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Tag Archives: Prion Diseases
Possible Future Treatment of CJD? (BBC News)
Summary University College London Hospitals NHS Foundation Trust (UCLH)’s National Prion Clinic has been granted the go-ahead to test the use of a man-made antibody treatment (PRN100), with a view to halting or slowing the progression of sporadic CJD. “We … Continue reading
Posted in Acute Hospitals, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Management of Condition, Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Prions), BBC Health News, Creutzfeldt-Jakob Disease, Creutzfeldt-Jakob Disease (CJD), Medical Research Council Prion Unit, Misfolded Prion Protein (PrP), MRC Prion Unit, National Care Team (CJD), National Hospital for Neurology and Neurosurgery: University College London Hospitals NHS Foundation Trust, National Prion Clinic, National Prion Clinic: University College London Hospitals NHS Foundation Trust, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS National Prion Clinic (NPC) in London, Prion Diseases, Prion Protein, PRN100, Rare Prion Diseases, Sporadic CJD, sporadic Creutzfeldt-Jakob Disease (sCJD), UCLH: University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust (UCLH): National Prion Clinic
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Pollution of All Types: A Broad Review of the Health Implications (Department of Health / BBC News)
Summary The Chief Medical Officer’s latest annual report summarises the latest emerging evidence about all types of pollution. The press release talks of four main topics: Pollution arising from healthcare. Pollution and health inequalities. Emerging pollution-related issues. Pollution measurement and … Continue reading
Posted in Acute Hospitals, BBC News, Community Care, Department of Health, Department of Health and Social Care (DHSC), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Integrated Care, National, NHS, Quick Insights, Standards, Statistics, Systematic Reviews, UK, Universal Interest
Tagged Air Pollution, Air Pollution and Public Health, Air Pollution and Risk of Dementia, Air Pollution Cost for Health, Air Pollution Costs, Air Pollution Economic Cost on Public Health, Air Pollution in the UK, Air Quality, Air Quality Abatement, Airborne Particulate Matter, Annual Report of the Chief Medical Officer 2017: Health Impacts of All Pollution, Avoidable Use of Catering Plastics: Straws Stirrers Cutlery Plates and Cups, BBC Health News, BBC Science and Environment News, Behaviour Change Theory, Big Data on Environmental Pollution, Bioaerosols, Biocides, Biological Changes and Apical Outcomes, Biological Pollutants, Biomarkers, Bisphenols and Phthalates, Blue Light, Burden of Disease From Pollutants, Carbon Nanotubes (CNTs), Catering Plastic, Catering Plastic: NHS Usage Reduction Pledge, Chemical Substances of Unknown or Variable Composition (UVCBs), Chief Medical Officer: Professor Dame Sally Davies, City of York Council, CleanSpace Monitoring, CleanSpace Tags, Committee on the Medical Effects of Air Pollutants (COMEAP), Communicating Complexity, Communication About Mortality Effects, Contaminated Land, Cost and Benefits of Air Quality, Department of Epidemiology and Biostatistics: Imperial College London, Department of Geology and Environmental Sciences: State University of New York in Fredonia, Department of Health Datasets, Dioxins and Polychlorinated Biphenyls (PCBs), Economic Consequences of Air Pollution, Economic Cost of Air Pollution on Health, Economic Cost of Pollution Impact on Health, Economic Valuation of Air Pollution, Endocrine-Disrupting Chemicals (EDCs), Environment Agency, Environmental and Health Service Pollution, Environmental Hazards and Emergencies Department: Public Health England, Environmental Health Professionals (EHPs), Environmental Justice, Environmental Public Health Tracking (EPHT), Environmental Risk Factors, Environmental Surveillance, Epidemiology, Epidemiology and Statistics, European Human Biomonitoring Initiative (HBM4EU), Exeter Medical School, Exeter Medical School: University of Exeter, Exposure to Fine Particulate Matter, Faculty of Health and Medicine: University of Lancaster, Flame Retardants (FR), Greenhouse Gases (GHG) in Healthcare, Health and Occupation Research (THOR) Surveillance Network, Health Based Economic Assessment of Air Pollution, Health Cost of Pollution, Health Data Research UK (HDR UK), Health Datasets, Health Economic Cost of Pollution, Health Impact of Pollution, Health Impacts of Air Pollution, Health Impacts of All Pollution, Health Inequalities, Health Pollution Cost, Helen Bird: Sustainability Charity WRAP (the Waste and Resources Action Programme), Imperial College Business School, Imperial College London, Indoor Air Pollution, Infection Control of CJD vCJD and Other Human Prion Diseases in Healthcare and Community Settings, International Agency for Research on Cancer (IARC), Intrinsically Photosensitive Retinal Ganglion Cells (iPRGCs), King’s College London, Lancaster Environment Centre: University of Lancaster, Lead Pollution, Light Pollution, Liveable Cities Perspective From London and Birmingham Dwellers, London Air Quality Network (LAQN), Long-Term Exposure to Ambient Air Pollution, Low Emission Strategy (LES), Magnetite (Iron Oxide Particles), Magnetite From Air Pollution, Magnetite Pollution Nanoparticles, Magnetite Pollution Particles, Microplastics, Microplastics in Bottled Water, Modifiable Risk Factors, MRC-PHE Centre for Environment and Health: Imperial College London, Nanomaterials (NMs), Nanoscale Magnetite, National Health and Nutrition Examination Survey (NHANES), Noise Pollution, Nottinghamshire Healthcare NHS Foundation Trust, Occupational Exposures, One Planet York Initiative, Open University, Orb Media, Outdoor Air Quality and Health, Overlapping Risk Factors, Particulate Matter, Perfluorinated Chemicals (PFCs), Pesticides, Pharmaceutical Pollution in England, Pharmaceutical Supply Chain Initiative (PSCI), Plastic Particles (Microplastics), Plastic Pollution, Pollution and Inequality, Pollution and Public Health, Pollution Assessment, Pollution in Health and Care, Pollution Inequalities, Pollution Interventions, Pollution Linked to One Sixth of Deaths, Pollution Measurement, Pollution of All Types, Pollution Surveillance, Polycyclicaromatic Hydrocarbons (PAHs), Potentially Modifiable Socio-Environmental Risk Factors, Potentially Modifiable Socio-Environmental Risk Factors for Dementia, Precautionary Principle, Prion Diseases, Professor Dame Sally Davies, Professor Dame Sally Davies: the Chief Medical Officer (CMO) for England, Public Health, Public Health and Health Improvement, Public Health England, Public Understanding of Risk: University of Cambridge, Radioactive Particles, Rapid Inquiry Facility (RIF), RecoMed: Helping Hospitals to Recycle PVC and Save Costs, Reducing Health Inequalities, Risks From Waste Sites, Ruth May: Chief Nursing Officer for England, School of Public Health: Imperial College London, Severe Flooding, Single-Use Catering Plastic Items, SIRUM: Saving Medicine - Saving Lives, Social Cost of Air Pollution, Societal and Environmental Impact of Pollution, Societal Cost of Air Pollution, Socio-Environmental Risk Factors, Soil Contamination, Solar-Assisted Large-Scale Cleaning System (SALSCS), State University of New York in Fredonia, Stockholm Convention on Persistent Organic Pollutants, Sustainable Development Management Plan (SDMP), Synthetic Polymer Contamination in Bottled Water, Trihalomethanes (THMs) in Drinking Water, UK Small Area Health Statistics Unit (SAHSU), UN’s Intergovernmental Panel on Climate Change (IPCC), University College London, University of Birmingham, University of Cambridge, University of Glasgow, University of Staffordshire, Unknown or Variable Composition Complex Reaction Products or Biological Materials (UVCB), Vehicular Pollution, Waste and Resources Action Programme (WRAP), West Midlands Deanery, World Health Organization’s International Agency for Research on Cancer (IARC), Yancheng Science Park: Jiangsu Province
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Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)
Summary Further evidence points to a theoretical risk of Alzheimer’s Disease being potentially transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). Full Text Link Reference New clues that Alzheimer’s may have been spread during surgery. London: NHS … Continue reading
Posted in Acute Hospitals, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease Contracted Via Brain Surgery, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Austria, Behind the Headlines, Brain Parenchymal Aβ Plaques, Cleaning and Decontamination, Congophilic Amyloid Angiopathy, Contaminated Surgical Instruments, Decontamination of Surgical Instruments, Dural Grafting, Human Transmission of Aβ, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Institute of Neurology: Medical University Vienna, Institute of Neuropathology: University Hospital Zurich, Medical University Vienna, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Surgical Transmission of Prions, Swiss Medical Weekly, Switzerland, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible Spongiform Encephalopathy Agents: General Principles of Decontamination and Waste Disposal, University Hospital Zurich
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Potential Risk of Alzheimer’s Disease Transmission (BBC News / NHS Choices / Nature / MRC)
Summary There may be a theoretical risk of Alzheimer’s Disease being transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). This hypothesis has arisen as a result of the examination of the brains of eight patients who had … Continue reading
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease and Blood Transfusion, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-Beta Deposition in APP Transgenic Mice, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Behind the Headlines, Brain Deposition of Amyloid, Brain-Derived Human Growth Hormone (HGH), Cadaver-Derived Growth Hormone, Cerebral Amyloid Angiopathy, Coexistence of Alzheimer-Type Neuropathology in Creutzfeldt-Jakob Disease, Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Contaminated Surgical Instruments, Contamination of Injections, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, Decontamination of Surgical Instruments, Department of Neurodegenerative Disease: UCL Institute of Neurology, Exogenous Induction of Cerebral β-Amyloidogenesis, Grey Matter and Vascular Amyloid-β (Aβ) Pathology, Human Pituitary-Derived Growth Hormone, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract, Medical Research Council, Medical Research Council (MRC), Medical Research Council Prion Unit, Misfolded Proteins, MRC Clinical Trials Unit at University College London, National Institute of Health Research (NIHR), National Prion Clinic: National Hospital for Neurology and Neurosurgery, National Prion Monitoring Cohort Study, Nature, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Neuropathologic Assessment of Alzheimer’s Disease, NHS National Prion Clinic (NPC) in London, Peripheral Administration of Tau Aggregates Triggers Intracerebral Tauopathy in Transgenic Mice, Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Seeded β-Amyloid in APP Transgenic Mice, Surgical Transmission of Prions, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible and Non-Transmissible Amyloidoses, UCLH / UCL Biomedical Research Centre, UCLH / UCL Dementia Biomedical Research Unit, University College London (UCL)
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Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)
Summary A natural human mutation (called V127) in the gene encoding prion protein may offer resistance to CJD. A study using mice with this genetic mutation appears to confirm resistance to prion diseases. This finding may in future help in … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Prions), BBC Health News, Behind the Headlines, Bovine Spongiform Encephalopathy (BSE), Brain-Eating Cannibals (Mortuary Feasts), CJD, Colorado State University, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Department of Neurodegenerative Disease: UCL Institute of Neurology, Evolved Protection Against Human Prions, Familial or Inherited CJD, Fore People (Tribe in Papua New Guinea), Kuru, M129V, Mad Cow Disease, Medical Research Council (MRC), Mice With Prion Disease Similar to Cruetzfeldt-Jakob Disease (CJD), Misfolded Prion Protein (PrP), Misfolded Proteins, MRC Prion Unit, MRC Prion Unit: UCL Institute of Neurology, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroprotection, Neuroprotection Research, Papua New Guinea, Papua New Guinea Institute of Medical Research, Prion Diseases, Prion Protein, Prion Protein (PrP) Variant G127V, Prion Protein Gene, Prion Research Center: Colorado State University, Prion-Infected Mice, Prof John Collinge: Medical Research Council's Prion Unit at University College London, Protective Prion Protein Variant, Sporadic CJD, Transgenic Mice, UCL Institute of Neurology, United States, University College London (UCL), USA, V127 Gene: Resistance to Prion Diseases, Variant CJD, vCJD Infection
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Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)
Summary Coinciding with Parkinson’s Awareness Week 2015 (April 20th – 26th 2015), the following Lancet review / seminar covers the clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis and treatment of Parkinson’s Disease. Full Text Link (Note: This article requires … Continue reading
Posted in Acute Hospitals, BBC News, Charitable Bodies, Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Non-Pharmacological Treatments, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Scotland, Systematic Reviews, UK, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Advances in Integrative Medicine, Association of RBD with Synucleinopathies, BBC Health News, Biomarkers, Braak Model, Braak Staging of Lewy Pathology in Parkinson’s Disease, Canada, CHCHD2, CIND-PD: Cognitive Impairment in Parkinson's Disease, Clinical Symptoms and Time Course of Parkinson’s Disease Progression, Complications of Dopaminergic Therapies for Parkinson’s Disease, Deep Brain Stimulation (DBS), Dementia in Parkinson's Disease, Department of Human Protein Sciences: Geneva University Hospitals, Department of Neurology: Geneva University Hospitals, DNAJC13, Dopamine, Dopamine Replacement Therapy (DRT), Dreaming in Dementia: REM Sleep Behaviour Disorder and Synucleinopathy, Drug Treatments for Parkinson’s Disease, Early Parkinson Disease, Edmond J Safra Program in Parkinson’s Disease: Toronto Western Hospital, EIF4G1, Faculty of Medicine: Geneva University Hospitals, Falls in Parkinson's Disease, Genetics of Parkinson's Disease, Geneva University Hospitals, Institute of Neurological Sciences in Glasgow, α-Synuclein, α-Synuclein Aggregation, Lancet, Lewy Body Parkinson Disease, LRRK2, LRRK2: Leucine-Rich Repeat Kinase 2 Gene, Monogenic Forms of Parkinson’s Disease (By Gene), Morton and Gloria Shulman Movement Disorders Clinic: Toronto Western Hospital, National Deep Brain Stimulation Service for Scotland, National Service in Scotland: NHS DBS Centres in Scotland, National Specialist Services Committee (Scotland), Neuroproteomics Group: Geneva University Hospitals, NHS DBS Centres in England, Non-Motor Fluctuations in Parkinson's Disease, Parkin (PARK2), Parkinson's Awareness Week, Parkinson’s Awareness Week (2015), Parkinson’s Disease Awareness Week (2015), Parkinson’s Disease Dementia, Parkinson’s Disease Diagnosis, Parkinson’s Disease Pathogenesis, Parkinson’s UK, Parkinson’s UK (Parkinsons Disease Society), Parkinson’s-Like Symptoms, Parkinsonian Symptoms, Parkinsonism, PDD: Parkinson's Disease with Dementia, Prion Diseases, Prion Protein, Proteomic Profiling of Parkinson's Disease-Relevant Brain Regions, Proteomics, Rapid Eye Movement (REM) Sleep Behaviour Disorder, Rapid Eye Movement (REM) Sleep Disorder, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, SNCA, SNCA: α-Synuclein Gene, Switzerland, Synucleinopathies, Synucleinopathy, Toronto Western Hospital, Translational Proteomics, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, University Medical Center: Geneva University Hospitals, University of Toronto, VPS35
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Risks of Variant Creutzfeldt-Jakob Disease: UK Blood Safety (Department of Health)
Summary This document presents the Government’s response to the Science and Technology Select Committee’s “After the Storm?” report on blood safety. It sets out the government’s commitment to evidence-based and cost effective ways to reduce risks of infection from blood transfusions, … Continue reading
Posted in Acute Hospitals, Community Care, Department of Health, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, National, NHS, Non-Pharmacological Treatments, Patient Care Pathway, Quick Insights, Standards, UK
Tagged Abnormal Proteins (Prions), Advisory Committee on Dangerous Pathogens, Advisory Committee on Dangerous Pathogens (ACDP), Advisory Committee on Dangerous Pathogens (ACDP) Transmissible Spongiform Encephalopathy (TSE) Sub Group, Advisory Committee on the Safety of Blood, Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO), After the Storm?, Behavioural Deferrals for Potential Blood Donors, Blood Organ and Tissue Donation, Blood Safety, Blood Transfusions, Bovine Spongiform Encephalopathy (BSE), CJD, CJD Resource Centre Oversight Committee, CJD Risk Management, CJD Surveillance, Contaminated Surgical Instruments, Creutzfeldt-Jakob Disease (CJD), Creuzfeldt Jacob Disease (CJD), Decontamination of Surgical Instruments, Donor Blood, DuPont’s Rely+On Prion Inactivator, Enhanced Surveillance: At Risk Individuals, Epidemiology, Epidemiology and Statistics, Haematology, Haemovigilance, House of Commons, House of Commons Science and Technology Committee, Infection and Infectious Diseases, Joint United Kingdom Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee (JPAC), Mad Cow Disease, Medical Instruments, Medical Procedures, Medicines and Healthcare Products Regulatory Agency (MHRA), Misfolded Prion Protein (PrP), MRC Prion Unit, MRC Prion Unit Blood Test, National CJD Research and Surveillance Unit (NCJDRSU), National Expert Panel on New and Emerging Infections, National Institute of Biological Standards and Controls (NIBSC), NCJDRSU: National CJD Research and Surveillance Unit, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS Blood and Transplant (NHSBT), Novel Pathogens, Parliament, Pathogens, PHE: Public Health England, Population-Level Risk Assessment, Prevalence of CJD, Prion Diseases, Prion Filtration, Prion Inactivation, ProMetic’s P-Capt Prion Filter, Public Health, Public Health England (PHE), Public Health Surveillance, Rapid Review Panel (RRP), Science and Technology Committee (House of Commons), Scientific Advisory Committee (SAC), Scottish National Blood Transfusion Service (SNBTS), Serious Hazards of Transfusion (SHOT), Spongiform Encephalopathy Advisory Committee (SEAC), Standing Advisory Committee for Transfusion Transmitted Infections, Surgical Transmission of Prions, Surveillance, Tissues and Organs (SaBTO), Transfusion-Transmitted Infection, UK Blood Safety, UK Blood Services, UK Blood Services Joint Professional Advisory Committee, UK Blood Supply, UK Parliament, United Kingdom Haemophilia Centre Doctors’ Organisation (UKHCDO), Variant CJD and Blood, Variant Creutzfeldt-Jakob Disease, vCJD Blood Testing, vCJD Carriers in UK, vCJD Clinical Governance Advisory Group, vCJD Infection
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