Tag Archives: Neurodegenerative Disorders

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

Posted on September 20, 2019 by Dementia and Elderly Care News

Summary Terazosin, a drug developed originally to treat benign prostatic hyperplasia (BPH), may slow the progression of Parkinson’s Disease. It is thought that Terazosin may help by activating an enzyme (PGK1) which prevents cell death in the relevant brain regions. … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Universal Interest | Tagged BBC Health News, Beihang University (Beijing), Beijing Advanced Innovation Center for Big Data-Based Precision Medicine: Beihang University, Beijing Institute for Brain Disorders: Capital Medical University, Bellvitge University Hospital-IDIBEL, Benign Prostatic Hyperplasia (BPH), Capital Medical University (Beijing), Carver College of Medicine: University of Iowa, Center of Regenerative Medicine in Barcelona (CMRB), Center of Stroke: Beijing Institute for Brain Disorders, China, Department of Molecular and Translational Medicine: University of Brescia, Department of Pathology and Experimental Therapeutics: Bellvitge University Hospital-IDIBELL, Departments of Pharmaceutical Care and Neurology: University of Iowa, Disease-Modifying Treatments for Parkinson's Disease, Drugs Development and Re-Purposing, Hospital Duran i Reynals, Hospitalet de Llobregat (Barcelona), Hospitalet de Llobregat and Institute of Biomedicine of the University of Barcelona (IBUB), Howard Hughes Medical Institute: University of Iowa, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institute of Hypoxia Medicine: Xuanwu Hospital, Italy, Journal of Clinical Investigation, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education (China), Loss of Dopaminergic Neurons in pars compacta of Substantia Nigra (SNpc), Networking Biomedical Research Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Neurodegenerative Disorders, Neurodegenerative Research, Off-Label Drug Repurposing Trials, Peking University, PGK1, Phosphoglycerate Kinase 1 (PGK1), Potential Repurposing of Drugs to Slow Progression of Parkinson’s Disease, Repurposing of Drugs, School of Life Sciences: Peking University, Spain, State Key Laboratory of Membrane Biology: Peking University, Substantia Nigra, Terazosin, United States, University of Brescia, University of Iowa, USA, Xuanwu Hospital (China) | Leave a comment

Time for a Complete Reset in Alzheimer’s Disease / Dementia Drugs Research: Never Too Late? (BBC News / Brain / NHS Digital)

Posted on May 1, 2019 by Dementia and Elderly Care News

Summary A new type of dementia, previously misdiagnosed as Alzheimer’s Disease, has been discovered to be prevalent in the oldest of old persons. Perhaps a third of elderly people earlier thought to have Alzheimer’s Disease may have had Limbic-predominant age-related … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Amnestic MCI, Australia, Austria, Bazian, BBC Health News, Behind the Headlines, Brain (Journal), Central Clinical School Faculty of Medicine and Health (Sydney Australia), Clinical and Neurocognitive Features of LATE, Consensus Guidelines for LATE-NC Staging, Consensus Proposed LATE-NC TDP-43 Stages, Dementia-Related Misdiagnosis, Differential Diagnosis, Drug Trials, Drug Trials Failure Rate, Emory University (Atlanta), FTLD-TDP: Frontotemporal Lobar Degeneration With TDP-43 Proteinopathy, Harvard University, Hippocampal Atrophy, Illinois Institute of Technology, Institute of Neurology: Medical University of Vienna, Japan, LATE Biomarkers, LATE Neuropathological Change (LATE-NC), LATE Working Group, Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), Mayo Clinic (Jacksonville), Mayo Clinic: Rochester, Medical University of Vienna, Misdiagnosis, Misdiagnosis (Potential), Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuropathology, Neuropathology in FTLD-tau and FTLD-TDP, Newcastle University, NHS Digital (Formerly NHS Choices), Oldest Old, Oldest Old Age, Oldest People With Dementia, Prevalence of Dementia in Oldest Old, Public Health Impact of LATE, Recommendations for Routine Autopsy Evaluation and Classification of LATE-NC, Rush University Medical Center, Stanford University, Subtypes of Dementia, Sweden, TDP-43 Protein, TDP-43 Proteinopathy, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, United States, University of California, University of Cambridge, University of Kentucky, University of Minnesota, University of Pennsylvania, University of Southern California, University of Sydney Brain and Mind Centre, University of Texas Southwestern Medical Center, University of Washington, Uppsala University, USA | Leave a comment

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Posted on January 28, 2019 by Dementia and Elderly Care News

Summary People with a rare hereditary form of Alzheimer’s Disease (Dominantly Inherited Alzheimer’s Disease) have raised levels of a protein called neurofilament light chain (NfC) in their blood, arising from damage to previously healthy nerve cells. These elevated levels of … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged APP or PSEN Mutations, Australia, Basel, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Columbia University Medical Center, Dementia Research Centre, Dementia Research Centre: University College London, Department of Biomedical Sciences: Macquarie University, Department of Cellular Neurology: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration: Queen Square Institute of Neurology, Department of Neurology: Columbia University Medical Center, Department of Neurology: Keck School of Medicine at USC, Department of Neurology: Ludwig-Maximilians-Universität München, Department of Neurology: Massachusetts General Hospital, Department of Neurology: Mayo Clinic Jacksonville, Department of Neurology: Washington University School of Medicine, Department of Neuroscience: Icahn School of Medicine at Mount Sinai, Department of Psychiatry and Psychotherapy: University of Tübingen, Department of Radiology: Washington University School of Medicine, Departments of Medicine Biomedicine and Clinical Research: University Hospital Basel, Division of Biostatistics: Washington University School of Medicine, Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN), Dominantly Inherited Alzheimer's Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Edith Cowan University: Western Australia, Florey Institute of Neuroscience and Mental Health: University of Melbourne, German Center for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Germany, Harvard Medical School, Hereditary Alzheimer's Disease, Hertie Institute for Clinical Brain Research, Icahn School of Medicine at Mount Sinai (New York), Indiana Alzheimer Disease Center and Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Indiana University School of Medicine, Ludwig-Maximilians-Universität München, Macquarie University, Macquarie University (New South Wales), Massachusetts General Hospital, National Institute on Aging, National Institute on Aging (NIA), National Institute on Aging (US), Nature Medicine, Neurodegeneration Division: The Florey Institute of Neuroscience and Mental Health, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofilament Light Chain (NfC), Neurofilament Light Chain (NFL), Neurofilament Light Protein (NF-L), Neurofilament Light Protein in Blood: Potential Biomarker of Neurodegeneration, Neurologic Clinic and Policlinic: University Hospital Basel, Neuroscience Research Australia, Non-Invasive Biomarkers, Plasma Biomarkers, Preclinical Alzheimer's Disease, Preclinical Biomarkers and Dementia, Preclinical Biomarkers in Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, School of Medical Health and Sciences: Edith Cowan University, School of Medical Sciences: University of New South Wales, Serum Neurofilament Light Chain Protein, Switzerland, Taub Institute for Research on Alzheimer's Disease and the Aging Brain: Columbia University Medical Center, United States, University College London, University Hospital Basel, University of Basel, University of Melbourne, University of New South Wales, University of Tübingen, US National Institute on Aging, USA, Warren Alpert Medical School of Brown University, Washington University School of Medicine | Leave a comment

Dementia Research Centre in Wales (BBC News)

Posted on October 26, 2018 by Dementia and Elderly Care News

Summary A brief piece, from BBC News, on the work and aims of the £20 million Dementia Research Institute at Cardiff University. Full Text Link Reference Clarke, O. (2018). Fruit flies’ brains studied to help crack dementia. London: BBC Health … Continue reading →

Posted in BBC News, For Researchers (mostly), In the News, National, Quick Insights, UK, Universal Interest, Wales | Tagged BBC Health News, BBC Wales News, Biomarkers Research Programmes, Bioscience Careers, Brain Research Imaging Centre at Cardiff University (CUBRIC), Cardiff University, Dementia Action Plan for Wales: 2018-2022, Dementia Research, Dementia Research Careers, Dementia Research Institute (Cardiff), Dementia Research Institute (DRI), Dementia Research Institute at Cardiff University, Drosophila melanogaster, Fruit Flies, Genetic Research, Immune Pathways and Stem Cell (iPSC) Models of Neurodegenerative Disease, Immunology, Inflammation, Inflammatory Response, National Dementia Vision for Wales, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurodevelopmental Disorders: Abnormal Brain Development, Neuroinflammation, Neuroinflammation Research Cluster, Neuroscience, Research and Development, Research and Innovation, Research Careers, Research Commitment, Research Culture, Research Funding, Transgenic Drosophila, Vaughan Gething: Welsh Health Secretary, Welsh Government, Welsh Government Dementia Oversight of Implementation and Impact Group (DOIIG) | Leave a comment

Pre-Eclampsia and Risk of Dementia (BMJ)

Posted on October 24, 2018 by Dementia and Elderly Care News

Summary Danish research indicates that pre-eclampsia is associated with a subsequent increased risk of dementia in later life, particularly with vascular dementia. Full Text Link Reference Basit, S. Wohlfahrt, J. [and] Boyd, HA. (2018). Pre-eclampsia and risk of dementia later … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, Universal Interest | Tagged BMJ Publishing Group Ltd, British Medical Journal (BMJ), Cardiovascular System Disorders, Cognitive Impairment (Potential Risk Factors), Danish Civil Registration System, Dementia Risk Factors, Denmark, Department of Epidemiology Research: Statens Serum Institut, Epidemiology, Epidemiology and Statistics, Neurocognitive Disorders, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurological Disorders, Obstetrics and Gynaecology, Overlapping Risk Factors, Pre-Eclampsia, Pre-Eclampsia and Risk of Dementia, Risk Factors, Statens Serum Institut (Copenhagen), STOX1 Gene, Vascular Consequences of Pre-Eclampsia, Vascular Dementia, Vascular Risk Factors | Leave a comment

Risk of Dementia in Patients Using Antidepressants? (Behavioural Neurology / BBC News)

Posted on October 23, 2018 by Dementia and Elderly Care News

Summary Evidence indicating that use of antidepressants is associated significantly with an increased risk of developing dementia: Full Text Link Reference Wang, YC. Tai, PA. [and] Poly, TN. [et al] (2018). Increased risk of dementia in patients with antidepressants: a … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights, Systematic Reviews, Universal Interest | Tagged Anti-Depressant Drugs, Antidepressant Prescriptions in England, Antidepressants, Antidepressants and Risk of Dementia, BBC Health News, Behavioural Neurology (Journal), Buddhist Tzu Chi University (Hualien Taiwan), Cognitive Impairment (Potential Risk and Protective Factors), Cognitive Impairment (Potential Risk Factors), College of Medical Science and Technology: Taipei Medical University, Dementia Prevention, Dementia Risk Factors, Dementia Risk Reduction and Prevention, Department of Dermatology: Wan Fang Hospital, Department of Emergency: Min-Sheng General Hospital, Department of Surgery: Buddhist Tzu Chi University, Epidemiology, Epidemiology and Statistics, Graduate Institute of Biomedical Informatics: Taipei Medical University, Min-Sheng General Hospital (Taoyuan City Taiwan), Modifiable Risk Factors, Mono-Amine Oxidase Inhibitors (MAOIs), Monoamine-Oxidase B Inhibitors, Neurocognitive Disorders, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Overlapping Risk Factors, Prevention, Prevention Agenda, Prevention of Dementia, Primary and Secondary Prevention of Dementia, Risk Factors, School of Medicine: Buddhist Tzu Chi University, Selective Serotonin Reuptake Inhibitors (SSRIs), SSRIs: Selective Serotonin Reuptake Inhibitors, Systematic Reviews and Meta-Analyses, Taipei Medical University, Taiwan, TMU Research Center of Cancer Translational Medicine (Taipei Taiwan), Tricyclic Antidepressants, Tricyclics (TCAs), Wan Fang Hospital (Taipei Taiwan) | Leave a comment

Hallucinations and Delusions in Dementia With Lewy Bodies (Behavioural Neurology)

Posted on October 13, 2018 by Dementia and Elderly Care News

Summary Hallucinations and delusions are common in Dementia with Lewy Bodies (DLB). A study shows that DLB patients who experience delusional symptoms tend to have poorer cognitive function and more severe BPSD. Oddly, DLB patients with diabetes appear to be less … Continue reading →

Posted in For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, Universal Interest | Tagged Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Behavioural Neurology (Journal), China Medical University Hospital, China Medical University Hospital (Taiwan), Cognitive Symptoms, Delusions, Delusions and Other Neuropsychiatric Symptoms, Delusions of Other Persons Stealing, Dementia With Lewy Bodies (DLB), Department of Internal Medicine: China Medical University Hospital, Department of Neurology: Show Chwan Memorial Hospital, Department of Neurology: Tainan Municipal Hospital, Division of Endocrinology and Metabolism: China Medical University Hospital, DLB, DLB Comorbid With Diabetes, DLB Patients With Diabetes, DLB: Dementia with Lewy Bodies, Family Plans to Abandon Him / Her (Delusional), Fluctuating Cognition, Fluctuations, Hallucinations, Hallucinations and Delusions in Dementia With Lewy Bodies, House Not His / Her Home (Delusional), Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Media Persons in House (Delusional), Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neuropsychiatric Disturbances, Neuropsychiatric Symptoms, Other Persons Stealing (Delusional), Others Not Whom They Claim (Delusional), Parkinsonism, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, Self in Danger (Delusional), Show Chwan Medical Care Corporation, Show Chwan Memorial Hospital (Taiwan), Spouse Having Affair (Delusional), Tainan Municipal Hospital (Taiwan), Taiwan, Unwelcome Guest in House (Delusional), Visual Hallucinations | Leave a comment

Tag Archives: Neurodegenerative Disorders

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

More on Possible Blood Tests for Pre-Symptomatic Alzheimer’s Disease (NHS Digital / Nature Medicine)

Dementia Research Centre in Wales (BBC News)

Pre-Eclampsia and Risk of Dementia (BMJ)

Risk of Dementia in Patients Using Antidepressants? (Behavioural Neurology / BBC News)

Hallucinations and Delusions in Dementia With Lewy Bodies (Behavioural Neurology)

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