Tag Archives: Protein Misfolding

The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)

Summary An experimental drug for the treatment of Huntington’s Disease shows early signs of being able to lower the level of misfolded proteins (safely) in the brains of patients, thereby having the potential to slow or halt the progression of … Continue reading

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Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading

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Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading

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Urine Test for Creutzfeldt-Jakob Disease (CJD)? (BBC News / MRC / JAMA Neurology / NEJM)

Summary It may one day be possible to use a non-invasive diagnostic urine test to discover whether or not patients have sporadic Creutzfeldt-Jakob Disease (sCJD). Full Text Link Reference A urine test for Creutzfeldt-Jakob Disease may be possible. London: Medical … Continue reading

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Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)

Summary Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain. “ …those regions of the brain in which tissues … Continue reading

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Funding Initiative (JPco-fuND) for International Dementia Research (MRC)

Summary The EU Joint Programme for Neurodegenerative Disease Research (JPND) has announced €35 million (£25.7 million) funding for research into neurodegenerative diseases. Nine of the 21 research projects involved will benefit UK research teams; these will receive MRC funds through … Continue reading

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Giant Steps: Re-Tracing the Development of a Promising Research Approach

Summary Following the announcement earlier this week of a probable (if still early-stage) historic breakthrough in finding a potential approach to preventing neurodegeneration across Alzheimer’s, Parkinson’s and Huntington’s Diseases, readers may be interested in viewing the publication history of research … Continue reading

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