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Tag Archives: Novel Targets in Neurodegeneration
Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)
Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, National, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Abnormal Proteins (Tau), Alzheimer’s Disease, Amyloid and Tau Imaging, Atomic Structure of Tau Filaments, BBC Health News, Behind the Headlines, Cryo-Electron Microscopy (Cryo-EM), Cryo-EM Structures of PHFs and SFs, Cryo-EM Structures of Tau Filaments, Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Drug Trials Failure Rate, European Union, Indiana University, Indiana University School of Medicine, Laboratory of Molecular Biology (LMB) Neuroscience Division, Medical Research Council (MRC), Misfolded Proteins, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology (LMB), MRC Laboratory of Molecular Biology: Cambridge, MRC: Medical Research Council, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Research, Neurofibrillary Tangles, Neurofibrillary Tangles (NFTs), Neuropathologic Disorders, Neuropathology, Novel Targets in Neurodegeneration, Paired Helical Filaments (PHFs) and Straight Filaments (SFs), Protein Misfolding, Protofilament Interface in PHFs and SFs, Tau, Tau Aggregation, Tau Filaments, Tau Pathogenesis, Tau Pathology, Tau Protein, Tauopathy, Ultrastructural Polymorphs, United States, US National Institutes of Health, USA
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Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)
Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading
Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA
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Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)
Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading
Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK
Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton
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Brain and Immune System: Not Unconnected? (NHS Choices / Nature)
Summary Researchers have discovered previously unsuspected lymphatic vessels in the outer layers of the brain. The brain and central nervous system were not previously thought to be connected to the lymphatic system, so this discovery may pave the way for … Continue reading
Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Behind the Headlines, Brain and Immune System, Carter Center for Immunology Research: University of Virginia, CCN3, Center for Brain Immunology and Glia: University of Virginia, Central Nervous System Lymphatic Vessels, Cerebrospinal Fluid, Cerebrospinal Fluid (CSF), Department of Cell Biology: University of Virginia, Department of Microbiology Immunology and Cancer Biology: University of Virginia, Department of Neuroscience: University of Virginia, Department of Pathology (Neuropathology): University of Virginia, Dr Denise Fitzgerald: Queen's University Belfast, Fondation pour la Recherche Médicale, Immune System, Inflammation, Lymph Drainage, Lymphatic Drainage System, Lymphatic System, Lymphatic Vasculature in Central Nervous System, Medical Scientist Training Program, Meninges, Multiple Sclerosis, Myelin Regeneration, Myelin Repair, National Institutes of Health (NIH), National Institutes of Health (US), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroimmunology, Neuroinflammation, Neuroinflammatory and Neurodegenerative Diseases, NHS Digital (Previously NHS Choices), Novel Targets in Neurodegeneration, Regenerative Capacity, School of Medicine: University of Virginia, Transverse Myelitis, University of Virginia, USA, White Blood Cells: T-Regulatory Cells
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Possible Link Between Alzheimer’s Disease and Schizophrenia? (BBC News / PNAS)
Summary A “weak spot” in the brain, which may be play some common role(s) underlying both Alzheimer’s Disease and schizophrenia, appears to have been identified using functional Magnetic Resonance Imaging (fMRI) brain scans. The brain area in question has been … Continue reading
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Mental Health, Quick Insights, UK, Universal Interest
Tagged BBC Health News, Brain Scans, Bristol Brain Bank, California Verbal Learning Test (CVLT), Dementia Praecox (Old Medical Nomeclature), Dementia Praecox (Premature Dementia or Precocious Madness), Department of Neurology: University Hospital Mannheim, Division of Brain Sciences: Imperial College London, Division of Mental Health and Addiction: Oslo University Hospital, Felix Platter-Hospital (Basel), fMRI, Functional Magnetic Resonance Imaging (fMRI), Functional Magnetic Resonance Imaging of the Brain (FMRIB) Centre: University of Oxford, Genetic Risk Factors, Germany, Heidelberg, Human Connectome Project (HCP), Human Connectome Project (HCP) Consortium, Imperial College London, Induced Pluripotent Stem Cells (iPSCs), Institute of Psychiatry Psychology and Neuroscience at King's College London, John Radcliffe Hospital, KG Jebsen Centre for Psychosis Research: Oslo University Hospital, Kings College London, Medical Research Council (MRC), Medical Research Council's Laboratory of Molecular Biology, Memory Clinic: University Center for Medicine of Aging Basel, MRC: Medical Research Council, MRI Brain Imaging, MRI Scans, Neural Networks, Neurodegeneration, Neurodegenerative Diseases, Neurodegenerative Research, Neuroimaging, Neuroimaging in Dementia Diagnosis, Neuroimaging of Dementia, Neuroimaging of Neuropsychiatric Disorders (Human Connectome Project), Neuroscience, Norway, Norwegian Centre for Mental Disorders Research (NORMENT): Oslo University Hospital, Novel Targets in Neurodegeneration, Nuffield Department of Clinical Neurosciences: University of Oxford, Organoids (Madeline Lancaster), Oslo, PNAS, Potential Link Between Alzheimer's Disease and Schizophrenia, Premature Dementia (Old Medical Nomeclature), Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Professor Ed Bullmore: Head of Psychiatry at University of Cambridge, Professor Ed Bullmore: Vice-President of ImmunoPsychiatry at GSK, Research Group for Life-Span Changes in Brain and Cognition: University of Oslo, Schizophrenia, Switzerland, UK Brain Banks Network, UK Medical Research Council's Laboratory of Molecular Biology, University Center for Medicine of Aging Basel: Felix Platter-Hospital, University College London, University College London (UCL), University Hospital Mannheim, University of Cambridge, University of Heidelberg, University of Oslo, University of Oxford, Wechsler Abbreviated Scale of Intelligence (WASI)
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Dementia Consortium (Alzheimer’s Research UK)
Summary The Dementia Consortium has been established to fund academic dementia research experts from the UK and overseas in their efforts to develop early research findings concerning Alzheimer’s Disease, and other forms of dementia, into validated drug targets. “The Dementia … Continue reading
Posted in Alzheimer’s Research UK, Charitable Bodies, For Doctors (mostly), For Researchers (mostly), International, Pharmacological Treatments, Quick Insights, UK
Tagged ARUK: Alzheimer’s Research UK, Big Pharma, Collaboration, Collaborative Drug Discovery Programmes, Collaborative Projects, Dementia Consortium, Dementia Research, Dementia Research Priorities, Drug Discovery Programmes, Drug Identification, Drug Target Validation, Eisai Ltd, Eli Lilly, Fast-Tracking New Potential Treatments, Justin Bryans: MRC Technology, Lilly, MRC Technology, MRC Technology (Independent Life Science Technology Transfer Charity), MRCT: MRC Technology, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, New Drug Applications (NDAs), Novel Targets in Neurodegeneration, Pharmaceutical Industry, Pharmacological Research, Pharmacological Treatments, Pharmacotherapy, Pre-Competitive Collaboration, Technology Transfer, Translational Research
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