Tag Archives: Transgenic Mice

Further Evidence on the Association Between Poor Oral Health and the Risk of Developing Alzheimer’s Disease. New Possibilities for Treatment? (BBC News / Science Advances)

Summary Analysis of brain tissue, spinal fluid, and saliva from persons with Alzheimer’s Disease indicates the presence of Porphyromonas gingivalis (the bacterium associated with chronic gum disease) in the brain and central nervous system. Animal research using mice indicates that … Continue reading

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Animal Study Explores the Potential of a Novel Diabetes Drug for Reducing Memory Loss in Dementia – In Mice (NHS Choices / Brain Research)

Summary Early animal research indicates that a new drug designed for the future treatment of diabetes may (one day) have an alternative re-use for reducing the memory-loss symptoms of Alzheimer’s Disease. Mice given a modified version of a so-called triple … Continue reading

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Flashing Light: A Potential Alternative to Drug Treatment to Prevent Amyloid Plaque Formation? (BBC News / Nature)

Summary Animal research on genetically modified mice suggests that a specialised form of flashing light therapy might help slow the progression of Alzheimer’s Disease. It appears that shining a strobe light, flashing at a rate of 40Hz, into rodents’ eyes … Continue reading

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More on the Underlying Relationships Between Alzheimer’s Disease and Diabetes? (NHS Choices / Diabetologia)

Summary Further evidence has emerged concerning shared genetic linkages and biological processes underlying potential links between Alzheimer’s Disease and Type 2 Diabetes. Full Text Link Reference Diabetes drugs may be useful for Alzheimer’s, mice research finds. London: NHS Choices Behind … Continue reading

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Memories Lost in Alzheimer’s Disease: Potentially Retrievable? (NHS Choices / Nature)

Summary Research on transgenic mice suggests that memories are not destroyed irretrievably by Alzheimer’s Disease; there appears to be problems recalling these lost memories. Lost memories may be retrievable, under experimental conditions, by exposing “Engram Cells” with bright blue light … Continue reading

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Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Summary Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, … Continue reading

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EPPS Clears Amyloid Plaques in Mice: Alzheimer’s Disease Potentially Reversible? (BBC News / NHS Choices / Nature Communications)

Summary Korean researchers have identified a chemical (EPPS) which appears to be capable of clearing amyloid plaques from the brains of transgenic mice. The amount of plaques present in these animals’ brains was reduced in treated mice, and the treated … Continue reading

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