Tag Archives: Substantia Nigra

Medicine to Ease Enlarged Prostate Re-Purposed for Parkinson’s Disease? (BBC News / Journal of Clinical Investigation)

Summary Terazosin, a drug developed originally to treat benign prostatic hyperplasia (BPH), may slow the progression of Parkinson’s Disease. It is thought that Terazosin may help by activating an enzyme (PGK1) which prevents cell death in the relevant brain regions. … Continue reading

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Parkinson’s Disease Awareness Week 2017 (BBC News / Nature Biotechnology / Parkinson’s UK)

Summary Researchers hope one day to be able to replace the damaged dopamine-producing neurons at the root-cause of by Parkinson’s Disease by injecting new replacement brain cells, possibly derived from re-programmed astrocytes. Full Text Link Reference Brain cell therapy ‘promising’ … Continue reading

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Earlier Diagnosis of Parkinson’s Disease? (BBC News / Acta Neuropathologica Communications)

Summary Recent animal research, using rats, suggests there may be a cheap and non-invasive method of detecting Parkinson’s Disease early – before symptoms develop – by identifying changes in the eye. The same study also offers early evidence for a … Continue reading

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REM Sleep Behaviour Disorder: an Early Window on Neurodegeneration (Tremor and Other Hyperkinetic Movements)

Summary Rapid eye movement (REM) sleep behaviour disorder (RBD), involving loss of the normal atonia during REM sleep and causing patients to “act out” their dreams, offers several promising research opportunities. Patients with RBD are at high risk of developing synuclein-mediated … Continue reading

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Review and Timeline of Lewy Pathology (Nature Reviews. Neurology)

Summary This article traces developments in Lewy pathology since Fritz Heinrich Lewy’s 1912 discovery of the protein aggregates underlying Parkinson Disease (PD) in brain regions other than the substantia nigra. It was Konstantin Nikolaevich Tretiakoff who in 1919 found similar … Continue reading

Posted in For Doctors (mostly), For Researchers (mostly), International, Parkinson's Disease, Quick Insights, Systematic Reviews, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment