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Tag Archives: Structural MRI
Middle-Age Obesity and Accelerated Brain Ageing (BBC News / Neurobiology of Aging)
Summary Researchers at the Cambridge Centre for Ageing and Neuroscience, examining the loss of white matter in the brains of lean and overweight persons, have discovered that the brains of overweight people tend to resemble those of leaner people who … Continue reading →
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, UK, Universal Interest
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Tagged Accelerated Brain Ageing, BBC Health News, Behavioural Risk Factors, Brain Ageing, Brain Mapping Unit: University of Cambridge, Cambridge, Cambridge Center for Ageing and Neuroscience (Cam-CAN), Cambridge Centre for Ageing and Neuroscience, Cambridge Centre for Ageing and Neuroscience (Cam-CAN), Cerebral White Matter Changes, Cerebral White Matter Volume in Overweight and Obese Individuals, Compromised White Matter Integrity and Obesity, Dementia Risk Factors, Department of Clinical Biochemistry: University of Cambridge, Department of Psychiatry: University of Cambridge, Effects of Weight Diet and Exercise on Brain and Memory, Epidemiology, Institute of Metabolic Sciences: University of Cambridge, Institute of Public Health: University of Cambridge, Lifestyle Factors, Lifestyle Risk Factors, Magnetic Resonance Imaging (MRI), Middle-Age Obesity, Modifiable Risk Factors, MRC Cognition and Brain Sciences Unit (Cambridge), MRI Scans, Neurobiology of Aging (Journal), Obesity, Obesity and Risk of Neurodegeneration, Obesity is the New Smoking, Obesity Risk Factor, Obesity Time-Bomb, Risk Factors, Structural Brain Ageing, Structural MRI, Unhealthy Behaviours, Unhealthy Lifestyles, United States, University of Cambridge, USA, Voxel-Based Morphometry (VBM), Wellcome Trust, Wellcome Trust Medical Research Council Institute of Metabolic Science at Cambridge University, White Matter Structural Integrity, White Matter Volume, Yale School of Medicine: Yale University, Yale University
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Leg Power Helps Sustain Cognitive Ability? (BBC News / Gerontology)
Summary A King’s College London study involving over 300 twins indicates that older women with stronger legs tend to perform better with respect to brain ageing. Full Text Link Reference Fit legs equals fit brain, study suggests. London: BBC Health … Continue reading →
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Quick Insights, Statistics, UK, Universal Interest
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Tagged Active Ageing, Active and Healthy Ageing, Active Lifestyle, Activity, Ageing, Ageing Well, BBC Health News, Benefits of Activity, BioResource Clinical Research Facility and Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust, Brain Ageing, Cambridge Neuropsychological Test Automated Battery (CANTAB), Cognitive Ageing, Department of Twin Research and Genetic Epidemiology: King’s College London, Discordant Twin Approach, Environmental and Lifestyle Factors, European Community’s Seventh Framework Programme, Functional MRI, Gerontology, Healthy Ageing, Healthy Cognitive Ageing, Healthy Lifestyles, Kings College London, Leg Extensor Power Rig, Leg Power, Leg Power and Preservation of Cognitive Ability, Lifestyle Factors, Monozygotic Twins, Muscular Fitness: LEP, National Institute for Health Research (NIHR), Neuroprotective Lifestyles, Older Female Twins, Physical Activity, Physical Exercise, Physical Performance, Postmenopausal Women, Structural MRI, Twin Studies, Wellcome Trust
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Blood Test Potentially Able to Predict Alzheimer’s Disease Onset (BBC News / Alzheimer’s & Dementia)
Summary Research published in the Alzheimer’s & Dementia: the Journal of the Alzheimer’s Association may indicate a significant step forwards in developing a blood test which could be able to predict the risk of Alzheimer’s Disease onset with 87% accuracy. Research … Continue reading →
Posted in BBC News, Charitable Bodies, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, UK, Universal Interest
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Tagged A2M (Protein), A2M: Alpha-2-Macroglobulin, Ab40 (Protein), AddNeuroMed Consortium, Alzheimer's Association, Alzheimer's Disease: Diagnosis, Alzheimer’s & Dementia: the Journal of the Alzheimer's Association, Alzheimer’s Early Screening, Amyloid-β (Aβ), ApoA1 (Protein), ApoE (Protein), Aristotle University, B2M (Protein), BBC Health News, BDNF (Protein), Big Pharma, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Tests, Blood-Based Biomarkers, Brain Imaging, Brain Research, Case Finding, CathepsinD (Protein), Ceruloplasmin (Protein), CFH (Protein), CFH: Complement Factor H, Clinical Dementia Rating Scale, Clinical Trials and Treatment Assessments, Clusterin, Cognitive Impairment, Conversion to Dementia From Prodromal Disease, CRP: C-Reactive Protein, Dementia Case Finding, Dementia Consortium, Dementia Diagnosis, Dementia Innovation, Dementia Research, Dementia Screening, Department of Neurobiology Care Sciences and Society: Karolinska Institutet, Department of Neuroimaging Genetics: QIMR Berghofer Medical Research Institute, Department of Old Age Psychiatry: King's College London, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostic Imaging, Diagnostics, Disease-Modifying Therapies for Dementia, Drug Development for Alzheimer's Disease, Drug Discovery Programme, Drug Identification, Drug Trials Failure Rate, Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Differential Diagnosis, Early Screening, EMD Millipore Corporation, Exeter University, George Washington University School of Medicine and Health Sciences, GlaxoSmithKline Medicines Research Centre, Global Clinical Development Fund, INSERM: University of Toulouse, Kings College London, Kuopio University Hospital, Lund University, Lund University (Sweden), Magnetic Resonance Imaging (MRI), McGill Centre for Studies in Aging, MCI: Mild Cognitive Impairment, Mild Cognitive Impairment (MCI), MMSE: Mini-Mental State Examination, MRI Scans, NCAM (Protein), Non-Invasive Biomarkers, NSE (Protein), NSE: Neuron-Specific Enolase, p-tau217, Pharmaceutical Industry, Plasma Aβ Peptides, Plasma Proteins, Prealbumin (Protein), Preclinical Alzheimer's Disease, Preclinical Biomarkers in Alzheimer's Disease, Predictive Ability (of Tests), Prodromal Alzheimer's Disease, Proteome Sciences plc, QIMR Berghofer Medical Research Institute, RANTES (Protein), RANTES: Regulated on Activation Normal T Cell Expressed and Secreted, Rapid Screening, Recruitment Onto Dementia Clinical Trials, SAP (Protein), SAP: Serum Amyloid Protein, Screening, Screening for Dementia, Structural MRI, Translational Research, TTR: Transthyretin, University of Eastern Finland, University of Exeter Medical School: Exeter University, University of Oxford, University of Perugia, University of Toulouse, VCAM1 (Protein), Washington University School of Medicine
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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)
Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews
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Tagged Aβ, Aβopathy, Aβopathy Acceleration of Antecedent Tauopathy, Alzheimer's Disease: Hypothetical Model(s), Alzheimer’s Disease Biomarkers, Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Apolipoprotein E, Beta-Amyloid, Beta-Amyloid Plaques, Biomarker Assessments in Alzheimer’s Disease, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Brain Beta Amyloid Load, Brain Deposition of Amyloid, Cerebrospinal Fluid, Cerebrospinal Fluid (CSF), Clearance of Amyloid Beta Protein, Cognitive Impairment, Cognitive Response to Progression of Pathophysiology, CSF Aβ, CSF Biomarkers, CSF Tau, Department of Biomedical Statistics and Informatics: Mayo Clinic (Rochester), Department of Neurology: Mayo Clinic (Rochester), Department of Neurosciences: University of California-San Diego, Department of Radiology: Mayo Clinic (Rochester), Early Detection of Alzheimer’s Disease, Early Diagnosis of Alzheimer's Disease, Fluid and Imaging Biomarkers, Indexing Subjects by Time, Inter-Subject Variability, β-amyloid, β-Amyloid 1-42 (Aβ42), Lancet Neurology, Longitudinal Population