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Tag Archives: Solanezumab Trials
Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)
Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading
Posted in BBC News, For Researchers (mostly), In the News, International, Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Alzheimer’s and Dementia (Journal), Alzheimer’s Disease Clinical Trials, Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Avid Radiopharmaceuticals (Philadelphia), BBC Health News, Big Pharma, Clearance of Amyloid Beta Protein, Drug Trials, Drug Trials Failure Rate, Eli Lilly, Eli Lilly and Company (Indianapolis), EXPEDITION Studies, Intervention Trials, β-amyloid, LZAM, LZAN, Mild Alzheimer’s Disease, Misfolded Proteins, Neurofibrillary Tangles, Neuronal Loss, Progression of Mild Cognitive Impairment to Dementia, Progression to Alzheimer's Disease, Reasons for Termination of Trials, Solanezumab (Eli Lilly), Solanezumab EXPEDITION Trials, Solanezumab for Mild-to-Moderate Alzheimer’s Disease, Solanezumab Trials, Solanezumab: Humanised Monoclonal Antibody, United States, USA
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Solanezumab Trials Results for Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)
Summary Solanezumab is a monoclonal antibody which binds soluble amyloid preferentially and had shown some promise of promoting better clearance of amyloid-beta from the brain in pre-clinical studies. Two placebo controlled trials (EXPEDITION 1 and EXPEDITION 2) of 1012 and … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), International, Pharmacological Treatments
Tagged Alzheimer's Disease and Memory Disorders Center: Baylor College of Medicine (Houston), Alzheimer's Disease Assessment Scale (ADAS-Cog11), Alzheimer's Disease Cooperative Study Steering Committee, Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL), Alzheimer's Disease Cooperative Study: University of California at San Diego, Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Baylor College of Medicine, Beta-Amyloid, Beta-Amyloid Plaques, Center for Human Experimental Therapeutics: University of Rochester Medical Center, Centre Hospitalier Universitaire Toulouse, Clinical Trials Number: NCT00904683, Clinical Trials Number: NCT00905372, Department of Neuropathology: University of Tokyo, Eli Lilly, Gerontopole: Unité Mixte de Recherche, Gliosis, Indiana Alzheimer Disease Center: Indiana University, Indiana University, β-amyloid, Neurofibrillary Tangles, Neuronal Loss, New England Journal of Medicine, Solanezumab for Mild-to-Moderate Alzheimer’s Disease, Solanezumab Study Group, Solanezumab Trials, Solanezumab: Humanised Monoclonal Antibody, University of California at San Diego, University of Pennsylvania, University of Rochester Medical Center
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