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Tag Archives: Protein Plaques
Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)
Summary Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain. “ …those regions of the brain in which tissues … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Tau), Aβ Accumulation, Aβ Seeds, Aβ-Plaques, Allen Brain Atlas, Allen Brain Atlas: 3-D Digital Images of Gene Expression, Amyloid and Tau Imaging, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Behind the Headlines, Braak Staging, Braak Staging of Alzheimer’s Disease, Department of Chemistry: University of Cambridge, Department of Molecular Biosciences: Northwestern University, Histopathological Staging of Alzheimer's Disease, Immune System, Immune System and Neurodegenerative Diseases, Levels of Genes Associated with Inflammation Mapped to Brain Areas, Mapping Brain Areas Affected in Early-Stage Alzheimer's Disease, Mapping Brain Areas Genetically Primed For Protein Overgrowth, Mapping Brain Areas Showing First Signs of Alzheimer's Disease, Mapping Brain Areas Susceptible to Protein Growth Due to Levels of Protein Expression, Mapping Brain Areas Vulnerable to Protein Overgrowth, Mapping Brain Areas: Allen Brain Atlas, Neurofibrillary Tangles, Northwestern University (USA), Pathological Staging, Patterns in the Development of Alzheimer’s Disease, Protein Aggregation, Protein Homeostasis, Protein Misfolding, Protein Overgrowth, Protein Plaques, Protein Seeds (Amyloid), Science Advances, Tau Aggregation, Tau Tangles, Tissue-Specific Progression of Alzheimer's Disease, University of Cambridge, USA, Vulnerability Patterns for Alzheimer's Disease
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EPPS Clears Amyloid Plaques in Mice: Alzheimer’s Disease Potentially Reversible? (BBC News / NHS Choices / Nature Communications)
Summary Korean researchers have identified a chemical (EPPS) which appears to be capable of clearing amyloid plaques from the brains of transgenic mice. The amount of plaques present in these animals’ brains was reduced in treated mice, and the treated … Continue reading
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), Aβ-Plaques, Amyloid, Amyloid Beta Protein, Amyloid Hypothesis, Amyloid Precursor Protein (APP), Amyloid Proteins, Amyloid-Beta Clearance in APP Transgenic Mice, Amyloid-β Protein, Amyloidopathy, Anti-Amyloid Therapies, APP/PS1 Transgenic Mouse Model, BBC Health News, Behind the Headlines, Beta-Amyloid Plaques, Biological Chemistry Program: Korea University of Science and Technology (UST), Brain Science Institute: Korea Institute of Science and Technology (KIST), Center for Neuro-Medicine: Korea Institute of Science and Technology (KIST), Center for Neuroscience: Korea Institute of Science and Technology (KIST), EPPS Removal of Ab Plaques and Oligomers in APP/PS1 Mice, EPPS Rescues Hippocampus-Dependent Cognitive Deficits (in Mice), GoshenBiotech Inc, Korea, Korea Institute of Science and Technology, Korea Institute of Science and Technology (KIST), Korea University of Science and Technology (UST), Mice, Nature Communications, Neurodegeneration, Neurodegenerative Research, Protein Plaques, Republic of Korea, Research Institute: GoshenBiotech Inc., Transgenic Mice
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Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)
Summary Recent research into transgenic mice (and early, small-scale investigations with people) suggests that the anti-depressant citalopram could be used to slow the onset of Alzheimer’s Disease. This work in the United States appears to show that citalopram may counteract … Continue reading
Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, International, Quick Insights, Universal Interest
Tagged Amyloid Beta, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Antidepressants, Antidepressive Agents, Avid Radiopharmaceuticals, BBC Health News, Beta-Amyloid, Beta-Amyloid Plaques, Citalopram, CSF Aβ Production, Department of Neurology: Washington University, Department of Neurology: Washington University School of Medicine, Eli Lilly Inc., Genetically Engineered Mice, Hope Center for Neurological Disorders: Washington University, Hope Center for Neurological Disorders: Washington University School of Medicine, β-amyloid, Knight Alzheimer's Disease Research Center, Knight Alzheimer's Disease Research Center: Washington University Medical Center, Mice, Mouse Model of Alzheimer's Disease, Off-Label Drug Repurposing Trials, Pittsburgh Compound B (PIB), PNAS, Positron Emission Tomography (PET), Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Proceedings of the National Academy of Sciences (PNAS), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Protein Plaques, Repurposing of Drugs, Science Translational Medicine, Selective Serotonin Reuptake Inhibitors (SSRIs), SSRIs: Selective Serotonin Reuptake Inhibitors, Transgenic Mice, United States, University of Pennsylvania, University of Washington, USA, Washington University Medical Center, Washington University School of Medicine
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