Tag Archives: Novel Targets in Neurodegeneration

Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Posted on July 6, 2017 by Dementia and Elderly Care News

Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, National, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Abnormal Proteins (Tau), Alzheimer’s Disease, Amyloid and Tau Imaging, Atomic Structure of Tau Filaments, BBC Health News, Behind the Headlines, Cryo-Electron Microscopy (Cryo-EM), Cryo-EM Structures of PHFs and SFs, Cryo-EM Structures of Tau Filaments, Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Drug Trials Failure Rate, European Union, Indiana University, Indiana University School of Medicine, Laboratory of Molecular Biology (LMB) Neuroscience Division, Medical Research Council (MRC), Misfolded Proteins, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology (LMB), MRC Laboratory of Molecular Biology: Cambridge, MRC: Medical Research Council, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Research, Neurofibrillary Tangles, Neurofibrillary Tangles (NFTs), Neuropathologic Disorders, Neuropathology, Novel Targets in Neurodegeneration, Paired Helical Filaments (PHFs) and Straight Filaments (SFs), Protein Misfolding, Protofilament Interface in PHFs and SFs, Tau, Tau Aggregation, Tau Filaments, Tau Pathogenesis, Tau Pathology, Tau Protein, Tauopathy, Ultrastructural Polymorphs, United States, US National Institutes of Health, USA | Leave a comment

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Posted on June 23, 2017 by Dementia and Elderly Care News

Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading →

Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA | Leave a comment

European Medicines Agency Consultation on Pharmacological Treatments for Dementia (EMA)

Posted on February 3, 2016 by Dementia and Elderly Care News

Summary The European Medicines Agency (EMA) has released an updated draft guideline on medicines for the treatment of Alzheimer’s Disease and other types of dementia, for consultative feedback. Full Text Link Reference Consultation on revised guideline on medicines to treat … Continue reading →

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Posted on January 10, 2016 by Dementia and Elderly Care News

Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading →

Posted in Alzheimer’s Research UK, Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK | Tagged APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Brain and Immune System, Brain Inflammation, Brain: a Journal of Neurology, Centre for Biological Sciences: University of Southampton, Colony-Stimulating Factor 1 Receptor (CSF1R), CSF1R Inhibition in Models of Alzheimer's Disease, CSF1R Receptor, CSF1R-Dependent Pro-Mitogenic Cascade, CSF1R-Inhibition Strategies, Dementia Consortium, Division of Biomedical and Life Sciences: Lancaster University, Faculty of Health and Medicine: Lancaster University, Genetically Engineered Mice, GW2580, Immune Suppression, Immune System, Improved Performance in Memory and Behavioural Tasks, Inflammation, Institute for Life Sciences: University of Southampton, Lancaster, Lancaster University, Medical Research Council (MRC), Mice, Microglia, Microglial Multiplication, Microglial Proliferation, Modification of CSF1R Activation to Reduce Microglial Activation, Mouse Model of Alzheimer's Disease, MRC New Investigator Research Grant (NIRG), MRC: Medical Research Council, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Disorders, Neuroimmunology, Neuroinflammation, Novel Targets in Neurodegeneration, Pharmacological Targeting of CSF1R, Prevention of Synaptic Degeneration, Southampton, Transgenic Mice, Tyrosine Kinase Inhibitor (GW2580), University of Southampton | Leave a comment

Brain and Immune System: Not Unconnected? (NHS Choices / Nature)

Posted on June 15, 2015 by Dementia and Elderly Care News

Summary Researchers have discovered previously unsuspected lymphatic vessels in the outer layers of the brain. The brain and central nervous system were not previously thought to be connected to the lymphatic system, so this discovery may pave the way for … Continue reading →

Frontotemporal Dementia: Basic Disease Processes Uncovered? (Alzheimer’s Society / Journal of Cell Biology)

Posted on April 1, 2015 by Dementia and Elderly Care News

Summary Researchers studying the connections between neurons in fruit flies may have identified mechanisms which are involved neurodegeneration in Frontotemporal Dementia (FTD). FTD affects the frontal and temporal lobes (in human brains). A protein called CHMP2B can cause neuronal connections … Continue reading →

Posted in Alzheimer's Society, Animal Studies, Charitable Bodies, For Doctors (mostly), For Researchers (mostly), International, Quick Insights, UK, Universal Interest | Tagged Activator Protein-1), Age-Related Neurodegenerative and Neurovascular Diseases, c-Jun N-terminal kinase (JNK), CHMP2B, Disease Modifying Treatment by 2025 (Aim), Drosophila melanogaster, Endosomal JNK-Scaffold POSH (Plenty-of-SH3s), ESCRT-III Dysfunction, Frontotemporal Dementia, Frontotemporal Dementia (FTD), Fruit Flies, Fruit Fly Model of Frontotemporal Dementia, JCB: Journal of Cell Biology, Journal of Cell Biology, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neurology, Novel Targets in Neurodegeneration, Pick’s Disease (Frontotemporal Dementia), POSH (Plenty-of-SH3s), Potential Drug Targets, RAB8 Deficiency, Rab8 POSH and TAK1 (Regulation of Synaptic Growth), RAB8 Protein, Synaptic Overgrowth and Endosomal Dysfunction, Transgenic Drosophila | Leave a comment

Big Data Portal for Alzheimer’s Dementia Drug Discovery (NIH / Synapse AMP-AD)

Posted on March 8, 2015 by Dementia and Elderly Care News

Summary The National Institutes of Health (NIH) in the USA has opened a public-private partnership online resource to facilitate neurodegenerative research and drug development. The launch of the Alzheimer’s Big Data Portal provides an open-source “public knowledge portal” for the … Continue reading →

Posted in Charitable Bodies, For Doctors (mostly), For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights | Tagged Academia-Industry Partnerships, Academia-Industry Synergies, Accelerating Alzheimer's Research and Drug Development, Accelerating Medicine Partnership for Alzheimer's Disease (NIA-AMP AD) Target Discovery and Preclinical Validation Project, Accelerating Medicines Partnership (AMP), Accelerating Medicines Partnership-Alzheimer's Disease (AMP-AD), Alfred P. Sloan Foundation, Alzheimer’s Disease Biomarkers, Alzheimer’s Disease Cooperative Study, Alzheimer’s Disease Neuroimaging Initiative (ADNI), AMP-AD Program, Big Data, Big Data Portal for Alzheimer’s Dementia Drug Discovery, Big Pharma, Biomarkers, Biopharmaceutical Companies, Broad Institute of MIT and Harvard, Collaboration, Collaborative Drug Discovery Programmes, Collaborative Projects, Cross-Sector Partnerships, Dementia Research, Drug Development for Alzheimer's Disease, Drug Discovery Programmes, Drug Identification, Drug Target Validation, Drug-Development Pipeline, Drugs for Treatment of Alzheimer’s Disease, Emory University, Foundation for the NIH (FNIH), Genetic Research, Genetic Testing, Genetic Triggers, Genetics of Alzheimer's Disease, Global Open Data Initiative, Human Epigenome Atlas, Icahn School of Medicine at Mount Sinai, Institute for Systems Biology (Seattle), International Alzheimer's Disease Research Portfolio (IADRP), International Collaborations, International Organisations, International Programmes, Market Failure (Dementia Research and Drug Development), Mayo Clinic in Jacksonville, Medical Research, Multidisciplinary Research Teams, National Institutes of Health (NIH), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, NIA Genetics of Alzheimer’s Data Storage Site (NIAGADS), NIH Big Data to Knowledge (BD2K) Initiative, NIH Network for Excellence in Neuroscience Clinical Trials, Non-Profit Collaborations, Novel Targets in Neurodegeneration, Open Data, Open Data and Big Data, Open Data in Health and Social Care, Open Data Learning Capacity and Culture, Open Data: Unlocking Innovation, Open Source Solutions, Pharmaceutical Industry, Pharmacological Research, Potential of Open Data in Health and Social Care, Pre-Competitive Collaboration, Precision Medicine Initiative, Preclinical Biomarkers in Alzheimer's Disease, Public-Private Partnership (PPP), Public-Private Partnerships, Research and Development, Research and Innovation, Research Commitment, Research Consortia, Research Culture, Research Networks, Research Programmes, Roadmap Epigenomics Project, Rush University Medical Center: Chicago, Sage Bionetworks, Synapse, Synapse Access and Compliance Team, Target Discovery and Preclinical Validation, Technology Transfer, Temporal Evolution of Alzheimer’s Disease Biomarkers, Therapeutic Target(s): Identification, Translational Research, Transparency and Open Data, United States, University of California, University of Florida, US National Institute of Aging, US National Institutes of Health (NIH), USA | Leave a comment

Tag Archives: Novel Targets in Neurodegeneration

Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

European Medicines Agency Consultation on Pharmacological Treatments for Dementia (EMA)

Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Brain and Immune System: Not Unconnected? (NHS Choices / Nature)

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