Tag Archives: Science Translational Medicine

Further Research Supports Speculation of Link Between Gut and Parkinson’s Disease (BBC News / Science Translational Medicine)

Summary Further evidence implying that the gut may be involved in the development of Parkinson’s Disease has emerged. Toxic (alpha-synuclein) proteins associated with Parkinson’s Disease tend to accumulate in the appendix, and it seems that people who have had their … Continue reading

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Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

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Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)

Summary Recent research into transgenic mice (and early, small-scale investigations with people) suggests that the anti-depressant citalopram could be used to slow the onset of Alzheimer’s Disease. This work in the United States appears to show that citalopram may counteract … Continue reading

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BBC’s Day of the Body Clock (BBC News / PNAS / Science / NHS Choices / Lancet)

Summary Cancer, heart disease, type-2 diabetes, infections and obesity have been linked to insufficient and / or disrupted sleep. Full Text Link Reference Gallagher, J. (2014). ‘Arrogance’ of ignoring need for sleep. London: BBC Health News, May 12th 2014. Irregular … Continue reading

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Giant Steps: Re-Tracing the Development of a Promising Research Approach

Summary Following the announcement earlier this week of a probable (if still early-stage) historic breakthrough in finding a potential approach to preventing neurodegeneration across Alzheimer’s, Parkinson’s and Huntington’s Diseases, readers may be interested in viewing the publication history of research … Continue reading

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Breakthrough Discovery of Chemical to Prevent Neurodegeneration Across Alzheimer’s, Parkinson’s and Huntington’s Diseases (BBC News / NHS Choices / Science Translational Medicine)

Summary A chemical substance has been identified which shows signs of being able to halt a range of neurodegenerative diseases in mice. This may well be a historic event in research, although more research is required; the development of drug treatments … Continue reading

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Protein Involved in Old-Age Memory Loss? (BBC News / Science Translational Medicine)

Summary US researchers working with the donated brains of eight dead people and also performing experiments on mice have discovered indications that low levels of a protein in the brain (called RbAp48) may be responsible for memory loss. This discovery might, one day, lead to treatments … Continue reading

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