienna, Misdiagnosis, Misdiagnosis (Potential), Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NHS Digital (Formerly NHS Choices), Oldest Old, Oldest Old Age, Oldest People With Dementia, Prevalence of Dementia in Oldest Old, Public Health Impact of LATE, Recommendations for Routine Autopsy Evaluation and Classification of LATE-NC, Rush University Medical Center, Stanford University, Subtypes of Dementia, Sweden, TDP-43 Protein, TDP-43 Proteinopathy, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, United States, University of California, University of Cambridge, University of Kentucky, University of Minnesota, University of Pennsylvania, University of Southern California, University of Sydney Brain and Mind Centre, University of Texas Southwestern Medical Center, University of Washington, Uppsala University, USA | Leave a comment

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Posted on January 28, 2019 by Dementia and Elderly Care News

Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged APP or PSEN Mutations, Australia, Basel, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Columbia University Medical Center, Dementia Research Centre, Dementia Research Centre: University College London, Department of Biomedical Sciences: Macquarie University, Department of Cellular Neurology: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration: Queen Square Institute of Neurology, Department of Neurology: Columbia University Medical Center, Department of Neurology: Keck School of Medicine at USC, Department of Neurology: Ludwig-Maximilians-Universität München, Department of Neurology: Massachusetts General Hospital, Department of Neurology: Mayo Clinic Jacksonville, Department of Neurology: Washington University School of Medicine, Department of Neuroscience: Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Psychotherapy: University of Tübingen, Department of Radiology: Washington University School of Medicine, Departments of Medicine Biomedicine and Clinical Research: University Hospital Basel, Division of Biostatistics: Washington University School of Medicine, Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN), Dominantly Inherited Alzheimer's Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Edith Cowan University: Western Australia, Florey Institute of Neuroscience and Mental Health: University of Melbourne, German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Germany, Harvard Medical School, Hereditary Alzheimer's Disease, Hertie Institute for Clinical Brain Research, Icahn School of Medicine at Mount Sinai (New York), Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Indiana University School of Medicine, Ludwig-Maximilians-Universität München, Macquarie University, Macquarie University (New South Wales), Massachusetts General Hospital, National Institute on Aging, National Institute on Aging (NIA), National Institute on Aging (US), Nature Medicine, Neurodegeneration Division: The Florey Institute of Neuroscience and Mental Health, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NfC), Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Neurologic Clinic and Policlinic: University Hospital Basel, Neuroscience Research Australia, Non-Invasive Biomarkers, Plasma Biomarkers, Preclinical Alzheimer's Disease, Preclinical Biomarkers and Dementia, Preclinical Biomarkers in Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, School of Medical Health and Sciences: Edith Cowan University, School of Medical Sciences: University of New South Wales, Serum Neurofilament Light Chain Protein, Switzerland, Taub Institute for Research on Alzheimer's Disease and the Aging Brain: Columbia University Medical Center, United States, University College London, University Hospital Basel, University of Basel, University of Melbourne, University of New South Wales, University of Tübingen, US National Institute on Aging, USA, Warren Alpert Medical School of Brown University, Washington University School of Medicine | Leave a comment

Dementia Research Centre in Wales (BBC News)

Posted on October 26, 2018 by Dementia and Elderly Care News

Summary A brief piece, from BBC News, on the work and aims of the £20 million Dementia Research Institute at Cardiff University. Full Text Link Reference Clarke, O. (2018). Fruit flies’ brains studied to help crack dementia. London: BBC Health … Continue reading →

Posted in BBC News, For Researchers (mostly), In the News, National, Quick Insights, UK, Universal Interest, Wales | Tagged BBC Health News, BBC Wales News, Biomarkers Research Programmes, Bioscience Careers, Brain Research Imaging Centre at Cardiff University (CUBRIC), Cardiff University, Dementia Action Plan for Wales: 2018-2022, Dementia Research, Dementia Research Careers, Dementia Research Institute (Cardiff), Dementia Research Institute (DRI), Dementia Research Institute at Cardiff University, Drosophila melanogaster, Fruit Flies, Genetic Research, Immune Pathways and Stem Cell (iPSC) Models of Neurodegenerative Disease, Immunology, Inflammation, Inflammatory Response, National Dementia Vision for Wales, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurodevelopmental Disorders: Abnormal Brain Development, Neuroinflammation, Neuroinflammation Research Cluster, Neuroscience, Research and Development, Research and Innovation, Research Careers, Research Commitment, Research Culture, Research Funding, Transgenic Drosophila, Vaughan Gething: Welsh Health Secretary, Welsh Government, Welsh Government Dementia Oversight of Implementation and Impact Group (DOIIG) | Leave a comment

Pre-Eclampsia and Risk of Dementia (BMJ)

Posted on October 24, 2018 by Dementia and Elderly Care News

Summary Danish research indicates that pre-eclampsia is associated with a subsequent increased risk of dementia in later life, particularly with vascular dementia. Full Text Link Reference Basit, S. Wohlfahrt, J. [and] Boyd, HA. (2018). Pre-eclampsia and risk of dementia later … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, Universal Interest | Tagged BMJ Publishing Group Ltd, British Medical Journal (BMJ), Cardiovascular System Disorders, Cognitive Impairment (Potential Risk Factors), Danish Civil Registration System, Dementia Risk Factors, Denmark, Department of Epidemiology Research: Statens Serum Institut, Epidemiology, Epidemiology and Statistics, Neurocognitive Disorders, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurological Disorders, Obstetrics and Gynaecology, Overlapping Risk Factors, Pre-Eclampsia, Pre-Eclampsia and Risk of Dementia, Risk Factors, Statens Serum Institut (Copenhagen), STOX1 Gene, Vascular Consequences of Pre-Eclampsia, Vascular Dementia, Vascular Risk Factors | Leave a comment

Tag Archives: Neurodegenerative Disorders

Football and Dementia Risk: Mortality From Neurodegenerative Disease Higher in Former Professional Soccer Players (BBC News / Drake Foundation / NEJM / Bazian)

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Dementia Research Centre in Wales (BBC News)

Pre-Eclampsia and Risk of Dementia (BMJ)

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