Studies of Diagnostic Biomarkers, Mayo Clinic: Rochester, Metabolic FDG-PET, Molecular PIB-PET, Neurodegeneration, Neurofibrillary Tangles (NFTs), Neuroimaging, Neuroimaging of Dementia, Neuroimaging Tools, Ordering of Alzheimer's Disease Biomarkers, Pathophysiological Processes in Alzheimer’s Disease, Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Proteinopathies, School of Public Health and Helen Wills Neuroscience Institute: University of California, Sequence of Pathological Events in Alzheimer’s Disease, Structural MRI, Tau, Tau Pathology, Tau Protein, Temporal Evolution of Alzheimer’s Disease Biomarkers, Temporal Ordering of Biomarkers, Test to Detect Early-Stage Alzheimer’s Disease, United States, University of California, University of Pathology and Laboratory Medicine and Institute on Aging: University of Pennsylvania, University of Pennsylvania School of Medicine, USA, Veterans Affairs and University of California
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Brain Scans Distinguish Between Dementia Types (BBC News / Neurology)
Summary Scientists at the University of Pennsylvania believe they may have discovered how to distinguish between different types of dementia without the need for invasive lumbar puncture tests to obtain cerebrospinal fluid (csf). Alzheimer’s and frontotemporal dementia share similar features and symptoms and can … Continue reading →
Posted in BBC News, Diagnosis, For Doctors (mostly), For Researchers (mostly), In the News, International, Quick Insights, Systematic Reviews, Universal Interest
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Tagged Alzheimer Precision Medicine (APM) Paris, Amyloid Beta, Amyloid Beta Protein, Assessment and Diagnosis, Azienda sanitaria universitaria integrata di Udine, Beta-Amyloid, Carlo Besta Foundation and Neurological Institute (Milan), Cerebrospinal Fluid (CSF), Cerebrospinal Fluid (CSF) Biomarkers, Cochrane Database of Systematic Reviews, CSF, CSF Aβ, CSF Tau, CSF tt/Aβ Ratios, Department of Clinical and Experimental Medicine: University of Pisa, Department of Neurosciences Psychology Drug Research and Child Health (NEUROFARBA), Diagnosis and Assessment, Diagnosis and Screening: Frontotemporal Dementia, Diagnosis of Alzheimer's Disease, Diagnostic Errors, Diagnostic Markers, Dipartimento di Medicina Interna: Azienda sanitaria universitaria integrata di Udine, Dipartimento di Scienze Biomediche e Cliniche "L. Sacco": Università degli Studi di Milano, Early Differential Diagnosis, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Fondazione IRCCS Ca' Granda (Milan), France, Frontotemporal Dementia, Frontotemporal Lobar Degeneration (FTLD), FTLD: Frontotemporal Lobar Degeneration, Italy, β-amyloid, Magnetic Resonance Imaging (MRI), MRI, MRI Scans, Neuroepidemiology Unit: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Ospedale Maggiore Policlinico, Pitié-Salpêtrière Hospital, Sorbonne University, Structural MRI, Switzerland, Systematic Reviews and Meta-Analyses, Tau, Tau Protein, Total Tau (T-tau), Universita' degli studi di Milano, University Hospitals and University of Geneva, University of Florence, University of Pennsylvania, University of Pisa, UOC Pronto Soccorso e Medicina D'Urgenza: Università degli Studi di Milano
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Biomarkers Predicting Cognitive Decline and Alzheimer’s Disease
[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 2 Issue 3, October 2011]. Summary The process of developing Alzheimer’s Disease is known to begin years before the formal diagnosis of clinical dementia. The concept … Continue reading →
Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), International, Systematic Reviews, Universal Interest
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Tagged ASYMAD, Asymptomatic Alzheimer’s Disease, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Cerebrospinal Fluid, Cerebrospinal Fluid (CSF), CSF Aβ, CSF Tau, Early Diagnosis of Alzheimer's Disease, Fluid and Imaging Biomarkers, Metabolic FDG-PET, Molecular PIB-PET, Preclinical Alzheimer's Disease, Structural MRI
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