Tag Archives: Neurodegenerative Disorders

More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Summary Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia. “The researchers found that both the … Continue reading

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Cerebral Amyloid Angiopathy (JGCR)

Summary Cerebral Amyloid Angiopathy (CAA) is characterised mainly by impaired perceptual speed, episodic memory, semantic memory, attention and executive function. It has much in common with global cognitive impairment, and diagnosis may overlap with that for Alzheimer’s Disease or other … Continue reading

Posted in Depression, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading

Posted in BBC News, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Person-Centred Care, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Football and Dementia Risk: Mortality From Neurodegenerative Disease Higher in Former Professional Soccer Players (BBC News / Drake Foundation / NEJM / Bazian)

Summary The Football’s InfluencE on Lifelong health and Dementia risk (FIELD) study, based at Glasgow University and supported by The Football Association and The Professional Footballers’ Association, found that former Scottish professional football players tend to be over 3.5 times more … Continue reading

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Scotland, Statistics, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

Summary Terazosin, a drug developed originally to treat benign prostatic hyperplasia (BPH), may slow the progression of Parkinson’s Disease. It is thought that Terazosin may help by activating an enzyme (PGK1) which prevents cell death in the relevant brain regions. … Continue reading

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Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)

Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading

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More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading

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Dementia Research Centre in Wales (BBC News)

Summary A brief piece, from BBC News, on the work and aims of the £20 million Dementia Research Institute at Cardiff University. Full Text Link Reference Clarke, O. (2018). Fruit flies’ brains studied to help crack dementia. London: BBC Health … Continue reading

Posted in BBC News, For Researchers (mostly), In the News, National, Quick Insights, UK, Universal Interest, Wales | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Pre-Eclampsia and Risk of Dementia (BMJ)

Summary Danish research indicates that pre-eclampsia is associated with a subsequent increased risk of dementia in later life, particularly with vascular dementia. Full Text Link Reference Basit, S. Wohlfahrt, J. [and] Boyd, HA. (2018). Pre-eclampsia and risk of dementia later … Continue reading

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Risk of Dementia in Patients Using Antidepressants? (Behavioural Neurology / BBC News)

Summary Evidence indicating that use of antidepressants is associated significantly with an increased risk of developing dementia: Full Text Link Reference Wang, YC. Tai, PA. [and] Poly, TN. [et al] (2018). Increased risk of dementia in patients with antidepressants: a … Continue reading

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights, Systematic Reviews, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment